scholarly journals The role of an innovative disinfection system based on silver and hydrogen peroxide in infection prevention

2021 ◽  
Vol 343 ◽  
pp. 10003
Author(s):  
Martin Heinisch ◽  
Laura Heinisch ◽  
Dan Miricescu
Keyword(s):  
Hydrogen Peroxide ◽  
Genetic Information ◽  
Infection Prevention ◽  
Surface Proteins ◽  
Transmission Route ◽  
The Novel ◽  
Disinfection Methods ◽  
Virus Integration ◽  
Virus Spreading

Due to the current pandemic situation caused by SARS-CoV-2 the need of effective precautionary methods is increasing. Besides the transmission of this virus by aerosols induced to air, it is assumed that the transmission route of SARS-CoV-2 is mainly by contaminated surfaces. It has been demonstrated that viruses can contaminate dry surfaces and can be further transmitted to the host even after extended time. The amount of disinfection and hygiene systems has increased drastically over the recent year. Although, the conventional disinfection method via spraying and wiping is labour intensive and efficacy is dependent on the application. Aim of this study was to improve conventional disinfection methods. This new disinfection system based on hydrogen peroxide and silver nanoparticles displays a quick and effective alternative. The composition which was proposed in this study shows unique features in terms of application, health risk and effectivity. The novel application by vaporization helps to disinfect the environment and even the air to reduce virus spreading. New disinfection formulation shows efficacy on the surface proteins and genetic information of the virus. Integration of the effective disinfection method shown in this study in the current precaution measurements will help to reduce the spread of SARS-CoV-2.

scholarly journals New N-(oxazolylmethyl)-thiazolidinedione Active against Candida albicans Biofilm: Potential Als Proteins Inhibitors

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2522 ◽  
Author(s):  
Gabriel Marc ◽  
Cătălin Araniciu ◽  
Smaranda Oniga ◽  
Laurian Vlase ◽  
Adrian Pîrnău ◽  
...  
Keyword(s):  
Biofilm Formation ◽  
Infection Prevention ◽  
Public Health Problem ◽  
Opportunistic Pathogen ◽  
Surface Proteins ◽  
Form Complex ◽  
New Approach ◽  
New Class ◽  
New Compounds

C. albicans is the most frequently occurring fungal pathogen, and is becoming an increasing public health problem, especially in the context of increased microbial resistance. This opportunistic pathogen is characterized by a versatility explained mainly by its ability to form complex biofilm structures that lead to enhanced virulence and antibiotic resistance. In this context, a review of the known C. albicans biofilm formation inhibitors were performed and a new N-(oxazolylmethyl)-thiazolidinedione scaffold was constructed. 16 new compounds were synthesized and characterized in order to confirm their proposed structures. A general antimicrobial screening against Gram-positive and Gram-negative bacteria, as well as fungi, was performed and revealed that the compounds do not have direct antimicrobial activity. The anti-biofilm activity evaluation confirmed the compounds act as selective inhibitors of C. albicans biofilm formation. In an effort to substantiate this biologic profile, we used in silico investigations which suggest that the compounds could act by binding, and thus obstructing the functions of, the C. albicans Als surface proteins, especially Als1, Als3, Als5 and Als6. Considering the well documented role of Als1 and Als3 in biofilm formation, our new class of compounds that target these proteins could represent a new approach in C. albicans infection prevention and management.

Concise Review: SARS-CoV-2 Persistence in the Environment and Its Sensitivity to Biocides

2020 ◽  
Vol 3 (2) ◽  
pp. 61-65
Author(s):  
E.B. Brusina ◽  
E.A. Chezganova
Keyword(s):  
Hydrogen Peroxide ◽  
Healthcare Workers ◽  
The Novel ◽  
Experimental Conditions ◽  
Disinfection Methods ◽  
Hydrogen Peroxide Treatment ◽  
Wide Range ◽  
Research Findings ◽  
Favourable Environment ◽  
Novel Coronavirus

