scholarly journals Design and Fabrication of Integrated Microchannel and Peristaltic Micropump System for Inertial Particle Separation

2018 ◽  
Vol 153 ◽  
pp. 08002
Author(s):  
Utku Sönmez ◽  
Muhammed Bekin ◽  
Levent Trabzon
Keyword(s):  
Flow Rate ◽  
Particle Separation ◽  
Stepper Motor ◽  
Inertial Particle ◽  
External Force Field ◽  
Micro Total Analysis Systems ◽  
Peristaltic Micropump ◽  
3D Printed ◽  
Controlled Flow ◽  
Compact Design

In particle separation applications, conventional syringe pumps are widely used to supply fluid flow into microchannels at a controlled flow rate. However, their bulky structures lack the development of compact particle separation systems which is essential for all LoC (Lab on a Chip) systems. In this study, we designed and fabricated a peristaltic micropump which can be integrated into an inertial particle separation microchannel at the same layer with a compact design. Since inertial particle separation can be done without a need for an external force field, we aimed to develop a μTAS (Micro Total Analysis Systems) system which is able to realize particle separation in an integrated micropump-microchannel system. The circular micropump channel made of two PDMS layers and its width is optimized. The 3D-Printed micropump is actuated by a stepper motor, and the rate of pumped fluid is monitored by an LCD screen connected and programmed to system according to the system parameters. Micropump has a theoretical capacity of supplying particle carrying fluid at the flow rate of 25.47 ml/min when the stepper motor is rotated at 330 rpm.

Hydraulic model of a water cooling system in a chemical plant

1988 ◽  
Vol 53 (4) ◽  
pp. 788-806
Author(s):  
Miloslav Hošťálek ◽  
Jiří Výborný ◽  
František Madron
Keyword(s):  
Flow Rate ◽  
Cooling System ◽  
Cooling Water ◽  
Graph Algorithm ◽  
Automatic Generation ◽  
Hydraulic Calculation ◽  
Return Flow ◽  
Flow Rates ◽  
Pressure Losses ◽  
Controlled Flow

Steady state hydraulic calculation has been described of an extensive pipeline network based on a new graph algorithm for setting up and decomposition of balance equations of the model. The parameters of the model are characteristics of individual sections of the network (pumps, pipes, and heat exchangers with armatures). In case of sections with controlled flow rate (variable characteristic), or sections with measured flow rate, the flow rates are direct inputs. The interactions of the network with the surroundings are accounted for by appropriate sources and sinks of individual nodes. The result of the calculation is the knowledge of all flow rates and pressure losses in the network. Automatic generation of the model equations utilizes an efficient (vector) fixing of the network topology and predominantly logical, not numerical operations based on the graph theory. The calculation proper utilizes a modification of the model by the method of linearization of characteristics, while the properties of the modified set of equations permit further decrease of the requirements on the computer. The described approach is suitable for the solution of practical problems even on lower category personal computers. The calculations are illustrated on an example of a simple network with uncontrolled and controlled flow rates of cooling water while one of the sections of the network is also a gravitational return flow of the cooling water.

Electrostatic Sensor for Real–Time Mass Flow Rate Measurement of Particle Conveying in Pneumatic Pipeline

2012 ◽  
Author(s):  
Mohd. Fua’ad Rahmat ◽  
Wee Lee Yaw
Keyword(s):  
Real Time ◽  
Mass Flow Rate ◽  
Mass Flow ◽  
Flow Rate ◽  
Cross Correlation ◽  
High Accuracy ◽  
Industrial Processes ◽  
Rate Measurement ◽  
Flow Rate Measurement ◽  
Controlled Flow

This paper discussed the electrostatic sensors that have been constructed for real–time mass flow rate measurement of particle conveying in a Pneumatic pipeline. Many industrial processes require continuous, smooth, and consistent delivery of solids materials with a high accuracy of controlled flow rate. This requirement can only be achieved by installing a proper measurement system. Electrostatic sensor offers the most inexpensive and simplest means of measuring solids flows in pipes. Key words: Electrostatic sensor, cross-correlation, peripheral velocity

