Diagnosis: Ankylosing Spondylitis (Bechterew Disease) without Clinical Signs of Acute Inflammation

2008 ◽  
Keyword(s):  
Ankylosing Spondylitis ◽  
Acute Inflammation ◽  
Clinical Signs ◽  
Bechterew Disease

A retrospective study of non-specific rhinitis in 22 cats and the value of nasal cytology and histopathology

2003 ◽  
Vol 5 (5) ◽  
pp. 279-285 ◽  
Author(s):  
L Michiels ◽  
M.J Day ◽  
F Snaps ◽  
P Hansen ◽  
C Clercx
Keyword(s):  
Retrospective Study ◽  
Acute Inflammation ◽  
Clinical Signs ◽  
Final Diagnosis ◽  
Poor Quality ◽  
Mucosal Inflammation ◽  
Initial Population ◽  
Normal Cytology ◽  
Nasal Disease ◽  
Histological Results

Case records from 40 cats subjected to rhinoscopic examination for investigation of chronic nasal disease were reviewed. Cases in which no specific underlying cause (eg neoplasia) was detected were further selected for detailed retrospective study. In these 22 cats (55% of the initial population), a final diagnosis of non-specific chronic nasal disease was made. The radiographic, rhinoscopic, cytological and histopathological findings were reviewed. Mucosal biopsy specimens were obtained in 20 cases. Despite clinical signs of more than 4 weeks duration, histopathology indicated acute inflammation in four cases. Two cases had chronic lymphoplasmacytic inflammation and 14 had mixed (lymphoplasmacytic and neutrophilic) inflammation. Specimens for cytology were obtained from 17 cases by brush sampling. Three of these samples were not diagnostic due to the poor quality of the slides; one showed normal cytology. Acute inflammation was diagnosed by cytology ( n=11) more commonly than chronic ( n=1) or mixed inflammation ( n=1). Concurrent samples, of quality suitable for both histopathological and cytological interpretation, were collected from 12 cases only. Cytological results were in agreement with the histological results in 25% of these cases, the main discrepancy being the nature of the dominant inflammatory cell type. Therefore cytology does not appear to be a reliable means for detection of chronic inflammation. Further studies are needed in order to investigate the correlation between the nature of mucosal inflammation as defined by both histological and cytological evaluation, and the relationship of these test results to prognosis and therapy.

scholarly journals Effect of secukinumab on clinical and radiographic outcomes in ankylosing spondylitis: 2-year results from the randomised phase III MEASURE 1 study

2016 ◽  
Vol 76 (6) ◽  
pp. 1070-1077 ◽  
Author(s):  
Jürgen Braun ◽  
Xenofon Baraliakos ◽  
Atul Deodhar ◽  
Dominique Baeten ◽  
Joachim Sieper ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Response Rates ◽  
Phase Iii ◽  
X Rays ◽  
Serious Adverse Events ◽  
Radiographic Outcomes ◽  
Clinical Signs And Symptoms ◽  
Radiographic Changes

ObjectiveTo evaluate the effect of secukinumab, an interleukin-17A inhibitor, on clinical signs and symptoms and radiographic changes through 2 years in patients with ankylosing spondylitis (AS).MethodsIn the phase III MEASURE 1 study, patients were randomised to receive intravenous secukinumab 10 mg/kg (at baseline, week 2 and week 4) followed by subcutaneous secukinumab 150 mg (intravenous 150 mg; n=125) or 75 mg (intravenous 75 mg; n=124) every four weeks, or matched placebo (n=122). Placebo-treated patients were re-randomised to subcutaneous secukinumab 150 or 75 mg from week 16. Clinical efficacy assessments included Assessment of SpondyloArthritis international Society 20 (ASAS20) response rates through week 104. Radiographic changes at week 104 were assessed using the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS).Results97 (77.6%) and 103 (83.1%) patients in the intravenous 150 mg and intravenous 75 mg groups, respectively, completed week 104. In the full analysis set (intent-to-treat), ASAS20 response rates at week 104 were 73.7% and 68.0% in the intravenous 150 mg and intravenous 75 mg groups, respectively. Among patients with evaluable X-rays who were originally randomised to secukinumab (n=168), mean change in mSASSS from baseline to week 104 was 0.30±2.53. Serious adverse events were reported in 12.2% and 13.4% of patients in the 150 mg and 75 mg groups, respectively.ConclusionsSecukinumab improved AS signs and symptoms through 2 years of therapy, with no unexpected safety findings. Data from this study suggest a low mean progression of spinal radiographic changes, which will need to be confirmed in longer-term controlled studies.Trial registration numberNCT01358175.