AbstractThe novel coronavirus SARS-CoV-2 has caused a global health threat. This review summarizes comprehensive research findings about the SARS-CoV-2 persistence in inanimate surfaces and opportunities for applying biocides to limit spread of COVID-19. SARS-CoV2 is highly stable at 4°C but sensitive to heat and extremely stable in a wide range of pH values at room temperature. Coronaviruses also well survive in suspension. Desiccation has a more severe effect. SARS-CoV-2 can survive in the air for hours and on surfaces for days. Hospitals are significant epicenters for the human-to-human transmission of the SARS-CoV-2 for healthcare workers. The most contaminated SARS-CoV-2 zones and objects in isolation wards, in intensive care unit specialized for novel coronavirus pneumonia, are under discussion. SARS-CoV2 is sensitive to standard disinfection methods. Studies revealed that 62-71% ethanol, 0.5% hydrogen peroxide or 0.1% sodium hypochlorite inactivated SARS-CoV2 in 1 minute exposition; while 0.05-0.2% benzalkonium chloride or 0.02% chlorhexidine digluconate were less effective. Both ethanol and isopropanol were able to reduce viral titers after 30-seconds exposure. It was found for reusing personal protective equipment vaporized hydrogen peroxide treatment exhibits the best combination of rapid inactivation of SARS-CoV-2 and preservation of N95 respirator integrity under the experimental conditions. Overall, SARS-CoV-2 can be highly stable in a favourable environment, but it is also susceptible to standard disinfection methods. Environmental infection control of the air and especially for surfaces is considered as a mandatory step in addition to limiting person-to-person contact.

scholarly journals Infectious Disease: Protecting Workers and Organizations-The Role of Compensation & Benefits

2020 ◽  
Vol 53 (1) ◽  
pp. 43-55
Author(s):  
William Marty Martin ◽  
Yvette Lopez ◽  
Thomas P. Flannery ◽  
Bill Dixon
Keyword(s):  
Infectious Diseases ◽  
Prevention And Control ◽  
Infection Prevention ◽  
Seasonal Influenza ◽  
Infection Prevention And Control ◽  
The Novel ◽  
Health And Wellness ◽  
Novel Coronavirus ◽  
And Control

Infectious diseases at work can be endemic such as seasonal influenza and emerging such as the novel coronavirus 2019. Infectious diseases have an impact on employees and other types of workers. Compensation and benefits professionals are often at the forefront of preventing workplace infections, addressing workplace infections, and ensuring the continuity of talent when workplace outbreaks and business shutdowns occur. This article provides an overview of pertinent laws, key compensation decisions, and ways to refocus existing benefit programs to meet the challenge of not only just safety, health, and wellness but also infection prevention and control.

scholarly journals 1727. Sustained Antimicrobial Activity of a Novel Disinfectant Against Healthcare Pathogens

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S55-S55 ◽  
Author(s):  
William Rutala ◽  
Maria Gergen ◽  
Emily Sickbert-Bennett ◽  
Deverick J Anderson ◽  
David Weber
Keyword(s):  
Hydrogen Peroxide ◽  
Antimicrobial Activity ◽  
Stainless Steel ◽  
The Novel ◽  
Log10 Reduction ◽  
Final Time ◽  
E Coli ◽  
Environmental Surfaces ◽  
The Mean

Abstract Background Environmental contamination plays an important role in the transmission of MRSA, VRE, and C. difficile. Suboptimal compliance with hand hygiene or inappropriate glove use can result in indirect transfer of these pathogens to patients. This study evaluates a novel disinfectant that claims to kill microbes on surfaces for ≥24 hours. Methods We investigated the persistent antimicrobial activity of a novel disinfectant using an EPA protocol for sustained disinfecting activity. In brief, surfaces are inoculated, treated with the novel disinfectant, allowed to dry, and then abraded using a standardized abrasion machine under multiple alternating wet and dry wipe conditions (N = 12) interspersed with 6 re-inoculations. After 24 hours, the surface was re-inoculated a final time and ability of the disinfectant to kill ≥99.9% of 9 test microbes within 5 minutes was measured on 3 test surfaces (glass, formica, and stainless steel). Results The novel disinfectant demonstrated a 3–5 log10 reduction in 5 minutes when testing S. aureus, VRE, C. auris, CRE E. coli and antibiotic-sensitive strains of E. coli, and Enterobacter sp. (table). The disinfectant demonstrated lower killing for CRE isolates of Enterobacter sp. and K. pneumoniae, and for antibiotic-sensitive K. pneumoniae (~2 log10 reduction in 5 minutes). When the novel disinfectant was compared with 3 other commonly used disinfectants using the same methodology with S. aureus, the mean log10 reductions were: 4.4 (novel disinfectant); 0.9 (quat-alcohol); 0.2 (improved hydrogen peroxide); and 0.1 (chlorine). Conclusion Persistent disinfectants may reduce or eliminate the problem of recontamination and minimize the role of environmental surfaces in transmission of healthcare pathogens. Disclosures W. Rutala, PDI: Consultant and Speaker’s Bureau, Consulting fee and Speaker honorarium. D. Weber, PDI: Consultant, Consulting fee

scholarly journals The Possibility of Blocking the Process of DNA Base Pairs Opening by Hydrogen Peroxide

