Thrombin generation in paediatric patients with congenital heart disease

2008 ◽  
Vol 28 (S 01) ◽  
pp. S61-S66 ◽  
Author(s):  
G. Cvirn ◽  
A. Rosenkranz ◽  
B. Leschnik ◽  
W. Raith ◽  
W. Muntean ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Negative Correlation ◽  
Congenital Heart ◽  
Thrombin Generation ◽  
Significant Negative Correlation ◽  
Peak Height ◽  
Global Test ◽  
Paediatric Patients ◽  
Age Range

SummaryThrombin generation was studied in paediatric patients with congenital heart disease (CHD) undergoing cardiac surgery using the calibrated automated thrombography (CAT) in terms of the lag time until the onset of thrombin formation, time to thrombin peak maximum (TTP), endogenous thrombin potential (ETP), and thrombin peak height. The suitability to determine the coagulation status of these patients was investigated. Patients, material, methods: CAT data of 40 patients with CHD (age range from newborn to 18 years) were compared to data using standard coagulation parameters such as prothrombin (FII), antithrombin (AT), tissue factor pathway inhibitor (TFPI), prothrombin fragment 1.2 (F 1.2), thrombin-antithrombin (TAT), activated partial thromboplastin time (aPTT), and prothrombin time (PT). Results: A significant positive correlation was seen between ETP and FII (p < 0.01; r = 0.369), as well as between peak height and F II (p < 0.01; r = 0.483). A significant negative correlation was seen between ETP and TFPI values (p < 0.05; r = –0.225) while no significant correlation was seen between peak height and TFPI. A significant negative correlation was seen between F 1.2 generation and ETP (p < 0.05; r = –0.254) and between F 1.2 generation and peak height (p < 0.05; r = –0.236). No correlation was seen between AT and ETP or peak. Conclusions: CAT is a good global test reflecting procoagulatory and inhibitory factors of the haemostatic system in paediatric patients with CHD.

scholarly journals The relationship between hopelessness and perceived social support levels of parents with children with congenital heart disease

2021 ◽  
Vol 8 (11) ◽  
pp. 655-661
Author(s):  
Tugba Nur Oden ◽  
Rahsan Cam
Keyword(s):  
Social Support ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Perceived Social Support ◽  
Significant Negative Correlation ◽  
Cross Sectional ◽  
The Family ◽  
The Mean ◽  
The Relationship

Objective: This study was conducted to evaluate the relationship between hopelessness and perceived social support levels of parents with children with congenital heart disease (CHD). Material and Methods: This cross-sectional study was conducted with parents of children who underwent surgery for CHD, and data were collected from 100 parents who agreed to participate in the study. A descriptive information form for the sociodemographic characteristics of the parents, “Beck Hopelessness Scale (BHS)” and “Multidimensional Scale of Perceived Social Support (MSPSS)” were used to collect the data. Data were analysed using descriptive statistics and Spearman’s correlation tests. Results: The mean score of the hopelessness level of the parents participating in the study was 6.15±4.23, and the mean perceived general social support score was 69.55±15.47. There was a significant negative correlation between the hopelessness levels of mothers and social support (SS) received from the family, from significant others, and general SS scores. There was a significant positive correlation between the hopelessness levels of the mothers and the SS level received from the family (p<0.05). Conclusion: In this study, the parents of children with CHD have low levels of hopelessness and perceived SS levels are high. Moreover, the relationship between hopelessness and perceived SS levels varies according to the sex of the parents. In our study, the SS level of mothers had a higher effect on the hopelessness level. It is recommended that the SS levels of the parents of children with CHD should be increased to help them cope with hopelessness.

Role of CT and MRI prior to redo sternotomy in paediatric patients with congenital heart disease

2014 ◽  
Vol 69 (6) ◽  
pp. 574-580 ◽  
Author(s):  
A. Adibi ◽  
K. Mohajer ◽  
A. Plotnik ◽  
A. Tognolini ◽  
R. Biniwale ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Paediatric Patients ◽  
Ct And Mri

Chronic Kidney Disease in Adolescents after Surgery for Congenital Heart Disease

2020 ◽  
Vol 10 (5) ◽  
pp. 353-361
Author(s):  
Mirela Bojan ◽  
Laurence Pieroni ◽  
Cristian Mirabile ◽  
Marc Froissart ◽  
Damien Bonnet
Keyword(s):  
Chronic Kidney Disease ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Kidney Disease ◽  
Cystatin C ◽  
Congenital Heart ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Orthostatic Proteinuria ◽  
Age Range

