scholarly journals Delayed cord clamping for prevention of iron deficiency anemia in term infants

2012 ◽  
Vol 52 (4) ◽  
pp. 223
Author(s):  
Olga Rasiyanti Siregar ◽  
Bugis Lubis ◽  
Muara Lubis ◽  
Bidasari Lubis ◽  
Guslihan Dasa Tjipta
Keyword(s):  
Iron Deficiency ◽  
Iron Status ◽  
Ferritin Level ◽  
Newborn Infants ◽  
Deficiency Anemia ◽  
Delayed Cord Clamping ◽  
Term Infants ◽  
Cord Clamping ◽  
Early Cord Clamping ◽  
Umbilical Cords

Background Iron deficiency childhood is a concern due to its potentially detrimental effectson development, some of which may be irreversible even after irontreatment. Delayed cord clamping may prevent IDA by increasingan infant's iron reserve at birth.Objective We aimed to evaluate the effect of delayed umbilicalcord clamping at birth on the iron status in newborns at age 24hours of life.Methods This randomized, single􀁒blind study was conducted fromMarch to May 2009, at two general hospitals in Medan, NorthSumatera Province. Eligible newborn infants were randomlyassigned to one of two groups: early cord clamping (Eee)performed 15 seconds after delivery or delayed cord clamping(DeC) performed 2 minutes after delivery. Infants were placed ontheir mothers' abdomens before the umbilical cords were clamped.Hematologic status was determined from umbilical cord blood.Results Sixty􀁒three subjects were included in our study, consistingof31 infants in the Eee group and 32 infants in the Dec group.We found that mean neonatal hemoglobin level was higher inthe Dec group than in the Eee group ( 18.4 g% and 16.2 g%,respectively, P=O.OOOl). Also, mean ferritin level was higher inthe Dec group than in the Eee group (556 mg/dL and 329 mg/dL, respectively, p=o.o 15). Other hematological status indicators,including mean hematocrit and mean corpuscular volume (MeV)level, were also higher in the Dec group. However, mean redblood cell levels were not significantly groups. Nor was there a significant level between the Dec and Eee groups.Concl usion Dela y ed cord c l a m p i n g m a y improve ironstatus and prevent IDA in term infants. [Paediatr Indones.2012;52:223-8].

scholarly journals Delayed cord clamping for prevention of iron deficiency anemia in term infants

2012 ◽  
Vol 52 ◽  
pp. 223-228
Author(s):  
Olga Rasiyanti Siregar ◽  
Bugis M. Lubis ◽  
Muara P Lubis ◽  
Bidasari Lubis ◽  
Guslihan Dasa Tjipta
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Delayed Cord Clamping ◽  
Term Infants ◽  
Cord Clamping

Increment in Phototherapy After Adopting Delayed Cord Clamping Practice

2021 ◽  
pp. 097321792110607
Author(s):  
Chinmay Chetan ◽  
Nishant Banait ◽  
Vikramaditya Athelli ◽  
Bhvya Gupta ◽  
Prince Pareek ◽  
...  
Keyword(s):  
Tertiary Care ◽  
World Health ◽  
Care Hospital ◽  
Delayed Cord Clamping ◽  
Term Infants ◽  
Cord Clamping ◽  
Early Cord Clamping ◽  
Baseline Characteristics ◽  
Health Organization ◽  
Larger Sample

Introduction: World Health Organization (WHO) in 2014 recommended delayed cord clamping (DCC) in all babies who cry immediately after birth. Despite many benefits, there are concerns of increased rate of phototherapy in babies receiving DCC. This study was done to determine the increment in the rate of phototherapy required in infants managed with DCC vs infants managed with early cord clamping (ECC). Methods: A retrospective observational study was conducted in a tertiary care hospital in Pune, India. All the infants born between January 2018 and July 2018, for whom ECC was done, were compared with infants who were born between January 2019 and July 2019, after DCC policy was adopted. All the infants with birth weight ≥2 kg and gestation ≥35 weeks, who were with their mother, were included. Baseline characteristics were compared for both the groups. American Academy of Pediatrics guidelines for treatment of neonatal jaundice were used to determine the need for phototherapy. Number of infants in both the groups who required phototherapy were compared. Results: The ECC group had 565 infants while DCC group had 731 infants. There was no difference in the baseline characteristics of the 2 groups. Jaundice requiring phototherapy was noted in 31% of infants in the ECC group, compared to 45% in infants in the DCC group (relative risk: 1.47 [1.27-1.71] [ P < .001]). Conclusion: In this study, DCC increased the need for phototherapy by 47% in late preterm and term infants. Randomized control trials with larger sample size are required to confirm this finding.