Hyperplasia of the Coronoid Process in Patients With Ankylosing Spondylitis (Bechterew Disease)

2008 ◽  
Vol 19 (4) ◽  
pp. 1114-1118 ◽  
Author(s):  
Matthias Wenghoefer ◽  
Markus Martini ◽  
Jean-Piere Allam ◽  
Natalja Novak ◽  
Rudolf Reich ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Coronoid Process ◽  
Bechterew Disease

scholarly journals Fatal disseminated toxoplasmosis in a brown-throated sloth (Bradypus variegatus) from Northern Brazil – Case report

2020 ◽  
Author(s):  
Fabiano José Ferreira de Sant’Ana ◽  
Juliana dos Santos Batista ◽  
Guilherme Reis Blume ◽  
Luciana Sonne ◽  
Claudio Severo Lombardo de Barros
Keyword(s):  
Case Report ◽  
Acute Inflammation ◽  
Clinical Signs ◽  
Northern Region ◽  
Aetiological Agent ◽  
Pathological Findings ◽  
Tissue Sections ◽  
Northern Brazil ◽  
Bradypus Variegatus ◽  
Loss Of Appetite

AbstractThe clinical and pathological findings of a case of fatal disseminated toxoplasmosis in a captive brown-throated sloth (Bradypus variegatus) from the northern region of Brazil are reported. Clinical signs were nonspecific and included apathy, prostration, dyspnoea, and loss of appetite. Treatment with penicillin was attempted, but the animal died within five days of the onset of clinical signs. Microscopically, there was acute inflammation in the liver, spleen, and lungs associated with necrosis and a few cysts and extracytoplasmic tachyzoites, with a morphology compatible with Toxoplasma gondii. Tissue sections were submitted for immunohistochemistry that confirmed T. gondii as the aetiological agent. To the authors’ knowledge, this is the first report of toxoplasmosis in B. variegatus.

scholarly journals Female- and Intruder-induced Ultrasonic Vocalizations in C57BL/6J Mice as Proxy Indicators for Animal Wellbeing

2019 ◽  
Vol 69 (5) ◽  
pp. 374-383
Author(s):  
Brian J Smith ◽  
Kate E P Bruner ◽  
Lon V Kendall
Keyword(s):  
Adult Female ◽  
Acute Inflammation ◽  
Clinical Signs ◽  
Ultrasonic Vocalizations ◽  
Sublethal Dose ◽  
Male Mice ◽  
Female Mice ◽  
Female Urine ◽  
Proxy Indicators ◽  
Affiliative Behaviors

Female urine-induced male mice ultrasonic vocalizations (FiUSV) are ultrasonic vocalizations produced by adult male mice after presentation of adult female urine, whereas intruder-induced ultrasonic vocalizations (IiUSV) are produced by resident adult female mice when interacting with an intruder female mouse. These affiliative behaviors may be reduced when mice have decreased wellbeing or are in pain and distress. To determine whether FiUSV and IiUSV can be used as proxy indicators of animal wellbeing, we assessed FiUSV produced by male C57BL/6J mice in response to female urine and IiUSV produced by female C57BL/6J mice in response to a female intruder at baseline and 1 and 3 h after administration of a sublethal dose of LPS (6 or 12.5 mg/kg IP) or an equal volume of saline. Behavior was assessed by evaluating orbital tightness, posture, and piloerection immediately after USV collection. We hypothesized that LPS-injected mice would have a decreased inclination to mate or to interact with same-sex conspecifics and therefore would produce fewer USV. At baseline, 32 of 33 male mice produced FiUSV (149 ± 127 USV in 2 min), whereas all 36 female mice produced IiUSV (370 ± 156 USV in 2 min). Saline-injected mice showed no change from baseline at the 1- and 3-h time points, whereas LPS-injected mice demonstrated significantly fewer USV than baseline, producing no USV at both 1 and 3 h. According to orbital tightness, posture, and piloerection, LPS-injected mice showed signs of poor wellbeing at 3 h but not 1 h. These findings indicate that FiUSV and IiUSV can be used as proxy indicators of animal wellbeing associated with acute inflammation in mice and can be detected before the onset of clinical signs.

scholarly journals Undifferentiated seronegative spondyloarthritis with inflammatory bowel disease and a family history of psoriasis. Sicca syndrome

2013 ◽  
pp. 189-191
Author(s):  
Norma Marigliano ◽  
Domenico Galasso
Keyword(s):  
Inflammatory Bowel Disease ◽  
Psoriatic Arthritis ◽  
Ankylosing Spondylitis ◽  
Bowel Disease ◽  
Acute Inflammation ◽  
Clinical Manifestations ◽  
Hla B27 ◽  
History Of ◽  
Seronegative Spondyloarthritis ◽  
Inflammatory Bowel