Background: The onset of chronic kidney disease (CKD) is an important prognostic factor in young adults with congenital heart disease (CHD). Although it is likely that CKD is manifest early in CHD patients, the prevalence among adolescents is still unknown. The National Kidney Foundation’s Kidney Disease Improving Global Outcomes guidelines 2012 recommend new equations for the estimated glomerular filtration rate (eGFR) and highlight the importance of albuminuria for CKD screening. The objective of the present study was to estimate the prevalence of CKD in CHD adolescents. Methods: This observational cross-sectional study included 115 patients aged 10–18 years attending the cardiologic outpatient clinic at our institution as a follow-up after cardiac surgery in infancy related to various CHDs. CKD assessment used the CKD criteria 2012, including eGFR equations based on serum creatinine and cystatin C, and measurement of albuminuria. Results: No patient had an eGFR <60 mL min–1 1.73 m–2. However, 28.7% of all patients (95% CI 20.7–37.9) had eGFRbetween 60 and 89 mL min–1 1.73 m–2 when estimated by the bedside Schwartz creatinine-based equation,and 17.4% (95% CI 11.2–24.1) had eGFRbetween 60 and 89 mL min–1 1.73 m–2 when estimated by the Zappitelli equation, combining creatinine and cystatin C. Of all patients, 20.0% (95% CI 12.1–26.7) had orthostatic proteinuria, and none had persistent albuminuria. Conclusions: There was no evidence of CKD in the present population aged 10–18 years. The significance of an eGFR between 60 and 90 mL min–1 1.73 m–2 is not concordant for this age range and requires further investigations.

scholarly journals Serum immunoreactive erythropoietin in children with cyanotic and acyanotic congenital heart disease

Blood ◽  
1987 ◽  
Vol 70 (3) ◽  
pp. 822-826 ◽  
Author(s):  
P Haga ◽  
PM Cotes ◽  
JA Till ◽  
BD Minty ◽  
EA Shinebourne
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Oxygen Content ◽  
Congenital Heart ◽  
Geometric Mean ◽  
Significant Negative Correlation ◽  
Mean Value ◽  
Arterial Oxygen ◽  
Arterial Oxygen Content ◽  
Acyanotic Congenital Heart Disease

Abstract Serum immunoreactive erythropoietin (siEp) was measured in 27 cyanotic and 21 acyanotic children with congenital heart disease, age 4 months to 10 years. The geometric mean value was 9 mIU/mL for each group with 95% range from 3 to 26 mIU/mL and 4 to 22 mIU/mL for the cyanotic and acyanotic subjects, respectively. The levels are similar to those found in normal adults using the same assay system. Three cyanotic subjects showed increased siEp values. One was anemic relative to his hypoxemia, and the other two showed signs of increasing hypoxia. There was a significant negative correlation between siEp and arterial oxygen content. However, siEp did not correlate significantly with hemoglobin, hematocrit, PaO2, or SaO2. Despite normal siEp levels, the cyanotic children showed compensatory erythropoiesis with significantly elevated hemoglobin and hematocrit levels, which did correlate inversely with PaO2 and SaO2. Arterial oxygen content was also significantly higher in the cyanotic subjects (p less than 0.02). The cyanotic children seemed to display the same pattern as observed in man and animals exposed to prolonged hypobaric hypoxia, where after an initial rise in erythropoietin values the levels fall to normal, while increased erythropoiesis is sustained.

Quality of life following paediatric heart transplant: are age and activity level factors?

2014 ◽  
Vol 25 (3) ◽  
pp. 476-480 ◽  
Author(s):  
John J. Parent ◽  
Lauren Sterrett ◽  
Randall Caldwell ◽  
Robert Darragh ◽  
Marcus Schamberger ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Heart Transplantation ◽  
Negative Correlation ◽  
Congenital Heart ◽  
Activity Level ◽  
Cognitive Limitations ◽  
School Function

AbstractBackground: We evaluated whether quality of life correlates to age and activity in children following heart transplantation. In addition, quality of life in children following heart transplantation was compared with previously reported values in children with congenital heart disease. Quality of life remains an important aspect of therapy. Methods: The Pediatric Quality of Life Inventory Generic Core Scales and Cardiac Module were administered to 14 children who had previously undergone heart transplantation. Patients wore a pedometer for 7 days to assess daily activity. Results: The age at assessment was 13.1±1.9 years. The patients were 7.1±5.7 years post heart transplantation. There was a negative correlation between age at first heart transplantation and emotional (r=−0.64; p<0.05) and school function (r=−0.57; p<0.05). A negative correlation between patient’s age at assessment and perceived physical appearance existed (r=−0.53; p<0.05). Daily steps negatively correlated with cognitive (r=−0.58; p<0.05), physical (r=−0.63; p<0.05), emotional (r=−0.62; p<0.05), and school function (r=−0.66; p<0.01). Heart transplantation patients reported better scores for treatment and symptoms (p<0.05) but lower physical health scores (p<0.01) than those with moderate congenital heart disease. Conclusions: Paediatric heart transplantation patients reported overall similar quality of life as patients with moderate congenital heart disease. Children receiving heart transplants at an older age may require additional emotional and educational support. Heart transplantation patients with higher activity levels may be more aware of their physical, emotional, and cognitive limitations, and thus score lower on these quality of life indicators.

