A Snapshot of Pediatric Patients with COVID-19 in a Pandemic Hospital

2020 ◽  
Vol 233 (01) ◽  
pp. 24-30
Author(s):  
Burcu Bursal Duramaz ◽  
Ozden Turel ◽  
Cigdem Korkmaz ◽  
Muhammed Talha Karadogan ◽  
Can Yilmaz Yozgat ◽  
...  
Keyword(s):  
Decision Making ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Suspected Case ◽  
Travel History ◽  
Upper Respiratory Infection ◽  
Chest Disease ◽  
Chest X Ray ◽  
Polymerase Chain

Abstract Aim Reports describing coronavirus disease 2019 (Covid-19) in children are fewer than adult studies due to milder clinical picture. We aimed to share our experience at a single center with an emphasis on collective decision making. Materials and Methods A suspected case was defined as the presence of symptoms suggestive of COVID-19 and/or positive contact history. SARS-CoV-2 PCR positive patients were defined as confirmed COVID-19. Between March 12, 2020, and May 15, 2020, all children presenting with fever, cough, or respiratory difficulty were investigated for COVID-19. A total of 719 children were examined at outpatient clinics, and 495 were tested with polymerase chain reaction (PCR) for suspicion of COVID-19. A team was organized for monitoring and treating patients either as outpatients or hospitalization. Patients were evaluated in terms of age, gender, travel history, epidemiological history, clinical symptoms and signs, laboratory and radiological findings, treatment, and outcome. Results Sixty patients were hospitalized for suspicion of COVID-19. Forty-three patients were diagnosed as probable or confirmed COVID-19. 21 of 43 patients (48.8%) were PCR confirmed. The remaining 22 were diagnosed by epidemiologic history, clinical assessment, and computerized thorax tomography (CT) findings. The median age was 126 and 78.5 months in PCR positives and PCR negatives, respectively and the youngest patient was a 28 days old baby. Nineteen of the patients had an upper respiratory infection (44.1%). Although five patients had no clinical signs, chest X-ray, or CT revealed pneumonia. Conclusions As previously reported, the clinical manifestations of COVID-19 in children are mostly mild. Even very young kids can become infected following exposure to sick family members. International and local guidelines are valuable for decision making since it is a new disease. A combination of chest disease, infectious diseases, and emergency care physicians approach will aid the appropriate management of cases.

scholarly journals Clinical characteristics of COVID-19 in children compared with adults in Shandong, China

2020 ◽  
Author(s):  
Wenjun Du ◽  
Jinhong Yu ◽  
Hui Wang ◽  
Xiaoguo Zhang ◽  
Shouwei Zhang ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Health Workers ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Case Series ◽  
Signs And Symptoms ◽  
Asymptomatic Patients ◽  
Positive Indicators ◽  
Clinical Signs And Symptoms

Abstract Aims & Background: The COVID-19 outbreak spread in China and is a threat to the world. We reported on the epidemiological, clinical, laboratory, and radiological characteristics of children cases to help health workers better understand and provide timely diagnosis and treatment.Methods: Retrospectively, two research centers’ case series of 67 consecutive hospitalized cases including 14 children cases with COVID-19 between 23 Jan 2020 to 15 Feb 2020 from Jinan and Rizhao were enrolled in this study. Epidemiological, clinical, laboratory, and radiological characteristics of children and adults were analyzed and compared.Results: Most cases in children were mild(21.4%) and conventional cases(78.6%), with mild clinical signs and symptoms, and all cases were of family clusters. Fever (35.7%) and dry cough(21.4%) were described as clinical manifestations in children cases. Dry cough and phlegm were not the most common symptoms in children compared with adults(p=0.03). In the early stages of the disease, lymphocyte counts did not significantly decline but neutrophils counts did in children compared with adults(p=0.00).There was an elevated level of LDH(p=0.01) and a lower level of CRP(p=0.00)and IL-6(p=0.01) in children compared with adults. There were 8 (57.1%)asymptomatic cases and 6 (42.9%)symptomatic cases among the 14 children cases. The age of asymptomatic patients was younger than that of symptomatic patients(p=0.03). Even among asymptomatic patients, 5(62.5%)cases had pneumonia including 3 (60%) cases with bilateral pneumonia, which was not different compared with that of asymptomatic cases(p=0.58, p=0.74).Conclusions: The clinical symptoms of children are mild, and the positive indicators of laboratory tests are rare, which may easily cause clinical misdiagnoses.

