Synthesis of Fluorinated and Trifluoromethyl-Substituted Alkenes through the Modified Julia Olefination: An Update

Synthesis ◽  
2015 ◽  
Vol 47 (11) ◽  
pp. 1534-1546 ◽  
Author(s):  
Emmanuel Pfund ◽  
Thierry Lequeux ◽  
David Gueyrard
Keyword(s):  
Large Range ◽  
Short Review ◽  
The Novel ◽  
Smiles Rearrangement ◽  
Julia Olefination

The modified Julia olefination is now a powerful tool for the synthesis of a large range of functionalized alkenes. This short review covers the last five years and provides an overview of the synthesis of mono-, difluoro-, and trifluoromethyl-substituted alkenes via the modified Julia olefination focusing on the novel scope of this reaction.1 Introduction2 Monofluoroalkenes2.1 Disubstituted α- and β-Monofluoroalkenes2.2 Bis(trifluoromethyl)phenyl Sulfones2.3 Conjugated Monofluoroalkenes2.4 Intramolecular Julia Olefination2.5 Smiles Rearrangement from Fluorinated Keto Sulfones2.6 Fluoroallylamines2.7 Fluorinated exo-Glycals2.8 Monofluoroalkenes with an α-Stereocenter at the Allylic Position3 1,1-Difluoroalkenes4 Trifluoromethyl-Substituted Alkenes5 Conclusion

scholarly journals New Approach in the Application of Conjugated Polymers: The Light-Activated Source of Versatile Singlet Oxygen Molecule

Materials ◽  
2021 ◽  
Vol 14 (5) ◽  
pp. 1098
Author(s):  
Agata Blacha-Grzechnik
Keyword(s):  
Conjugated Polymers ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Photophysical Properties ◽  
Short Review ◽  
The Novel ◽  
New Approach ◽  
Intermolecular Energy ◽  
Intermolecular Energy Transfer ◽  
High Absorption

For many years, the research on conjugated polymers (CPs) has been mainly focused on their application in organic electronics. Recent works, however, show that due to the unique optical and photophysical properties of CPs, such as high absorption in UV–Vis or even near-infrared (NIR) region and efficient intra-/intermolecular energy transfer, which can be relatively easily optimized, CPs can be considered as an effective light-activated source of versatile and highly reactive singlet oxygen for medical or catalytic use. The aim of this short review is to present the novel possibilities that lie dormant in those exceptional polymers with the extended system of π-conjugated bonds.

Short Review on Novel Dosage Form

2021 ◽  
pp. 301-303
Author(s):  
Tushar N. Sonawane ◽  
Pradip D. Dhangar ◽  
Sagar D Patil ◽  
Azam Z. Shaikh
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Drug Effects ◽  
Short Review ◽  
Delivery Systems ◽  
The Novel ◽  
Novel Drug Delivery System ◽  
Novel Drug

Novel Drug Delivery Systems are one of the widely use delivery system in the presence scenario. Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of the traditional drug delivery systems. In the form of a Novel Drug Delivery System an existing drug molecule can get a new life. The novel drug delivery system is Increases bioavailability and it Can be used for long-term treatments of chronic illness, Sustained maintenance of plasma drug levels as well as it Decreased adverse drug effects in the total amount of drugs required thus reducing side effects it Improved patient compliance due to reduction in number and frequency of doses required. There is less damage sustained by normal tissue due to targeted drug delivery. In this paper our main focus to give the throughout knowledge of some newer (Novel drug delivery system) to understand the concept of the Novel dossage form.

Recent Advances in The Smiles Rearrangement: New Opportunities for Arylation

Synthesis ◽  
2021 ◽  
Author(s):  
David Whalley ◽  
Michael Greaney
Keyword(s):  
Short Review ◽  
Smiles Rearrangement ◽  
Heterocycle Synthesis ◽  
Recent Advances ◽  
New Directions

The Smiles rearrangement has undergone a renaissance in recent years providing new avenues for non-canonical arylation techniques in both the radical and polar regimes. This Short Review will discuss recent applications of the reaction (from 2017 onwards), including its relevance to areas such as heterocycle synthesis, functionalisation of alkenes and alkynes as well as glimpses at new directions for the field.