Background: Seronegative spondyloarthritis is characterized by the presence of subcutaneous nodules, asymmetrical peripheral arthritis, sacroileitis with or without spondylitis, and rheumatoid-factor negativity. Other common clinical manifestations include oral ulcers, conjunctivitis, and cutaneous lesions such as psoriasis. Familial aggregation has also been described. According to the 1986 classification, corresponding clinical entities include ankylosing spondylitis, psoriatic arthritis, Reiter’s syndrome, arthritis associated with inflammatory bowel disease (IBD), and undifferentiated spondyloarthritis. The disease is also frequently associated with the HLA B27 antigen. From the clinical point of view, there are often incomplete forms of spondyloarthritis, such as reactive arthritis triggered by asymptomatic infections, psoriatic arthritis without psoriasis itself, initial phases of specific forms of spondyloarthritis or the phase of ankylosing spondylitis characterized by sacroiliac lesions, and all forms that remain undifferentiated for long periods of time. Moreover, there are close relations between arthropathy and IBDs, such as Crohn’s disease, ulcerative colitis, and Whipple’s syndrome. Recently, microscopic inflammatory bowel lesions and psoriatic arthritis have been described. Case report: A 30-year-old man (HLA B27-negative) who had been vaccinated against TBC and HBV presented with a 6-year history of recurrent episodes of predominantly left-sided sciatica. The pain was worse at night and during rest. He was suffering from bilateral sacroileitis without spondylitis. Three to five times a day, usually after eating, he passed watery feces containing mucous and small amounts of bright red blood. Colonoscopy revealed pancolitis with histological evidence of chronic inflammation interspersed with areas of acute inflammation, edema, hyperemia, and glandular distortion. One year later, the clinical manifestations and histological findings were essentially unchanged: glandular distortions, chronic and acute inflammation of the lamina propria and crypt microabscesses. There were no granulomas and no evidence of uveitis. The inflammatory index was positive; FR, ENA, ANA titers were negative. He began therapy with adalimumab (loading dose 80 mg followed by 40 mg every 15 days) and mesalazine (2.4 g per os), and the clinical manifestations of the disease improved significantly.

Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis

2014 ◽  
Vol 5 (12) ◽  
pp. 3241-3251 ◽  
Author(s):  
M. E. Figueira ◽  
M. B. Câmara ◽  
R. Direito ◽  
J. Rocha ◽  
A. T. Serra ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Acute Inflammation ◽  
Clinical Signs ◽  
Chemical Characterization ◽  
Experimental Models ◽  
Pharmacological Effects ◽  
Red Raspberry ◽  
Collagen Induced Arthritis ◽  
Fruit Extract

A red raspberry extract reduces inflammation and the development of clinical signs of arthritis in Wistar rats.

scholarly journals Clonorchis Sinensis-Derived Protein Attenuates Inflammation and New Bone Formation in Ankylosing Spondylitis

2020 ◽  
Author(s):  
Yu Jeong Lee ◽  
Moon-Ju Kim ◽  
Sungsin Jo ◽  
So-Hee Jin ◽  
Pu-Reum Park ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Ankylosing Spondylitis ◽  
Bone Formation ◽  
Mononuclear Cells ◽  
Clonorchis Sinensis ◽  
Clinical Signs ◽  
Protective Effects ◽  
New Bone Formation ◽  
Micro Computed Tomography ◽  
Peripheral Blood Mononuclear

Abstract Background: Helminth infections and their components have been shown to have potential to modulate immunity and attenuate immune response. The objective of this study was to evaluate potential protective effects of Clonorchis sinensis–derived protein (CSp) on ankylosing spondylitis (AS).Methods: Cytotoxicity of CSp at different doses was assessed by MTS and flow cytometry before performing experiments. Peripheral blood mononuclear cells (PBMCs) and Synovial fluid mononuclear cells (SFMCs) were obtained from AS patients. Inflammatory cytokine-producing cells were analyzed using flow cytometry. SKG mice were treated with CSp or vehicle. Inflammation and new bone formation were evaluated using immunohistochemistry, positron emission tomography (PET) and micro–computed tomography (CT).Results: Treatment with CSp resulted in no reduced cell viability of PBMCs or SFMCs. In experiments culturing PBMCs and SFMCs, the frequencies of IFN-g and IL-17A producing cells were significantly reduced after CSp treatment. In the SKG mouse model, CSp treatment significantly suppressed arthritis and enthesitis. Micro-CT analysis of hind paw revealed less new bone formation in CSp-treated mice than in vehicle-treated mice. Conclusions: We provide the first evidence demonstrating that CSp can ameliorate clinical signs and cytokine derrangements in AS. In addition, such CSp treatment could reduce new bone formation of AS.