scholarly journals Idiopatic fibrosing alveolitis in a newborn

2019 ◽  
Vol 64 (5) ◽  
pp. 226-229
Author(s):  
N. Kh. Gabitova ◽  
I. N. Cherezova ◽  
K. A. Cherezova
Keyword(s):  
Clinical Symptoms ◽  
Dynamic Control ◽  
Fatal Outcome ◽  
Clinical Manifestations ◽  
Lung Damage ◽  
Symptomatic Therapy ◽  
Fibrosing Alveolitis ◽  
X Ray ◽  
Chest X Ray ◽  
Lung Tissue Damage

The article describes a clinical case of idiopathic fibrosing alveolitis – a rare antenatal disease of a newborn. The disease began with the clinical manifestations of transient tachypnea in a full-term child born in the operative way. Chest X-ray was used for dynamic control of lung tissue damage. Due to the absence of specific clinical symptoms of interstitial lung damage, the disease was considered as a course of congenital pneumonia. The researchers used antibacterial and symptomatic therapy. Despite treatment, the respiratory failure progressed, resulting in fatal outcome.

scholarly journals Clinical manifestations, laboratory markers, and renal ultrasonographic examinations in 1-month to 12-year-old Iranian children with pyelonephritis: a six-year cross-sectional retrospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Daryoosh Fahimi ◽  
Leila Khedmat ◽  
Azadeh Afshin ◽  
Zahra Noparast ◽  
Maryam Jafaripor ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Early Diagnosis ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Ureteral Stones ◽  
Cross Sectional ◽  
Laboratory Markers ◽  
Febrile Uti ◽  
Iranian Children

Abstract Background Upper urinary tract infection (UTI) or pyelonephritis may increase the pathogenesis rate and risk of severe complications in children due to kidney atrophy. Objective A set of clinical symptoms, laboratory markers, and ultrasound findings were assessed to achieve the early diagnosis and prognosis of pyelonephritis in hospitalized pediatrics. Methods A cross-sectional study with 104 Iranian children (95 girls and 9 boys) aged 1 month to 12 years with acute pyelonephritis during 2012–2018 was conducted. The ultrasound examination of kidneys and urinary tract during hospitalization, the incidence of clinical symptoms, and laboratory markers in blood and urine were monitored to identify the best predictive factors of early diagnosis of this bacterial infection. Results Three-fourth of the patients had one of the four clinical symptoms of abdominal pain, constipation, dysuria, and vomiting, while others were asymptomatic. A much frequency of pyuria (88.46%), Escherichia coli in urine (92.31%), leukocytosis (81.73%), and high ESR (> 10 mm/h, 92.30%) and CRP (> 10 mg/L, 82.82%) was observed. The kidney and urinary tract ultrasonography only in 32.7% of children revealed findings in favor of pyelonephritis (cystitis, ureteral stones, and hydronephrosis). Conclusion There was a high frequency of clinical signs and laboratory markers associated with pyelonephritis. Ultrasound alone was not an efficient tool to track febrile UTI as most patients presented normal sonography.

scholarly journals Relationship Between Rhinitis, Asthma, and Eczema and the Presence of Sensitization in Young Swiss Adults

2018 ◽  
Vol 9 ◽  
pp. 215265671877360 ◽  
Author(s):  
Urs C. Steiner ◽  
Lucas M. Bachmann ◽  
Micheal B. Soyka ◽  
Stephan Regenass ◽  
Lukas Steinegger ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Allergic Sensitization ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Rapid Test ◽  
Signs And Symptoms ◽  
Causative Factor ◽  
Common Disease ◽  
Common Symptom ◽  
Perennial Rhinitis