2019 ◽  
Vol 64 (6) ◽  
pp. 500
Author(s):  
O. O. Zdorevskyi ◽  
S. N. Volkov
Keyword(s):  
Hydrogen Peroxide ◽  
Cancer Cells ◽  
Genetic Information ◽  
Information Transfer ◽  
Ion Beam ◽  
Water Radiolysis ◽  
Base Pairs ◽  
Ion Beam Therapy ◽  
Nucleic Bases

One of the most progressive methods of cancer treatment is the ion beam therapy. Simulations of the water radiolysis show that the most long-living species in the cell medium are hydrogen peroxide (H2O2) molecules. But up to the present time, the role of H2O2 molecules in the deactivation of cancer cells has not been determined yet. To understand the possible role of H2O2 in the ion beam therapy, the competitive interaction of H2O and H2O2 molecules with nucleic bases in a pair on the different stages of genetic information transfer is studied in the present work. The method of atom-atomic potential functions is used in the calculations. It is shown that some configurations of A·T, and G·C complementary pairs are stabilized muchbetter by an H2O2 molecule as compared to a water molecule. The formation of such interaction complexes can terminate the processes of DNA unzipping by enzymes and consequently block the genetic information transfer processes in cancer cells during the ion beam treatment. An experimental method of verification of the interaction of hydrogen peroxide with nucleic base pairs is proposed.

ROLE OF THE NOVEL INTRODUCED PAN-INTESTINAL CAPSULE ENDOSCOPY SYSTEM IN CELIAC DISEASE

2019 ◽  
Author(s):  
F Foerster ◽  
K Mönkemüller ◽  
PR Galle ◽  
H Neumann
Keyword(s):  
Celiac Disease ◽  
Capsule Endoscopy ◽  
The Novel

The role of copper ions in hydrogen peroxide bleaching: Their origin, removal, and effect on pulp quality

TAPPI Journal ◽  
2012 ◽  
Vol 11 (7) ◽  
pp. 37-46 ◽  
Author(s):  
PEDRO E.G. LOUREIRO ◽  
SANDRINE DUARTE ◽  
DMITRY V. EVTUGUIN ◽  
M. GRAÇA V.S. CARVALHO
Keyword(s):  
Hydrogen Peroxide ◽  
Copper Ions ◽  
Peroxide Bleaching ◽  
Metals Removal ◽  
Peroxide Decomposition ◽  
Equipment Corrosion ◽  
And Performance ◽  
And Control ◽  
Main Effects

This study puts particular emphasis on the role of copper ions in the performance of hydrogen peroxide bleaching (P-stage). Owing to their variable levels across the bleaching line due to washing filtrates, bleaching reagents, and equipment corrosion, these ions can play a major role in hydrogen peroxide decomposition and be detrimental to polysaccharide integrity. In this study, a Cu-contaminated D0(EOP)D1 prebleached pulp was subjected to an acidic washing (A-stage) or chelation (Q-stage) before the alkaline P-stage. The objective was to understand the isolated and combined role of copper ions in peroxide bleaching performance. By applying an experimental design, it was possible to identify the main effects of the pretreatment variables on the extent of metals removal and performance of the P-stage. The acid treatment was unsuccessful in terms of complete copper removal, magnesium preservation, and control of hydrogen peroxide consumption in the following P-stage. Increasing reaction temperature and time of the acidic A-stage improved the brightness stability of the D0(EOP)D1AP bleached pulp. The optimum conditions for chelation pretreatment to maximize the brightness gains obtained in the subsequent P-stage with the lowest peroxide consumption were 0.4% diethylenetriaminepentaacetic acid (DTPA), 80ºC, and 4.5 pH.

Patterns: Rosamond Lehmann

2018 ◽  
Author(s):  
Vike Martina Plock
Keyword(s):  
Coming Of Age ◽  
Public Image ◽  
Market Forces ◽  
The Novel ◽  
Fashion Industry ◽  
To The Lighthouse ◽  
Fashion Magazines ◽  
Female Authorship ◽  
Rosamond Lehmann

This chapter analyzes the role of fashion as a discursive force in Rosamond Lehmann’s 1932 coming-of-age novel Invitation to the Waltz. Reading the novel alongside such fashion magazines as Vogue, it demonstrates Lehmann’s awareness that 1920s fashion, in spite of its carefully stylized public image as harbinger of originality, emphasized the importance of following preconceived (dress) patterns in the successful construction of modern feminine types. Invitation to the Waltz, it argues, opposes the production of patterned types and celebrates difference and disobedience in its stead. At the same time, the novel’s formal appearance is nonetheless dependent on the very same tenets it criticizes. On closer scrutiny, it is seen to reveal its resemblance to Virginia Woolf’s To the Lighthouse (1927). A tension between imitation and originality determines sartorial fashion choices. This chapter shows that female authorship in the inter-war period was subjected to the same market forces that controlled and sustained the organization of the fashion industry.

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