Effects of Pinealectomy and of Sham-Pinealectomy on Blood Glucose Levels in the Alloxan-Diabetic Rat

1978 ◽  
Vol 10 (05) ◽  
pp. 389-392 ◽  
Author(s):  
K. Gorray ◽  
W. Quay
Keyword(s):  
Blood Glucose ◽  
Diabetic Rat ◽  
Glucose Levels ◽  
Blood Glucose Levels

Antidiabetic effect of Psychotria malayana Jack in induced type 1 diabetic rat

MEDISAINS ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 19
Author(s):  
Fairuz Fairuz ◽  
Hasna Dewi ◽  
Humaryanto Humaryanto
Keyword(s):  
Blood Glucose ◽  
Side Effects ◽  
Type I Diabetes ◽  
Langerhans Cell ◽  
Diabetic Rat ◽  
Type I ◽  
Antidiabetic Effect ◽  
Glucose Levels ◽  
Blood Glucose Levels

Background: Therapies for hyperglycemic treatment, including insulin and oral diabetes medications, have been confirmed to cause several side effects. Thus, finding new drugs with fewer side effects is of high importance. Salung leaf herb (Psychotria malayana Jack) reported used in traditional societies as a treatment for diabetes. However, the scientific proof of this plant for diabetes treatment is still lacking.Objective: To evaluate the antidiabetic effect of the P. malayana jack in induced type 1 diabetic rats by assessing blood glucose level and pancreatic cells in white rats.Methods: Alloxan used to induce type I diabetes. Rats randomly divided into six groups. A Group P1 received 250 mg/kg BW; group P2 received 500 mg/kg BW, group P3 received 1000 mg/kg BW. While group 4 basal received no treatment, group 5 received distilled water as a negative control, and group 6 received glibenclamide as a positive control. Medications are given for six days. Glucose levels were measured, and observation of pancreatic Langerhans cell damages.Results:  A decrease in blood glucose levels observed in all treatment groups. The most significant reduction (49.76%; 1000 mg/kg BW) occurred in the P3 group. Morphological features of pancreatic Langerhans cell damage were slightly high in the P1 group.Conclusion: P. malayana Jack can consider having an antidiabetic effect in a type 1 diabetic rat by reducing blood glucose levels.

scholarly journals ARISTOLOCHIA BRACTEOLATA – ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY IN DEXAMETHASONE-INDUCED DIABETIC RAT MODEL

2017 ◽  
Vol 10 (8) ◽  
pp. 75
Author(s):  
Ganga Rajum ◽  
Hema Sundar Reddy T ◽  
Hema Sundar Reddy T
Keyword(s):  
Blood Glucose ◽  
Methanolic Extract ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Standard Drug ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Antihyperlipidemic Activity ◽  
Aristolochia Bracteolata

  Objective: The present study was aimed to evaluate antihyperglycemic and antihyperlipidemic activities of methanolic extract of Aristolochia bracteolata (MEAB) against dexamethasone-induced diabetic rat model.Methods: Methanolic extract was prepared by soxhlet extraction and was evaluated for antihyperglycemic and antihyperlipidemic activity using dexamethasone-induced model. The MEAB was administered orally at a dose of 200 and 400 mg/kg body weight glibenclamide was used as standard drug. On 0th and 11th day, blood was collected by retro-orbit plexus.Results: In this model blood glucose levels were determined on 0th and 11th days and MEAB significantly reduced the blood glucose levels in diabetic rats. The effect of MEAB on serum lipid profile such as total cholesterol (TC), triglycerides (TGs), low-density lipoprotein (LDL), very LDL (VLDL), and high-density lipoprotein (HDL) was also measured on the 11th day in the diabetic rats. Significant reduction in TC, TGs, LDL, and VLDL levels and improvement in HDL level were observed in diabetic rats.Conclusion: From the results, it was found that the MEAB possess antihyperglycemic and antihyperlipidemic activities.

Effect of Curcumin on the Level of Blood Lipid and Blood Glucose in Diabetic Rat Model

2014 ◽  
Vol 1051 ◽  
pp. 419-422
Author(s):  
Ming San Miao ◽  
Lin Guo ◽  
Shuo Tian ◽  
Tan Wang
Keyword(s):  
Blood Glucose ◽  
Rat Model ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Lipoprotein Cholesterol ◽  
Diabetic Rat ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Diabetic Rat Model

Objective: To investigate the effects of curcumin on blood lipid and blood glucose levels and its mechanism in diabetic rat model. Method: After streptozotocin (STZ) induced diabetic rat model, large, medium and small doses of curcumin group were partly given curcumin solution 400,200,100mg·kg-1, administered once a day, continuously 30 days. In 30 th day, determine blood glucose (BG) value, after the last injection , determine the serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels. Results: Compared with the model group rats, each dose of curcumin group rats’ BG, TC, TG and LDL-C levels were significantly decreased, HDL-C levels was increased significantly. Conclusion: Curcumin has a certain impact on blood lipids and blood glucose in diabetic rat model.