Background Rhinitis is a very common disease with allergies being the most frequent causative factor. It can co-occur together with asthma and eczema in atopic as well as in nonatopic patients. Objectives To assess the prevalence of allergic sensitization within patient groups with rhinitis in consideration of the co-occurring disorders of asthma and eczema. Methods Students of the third year of medical school completed an anonymous questionnaire on age, gender, and clinical symptoms, such as seasonal rhinitis, perennial rhinitis, asthma, and eczema, and underwent an ImmunoCAP Rapid test. We calculated the prevalence of sensitization within subgroups of patients reporting allergic disorders, such as rhinitis, asthma, and eczema. Results Questionnaires and ImmunoCAP Rapid tests of 1513 medical students were analyzed. The participants’ self-reported presence of seasonal/perennial rhinitis, asthma, and eczema was compared to the presence of sensitization. Data of 1467 subjects could be analyzed. Seasonal rhinitis was the most common symptom, followed by eczema, asthma, and perennial rhinitis. The participants were differentiated into 16 subgroups according to the combined clinical manifestations of the different symptoms and association to sensitization within subgroups. The prevalence of sensitization ranged from 18% in subjects reporting only eczema without any other symptom to 100% in those reporting to have asthma, seasonal/perennial rhinitis, and eczema together. In subjects reporting no sign or symptom at all, the prevalence of sensitization was 19%. Seasonal rhinitis was the strongest single predictor for sensitization with the highest proportion of sensitized participants in all symptom combinations (67%–100%), followed by perennial rhinitis (31%–100%), asthma (30%–100%), and eczema (18%–100%). Conclusion Rhinitis most often is associated with allergen sensitization, and the probability of sensitization is substantially enhanced by co-occurrence of asthma. A careful assessment of clinical signs and symptoms is important and enables the selection of patients in whom targeted diagnostic analysis and therapy is appropriate. Trial registration: retrospectively registered by the Cantonal Ethics Committee Zurich on 22.01.2016; Nr: 08-2016.

Systemic Mycosis in Three Dogs from Nonendemic Regions

2012 ◽  
Vol 48 (6) ◽  
pp. 411-416 ◽  
Author(s):  
Carmela L. Pratt ◽  
Rance K. Sellon ◽  
Erick S. Spencer ◽  
Ty W. Johnson ◽  
Daniel J. Righter
Keyword(s):  
Fungal Infections ◽  
Clinical Signs ◽  
Acute Onset ◽  
Ocular Involvement ◽  
Chain Reaction ◽  
Travel History ◽  
Disseminated Histoplasmosis ◽  
Polymerase Chain ◽  
Disseminated Disease ◽  
Dermal Lesions

Three dogs were examined for clinical signs ultimately attributed to systemic fungal infections. One dog was evaluated for chronic, ulcerated dermal lesions and lymphadenomegaly; one dog was examined for acute onset of unilateral blepharospasm; and one dog had diarrhea and hematochezia. Two of the dogs were diagnosed with blastomycosis (one with disseminated disease and the other with the disease localized to the left eye). The third dog was diagnosed with disseminated histoplasmosis. None of the dogs originated from, or had traveled to, typical regions endemic for these fungal diseases. All diagnoses were established from histopathology and either polymerase chain reaction (PCR) or cytology and culture. The two dogs diagnosed with blastomycosis were treated with either itraconazole or ketoconazole with apparent resolution of the infections. The dog with ocular involvement had an enucleation prior to beginning therapy. The dog diagnosed with histoplasmosis was euthanized without treatment. In patients with characteristic clinical features, systemic fungal infections should still be considered as differential diagnoses regardless of their travel history.

scholarly journals Detection of pneumonia among children under six years by clinical evaluation

