scholarly journals Does Vitamin D has Preventive or Treatment Potential to Covid-19 Illness?: A Brief Review

2021 ◽  
Vol 10 (1) ◽  
pp. 67-74
Author(s):  
Akash Mishra ◽  
Eans Tara Tuladhar ◽  
Vijay Kumar Sharma ◽  
Mithileshwor Raut ◽  
Aseem Bhattarai ◽  
...  
Keyword(s):  
Vitamin D ◽  
Immune Modulation ◽  
Specific Treatment ◽  
Short Review ◽  
The Body ◽  
World Health ◽  
The Novel ◽  
Anti Inflammatory ◽  
Health Organization ◽  
The Relationship

The world’s health in 2020 was in the grip of the COVID-19 pandemic and its adverse consequences and is still continuing in 2021. Most countries have been locked down or going through different forms of lockdown to prevent the transmission of the infectious virus SARS-CoV-2. To date, there is no specific treatment or vaccination preventive measures. World Health Organization has approved few vaccines for emergency use. Still, the emergence of mutations within SARS-CoV has put forward challenges for vaccine developers. Whether infectious or non-infectious, all diseases have an inflammatory aspect to alarm the body system along with an anti-inflammatory counterbalance mechanism to minimize harmful effects whether through immune modulation or antioxidant reserves. An approach to counteract the novel disease, COVID19, was also sought in enhancing the anti-inflammatory aspect, at the level of prevention and at the level of treatment. One of the methodologies was the recommendation of micronutrient Vitamin D whose immune-modulatory role has been well appreciated in many disease conditions. This short review aims to explore the relationship between vitamin D status through susceptibility and clinical outcomes of COVID-19.

scholarly journals COVID-19: A Critical Review on Viral Biochemistry, Environmental Transmission, Therapeutics and Safety Measures

2020 ◽  
Vol 1 (6) ◽  
Author(s):  
Roshni Kumari ◽  
Kumari Pragati Nanda ◽  
Hena Firdaus ◽  
Soumen Dey
Keyword(s):  
Specific Treatment ◽  
Scattered Data ◽  
Review Article ◽  
World Health ◽  
The Novel ◽  
Safety Measures ◽  
Current Scenario ◽  
Novel Coronavirus ◽  
Health Organization

The outbreak of coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is declared pandemic by World Health Organization (WHO) keeping in view its infection rate and toxicity level. The entire world is struggling hard to survive the prevailing health emergency. The authors realise the urgent need of contributing an overview of the present scenario to the researchers who are breathlessly trying to combat this pandemic situation. This review aimed at binding all the scattered data and research available till now on COVID-19 disease starting from its origin to transmission and spread through environmental factors till treatment and the safety measures that should be implemented. This article would possibly help the readers by providing an outlook of current scenario on various perspectives of COVID-19 disease at a single glance. The types, origin and toxicity caused are discussed in brief. The role of contaminated aerosols (viral-laden smoke from tobacco, cigarettes), wastewater, fomites, human and faecal matter are important in spreading the novel coronavirus in the environment. There is no specific treatment till date but clinical trials and diagnosis on several known drugs are on-going. The precaution and safety measures could hopefully reduce number of infections and mortality. The number of infected cases confirmed till 2 August 2020 was 17660523 with 680894 deaths in the world. We tried in this review article to summarize the scattered data available on biochemistry of SARS-CoV-2, environmental spread of virus and the safety measures to combat COVID-19 pandemic.

scholarly journals Immunomodulators for Curtailing COVID-19: a Positive Approach

2020 ◽  
Vol 10 (3-s) ◽  
pp. 286-294 ◽  
Author(s):  
Shabir Ahmad Bhat ◽  
Shameem Ahmad Rather ◽  
Arsheed Iqbal ◽  
Haider Ali Qureshi ◽  
Naquibul Islam
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Viral Infections ◽  
Herbal Medicines ◽  
Specific Treatment ◽  
The Body ◽  
World Health ◽  
The People ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Past Experiences