Relationship between flow rate and NO production in postnatal mesenteric arteries

2001 ◽  
Vol 280 (1) ◽  
pp. G43-G50 ◽  
Author(s):  
Kristina M. Reber ◽  
Gennifer M. Mager ◽  
Charles E. Miller ◽  
Philip T. Nowicki
Keyword(s):  
Flow Rate ◽  
Kinase Inhibitor ◽  
Age Groups ◽  
Mesenteric Arteries ◽  
No Production ◽  
Herbimycin A ◽  
Wide Range ◽  
Intracellular Ca ◽  
Controlled Flow

We studied mesenteric arterial arcades from 3- and 35-day-old swine to determine the relationship between perfusate flow rate and release of nitric oxide (NO) into mesenteric effluent. Mesenteric arterial arcades were perfused under controlled-flow conditions with a peristaltic pump using warm oxygenated Krebs buffer. Basal rates of NO production were 43.6 ± 4.2 vs. 12.1 ± 2.5 nmol/min in 3- vs. 35-day-old mesentery during perfusion at in vivo flow rates (9 vs. 20 ml/min, respectively). Rate of NO production was directly related to flow rate over a wide range of flows (5–40 ml/min) in 3- but not 35-day-old mesentery. Both age groups demonstrated a brisk, albeit brief, increase in NO production in response to infusion of NO-dependent vasodilator substance P (10−8 M/min). Tyrosine kinase inhibitor herbimycin A andl-arginine analog l-NMMA significantly attenuated flow-induced increase in NO production, and phosphatase inhibitor phenylarsine oxide increased magnitude of flow-induced increase in NO production in 3-day-olds. Removal of extracellular Ca2+ and depletion of intracellular Ca2+ stores (Ca2+-free Krebs with EGTA plus thapsigargin) had no effect on NO production in either group. Thus, basal rate of NO production is greater in mesenteric arterial arcades from 3- than from 35-day old swine, a direct relationship between flow rate and NO production rate is present in mesentery from 3- but not 35-day-olds, and phosphorylation events are necessary for this interaction to occur.

scholarly journals Construction of a comprehensive endovascular test bed for research and device development in mechanical thrombectomy in stroke

2020 ◽  
pp. 1-8 ◽  
Author(s):  
Adithya S. Reddy ◽  
Yang Liu ◽  
Joshua Cockrum ◽  
Daniel Gebrezgiabhier ◽  
Evan Davis ◽  
...  
Keyword(s):  
Flow Rate ◽  
Hydraulic System ◽  
Mechanical Thrombectomy ◽  
Low Cost ◽  
Quality Analysis ◽  
Test Bed ◽  
Vessel Occlusion ◽  
Physiological Flow ◽  
3D Printed ◽  
Device Interaction

OBJECTIVEThe development of new endovascular technologies and techniques for mechanical thrombectomy in stroke has greatly relied on benchtop simulators. This paper presents an affordable, versatile, and realistic benchtop simulation model for stroke.METHODSA test bed for embolic occlusion of cerebrovascular arteries and mechanical thrombectomy was developed with 3D-printed and commercially available cerebrovascular phantoms, a customized hydraulic system to generate physiological flow rate and pressure, and 2 types of embolus analogs (elastic and fragment-prone) capable of causing embolic occlusions under physiological flow.RESULTSThe test bed was highly versatile and allowed realistic, radiation-free mechanical thrombectomy for stroke due to large-vessel occlusion with rapid exchange of geometries and phantom types. Of the transparent cerebrovascular phantoms tested, the 3D-printed phantom was the easiest to manufacture, the glass model offered the best visibility of the interaction between embolus and thrombectomy device, and the flexible model most accurately mimicked the endovascular system during device navigation. None of the phantoms modeled branches smaller than 1 mm or perforating arteries, and none underwent realistic deformation or luminal collapse from device manipulation or vacuum. The hydraulic system created physiological flow rate and pressure leading to iatrogenic embolization during thrombectomy in all phantoms. Embolus analogs with known fabrication technique, structure, and tensile strength were introduced and consistently occluded the middle cerebral artery bifurcation under physiological flow, and their interaction with the device was accurately visualized.CONCLUSIONSThe test bed presented in this study is a low-cost, comprehensive, realistic, and versatile platform that enabled high-quality analysis of embolus–device interaction in multiple cerebrovascular phantoms and embolus analogs.