2004 ◽  
Vol 10 (4-5) ◽  
pp. 482-487
Author(s):  
H. Shamo'on ◽  
A. Hawamdah ◽  
R. Haddadin ◽  
S. Jmeian
Keyword(s):  
Clinical Study ◽  
Chest Wall ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Prospective Clinical Study ◽  
X Rays ◽  
X Ray ◽  
Chest X Ray ◽  
Symptoms And Signs

To determine the most useful clinical symptoms and signs for detection of pneumonia in children, we carried out a prospective clinical study at Queen Alia Hospital, Amman, on 147 children admitted between August 2002 and January 2003 with clinical pneumonia. All the children had chest X-rays, which were read by the same radiologist. The most sensitive and specific signs and symptoms for prediction of pneumonia were coughing, tachypnoea [respiratory rate > 50/min] and chest wall indrawing. We found that presence of tachypnoea and lower chest wall indrawing can detect most cases of pneumonia. If all clinical signs are negative, chest X-ray findings are unlikely to be positive

scholarly journals Congenital Syphilis Coinfection in a Preterm Infant with Early Onset Sepsis due to Enterobacter cloacae

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Sakviseth Bin ◽  
Sethikar Im
Keyword(s):  
Early Onset ◽  
Clinical Symptoms ◽  
Congenital Syphilis ◽  
Treponema Pallidum ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Enterobacter Cloacae ◽  
Benzyl Penicillin ◽  
Fourfold Increase ◽  
Early Onset Sepsis

Introduction. Syphilis is a tropical disease, caused by a spirochete Treponema pallidum, which can be transmitted transplacentally from untreated mothers to the fetus during any stages of pregnancy. Clinical manifestations of early congenital syphilis are variable and nonspecific. The diagnosis is based on the serology status of the mother, newborn clinical symptoms, and comparative serology titer between mother and newborn. Case Presentation. A late preterm female infant, appropriate for gestational age, was treated for severe early onset sepsis due to Enterobacter cloacae since day 2 of life. The coinfection with Treponema pallidum was suspected and confirmed at day 4 with clinical signs and a fourfold increase of rapid plasma reagin (RPR) compared to mother’s serology. Combined with meropenem and amikacin, Benzyl-Penicillin was used for 10 days, thereby resulting in a significant clinical and laboratory improvement. The girl was discharged at day 18 and brought for regular follow-ups for both growth milestone and syphilis serology. RPR decreased fourfold at the age of 1 month. Conclusion. Syphilis should not be overlooked. The vertical transmission is preventable by an on-time treatment of the infected mother, triggered by a proper antenatal screening at the right time. Congenital syphilis should be ruled out in any challenging neonatal sepsis. The diagnosis tools and treatments are easily accessible and inexpensive in our economical settings.

scholarly journals Annular lichen planus, a rare variant of lichen planus

2020 ◽  
Vol 4 (10) ◽  
pp. 642-646
Author(s):  
I.I. Zakhur ◽  
◽  
S.V. Koshkin ◽  
V.A. Bobro ◽  
◽  
...  
Keyword(s):  
Lichen Planus ◽  
Rare Variant ◽  
Clinical Symptoms ◽  
Disease Onset ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Current Data ◽  
Hla System ◽  
Lichen Ruber ◽  
Lichen Ruber Planus

The paper reviews current data on lichen ruber planus, a disease characterized by multifactorial pathogenesis, polymorphic clinical symptoms, severe long recurrent course, and a significant resistance to treatment. In the last decades, a substantial growth in the prevalence of this dermatosis is observed. Moreover, the rate of atypical cases also increases. The most common symptoms at disease onset are a generalized rash, severe itching, and malaise. Many patients present with acute clinical signs. Patients with the different forms of the disease (in particular, those with oral lichen planus) report on the significant reduction in the quality of life. The authors describe the specificity of clinical polymorphism, the variability of clinical manifestations and HLA system in annular lichen planus. The aim of this paper is to summarize currently available data considering the diversity of clinical variants which are required for the understanding of the pathogenesis to improve the diagnosis in difficult cases and to control its course. The authors also address a case study of annular lichen planus in a 63-year-old woman. KEYWORDS: lichen ruber planus, dermatosis, histopathology, HLA system. FOR CITATION: Zakhur I.I., Koshkin S.V., Bobro V.A. Annular lichen planus, a rare variant of lichen planus. Russian Medical Inquiry. 2020;4(10):642–646. DOI: 10.32364/2587-6821-2020-4-10-642-646.

