scholarly journals Blood Groups: A Probable Link to Periodontal Diseases

2017 ◽  
Vol 05 (01) ◽  
pp. 047-050
Author(s):  
Aditi Jain ◽  
Devaraj G. ◽  
Harinder Kuckreja ◽  
KBS Kuckreja
Keyword(s):  
Blood Group ◽  
Periodontal Diseases ◽  
Dental Health ◽  
Study Groups ◽  
Abo Blood Group ◽  
Blood Group Antigens ◽  
Periodontal Health ◽  
Rhesus Factor ◽  
Periodontal Index ◽  
Group A

AbstractThe presence or absence of blood group antigens has been associated with various diseases, with antigens also acting as receptors for infectious agents. There is paucity of literature available in assessing the relative liability of blood group phenotypes to periodontal diseases. The objective of this study was to determine the association of the ABO blood group and Rhesus factor with periodontal disease to assess whether they can behave as predictors of periodontal diseases. The data was collected from randomly selected 100 individuals who were referred to the Department of Periodontics & Implantology, Mahatma Gandhi Dental College & Hospital, Jaipur for periodontal ailment management or for other reasons related to dental health. The subjects were categorized into three groups according to Russel's Periodontal index: healthy periodontium, gingivitis & periodontitis. Blood samples were collected to identify the ABO blood group and Rh factor by the slide method. The effect of blood subgroups on periodontal health, gingivitis and periodontitis was investigated separately. Results & Conclusion: More number of healthy subjects in blood group A. Gingivitis and periodontitis were found more in blood group O and blood group AB, respectively. Rh positive subjects had higher distribution in all study groups.

scholarly journals The Effect of ABO Blood Types on Periodontal Status

2007 ◽  
Vol 01 (03) ◽  
pp. 139-143 ◽  
Author(s):  
Turgut Demir ◽  
Adnan Tezel ◽  
Recep Orbak ◽  
Abubekir Eltas ◽  
Cankat Kara ◽  
...  
Keyword(s):  
Risk Factor ◽  
Significant Relationship ◽  
Periodontal Diseases ◽  
Dental Health ◽  
Abo Blood Groups ◽  
Periodontal Health ◽  
Periodontal Condition ◽  
Group A ◽  
Long Term Studies

ABSTRACTObjectives: The purpose of the present study was to determine whether there was a relationship between periodontal diseases and ABO blood groups.Methods: This epidemiological study was carried out on 1351 subjects who were randomly selected from individuals referred to the Faculty of Dentistry clinics for periodontal treatment or for other reasons regarding dental health. The study based on periodontal condition, blood group, and medical history. The subjects were divided into three groups as those with gingivitis, periodontitis, and the healthy ones. The effects of blood subgroups on periodontal health, gingivitis and periodontitis were investigated separately.Results: A relatively higher percentage of A group patients was found in gingivitis group and relatively higher percentage of O group patients was found in periodontitis group. A significant relationship was also determined between Rh factor and gingivitis.Conclusions: ABO blood subgroups and Rh factor may constitute a risk factor on the development of periodontal disease. However, long-term studies are needed to make a more comprehensive assessment of the effects of ABO group on periodontal diseases. (Eur J Dent 2007;1:139-143)

Normal Human Serum Contains Natural Antibodies Reactive With Autologous ABO Blood Group Antigens

Blood ◽  
1999 ◽  
Vol 93 (12) ◽  
pp. 4418-4424 ◽  
Author(s):  
Sergio H. Spalter ◽  
Srini V. Kaveri ◽  
Emmanuelle Bonnin ◽  
Jean-Claude Mani ◽  
Jean-Pierre Cartron ◽  
...  
Keyword(s):  
Human Serum ◽  
Blood Group ◽  
Autologous Blood ◽  
Natural Antibodies ◽  
Normal Human Serum ◽  
Abo Blood Group ◽  
Blood Group Antigens ◽  
Blood Group A ◽  
Group A ◽  
Normal Human

Abstract It is widely accepted that the serum of healthy individuals contains natural antibodies only against those blood group A or B antigens that are not expressed on the individual’s red blood cells. The mechanisms involved in tolerance to autologous blood group antigens remain unclear. In the present study, we show that IgM and IgG antibodies reactive with autologous blood group antigens are present in the immunoglobulin fraction of normal human serum. Natural IgG anti-A antibodies purified by affinity chromatography from IgG of individuals of blood group A exhibited an affinity for A trisaccharide antigen in the micromolar range and agglutinated A red cells at sixfold higher concentrations than those required for agglutination with affinity-purified anti-A IgG of individuals of blood group B. Whereas autoantibodies reactive with self A and B antigens are readily detected in purified IgG and IgM fractions, their expression is restricted in whole serum as a result of complementary interactions between variable regions of antibodies. These observations suggest that tolerance to autologous ABO blood group antigens is dependent on peripheral control of antibody autoreactivity.