scholarly journals Pengaruh Delayed Cord Clamping terhadap Kadar Hemoglobin (HB) dan Hematokrit (HT) pada Bayi

2020 ◽  
Vol 15 (1) ◽  
pp. 112-121
Author(s):  
Bunga Tiara Carolin ◽  
Suprihatin . ◽  
Ami Damayanti
Keyword(s):  
T Test ◽  
Deficiency Anemia ◽  
Control Group ◽  
Delayed Cord Clamping ◽  
Term Infants ◽  
Control Group Design ◽  
Cord Clamping ◽  
Group Data ◽  
The Mean ◽  
Experimental Group

The main serious problem in Indonesia is anemia, this is a major nutritional problem in children in Indonesia. The incidence of iron deficiency anemia in term infants 0-6 months is 40.8%. One of the efforts to deal with anemia in infants and toddlers is by delaying the clamping and cutting of the center because the newborn is still getting a blood transfusion from the placenta around 100 ml. The Objective to determine the effect of delaying cord clamping and cutting on hemoglobin (Hb) and hematocrit (Ht) levels in infants at Utama Anny Rahardjo Clinic. This research is an experimental research with posttest only control group design. The population in this study were all babies born from May - July 2019. Sampling in the study with purposive sampling so that 15 respondents were obtained as the control group and 15 respondents as the experimental group. Data analysis uses independent t-test. The mean Hb and Ht levels of the control group were 15.033 gr/dl and 46.25% and the mean in the experimental group was 19.332 gr/dl for Hb and Ht 59.11%. The results of the analysis by independent t-test obtained a significance value 0,000. The Conclusion there are differences in Hb and Ht levels in infants with immediate and delayed cord cutting and clamping.

scholarly journals A randomised control trial comparing the efficacy of cord milking over the delayed cord clamping on serum ferritin level in preterm neonates at 6 weeks of age

2020 ◽  
Vol 7 (5) ◽  
pp. 1017
Author(s):  
Sahana Devadas ◽  
Roshni R. ◽  
Mallesh K.
Keyword(s):  
Umbilical Cord ◽  
Iron Status ◽  
Ferritin Level ◽  
Clinical History ◽  
Randomised Control Trial ◽  
Preterm Neonates ◽  
Delayed Cord Clamping ◽  
Iron Stores ◽  
Cord Clamping ◽  
Umbilical Cord Milking

Background: Perinatal iron deficiency has received little attention in the past. Umbilical cord milking is a type of placental transfusion, they serve to potentially enhance neonatal blood volume and consequently the iron stores after birth. Among the neonates, the preterm infants are sick and vulnerable babies who are already deprived of iron stores. The aim of this study was to evaluate the effect of cord milking on ferritin values amongst preterm neonates.Methods: This is a hospital based randomized control trial which included the babies born at 29-36 weeks of gestation. The babies were randomized to two intervention groups; cord milking and delayed cord clamping group. Detailed clinical history taken, including details of labour and clinical examination. Blood samples were analysed for ferritin as required at 6 weeks of post-natal age.Results: Neonates under cord milking group had higher ferritin values (249.04±21.93 ng/mL) as compared to those neonates under delayed cord clamping group (179.66±32.94 ng/mL) and this was statistically very significant (p= <0.001).Conclusions: In preterm neonates, umbilical cord milking results in improved iron status as shown by higher ferritin values at 6 weeks of life. UCM can be a used as placental transfusion strategy in preterm neonates for improving iron status and preventing anemia of prematurity.