scholarly journals Conjunctival polymerase chain reaction-tests of 2019 novel coronavirus in patients in Shenyang,China

2020 ◽  
Author(s):  
Li Xu ◽  
Xinyue Zhang ◽  
Wei Song ◽  
Baijun Sun ◽  
Jinping Mu ◽  
...  
Keyword(s):  
Clinical Features ◽  
Clinical Symptoms ◽  
False Negative ◽  
Suspected Case ◽  
Negative Results ◽  
False Negative Results ◽  
Laboratory Results ◽  
Polymerase Chain ◽  
Novel Coronavirus ◽  
Negative Detection

Abstract Background We report the laboratory results of conjunctival PCR-tests and some clinical features of these patients infected with COVID-19 in shenyang China.Methods We collected conjunctival samples of the patients to do the laboratory tests by PCR.Medical observed patients were enrolled if they had clinical symptoms. Then we analysed the PCR results and clinical features in order to find some relationships.Results The study include 14 confirmly diagnosed cases ,16 suspected cases and some medical observed patients.1 of the identified case coverted from suspected case.22 medical observed cases were removed because none of them converted to identified cases.1 of the suspected converted to identified case recently.All the conjunctival results of PCR-test were negative.Discussion The reasons of the negative detection results of PCR in conjunctival swabs were discussed.Conclusion Conjunctiva may be a transmission way of COVID-19.And ocular conjunctival swabs could be a diagnostic method for identifying the infection of COVID-19.Emphasis on the false-negative results is vital.

scholarly journals The outbreak of the new coronavirus infection in pediatric TB department

2020 ◽  
Vol 98 (10) ◽  
pp. 6-10
Author(s):  
M. F. Gubkina ◽  
I. Yu. Petrakova ◽  
N. V. Yukhimenko ◽  
S. S. Sterlikova ◽  
Yu. Yu. Khokhlova ◽  
...  
Keyword(s):  
Viral Infections ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Lung Damage ◽  
Igg Antibodies ◽  
Pediatric Tb ◽  
Coronavirus Infection ◽  
Polymerase Chain ◽  
Body Temperature Increase ◽  
Observation Period

The objective: to analyze the course of the new coronavirus infection (COVID-19) in children with active respiratory tuberculosis. Subjects and methods. The article describes results of retrospective analysis of the course of the new coronavirus infection in 25 children (3-12 years old) with active respiratory tuberculosis during the outbreak of COVID-19 in an in-patient TB unit.Results. 24 (96%) persons got infected after the close exposure to the coronavirus infection, and 1 (4%) child didn't get infected. The diagnosis was verified by polymerase chain reaction (detection of RNK of SARS-CoV-2) in 33.3%, by enzyme immunoassay (detection of IgG antibodies to SARS-CoV-2 in 1 month after quarantine removal) in 100%. 58.3% of children with respiratory tuberculosis (14 people) infected with coronavirus infection had minimal respiratory symptoms, that did not differ from signs of other respiratory viral infections; clinical manifestations of the disease were completely absent in 41.7% (10) patients. Coronavirus pneumonia was diagnosed in 4 (16.7%) children who suffered from COVID-19, they had no clinical signs of lower respiratory tract disorders and no body temperature increase; 3 patients had no signs of respiratory viral infection; in all cases, the lung damage detected by computed tomography didn't exceed 10%. In 2 months after the removal of quarantine, no IgG antibodies to SARS-CoV-2 were detected in 2 out of 10 examined children (20.0%), thus there was a chance for re-infection. No mutual aggravating effect of coronavirus infection and tuberculosis was revealed in their combination over the entire observation period (4 months).

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