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is highly infectious, spreading swiftly from man to man which has not been previously recognized in humans. World Health Organization (WHO) on February 11, 2020 named the infection as COVID-19 as an acronym for ‘coronavirus disease-2019’ and on March 11, 2020 declared the outbreak as pandemic. It affects all the people without discrimination, however, older, immune compromised are more susceptible. The virus chiefly spread through droplet infection from infected person to healthy one by coughing, sneezing or with infected hands when touched to eyes, nose or mouth. Symptoms of the infection range from mild to severe ones. In severe cases (approx. 14% of cases) fever typically of high grade (104oF), breathlessness, pneumonia and severe acute respiratory syndrome may appear. So far no specific treatment or vaccine for novel coronavirus-2019 is there. From the past and recent past experiences we have learnt that herbal medicines have proven beneficial against various dreadful viral infections. Assessment of immune enhancing herbs in this paper may definitely be helpful for the body to fight COVID-19 infection. Keywords:   Severe acute respiratory syndrome coronavirus-2, COVID-19, Pneumonia, Immune, Herbs

Glycyrrhizin as a Potential Treatment for the Novel Coronavirus (COVID-19)

2021 ◽  
Vol 21 ◽  
Author(s):  
Habeb Al-Kamel ◽  
Oliver Grundmann
Keyword(s):  
Therapeutic Agent ◽  
Specific Treatment ◽  
Licorice Root ◽  
World Health ◽  
Regulatory Agencies ◽  
The Novel ◽  
Potential Treatment ◽  
Global Pandemic ◽  
Novel Coronavirus ◽  
Health Organization

: COVID-19 is an emerging viral infection of zoonotic origin that is closely related to the severe acute respiratory syndrome coronavirus (SARS-CoV) that caused an outbreak in 2003. Therefore, scientists named the new virus SARS-CoV-2. On March 11, 2020, The World Health Organization (WHO) recognized COVID-19 as a global pandemic. At present, three vaccines have been approved or are being considered for approval by national regulatory agencies to immunize against COVID-19. However, the vaccines do not yet remain widely available and no specific treatment against the virus is available. The pathogenesis and proliferation pathways of SARS-CoV-2 are still not well known. Thus, in this article, the saponin glycyrrhizin is discussed as a new potential therapeutic agent of natural origin (licorice root, Glycyrrhizaglabra) for the potential treatment of COVID-19 infections.

scholarly journals Clinical Characterization of COVID-19

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Hassan S. Naji
Keyword(s):  
White Blood Cells ◽  
Ground Glass Opacity ◽  
The Body ◽  
World Health ◽  
The Novel ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Cellular Immune

The world is on the brink of a pandemic due to the Novel coronavirus-19. The World Health Organization (WHO) urged countries all over the world to take necessary measures to control then new coronavirus disease (COVID-19) and further limit the overwhelmingly number of people infected and falling ill to the disease. It is widely known that COVID-19 affects the lung causing pneumonia with characteristic ground-glass opacity. Few research studies outlines the effect of the Novel coronavirus on other parts of the body such as stomach, liver, and kidneys. Interestingly, COVID-19 causes a cytokine storm that overwhelms the body leading to inhibition of body’s cellular immune responses by the virus through lowering the white blood cells count specifically lymphocytes, and platelets count. This paper summarizes the effect of COVID-19 on various body organs.

scholarly journals Obesity With Hypertension Events In Taccorong Village, Bulukumba District

2019 ◽  
Vol 3 (3) ◽  
pp. 121-128
Author(s):  
Wiwi Yuniarti ◽  
Muriyati ◽  
Hamdana
Keyword(s):  
Sampling Technique ◽  
Premature Death ◽  
The Body ◽  
World Health ◽  
Chi Square ◽  
Cross Sectional ◽  
The World ◽  
Health Organization ◽  
The Relationship ◽  
Experienced Grade