Antihyperglycemic Effect of the Aqueous Extract of Foeniculum vulgare in Normal and Streptozotocin-induced Diabetic Rats

2020 ◽  
Vol 20 (1) ◽  
pp. 54-63
Author(s):  
Fadwa El-Ouady ◽  
Nadia Lahrach ◽  
Mohammed Ajebli ◽  
Ahmed E. Haidani ◽  
Mohamed Eddouks
Keyword(s):  
Blood Glucose ◽  
Aqueous Extract ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Oral Glucose ◽  
Foeniculum Vulgare ◽  
High Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Antioxidant Effects

Background: Diabetes mellitus is associated with high blood glucose levels due to insulin shortcoming (insulinopenia) or defective insulin action. The objective of the study was to investigate the antidiabetic and antioxidant effects of Foeniculum vulgare in streptozotocin-induced diabetic rat. Methods: The effects of the leaves aqueous extract (LAE) of Foeniculum vulgare (F. vulgare) at a dose of 10 mg/kg on blood glucose levels were evaluated in normal and streptozotocin (STZ)- induced diabetic rats. Histopathological changes were also evaluated in liver in STZ-induced rats. Results: Single oral administration of F. vulgare LAE reduced blood glucose levels 6 h after administration in STZ diabetic rats (p<0.0001). Furthermore, blood glucose levels were decreased in both normal (p<0.05) and STZ diabetic rats (p<0.0001) after the fifteenth day of treatment. During this test, both groups did not show any significant change in their body weight. Moreover, this aqueous extract improved oral glucose tolerance in diabetic rats and revealed a positive effect on liver histology. On the other hand, the extract used in this experiment showed an inhibitory concentration (IC50) of 50% of free radicals with a concentration of 43±1.19 µg/ml. While the synthetic antioxidant (BHT) had an IC50 equal to 22.67±2.17µg /ml. Conclusion: This study demonstrates the antihyperglycemic, hypoglycemic and antioxidant effects of the leaves of F. vulgare in normal and diabetic rats.

Effects of Low Intensity Exercise Against Apoptosis and Oxidative Stress in Streptozotocin-induced Diabetic Rat Heart

2016 ◽  
Vol 125 (09) ◽  
pp. 583-591 ◽  
Author(s):  
M. Kanter ◽  
F. Aksu ◽  
M. Takir ◽  
O. Kostek ◽  
B. Kanter ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Cardiac Tissue ◽  
Diabetic Rat ◽  
Enzymatic Antioxidants ◽  
Citrate Buffer ◽  
Glucose Levels ◽  
Low Intensity ◽  
Blood Glucose Levels ◽  
Low Intensity Exercise

Abstract Background The aim of this study was to investigate the effects of low intensity exercise on heart of streptozotocin (STZ)-induced diabetic rats. Materials and Methods The rats were randomly divided into 3 experimental groups: A (control), B (diabetic untreated), and C (diabetic treated with low intensity exercise); each group contains 8 animals. B and C groups received STZ. Diabetes was induced in 2 groups by a single intraperitoneal (i.p) injection of STZ (40 mg/kg, freshly dissolved in 0,1 M citrate buffer, pH 4.2). 2 days after STZ treatment, diabetes in 2 experimental groups was confirmed by measuring blood glucose levels. Rats with blood glucose levels of 250 mg/dl or higher were considered to be diabetic. Animals in the exercise group were made to run the treadmill once a day for 4 consecutive weeks. Exercise started 3 days prior to STZ administration. Results After induction of diabetes, histological abnormalities were observed, including myofibrillar loss, vacuolization of cytoplasm and irregularity of myofibrils. These alterations were attenuated by low intensity exercise. Our data indicates a significant reduction of oxidative stress and apoptosis in cardiomyocytes after exercise. Treatment of diabetic animals with low intensity exercise, decreased the elevated tissue malondialdehyde (MDA) levels and increased the reduced activities of the enzymatic antioxidants superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in cardiac tissue. Conclusion These findings suggest that low intensity exercise has a therapeutic protective effect in diabetes by decreasing oxidative stress and apoptosis, and by preservation of myocardial integrity.