Elasto-inertial particle focusing in 3D-printed microchannels with unconventional cross sections

2019 ◽  
Vol 23 (3) ◽  
Author(s):  
Wenlai Tang ◽  
Ning Fan ◽  
Jiquan Yang ◽  
Zongan Li ◽  
Liya Zhu ◽  
...  
Keyword(s):  
Cross Sections ◽  
Inertial Particle ◽  
Particle Focusing ◽  
3D Printed

Fundamentals of elasto-inertial particle focusing in curved microfluidic channels

Lab on a Chip ◽  
2016 ◽  
Vol 16 (14) ◽  
pp. 2626-2635 ◽  
Author(s):  
Nan Xiang ◽  
Xinjie Zhang ◽  
Qing Dai ◽  
Jie Cheng ◽  
Ke Chen ◽  
...  
Keyword(s):  
Flow Rate ◽  
Process Model ◽  
Microfluidic Channels ◽  
Inertial Particle ◽  
Particle Focusing ◽  
Stage Process

We experimentally explore the elasto-inertial particle focusing in curved microfluidic channels and propose a six-stage process model illustrating the particle focusing with increasing flow rate.

scholarly journals Monitoring Infusion Pump Via Wireless (Occlusion part)

2020 ◽  
Vol 2 (1) ◽  
pp. 34-41
Author(s):  
Nisa'ul Sholihah ◽  
Abd Kholiq ◽  
Sumber Sumber
Keyword(s):  
Data Processing ◽  
Flow Rate ◽  
Medical Equipment ◽  
Infusion Pump ◽  
Minute Volume ◽  
Stepper Motor ◽  
Intravenous Fluids ◽  
Rate Data ◽  
Motor Controller ◽  
Is Design

Infuse pump is a medical equipment which is design to control and regulate the administration of intravenous fluids in the treatment.. This module uses the L298N motor driver as a stepper motor controller. The choice of the infuse pump setting is the volume setting from 100 ml to 500 ml and the speed setting of 30 ml / hour, 60 ml / hour, and 90 ml / hour. The author uses the Atmega 328 microcontroller as a droplet controller per minute, volume and speed. Occlusion in this device is in the detector of the droplets that are alerted in the presence of a sound buzzer. This tool is also equipped with monitoring volume, tpm and speed on a wireless-based PC using HC-11 as a transmission from module to PC. This tool is equipped with oclusion. The flow rate data processing in IDA from infusion got the highest error result at the setting of 30 ml / hour which was equal to 5.97%. the highest error for the calculation of droplets in the module is the setting of 30 ml / hour which is equal to 32% and manually at setting 60 which is 23%.

Single-Disk and Double-Disk Viscous Micropump

2004 ◽  
Author(s):  
Daniel B. Blanchard ◽  
Phillip M. Ligrani ◽  
Bruce K. Gale
Keyword(s):  
Flow Rate ◽  
Maximum Flow ◽  
Outer Diameter ◽  
Outlet Channel ◽  
Viscous Micropump ◽  
Pump Housing ◽  
Single Disk ◽  
Controlled Flow ◽  
Gap Height ◽  
Rhodamine Dye

