Comparison of Three Different Cord Clamping Techniques Regarding Oxidative-antioxidative Capacity in Term Newborns

2022 ◽  
Author(s):  
Ishak Kartal ◽  
Aslihan Abbasoglu ◽  
Seyithan Taysi
Keyword(s):  
Apgar Score ◽  
Antioxidant Status ◽  
Delayed Cord Clamping ◽  
Future Health ◽  
Term Infants ◽  
Uncomplicated Pregnancy ◽  
Cord Clamping ◽  
Early Cord Clamping ◽  
Total Antioxidant ◽  
Term Newborns

Objective As newborns are exposed to oxidative stress during delivery, cord clamping techniques play significant role on antioxidant status. In this study, we aimed to show the relationship between early cord clamping (ECC), delayed cord clamping (DCC) and cut umblical cord milking (C-UCM) techniques with total oxidant capacity (TOC), total antioxidant capacity (TAC) and peroxynitrite levels. Study Design Sixty-nine term infants were selected with APGAR score of 7 and above in the first and fifth minutes. The mothers of all infants had uncomplicated pregnancy, had no congenital anomaly, and delivered by cesarean section. Newborns were randomised to one of three groups: ECC (n: 23), DCC (n: 23) or C-UCM (n: 23). After all newborn babies were taken under radiant heater, blood samples were collected from the umbilical cord. The plasma samples were then frozen and stored at -80 °C until analysis and TOC, TAC and peroxynitrite levels were studied. Results The ages of the mothers participating in the study were between 17 and 42, with an average of 29.14 ± 6.28. 30 (43.5%) of the babies were girls and 39 (56.5%) were boys. The 5th minute APGAR score of the babies in early cord clamping group was significantly lower than the babies in delayed cord clamping and cut cord milking group (p = 0.034; p = 0.034; p <0.05). The TOC, OSI and Peroxynitrite measurements of three groups did not differ statistically. The TAC value of the C-UCM group was significantly higher than the patients with the ECC and DCC group (p = 0.002; p = 0.019; p <0.05). Conclusion C-UCM and DCC would be feasible methods by increasing antioxidant status and providing protective effect on the future health of the term newborns,

Increment in Phototherapy After Adopting Delayed Cord Clamping Practice

2021 ◽  
pp. 097321792110607
Author(s):  
Chinmay Chetan ◽  
Nishant Banait ◽  
Vikramaditya Athelli ◽  
Bhvya Gupta ◽  
Prince Pareek ◽  
...  
Keyword(s):  
Tertiary Care ◽  
World Health ◽  
Care Hospital ◽  
Delayed Cord Clamping ◽  
Term Infants ◽  
Cord Clamping ◽  
Early Cord Clamping ◽  
Baseline Characteristics ◽  
Health Organization ◽  
Larger Sample

Introduction: World Health Organization (WHO) in 2014 recommended delayed cord clamping (DCC) in all babies who cry immediately after birth. Despite many benefits, there are concerns of increased rate of phototherapy in babies receiving DCC. This study was done to determine the increment in the rate of phototherapy required in infants managed with DCC vs infants managed with early cord clamping (ECC). Methods: A retrospective observational study was conducted in a tertiary care hospital in Pune, India. All the infants born between January 2018 and July 2018, for whom ECC was done, were compared with infants who were born between January 2019 and July 2019, after DCC policy was adopted. All the infants with birth weight ≥2 kg and gestation ≥35 weeks, who were with their mother, were included. Baseline characteristics were compared for both the groups. American Academy of Pediatrics guidelines for treatment of neonatal jaundice were used to determine the need for phototherapy. Number of infants in both the groups who required phototherapy were compared. Results: The ECC group had 565 infants while DCC group had 731 infants. There was no difference in the baseline characteristics of the 2 groups. Jaundice requiring phototherapy was noted in 31% of infants in the ECC group, compared to 45% in infants in the DCC group (relative risk: 1.47 [1.27-1.71] [ P < .001]). Conclusion: In this study, DCC increased the need for phototherapy by 47% in late preterm and term infants. Randomized control trials with larger sample size are required to confirm this finding.

scholarly journals Delayed cord clamping for prevention of iron deficiency anemia in term infants

2012 ◽  
Vol 52 (4) ◽  
pp. 223
Author(s):  
Olga Rasiyanti Siregar ◽  
Bugis Lubis ◽  
Muara Lubis ◽  
Bidasari Lubis ◽  
Guslihan Dasa Tjipta
Keyword(s):  
Iron Deficiency ◽  
Iron Status ◽  
Ferritin Level ◽  
Newborn Infants ◽  
Deficiency Anemia ◽  
Delayed Cord Clamping ◽  
Term Infants ◽  
Cord Clamping ◽  
Early Cord Clamping ◽  
Umbilical Cords