Limited value of routine iron studies prior to initiation of erythropoietin therapy in patients with ovarian cancer

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 19677-19677
Author(s):  
G. Riebandt ◽  
S. A. South ◽  
K. Odunsi ◽  
S. Lele ◽  
K. Rodabaugh
Keyword(s):  
Ovarian Cancer ◽  
Growth Factors ◽  
Iron Deficiency ◽  
Cancer Patients ◽  
Iron Status ◽  
Ferritin Level ◽  
The Body ◽  
Deficiency Anemia ◽  
Functional Iron Deficiency ◽  
Iron Deficient

19677 Background: Anemia is a common consequence of cancer which significantly impacts patient quality of life. The mainstay of treatment for cancer- and chemotherapy-related anemia is erythropoietin therapy. However, approximately 30% to 50% of patients will not respond to these growth factors. The literature attributes this lack of response to functional iron deficiency, when iron stores are normal but the body cannot meet the increased rate of erythropoiesis. We evaluated the iron status of patients with ovarian malignancies receiving chemotherapy and erythropoietin therapy to establish a baseline for implementation of an intervention service. Methods: After obtaining Institutional Review Board approval, we identified 55 ovarian cancer patients receiving erythropoietin therapy from January to December 2005. We then performed a retrospective chart review for patients who had iron studies available. Results: Thirty-four patients had complete iron studies performed, while an additional 10 had only a ferritin level obtained. The mean hemoglobin for all patients was 9.9g/dl (6.9–13.1) with a mean MCV (mean corpuscular volume) of 92.7fl. Four (12%) patients were iron deficient based on ferritin <100ng/ml and iron saturation <20%. However, these patients had normal MCVs, indicating iron deficiency was not the etiology of their anemia. A few patients were assessed for B12 and folate deficiency, but none were identified. Interestingly, we had 22 patients with elevated ferritin levels (greater than 322ng/ml), with the highest being 2178ng/ml. Conclusions: Our results identified a few patients who were iron deficient, but none were diagnosed with iron deficiency anemia. Therefore, the role of routine iron screening in patients with a normal MCV prior to initiation of erythropoietin therapy is in question. We believe that functional iron deficiency may contribute to anemia in our population. Therefore, we suggest that all patients receive iron supplementation at erythropoietin therapy initiation. We plan to prospectively assess the optimal route of iron administration in ovarian cancer patients in order to improve the response rate to erythropoietic growth factors. No significant financial relationships to disclose.

scholarly journals Pemerahan dan penundaan penjepitan tali pusat terhadap kadar hemoglobin bayi baru lahir

2018 ◽  
Vol 5 (3) ◽  
pp. 195-200
Author(s):  
Ahmaniyah Ahmaniyah ◽  
Kamilah Hidajati ◽  
Ari Suwondo
Keyword(s):  
Treatment Group ◽  
Umbilical Cord ◽  
Vascular System ◽  
Sampling Technique ◽  
Deficiency Anemia ◽  
Control Group ◽  
Delayed Cord Clamping ◽  
Term Infants ◽  
Cord Clamping ◽  
Umbilical Cord Milking

The incidence of iron deficiency anemia in term infants from 0-6 months is 40.8%. Efforts to reduce anemia in infants and toddlers is by ensuring the baby gets blood from the placenta through the umbilical cord. Labor occurs when oxygen shifts from the heart to the lungs 8-10% of the fetal period to 50% in neonates. Immediate cord clamping vascular resistance from the disconnected placenta which results in the increased of resistance of the baby's vascular system and eliminates about 1/4 of the volume of blood and iron in the neonate. The time of cutting the umbilical cord is a determining factor for placental transfusion to the baby. Delay cord clamping and umbilical cord milking are expected to provide iron reserves in infant. The aim of this study was to determine the differences in umbilical cord milking and delayed cord clamping. The design used experimental study with posttest-Only Control Group. The sampling technique used simple random sampling differs into treatment group and control group. The treatment group was umbilical cord milking and the control group was delayed cord clamping. The highest average of Hb levels in the umbilical cord milking group was 17.3mmHg and the delayed cord clamping group was 15.75 mmHg. Difference test on umbilical cord milking group and delayed cord clamping group used independent T-test obtained P <0.05 (p = 0,001). It is recommended that midwives used umbilical cord milking as an alternative action in providing midwifery care to newborns when clamping and cutting the umbilical cord. It was proven that there were differences in the haemoglobin levels of newborns between the umbilical cord milking group and delayed cord clamping group.