scholarly journals The brain protective effect of dexmedetomidine during surgery for paediatric patients with congenital heart disease

2019 ◽  
Vol 47 (4) ◽  
pp. 1677-1684 ◽  
Author(s):  
Jin Gong ◽  
Rufang Zhang ◽  
Li Shen ◽  
Yewei Xie ◽  
Xiaobing Li
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Protective Effect ◽  
Congenital Heart ◽  
Venous Pressure ◽  
Controlled Study ◽  
Control Group ◽  
Time Points ◽  
Paediatric Patients ◽  
The Brain

Objective To study the brain protective effect of dexmedetomidine (DEX) during surgery in paediatric patients with congenital heart disease (CHD). Methods This randomized single-blind controlled study enrolled paediatric patients aged 0–3 years with CHD who underwent surgery and randomized them into two groups: one group received DEX and the control group received 0.9% NaCl during anaesthesia. Demographic data, heart rate (HR), mean arterial pressure (MAP) and central venous pressure (CVP) were recorded. Levels of neuron specific enolase (NES) and S-100β protein were determined using enzyme-linked immunosorbent assays. Results The study enrolled 80 paediatric patients with CHD. Compared with the control group, HR, MAP and CVP were significantly lower in the DEX group at all time-points except for T0. At all time-points except for T0, the levels of jugular venous oxygen saturation in the DEX group were significantly higher compared with the control group. At all time-points except for T0, the levels of arterial venous difference and cerebral extraction of oxygen were significantly lower in the DEX group compared with the control group. Levels of NES and S-100β protein in the DEX group were significantly lower compared with the control group at all time-points except for T0. Conclusion DEX treatment during surgery for CHD improved oxygen metabolism in brain tissues and reduced the levels of NES and S-100β protein.

INTRACARDIAC PHONOCARDIOGRAPHY IN THE DIAGNOSIS OF CONGENITAL HEART DISEASE

PEDIATRICS ◽  
1959 ◽  
Vol 23 (5) ◽  
pp. 837-853
Author(s):  
David H. Lewis ◽  
Ali Ertugrul ◽  
George W. Deitz ◽  
John D. Wallace ◽  
James R. Brown ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Cardiac Catheterization ◽  
Congenital Heart ◽  
Heart Sounds ◽  
New Technique ◽  
Pediatric Age ◽  
Important Place ◽  
Age Range

Intracardiac phonocardiography, the recording of sounds from within the heart, has been carried out with 63 patients with congenital heart disease. Studies have also been done with 11 patients in the pediatric age range who did not have heart disease. This new technique of recording heart sounds has been shown to provide a degree of localization of heart sounds and murmurs not heretofore obtainable. It is by virtue of this property that intracardiac phonocardiography has an important place in the diagnosis of congenital heart disease. Records from several lesions are shown to illustrate this point. It is believed that intracardiac phonocardiography should be made a part of the routine studies done at the time of cardiac catheterization. The prospects for intracardiac phonocardiography are discussed.

Oncotic pressure and paediatric cardiopulmonary bypass: establishing baseline data for complex congenital cardiac surgery and its relation to risk stratification.

Perfusion ◽  
2017 ◽  
Vol 32 (5) ◽  
pp. 378-382 ◽  
Author(s):  
Richard Crook ◽  
Richard Issitt
Keyword(s):  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Risk Stratification ◽  
Negative Correlation ◽  
Risk Adjustment ◽  
Congenital Heart ◽  
Significant Negative Correlation ◽  
Baseline Data ◽  
Albumin Concentration ◽  
Paediatric Patients

Objectives: Colloid osmotic pressure (COP) is a major determinant of fluid shift in paediatric patients undergoing corrective surgery for congenital heart disease (CHD) using cardiopulmonary bypass (CPB). However, very few baseline data are available for those patients requiring surgery within the first few weeks and months of life. Our aim was to determine if our CHD population exhibited COP similar to that of other extremely ill subsets of patients and, if so, whether this related to risk stratification model scores. Methods: Thirty consecutive patients under 10 kg underwent cardiac surgery with CPB. Data were collected on COP, albumin concentration, prime composition, post-operative length of ventilation and intensive care unit (ICU) stay as well as risk stratification utilising Risk Adjustment for Congenital Heart Surgery (RACHS-1) and Partial Risk Adjustment in Surgery (PRAiS) scoring systems. Results: The patients had a mean pre-bypass COP of 13.9±2.5 mmHg. A significant negative correlation was observed between pre-operative baseline COP and length of ventilation (r=0.7; p<0.001) and a significant negative correlation between PRAiS (r=0.64; p<0.001) and RACHS-1 (r=0.5; p=0.004) scores and baseline COP was seen. Conclusions: Neonatal and paediatric patients requiring surgical correction of complex congenital cardiac malformations exhibit extremely low baseline COP, comparable to other sick neonatal populations, and are lower than those previously reported. Baseline COP correlates significantly with predicted survival rates and time spent on a ventilator.

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