Background Iron deficiency childhood is a concern due to its potentially detrimental effectson development, some of which may be irreversible even after irontreatment. Delayed cord clamping may prevent IDA by increasingan infant's iron reserve at birth.Objective We aimed to evaluate the effect of delayed umbilicalcord clamping at birth on the iron status in newborns at age 24hours of life.Methods This randomized, single􀁒blind study was conducted fromMarch to May 2009, at two general hospitals in Medan, NorthSumatera Province. Eligible newborn infants were randomlyassigned to one of two groups: early cord clamping (Eee)performed 15 seconds after delivery or delayed cord clamping(DeC) performed 2 minutes after delivery. Infants were placed ontheir mothers' abdomens before the umbilical cords were clamped.Hematologic status was determined from umbilical cord blood.Results Sixty􀁒three subjects were included in our study, consistingof31 infants in the Eee group and 32 infants in the Dec group.We found that mean neonatal hemoglobin level was higher inthe Dec group than in the Eee group ( 18.4 g% and 16.2 g%,respectively, P=O.OOOl). Also, mean ferritin level was higher inthe Dec group than in the Eee group (556 mg/dL and 329 mg/dL, respectively, p=o.o 15). Other hematological status indicators,including mean hematocrit and mean corpuscular volume (MeV)level, were also higher in the Dec group. However, mean redblood cell levels were not significantly groups. Nor was there a significant level between the Dec and Eee groups.Concl usion Dela y ed cord c l a m p i n g m a y improve ironstatus and prevent IDA in term infants. [Paediatr Indones.2012;52:223-8].

scholarly journals A comparative study of early and delayed cord clamping in term deliveries

2018 ◽  
Vol 7 (12) ◽  
pp. 4929
Author(s):  
Nikita V. Gonnade ◽  
Surendra D. Nikhate ◽  
Himadri Bal ◽  
Nikita Shrivastava
Keyword(s):  
High Risk ◽  
Comparative Study ◽  
Post Partum ◽  
Delayed Cord Clamping ◽  
Cord Clamping ◽  
Select Group ◽  
Early Cord Clamping ◽  
High Risk Factor ◽  
The Difference ◽  
Group B

Background: Timing of clamping of the umbilical cord has always been a debatable issue. Early cord clamping (ECC) is defined as clamping of the cord within 30 seconds of delivery of the baby and delayed cord clamping (DCC) is defined as clamping of the cord between 30 to 120 seconds of delivery. Delayed cord clamping, despite some limitations, is said to be beneficial to the neonate.  A comparative study between ECC and DCC was carried out on a select group of term pregnant women without any high-risk factor and delivering at term. Aim of the study was to compare the effects of early versus delayed cord clamping on neonates and mothers. The focus was on the neonatal haemoglobin levels and adverse effects, if any on neonates and mothers in the two groups.Methods: 100 women satisfying the inclusion/exclusion criteria were recruited for the study. They were randomly divided into two groups of 50 each. Group A underwent early cord clamping and Group B delayed cord clamping. Mothers were observed for 1 hour post-delivery for any evidence of post-partum haemorrhage. Neonates were observed for any sign of tachypnea and blood sample was sent after 72 hours of delivery for analyzing Hb, hematocrit and bilirubin of the neonate.Results: The results revealed that neonates with DCC had a higher mean Hb level of 15.02 vis-à-vis the ECC group Hb of 11.69G/dl and the difference was statistically significant. Similarly mean hematocrit of DCC group was 48.67 while the ECC group mean was 42.36, the difference again was statistically significant. There was no significant side effects or complications in both mother and newborn babies.Conclusions: It was concluded that delayed cord clamping should be practiced in otherwise non high-risk deliveries.

Evaluation of the Effects of Delayed Cord Clamping in Infants of Diabetic Mothers

2019 ◽  
Author(s):  
Sabriye Korkut ◽  
Yüksel Oğuz ◽  
Davut Bozkaya ◽  
Gülenay Gençosmanoğlu Türkmen ◽  
Özgür Kara ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Respiratory Distress ◽  
Exchange Transfusion ◽  
Neonatal Intensive Care ◽  
Delayed Cord Clamping ◽  
Infants Of Diabetic Mothers ◽  
Cord Clamping ◽  
Early Cord Clamping ◽  
Diabetic Mothers