According to the world health organization 2015, says that hypertension is one of the main causes of premature death throughout and hypertension kills nearly 8 billion people every year in the world. Obesity is one of the risk factors for hypertension, because of the accumulation of fat in the body, the higher a person's body mass index, the higher the risk of developing hypertension. The purpose of this study is to know the relationship between obesity and the incidence of hypertension in the village of Taccorong caused Bulukumba district in 2018. The population in this study was the obese community in Taccorong village, Bulukumba regency, a population of 68 respondents, a sampling technique used by a purposive sampling technique. This type of research is analytic research with a cross-sectional approach. The test used for the relationship of obesity with the incidence of hypertension in Taccorong village Bulukumba district in 2018. Is the Pearson Chi-Square test, with the results of the study that obese respondents who experienced grade 1 hypertension were 18 respondents (85.7%) and obesity 1 respondents who had hypertension grade 2 were 3 respondents (14.3%). While the obese 2 respondents who experienced grade 1 hypertension were 6 respondents (31.6%) and obesity 2 respondents who experienced grade 2 hypertension as many as 13 respondents (68.4%). Based on the test results obtained values (p=0.000) then Ho is rejected and Ha is accepted. The conclusion of this study is that there is a correlation between obesity and the incidence of hypertension in Taccorong village, Bulukumba district in 2018. It is recommended for the Puskesmas Bonto Nyeleng Institution to pay attention to its working area to detect total obesity.

scholarly journals Can Probiotics and Diet Promote Beneficial Immune Modulation and Purine Control in Coronavirus Infection?

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1737 ◽  
Author(s):  
Ana H. A. Morais ◽  
Thais S. Passos ◽  
Bruna L. L. Maciel ◽  
Juliana K. da Silva-Maia
Keyword(s):  
Immune Modulation ◽  
Nutritional Therapy ◽  
World Health ◽  
Adequate Intake ◽  
Lactobacillus Gasseri ◽  
The World ◽  
Coronavirus Infection ◽  
Health Organization ◽  
The Relationship

Infection caused by the SARS-CoV-2 coronavirus worldwide has led the World Health Organization to declare a COVID-19 pandemic. Because there is no cure or treatment for this virus, it is emergingly urgent to find effective and validated methods to prevent and treat COVID-19 infection. In this context, alternatives related to nutritional therapy might help to control the infection. This narrative review proposes the importance and role of probiotics and diet as adjunct alternatives among the therapies available for the treatment of this new coronavirus. This review discusses the relationship between intestinal purine metabolism and the use of Lactobacillus gasseri and low-purine diets, particularly in individuals with hyperuricemia, as adjuvant nutritional therapies to improve the immune system and weaken viral replication, assisting in the treatment of COVID-19. These might be promising alternatives, in addition to many others that involve adequate intake of vitamins, minerals and bioactive compounds from food.

scholarly journals Vitamin D Deficiency in the Elderly Patients and Role of Vitamin D in the Prevention of COVID-19 Infection

2021 ◽  
Vol 3 (2) ◽  
pp. 8-9
Author(s):  
Nauman Khan ◽  
. Tahmina
Keyword(s):  
Vitamin D ◽  
Elderly Patients ◽  
The Elderly ◽  
The Body ◽  
Water Soluble ◽  
World Health ◽  
Short Report ◽  
Global Pandemic ◽  
Health Organization ◽  
Underlying Diseases

SARS Covid'19 is declared as a global pandemic by World Health Organization [1]. The aim of this short report is to find out the association of Vitamin D in prevention of Covid'19 in elderly patients who are already having other co-morbidities. People of any age are susceptible to Corona virus but the elderly patients and patients with chronic underlying diseases are at higher risk. Many elderly patients with COVID-19 are at risk of mal-nutrition [2]. Vitamins are of two types, Lipid soluble vitamins and water-soluble vitamins [3]. Lipid soluble vitamins can be stored in the body while water soluble vitamins cannot be stored in the body, hence needed to take regularly [4]. Vitamin D is a lipid soluble vitamin also it can be synthesized by our own body.

A short review on important drugs under clinical trial against Covid-19

2020 ◽  
Vol 21 ◽  
Author(s):  
Namita Misra
Keyword(s):  
Respiratory Illness ◽  
Short Review ◽  
World Health ◽  
Upper Respiratory Tract ◽  
Suspected Infection ◽  
Medicinal Treatment ◽  
Travel Restrictions ◽  
Personal Level ◽  
Health Organization ◽  
Tract Infections