Poetics of novel of A.N. Varlamov the “Soul my Paul”

2018 ◽  
Vol 7 (6) ◽  
pp. 57-64
Author(s):  
В. Серафимова ◽  
V. Serafimova
Keyword(s):  
Large Range ◽  
The Novel ◽  
The Past

The article deals with the composition of the new Chapter of the novel "my soul Paul", which consists of five parts, divided into chapters, and explores a large range of problems. Compositional clarity gives the novel intertwining storylines, United through the theme, the theme of the past, its relationship with the present and future, the theme of memory, the concept Of man-Creator, capable of self-improvement. The novel presents interesting examples of solving communicative problems, creating communicative situations.

scholarly journals Drawing the Complexity of Colombian Climate from Non-Extensive Extreme Behavior

2019 ◽  
Author(s):  
Isabel Hoyos ◽  
Boris A. Rodríguez
Keyword(s):  
Large Range ◽  
Regional Climate ◽  
The Novel ◽  
Temperature And Precipitation ◽  
Entropy Principle ◽  
Physical Information ◽  
Extreme Behavior ◽  
Q Index ◽  
High Degree ◽  
Range Of Values

We evaluate the complexity of Colombian climate from extreme behavior of gauge temperature and precipitation, using the the novel Tsallis' non-extensive entropy principle based on physical information through the q-index. We find the spatial structure of non additive universal categories (q-index) and compare with some complex systems with the potential to have some degree of dynamical affinity. Our results evidence the great dynamical variability of regional climate expressed in the large range of values of $q$-index, and the high degree of non-extensitivity for both temperature and precipitation.

The multifarious medical applications of carbon curvatures: A cohort review

2020 ◽  
Vol 16 ◽  
Author(s):  
Vishal Chavda ◽  
Vimal Patel
Keyword(s):  
Negative Curvature ◽  
Structural Characteristics ◽  
Short Review ◽  
Medical Applications ◽  
The Novel ◽  
Carbon Allotropes ◽  
Therapeutic Applications ◽  
Zero Curvature ◽  
Bio Imaging ◽  
Bio Material

Abstract:: Carbon curvatures are the novel therapeutic bio-material that are in research due to its multifarious applications in a variety of research aspects. All the carbon allotropes were grouped mathematically into three types based upon surface Gaussian curvatures: zero curvature (graphene), negative curvature (schwarzites), and positive curvatures (fullerenes, CNTs), because of they have physiochemical activities such as optoelectrical, chemical, thermal and magnetic properties. All these allotropes consisting sp2 hybridization with delocalized π bond electrons. Based on the types and number of aro-matic carbon rings, all have unique geometric structural characteristics, chirality, and solubility, which offers them as a po-tential candidate for biomedical and therapeutic applications. In this short review, we highlight the basic structural and phys-icochemical characteristics of carbon allotropes and their biomedical and therapeutic applications recently been studied by researchers and described the therapeutic applications of graphene and its derivatives in drug delivery, gene delivery, bio-imaging, biosensors, therapeutic diagnosis, and photo-stimulation therapies.

scholarly journals The Novel Synthesis of Silicon and Germanium Nanocrystallites

2000 ◽  
Vol 638 ◽  
Author(s):  
Susan M. Kauzlarich ◽  
Qi Liu ◽  
Shih-Chieh Yin ◽  
Howard W. H. Lee ◽  
Boyd Taylor
Keyword(s):  
Solid State Nmr ◽  
Large Range ◽  
Visible Region ◽  
Group Iv ◽  
The Novel ◽  
Germanium Tetrachloride ◽  
Quantum Confinement Effects ◽  
Optical And Electronic Properties ◽  
Silicon And Germanium