Antidiabetic effect of Ruta montana L. in streptozotocin-induced diabetic rats

2017 ◽  
Vol 28 (3) ◽  
Author(s):  
Omar Farid ◽  
Morad Hebi ◽  
Mohammed Ajebli ◽  
Ahmed EL Hidani ◽  
Mohamed Eddouks
Keyword(s):  
Blood Glucose ◽  
Diabetes Management ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Oral Glucose ◽  
Antidiabetic Effect ◽  
Beneficial Effects ◽  
Glucose Levels ◽  
Blood Glucose Levels

AbstractBackground:(L.) is known as a medicinal plant with many beneficial effects, including those that can be used in the treatment of diabetes. The objective of the study was to investigate the antidiabetic effect of this plant in diabetic rat.Methods:This study investigated the effects of an aerial part aqueous extract (APAE) ofResults:Both single and repeated oral doses of APAE (5 mg/kg) produced significant reductions in the blood glucose levels in normal and STZ-induced rats. Oral glucose tolerance test results showed that, after the administration of 3 g/kg of glucose, RM APAE (5 mg/kg) improved the increase in blood glucose levels in normal rats at the 30th min (p<0.01) and 90th min (p<0.001).Conclusions:RM APAE exhibits a potent hypoglycemic effect in normal rats and an antidiabetic effect in STZ-induced rats. This finding supports the use of this plant in traditional Moroccan medicine for diabetes management.

scholarly journals Evaluation of the Antihyperglycemic Effect of N-butanol Leaves Extracts of Iraqi Fumaria parviflora in Alloxan-prompt Diabetic Rats

2019 ◽  
pp. 1-7
Author(s):  
Enas Jawad Kadheem ◽  
Omar Hussein Ahmed
Keyword(s):  
Blood Glucose ◽  
Plant Extract ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
In Vivo Models ◽  
Antihyperglycemic Effect ◽  
Glucose Levels ◽  
Blood Glucose Levels

Objective: In this research, we evaluated the antihyperglycemic effect of leaves of Fumaria parviflora (F. parviflora) and implied mechanisms by using in vivo models of hyperglycemia. Materials and Methods: Fifty male Wistar rats weighing 180-220 g were applied for the research. Soxhlet ethanolic extract of leaves of F. parviflora (EFP ) was prepared. Alloxan-induced diabetic rats were orally remedied with the extract (50, 100 or 200 mg/kg/day), metformin (200 mg/kg/day) for two weeks. Another animal received only extract, alloxan (diabetic control) or vehicle (control). Results:  pretreatment effect of plant extract on blood glucose levels of diabetic rats Blood glucose levels in all extract pretreated groups was lower (p<0.05) when compared with the levels in rats that received alloxan alone, Rats that we are treated with plant extract had normal blood glucose levels that ranged for 73.00±1.5 to76.00±0.54 mg/dl at the beginning (first day) of experiment. Blood glucose levels in these animals declined during the period of extract administration, but the values obtained were not significant compared to control excluded those that were obtained on the 14th day, p < 0.05 Conclusion: Leaves of F. parviflora possess blood glucose-lowering effects  In Alloxan-Induced Diabetic  Rat, The findings of a study indicated that F. parviflora has a significant hypoglycemic effect on Alloxan-induced diabetic rats with no effects in blood glucose levels of normal rats.

scholarly journals Effect of Saurauia vulcani Korth. Leaves on Superoxide Dismutase, HbA1c Levels and Insulin Expression in Hyperglycemic Rats

2019 ◽  
Vol 7 (22) ◽  
pp. 3741-3744
Author(s):  
Chemayanti Surbakti ◽  
Panal Sitorus ◽  
Rosidah Rosidah ◽  
Denny Satria
Keyword(s):  
Superoxide Dismutase ◽  
Blood Glucose ◽  
Ethanol Extract ◽  
Glycosylated Haemoglobin ◽  
Diabetic Rat ◽  
Β Cells ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Insulin Expression ◽  
Hba1c Levels

AIM: This study aimed to investigate Saurauia vulcani Korth. leaves. the activity of ethanol extract in hypoglycemic, superoxide dismutase (SOD), glycosylated haemoglobin (HbA1c) and detection of insulin expression by immunochemistry METHODS: Saurauia vulcani Korth. Leaves powder was extracted by maceration method with ethanol 96%. The extract was administrated orally in doses of 100 mg/kg BW for 27 days. Diabetes was induced in rats by administered of Nicotinamide (NA) 230 mg/kg BW and streptozotocin (STZ) 65 mg/kg BW. Level of blood glucose, SOD, HbA1c were measured, and histopathology pancreas was observed to determine insulin expression with immunochemistry RESULTS: Ethanol extract of Saurauia vulcani Korth. Leaves (EESL) shown a significantly (*p < 0.05) reduced in blood glucose levels at 104.25 ± 2.562 mg/dL and HbA1c level at 32.53 ± 0.188 ng/mL, but increased SOD level at 60.64 ± 0.740 pg/mL and histopathology study shown secretion insulin as seen number of expressions of insulin / slice 31.00 ± 0.315. CONCLUSION: The result of this study showed EESL possess the hypoglycemic activity and increase the level of SOD but decrease the level of HbA1c in diabetic rat condition. The mechanism of the activity is suggested by stimulating the insulin secretion of pancreas β-cells which were damaged.

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