scholarly journals Prevention of LPS- induced Acute Respiratory Distress Syndrome in Sheep by Bone Marrow-Derived Mesenchymal Stem/Stromal Cells

2020 ◽  
Author(s):  
Sirous Sadeghian Chaleshtori ◽  
Mohammad Reza Mokhber Dezfouli ◽  
Javad Abbasi ◽  
Mohammad Mehdi Dehghan ◽  
Massoumeh Jabbari Fakhr ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Total Protein ◽  
Acute Inflammation ◽  
Complete Blood Count ◽  
Clinical Signs ◽  
Blood Gases ◽  
Control Group ◽  
Arterial Blood ◽  
Tnf Α

Abstract In this study, 10 male Shall sheep were used in two groups and bone marrow samples were collected and BM-MSCs isolated. Then experimental model of ARDS was induced by intrapulmonary injection of LPS to dose of 400 μg/kg. Twenty-four hours after LPS injection, 5×107 cells of BM-MSCs were autologous transferred in the group of treatment and 1ml PBS was infused in the group of control as intrapulmonary. Then, the symptoms of clinical, complete blood count, analysis of arterial blood gases and the concentrations of IL6,IL10,TNF-α,total protein, Ig M and albumin BAL were determined before and at times of 3,6,12,24,48,72, and 168 after transplantation/infusion. The results of the investigations 24 hours post-LPS injection(time 0) indicated the occurrence of acute inflammation which confirmed ARDS model. These changes included increase in RR, HR and RT, decrease in PO2 and SatO2 and increase in PCO2, WBC, neutrophils, macrophages, total protein, IL6, IL10, TNF-α, Ig M and albumin. But the stem/stromal cells transplantation reduced the severity of clinical signs induced by LPS, caused significant increase in PO2, SatO2 and IL-10 and significant decrease in PCO2, the total protein, TNF-α, IL-6, Ig M, albumin, WBCs, neutrophils and macrophages at different times of sampling both in compared with before transplantation(time 0) and in compared with the group of control. While in the control group, inflammation continued until the end of the study. These results showed that BM-MSCs are able to reduce inflammation and have an important role in reconstruction of the damaged lung.

scholarly journals ДИНАМІКА АКТИВНОСТІ ОКРЕМИХ ФЕРМЕНТІВ СИРОВАТКИ КРОВІ ЗА ЕКСПЕРИМЕНТАЛЬНОГО ІНВАЗУВАННЯ КРОЛІВ ЗБУДНИКОМ E. STIЕDAE

2012 ◽  
pp. 122-124
Author(s):  
О. Ф. Манжос ◽  
О. О. Передера ◽  
І. В. Лавріненко ◽  
Р. В. Передера ◽  
І. А. Жерносік
Keyword(s):  
Epithelial Cells ◽  
Biliary Tract ◽  
Acute Inflammation ◽  
Clinical Signs ◽  
Biochemical Changes ◽  
Cell Integrity ◽  
Early Stages ◽  
Cytolysis Syndrome

Розвиток печінкової форми еймеріозу кролів ха-рактеризується біохімічними змінами показниківсироватки крові. Показники активності фермен-тів сироватки крові − АсАТ, АлАТ, ЛДГ, ГГТП, ЛФ− на початкових стадіях захворювання не булиспецифічними, а лише вказували на компенсаторніреакції клітин печінки та жовчовивідних шляхів.На шосту добу експерименту, незважаючи на від-сутність клінічних ознак, реєстрували підвищенняактивності АлАТ, АсАТ, ГГТП, що свідчить пропорушення структури печінки. Домінуюче значен-ня АлАТ над АсАТ у хворих кроленят на шістна-дцяту добу дослідження є наслідком розвитку го-стрих запальних процесів у паренхімі печінки. Під-вищення активності ГГТП, АлАТ, АсАТ у сироват-ці крові відповідає наявності синдрому цитолізу,що розвивається після порушення цілісності клі-тин, у яких містяться дані ферменти: гепатоци-тів і епітеліальних клітин жовчовивідних шляхів. The development of hepatic form eymeriozu rabbitscharacterized by biochemical changes in serumparameters. Indicators of enzymes of serum AST, ALT,LDH HHTP, LF in the early stages of the disease werenot specific, but only pointed to the reactions of livercells and biliary tract. At 6 th day of the experiment,despite the absence of clinical signs recorded increasedactivity of ALT, AST, HHTP, indicating violation of thestructure of the liver. Preferential increase in activity ofALT over AST in patients with rabbits at the 16 th day ofresearch is the result of acute inflammation in the liverparenchyma. Higher values HHTP, ALT, AST in serumcorresponds to the presence of cytolysis syndrome thatdevelops after disruption of cell integrity, which includes data from enzymes: hepatocytes and biliary tract epithelial cells.

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