AbstractInterest in the synthesis of semiconductor nanoparticles has been generated by their unusual optical and electronic properties arising from quantum confinement effects. We have synthesized silicon and germanium nanoclusters by reacting Zintl phase precursors with either silicon or germanium tetrachloride in various solvents. Strategies have been investigated to stabilize the surface, including reactions with RLi and MgBrR (R = alkyl). This synthetic method produces group IV nanocrystals with passivated surfaces. These nanoparticle emit over a very large range in the visible region. These particles have been characterized using HRTEM, FTIR, UV-Vis, solid state NMR, and fluorescence. The synthesis and characterization of these nanoclusters will be presented.

scholarly journals Raman optical activity: A new light on proteins, carbohydrates and glycoproteins

2006 ◽  
Vol 28 (3) ◽  
pp. 27-31 ◽  
Author(s):  
Laurence D. Barron
Keyword(s):  
Structural Biology ◽  
Optical Activity ◽  
Large Range ◽  
Structural Information ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
The Novel ◽  
X Ray ◽  
X Ray Crystallography ◽  
Raman Optical Activity

The core techniques of structural biology, namely X-ray crystallography and multidimensional NMR, are often not applicable to many important samples due to fundamental experimental problems, such as the lack of suitable crystals in the X-ray case or excessive size or flexibility for NMR. Carbohydrates and glycoproteins are especially challenging in this respect. The novel technique of vibrational ROA (Raman optical activity), which combines the advantages of vibrational spectroscopy with the extra sensitivity to three-dimensional structure of chiroptical methods such as CD (circular dichroism), has much promise for studying a large range of biomolecules, from the smallest to the largest, in aqueous solution. Among other things, it is capable of providing structural information about both the polypeptide and the carbohydrate structure of intact glycoproteins and should become an indispensable spectroscopy tool for glycobiology.

scholarly journals Does Vitamin D has Preventive or Treatment Potential to Covid-19 Illness?: A Brief Review

2021 ◽  
Vol 10 (1) ◽  
pp. 67-74
Author(s):  
Akash Mishra ◽  
Eans Tara Tuladhar ◽  
Vijay Kumar Sharma ◽  
Mithileshwor Raut ◽  
Aseem Bhattarai ◽  
...  
Keyword(s):  
Vitamin D ◽  
Immune Modulation ◽  
Specific Treatment ◽  
Short Review ◽  
The Body ◽  
World Health ◽  
The Novel ◽  
Anti Inflammatory ◽  
Health Organization ◽  
The Relationship

The world’s health in 2020 was in the grip of the COVID-19 pandemic and its adverse consequences and is still continuing in 2021. Most countries have been locked down or going through different forms of lockdown to prevent the transmission of the infectious virus SARS-CoV-2. To date, there is no specific treatment or vaccination preventive measures. World Health Organization has approved few vaccines for emergency use. Still, the emergence of mutations within SARS-CoV has put forward challenges for vaccine developers. Whether infectious or non-infectious, all diseases have an inflammatory aspect to alarm the body system along with an anti-inflammatory counterbalance mechanism to minimize harmful effects whether through immune modulation or antioxidant reserves. An approach to counteract the novel disease, COVID19, was also sought in enhancing the anti-inflammatory aspect, at the level of prevention and at the level of treatment. One of the methodologies was the recommendation of micronutrient Vitamin D whose immune-modulatory role has been well appreciated in many disease conditions. This short review aims to explore the relationship between vitamin D status through susceptibility and clinical outcomes of COVID-19.

scholarly journals Henoch–Schoenlein Purpura Following Severe Acute Respiratory Syndrome Coronavirus-2 Infection: A Case Report and Short Review of Histopathological Changes in Dermis

2021 ◽  
Author(s):  
Saeed Soleiman-Meigooni ◽  
Ramin Hamidi-Farahani ◽  
Mousa Ahmadi ◽  
Ali Asgari ◽  
Ramin Yaghmaee
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Short Review ◽  
The Novel ◽  
Histopathological Changes ◽  
Immune Mediated ◽  
Novel Coronavirus ◽  
Purpuric Rash

As the novel Coronavirus pandemic continues to affect people worldwide, immune-mediated inflammatory syndromes have been reporting related to this virus. We presented a case of novel Coronavirus pneumonia, who developed a purpuric rash, abdominal pain, and hematuria, diagnosed with Henoch–Schoenlein purpura.

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