Abstract Objective To investigate the effect of delayed cord clamping (DCC) in infants of diabetic mothers. Study Design Women who had diabetes throughout their pregnancy and gave birth at 37 weeks of gestation or later were included in the study along with their babies. Early cord clamping was performed as soon as possible after birth, while DCC was performed by clamping 60 second after birth. The two groups were compared in terms of venous hematocrit (htc) levels and rates of hypoglycemia, jaundice requiring phototherapy, and respiratory distress. Results Venous htc levels at postnatal 6 and 24 hours were significantly higher in the DCC group (p = 0.0001). Polycythemia rates were higher in the DCC group at both 6 and 24 hours, but partial exchange transfusion (PET) was not needed in either group. There were no differences between the groups with regard to the rates of hypoglycemia or jaundice requiring phototherapy. Rate of admission to the neonatal intensive care unit (NICU) was lower in the DCC group. Conclusion Although DCC increased the rate of polycythemia, it did not result in PET requirement. Moreover, DCC reduced the severity of respiratory distress and the rate of admission to NICU due to respiratory distress.

scholarly journals Delayed Cord Clamping Prevalence Among US Hospitals

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 793-793
Author(s):  
Jasmine Nakayama ◽  
Cria Perrine ◽  
Heather Hamner ◽  
Ellen Boundy
Keyword(s):  
Cesarean Section ◽  
Infant Nutrition ◽  
Cesarean Section Rate ◽  
Teaching Hospitals ◽  
Delayed Cord Clamping ◽  
Term Infants ◽  
Non Profit ◽  
Funding Sources ◽  
Official Position ◽  
Cord Clamping

Abstract Objectives Delayed cord clamping (DCC) allows transfusion of placental blood to a newborn after birth and is recommended by the American College of Obstetricians and Gynecologists. DCC can increase hemoglobin levels and iron stores in term infants, preventing or delaying iron deficiency in young children. This study describes the prevalence of DCC in US hospitals overall and by facility characteristics. Methods The 2018 Maternity Practices in Infant Nutrition and Care survey is a census of US hospitals providing maternity care and assesses hospitals' practices, including “How many healthy newborns at your hospital have their umbilical cord clamped more than one minute after birth?” We estimated the prevalence of hospitals reporting that most (i.e., 80%+) healthy newborns received DCC overall and by facility characteristics (i.e., Baby-Friendly designation, teaching status, type, annual live births, and annual Cesarean section rate). Results 2,042 hospitals were included, and 50% reported that most healthy newborns received DCC. DCC prevalence was 49% at non-Baby Friendly hospitals and 53% at Baby-Friendly hospitals. The prevalence of healthy newborns receiving DCC was 50% at teaching hospitals and 51% at non-teaching hospitals. DCC prevalence ranged from 43% among private hospitals to 52% among non-profit hospitals, from 46% among hospitals with 2,000–4,999 births births/year to 53% among hospitals with &lt;500 births/year, and from 37% among hospitals with annual Cesarean section rates ≥35% to 61% among hospitals with annual Cesarean section rates &lt;25%. Conclusions This study provides a national baseline for DCC among US hospitals. Only half of hospitals report DCC for most healthy newborns with notable variation by annual Cesarean section rate. There are opportunities to increase DCC prevalence to meet recommendations through continued training of clinicians, modification of obstetric protocols, and greater awareness among patients. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Funding Sources No funding was provided for this study.

scholarly journals Effect of early and delayed cord clamping on hemoglobin and hematocrit among full term neonates.

2021 ◽  
Vol 28 (08) ◽  
pp. 1114-1119
Author(s):  
Saqib Aslam ◽  
◽  
Sadaf Minhas ◽  
Muhammad Azhar Farooq ◽  
Beenish Bashir Mughal ◽  
...  
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Full Term ◽  
P Value ◽  
Delayed Cord Clamping ◽  
Term Neonates ◽  
Cord Clamping ◽  
Significant Difference ◽  
Early Cord Clamping ◽  
The Mean