: Corona virus spreads from one to other person, either by touching the hands or by touching the surface contaminated with this virus, and then touching the nose or mouth. Covid-19 infected human symptoms are like any pneumonia symptoms, dry cough and high fever. Upper respiratory tract infections symptoms and sore throat are rare. First notified in china dated 12th December 2019 as a respiratory illness. In addition to travel restrictions and quarantine measures everyone should follow the World Health Organization advice guidelines on the management of humans infected with known or suspected infection with SARS-CoV-2 virus at the personal level. The development of vaccine or medicines for the same are under progress and this short review will summarize the most potential candidates such as Remdesivir, Lopinavir and Ritonavir, Chloroquine, Hydroxychloroquine, Hydroxychloroquine with Azithromycin, Favipiravir, Umifenovir, and Ribavirin for its medicinal treatment.

scholarly journals Potential of CRISPR/Cas13 System in Treatment and Diagnosis of COVID-19

2021 ◽  
Author(s):  
Amir Khodavirdipour ◽  
Motahareh Piri ◽  
Sarvin Jabbari ◽  
Mohammad Khalaj-kondori
Keyword(s):  
Diagnostic Tool ◽  
Human Kidney ◽  
World Health ◽  
Rapid Review ◽  
The Novel ◽  
Rapid Action ◽  
Antiparasitic Drug ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Treatment And Diagnosis

AbstractThe novel coronavirus disease 2019 (COVID-19) belongs to coronaviridae families, like sarbecovirus (SARS), and causes pyrexia, pertussis, and acute respiratory distress syndrome (ARDS) in major. Started from Wuhan, China now forced the World Health Organization (WHO) to call it a pandemic. These dreadful figures elevate the need for rapid action for a rapid diagnostic tool, an efficacious therapy, or vaccine for such widespread disease. Here we reviewed all the latest research and trials including conventional antiviral medicines that have a narrow and finite effect on COVID-19. Recently, some advances have been made by a nucleotide/nucleoside analogues (NUC) inhibitor (remdesivir), ivermectin (antiparasitic drug), and convalescent plasma, the later one has more recently been approved by the Food and Drug Administration (FDA). In addition, a clinical-grade soluble human angiotensin-converting enzyme (ACE2), named hrsACE2, was able to inhibit the infection of human blood vessel organoids, as well as the human kidney organoids, by the virus. As of now, innovative therapeutics based on the CRISPR/Cas13d might overcome the challenge of COVID-19 either as a treatment option or precise and rapid diagnostic tool due to its rapid and precise nature. In this updated comprehensive rapid review, we try to cover all recent findings in terms of genomics, diagnosis, prevention, and treatment.

scholarly journals Secular Trends of Underweight, Overweight, and Obesity in Children and Adolescents from Ukraine

2021 ◽  
Vol 18 (6) ◽  
pp. 3302
Author(s):  
Katarzyna Dereń ◽  
Justyna Wyszyńska ◽  
Serhiy Nyankovskyy ◽  
Olena Nyankovska ◽  
Marta Yatsula ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Age Groups ◽  
Overweight And Obesity ◽  
The Body ◽  
World Health ◽  
Public Health Issue ◽  
Significant Difference ◽  
Significant Public Health ◽  
Health Organization ◽  
Obesity In Children

Overweight and obesity, as well as underweight in children and adolescents, pose a significant public health issue. This study aimed to investigate the secular trend of the incidence of underweight, overweight, and obesity in children from Ukraine in 2013/2014 and 2018/2019. The studies were conducted in randomly selected primary and secondary schools in Ukraine. In total, 13,447 children (6468 boys and 6979 girls) participated in the study in 2013/2014 and 18,144 children (8717 boys and 9427 girls) participated in 2018/2019. Measurements of body weight and height were performed in triplicate. Underweight, overweight, and obesity were diagnosed according to the standards of the World Health Organization (WHO). In the group of girls, a significant difference between 2013/2014 and 2018/2019 measurements was found only among 7-year-olds. The percentage of girls at this age exceeding the body mass index (BMI) norm was lower in the 2018/2019 study. In boys, a significant difference was also found in 7-year-olds, and, as in girls, a lower share of overweight and obesity was found in 2018/2019. But for the ages of 12, 13, and 15, the significant differences had a different character—more overweight or obese boys were found in the 2018/2019 study. The proportion of underweight children was similar for the majority of age groups in both genders and did not differ in a statistically significant way.

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