scholarly journals Effect of Emblica Officinalis (amloki) on iron status in pregnant women with iron deficiency anaemia

2019 ◽  
Vol 14 (1) ◽  
pp. 1-6
Author(s):  
Tahmina Akter ◽  
Qazi Shamima Akhter
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Serum Iron ◽  
Iron Supplementation ◽  
Binding Capacity ◽  
Iron Status ◽  
Ferritin Level ◽  
Deficiency Anemia ◽  
Iron Level ◽  
Emblica Officinalis

Background: Common clinical practice of prescribing Iron supplementation for Iron deficiency anemia (IDA) in pregnancy is associated with a number of side effects. Emblica officinalis (amloki) is a well known dietary supplement used by traditional practitioners to treat anemia. Objective: To evaluate the effects of oral supplementation of Emblica officinalis on iron status in pregnant women with IDA. Methods: This prospective interventional study was carried out in the Department of Physiology, Dhaka Medical College (DMC), Dhaka from July 2016 to June 2017 on 43 pregnant women aged 18 to 36 years between 13th to 20th weeks of gestation with IDA. They were recruited from the Out-patient department of Obstetrics and Gynaecology, DMC Hospital. Among them 24 were supplemented with amloki and iron (IAS) and 19 women received only iron supplementation (IS). Study variables were estimated at the baseline and after 45 days of supplementation. Serum iron, ferritin and Total iron binding capacity (TIBC) were estimated following standard laboratory methods. Data were expressed as mean ± SD. Paired and Unpaired Student’s t-test were used for statistical analysis. Results: Serum iron levels were significantly higher (p<0.001) and serum TIBC were significantly lower (p<0.001) in both groups after supplementation compared to their baseline value. But post supplementation serum ferritin level was significantly higher (p<0.01) only in IAS group compared to that of the baseline. Again, after intervention, serum iron level was significantly higher (p<0.05) and serum TIBC was significantly lower (p<0.01) in IAS group when compared with those of IS group. Conclusions: Data concluded that oral Emblica officinalis supplement along with iron was more effective than only iron supplementation to improve serum iron status in pregnant women with IDA. J Bangladesh Soc Physiol. 2019, June; 14(1): 1-6

scholarly journals A Comparative Study of Interleukin 6, Inflammatory Markers, Ferritin, and Hematological Profile in Rheumatoid Arthritis Patients with Anemia of Chronic Disease and Iron Deficiency Anemia

Anemia ◽  
2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Eman Tariq Ali ◽  
Azza Sajed Jabbar ◽  
Ali Nazar Mohammed
Keyword(s):  
Rheumatoid Arthritis ◽  
Iron Deficiency ◽  
Serum Level ◽  
Iron Deficiency Anemia ◽  
Iron Status ◽  
Ferritin Level ◽  
Hematological Parameters ◽  
Blood Parameters ◽  
Deficiency Anemia ◽  
Anemia Of Chronic Disease