The development and testing of two novel micropumps called the single-disk and double-disk viscous pumps are described. A single disk and the top pump housing, or two disks are separated by a small gap that forms a fluid passage. A wiper, that is the height of this gap, is placed between the two disks, or between the single disk and top pump housing, and extends from the outer diameter of the disk(s) to the center region of the disk(s). The movement of the disk(s) induces viscous stresses on the fluid that forces the fluid through the pump area above the single disk, or between the two disks. The wiper acts to “wipe” the fluid from the disk(s) toward the outlet channel. The fluid flow through the double-disk pump is visualized using a red Rhodamine dye that is injected into the fluid passage upstream of the pumping area. Experimental flow rate for the single-disk and double-disk pumps are obtained for a disk diameter of 2.381 mm, and a gap height of 103 μm. The maximum flow rates obtained are 0.74 ml/min and 2.1 ml/min for the single-disk and double-disk pumps, respectively, for a rotational speed of 5000 rpm. Advantages of the disk pumps include simplicity of design, planar structure, continuous flow, well controlled flow rate, and mixing characteristics.

A STUDY OF FLUID-MEMBRANE INTERACTIONS THAT LIMIT THE OUTPUT OF PERISTALTIC MICROPUMPS

2011 ◽  
Vol 11 (02) ◽  
pp. 325-336 ◽  
Author(s):  
CHAN YOUNG PARK ◽  
MAIYA SHUR ◽  
C. FORBES DEWEY
Keyword(s):  
Fluid Flow ◽  
Numerical Model ◽  
Flow Rate ◽  
Middle Layer ◽  
Bottom Layer ◽  
Experimental Models ◽  
Hydrodynamic Performance ◽  
Fluid Membrane ◽  
Peristaltic Micropump ◽  
Relationship Of

In many microfluidic devices, fluid flow is generated using micropumps like peristaltic micropumps. However the hydrodynamic performance of peristaltic micropumps has not been fully understood and furthermore the effect of dynamic interaction of pumping membrane and fluid flow has not been studied yet. To fill this gap, we studied the hydrodynamic performance of a peristaltic micropump using a numerical model incorporating the fluid-solid interactions. The model consisted of 3 layers; the top layer was the flow channel of 10 μm high, the middle layer was the 5~30 μm thick pumping membrane and the bottom layer was the 3 or 5 pumping chambers. By applying a pumping sequence at a frequency between 16~166 Hz, we calculated flow rate for at least 4 cycles and used the fourth or fifth cycle to evaluate the flow rate per a cycle. We found that the numerical model closely replicated the frequency vs. flow rate relationship of a peristaltic micropump as shown earlier in experimental models. We further found that the flow rate of a peristaltic micropump could be improved by increasing the number of pumping chambers or the thickness of pumping membrane.

Introduction of an Integrated Turbo-Electrical Machine

2017 ◽  
Author(s):  
Sebastian Schuster ◽  
Christian Kreischer ◽  
Dieter Brillert
Keyword(s):  
Mass Flow Rate ◽  
Mass Flow ◽  
Flow Rate ◽  
Small Mass ◽  
High Mass ◽  
Electrical Machine ◽  
Flow Area ◽  
Machine Performance ◽  
High Fluid ◽  
Compact Design

Turbomachines are commonly designed for a high mass flow rate. However, because of new cycle concepts, turbomachines are also required to compress or expand at small mass flow rates. One example is the supercritical carbon dioxide Brayton cycle. The mass flow rate can be in the range of one kg/s at an almost high fluid density at the inlet to the compressor. This results in a small through flow area. In this paper, a turbomachine concept is presented that integrates the turbomachine parts into an electrical machine. Specifically, the turbomachine is located in the gap between the rotor and the stator of the electrical machine. In that way, a very compact design can be achieved. This paper aims to explain the basic concept. An aerodynamic design study is performed that demonstrates the important parameters for machine performance. Additionally, the design of the electrical machine is discussed based on a realistic application. Finally, conclusions for further development are drawn.

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