Objective: To compare the mean hemoglobin levels and frequency of polycythemia in full term neonates after early and delayed cord clamping. Study Design: Randomized Controlled Trial. Setting: KRL General Hospital Islamabad (Labor Room/ Neonatology). Periods: December 2017 to June 2018. Material & Methods: 190 full term neonates were selected and divided into 2 equal groups randomly: Early cord clamping group after delivery and late cord clamping group. Two hours after clamping the venous blood samples were taken for the hemoglobin and hematocrit levels. Mean and standard deviation were calculated for gestational age, birth weight, hemoglobin and hematocrit. Frequency and proportions were calculated for gender and polycythemia. Results: Mean gestational age of the mothers was 39.27 ± 1.50 weeks. Of 190 neonates, 91 (47.9%) were males, 99 (52.1%) were females. Mean birth weight was 3.64 ± 0.72 kg while mean Hb and HCT levels were 16.07 ± 2.30 g/dl and 63.26 ± 5.32% respectively. Keeping cut off value of 13.5 g/dl of Hb to label anemia or no, 35 (18.4%) neonates were anemic in this study. The polycythemia (HCT >65%) was present in 72 (37.9%) of neonates. There was no difference between groups in terms of gender, anemia, gestational age and birth weight (p values 0.663, 0.852, 0.700 and 0.491 respectively). The distribution of polycythemia was different among groups (p value 0.007). The mean hemoglobin level in group A was 15.52 ± 1.90 g/dl while in group B it was 16.62 ± 2.53 g/dl (p value 0.001). Mean Hb levels were statistically not different among some of the groups (gestational age <40 weeks, birth weight <4 kg) while HCT levels are significantly different among male group and category of birth weight >4 kg. Rest of the stratification groups showed significant difference. Conclusion: The delayed cord clamping in neonates results in increased mean hemoglobin and hematocrit levels with increased frequency of polycythemia as compared to early cord clamping.

scholarly journals Assessment of effectiveness of delayed cord clamping and umbilical cord milking in early term and preterm infants

2018 ◽  
Vol 5 (6) ◽  
pp. 2071
Author(s):  
Mahendra K. Jain ◽  
Nidhi Bhedru ◽  
Anubhuti Jain
Keyword(s):  
Umbilical Cord ◽  
Randomized Study ◽  
Delayed Cord Clamping ◽  
Term Infants ◽  
Early Term ◽  
Cord Clamping ◽  
Significant Difference ◽  
Insignificant Difference ◽  
Nicu Admission ◽  
Umbilical Cord Milking

Background: Early cord clamping and cutting of the umbilical cord is widely practiced as part of the management of labor; it could deprive the neonate of about a quarter of its blood volume and iron. This thesis is aimed at comparing effects of delayed cord clamping versus umbilical cord milking at birth in preterm and early term infants.Methods: This single centered randomized study was conducted in Department of Pediatrics and data collection was done on the basis of the preterm and early term infants delivered by vaginal or cesarean delivery in Department of Gynecology, Geetanjali Medical College and Hospital, Udaipur during period of January 2016 to January 2017. Total of 120 infants were included in the study.Results: Statistically it has been analyzed that in both pre-term and early term infants who underwent DDC and UCM, there was insignificant difference in level of hemoglobin (Hb), haematocrit (HCT), blood sugar, bilirubin level (TSB) and temperature of body. On the other hand, significant difference was observed in weight and cord pH of neonates of both groups. There is also insignificant difference in terms of NICU admission for RDS, sepsis, phototherapy, need of oxygen, saline boluses, PRBC transfusion, polycythemia.Conclusions: Thus, overall it was observed that there is insignificant difference in delayed cord clamping and umbilical cord milking group. Thus, both are found to be equally effective in improving hematologic parameters. 

scholarly journals Pengaruh Delayed Cord Clamping terhadap Kadar Hemoglobin (HB) dan Hematokrit (HT) pada Bayi

2020 ◽  
Vol 15 (1) ◽  
pp. 112-121
Author(s):  
Bunga Tiara Carolin ◽  
Suprihatin . ◽  
Ami Damayanti
Keyword(s):  
T Test ◽  
Deficiency Anemia ◽  
Control Group ◽  
Delayed Cord Clamping ◽  
Term Infants ◽  
Control Group Design ◽  
Cord Clamping ◽  
Group Data ◽  
The Mean ◽  
Experimental Group

The main serious problem in Indonesia is anemia, this is a major nutritional problem in children in Indonesia. The incidence of iron deficiency anemia in term infants 0-6 months is 40.8%. One of the efforts to deal with anemia in infants and toddlers is by delaying the clamping and cutting of the center because the newborn is still getting a blood transfusion from the placenta around 100 ml. The Objective to determine the effect of delaying cord clamping and cutting on hemoglobin (Hb) and hematocrit (Ht) levels in infants at Utama Anny Rahardjo Clinic. This research is an experimental research with posttest only control group design. The population in this study were all babies born from May - July 2019. Sampling in the study with purposive sampling so that 15 respondents were obtained as the control group and 15 respondents as the experimental group. Data analysis uses independent t-test. The mean Hb and Ht levels of the control group were 15.033 gr/dl and 46.25% and the mean in the experimental group was 19.332 gr/dl for Hb and Ht 59.11%. The results of the analysis by independent t-test obtained a significance value 0,000. The Conclusion there are differences in Hb and Ht levels in infants with immediate and delayed cord cutting and clamping.

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