Background. Interleukin-6 (IL-6) proinflammatory cytokine is associated with the pathogenesis of rheumatoid arthritis and development of anemia in it. This is a comparative study of inflammatory and hematological parameters in RA patients with anemia of chronic disease (ACD) and iron deficiency anemia (IDA). It aimed to demonstrate the changes in serum level of IL-6, ferritin level, and hematological parameters in different groups of patients with RA and to find out the potential correlation between serum level of IL-6 and ferritin level and the relationship between serum level of IL-6 and iron status. Methods. The study included 89 patients from both sexes divided into four groups (group 1: 30 iron deficiency anemia (IDA), 59 RA; group 2: 20 RA-COMBI; group 3: 23 RA-ACD; and group 4: 16 nonanemic RA). These different groups were compared with a healthy group of 50 healthy individuals. Different blood parameters (WBC, RBC, HGB, HCT, MCV, and MCH) have been evaluated. Serum concentrations of IL-6, hsCRP, anti-CCP, and ferritin were measured in all patients and healthy individual using enzyme-linked immunosorbent assay ELISA. Results. There were significant changes in most of blood parameters between the groups, and there was a significant increase in the levels of IL-6 among RA patients. This increase was highly significant among RA-ACD patients in particular, and this elevation has been directly correlated with clinical indices of disease activity such as hsCRP, ESR, anti-CCP, and ferritin. There was an inverse relationship between ferritin and all iron status parameter, such as RBC, HGB, and haematocrit. Conclusion. IL-6 and ferritin level estimation may be workable tests to differentiate the patients with IDA and ACD in RA.

scholarly journals Iron deficiency in preschool non-anemic Egyptian children

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Osama M. El-Asheer ◽  
Mary S. Naeem ◽  
Fardos A. Abdel-Hafez ◽  
Madleen A. A. Abdou ◽  
Khalil A. Mohamed
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Complete Blood Count ◽  
Binding Capacity ◽  
Iron Status ◽  
Ferritin Level ◽  
Transferrin Saturation ◽  
Deficiency Anemia ◽  
Healthy Children ◽  
Egyptian Children

Abstract Background Iron deficiency anemia remains a common cause of anemia in young children. The term iron deficiency without anemia, or the so-called latent iron deficiency, has become increasingly significant as it is not only difficult to identify this condition in non-anemic children, but it also adversely affects neurocognitive development, and unfortunately, some of these effects may be irreversible and not respond to treatment. This cross-sectional study was conducted to evaluate iron status in 68 apparently healthy, non-anemic Egyptian children aged 1–6 years. They were subjected to detailed history-taking, physical examination, complete blood count, and tests for serum iron, total iron binding capacity, serum ferritin, and transferrin saturation. Results Low serum ferritin level and low transferrin saturation were detected in 41.2% and 47% of the children, respectively. Iron deficiency parameters were significantly affected among toddlers aged “1” to “3” years compared with preschool children, and boys were found to be more affected than girls of the same age group. Conclusions A normal hemoglobin level does not exclude iron deficiency, which should be screened in healthy children to prevent the possible long-term effects of iron deficiency on their cognition and mental development.

scholarly journals Complementary Feeding and Iron Status: “The Unbearable Lightness of Being” Infants

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4201
Author(s):  
Vito Leonardo Miniello ◽  
Maria Carmen Verga ◽  
Andrea Miniello ◽  
Cristina Di Mauro ◽  
Lucia Diaferio ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Complementary Feeding ◽  
Time Window ◽  
Iron Status ◽  
Healthcare Providers ◽  
Deficiency Anemia ◽  
Iron Intake ◽  
Term Infants ◽  
Nutritional Interventions ◽  
Consensus Document

The complementary feeding (CF) period that takes place between 6 and 24 months of age is of key importance for nutritional and developmental reasons during the transition from exclusively feeding on milk to family meals. In 2021, a multidisciplinary panel of experts from four Italian scientific pediatric societies elaborated a consensus document on CF, focusing in particular on healthy term infants. The aim was to provide healthcare providers with useful guidelines for clinical practice. Complementary feeding is also the time window when iron deficiency (ID) and iron deficiency anemia (IDA) are most prevalent. Thus, it is appropriate to address the problem of iron deficiency through nutritional interventions. Adequate iron intake during the first two years is critical since rapid growth in that period increases iron requirements per kilogram more than at any other developmental stage. Complementary foods should be introduced at around six months of age, taking into account infant iron status.

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