ABO blood group and thrombotic vascular disease

2014 ◽  
Vol 112 (12) ◽  
pp. 1103-1109 ◽  
Author(s):  
Pier Mannuccio Mannucci ◽  
Massimo Franchini
Keyword(s):  
Blood Group ◽  
Molecular Mechanisms ◽  
Blood Type ◽  
Abo Blood Group ◽  
Blood Group Antigens ◽  
Increased Risk ◽  
Close Relationship ◽  
Group A ◽  
Thrombophilic Condition ◽  
Von Willebrand

SummaryABO blood group antigens are complex carbohydrate molecules expressed on red blood cells and a variety of tissues. The ABO blood type is implicated in the development of a number of human diseases and there is increasing evidence regarding its involvement in the pathogenesis of cardiovascular disorders, mainly through its effect on von Willebrand factor levels. In this review, after a brief analysis of the potential molecular mechanisms by which the blood group influences haemostasis, we focus on the clinical implications of such interaction. Overall, the literature data document the close relationship between venous thromboembolism (VTE) and non-O blood type, which is associated with an approximately two-fold increased risk of venous thrombosis. A supra-additive effect on VTE risk is observed when an inherited thrombophilic condition is associated with non-O blood group. A weaker association exists between non-O blood type and arterial thrombosis, which needs to be further investigated.

scholarly journals Inhibition of the Transcription Factor RUNX1 Causes Glycosyltransferase a Repression

Blood ◽  
2017 ◽  
Vol 130 (Suppl_1) ◽  
pp. 925-925
Author(s):  
Romy Kronstein-Wiedemann ◽  
Laura Schmidt ◽  
Jörn Lausen ◽  
Erhard Seifried ◽  
Torsten Tonn
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
Blood Group ◽  
Receptor Expression ◽  
Abo Blood Group ◽  
Blood Group Antigens ◽  
Hematopoietic Stem ◽  
Blood Group A ◽  
Homozygous Genotype ◽  
Group A

Abstract Background: The ABO blood group system is unequivocally the most important in clinical transfusion medicine. Furthermore ABO is implicated in the development of a number of human diseases. The ABO antigens are not confined to RBCs but are widely expressed in a variety of human cells and tissues. Thus, ABO matching is critical not only in blood transfusion but also in cell, tissue and organ transplantation. The molecular genetic basis of the ABO system has been known since 1990. However, despite extensive investigations about regulation of ABO blood group receptor expression, the mechanism is not fully resolved. Previously we found that miRNAs plays a critical role in regulation of ABO blood group antigen. Numerous miRNAs which were up- or downregulated in RBCs of blood group O and of heterozygous genotypes as compared to homozygous genotype possess potential binding sites in the 3'UTR of several transcription factors, such as SP1 and RUNX1. Here we show that silencing of the transcription factor RUNX1 leads to downregulation of blood group A antigen. Methods: We performed knockdown experiments for RUNX1 by lentiviral gene transfer of shRNA in primary hematopoietic stem cells (HSCs) and analyzed blood group A-antigen expression using different method, including flow cytometry, western blot and qPCR. Result: Knockdown of RUNX1 in HSCs leads to a 10-20% reduction of blood group A positive erythroid cells and a 30-40% reduction of blood group A antigens per cell in differentiated RBCs. Furthermore, microarray analysis showed a significant increase of miR-215-5p and miR-192-5p in RBCs of blood group O as compared to homozygous genotype. RUNX1 is known to be a target gene for these miRNAs. Conclusion: Glycosyltransferase A and B expression is regulated by different miRNAs, via simultaneously targeting of the transcription factors SP1 and Runx1 and glycosyltransferase A and B mRNA. The knowledge of the role of microRNAs and the transcription factors SP1 and RUNX1 in the expression of blood group antigens may be extended to other blood groups (Rhesus, Kell, Duffy) and may open the door for therapeutic interventions in diseases where blood group receptors promote disease pathology. Disclosures No relevant conflicts of interest to declare.

Normal Human Serum Contains Natural Antibodies Reactive With Autologous ABO Blood Group Antigens

Blood ◽  
1999 ◽  
Vol 93 (12) ◽  
pp. 4418-4424 ◽  
Author(s):  
Sergio H. Spalter ◽  
Srini V. Kaveri ◽  
Emmanuelle Bonnin ◽  
Jean-Claude Mani ◽  
Jean-Pierre Cartron ◽  
...  
Keyword(s):  
Human Serum ◽  
Blood Group ◽  
Autologous Blood ◽  
Natural Antibodies ◽  
Normal Human Serum ◽  
Abo Blood Group ◽  
Blood Group Antigens ◽  
Blood Group A ◽  
Group A ◽  
Normal Human

It is widely accepted that the serum of healthy individuals contains natural antibodies only against those blood group A or B antigens that are not expressed on the individual’s red blood cells. The mechanisms involved in tolerance to autologous blood group antigens remain unclear. In the present study, we show that IgM and IgG antibodies reactive with autologous blood group antigens are present in the immunoglobulin fraction of normal human serum. Natural IgG anti-A antibodies purified by affinity chromatography from IgG of individuals of blood group A exhibited an affinity for A trisaccharide antigen in the micromolar range and agglutinated A red cells at sixfold higher concentrations than those required for agglutination with affinity-purified anti-A IgG of individuals of blood group B. Whereas autoantibodies reactive with self A and B antigens are readily detected in purified IgG and IgM fractions, their expression is restricted in whole serum as a result of complementary interactions between variable regions of antibodies. These observations suggest that tolerance to autologous ABO blood group antigens is dependent on peripheral control of antibody autoreactivity.

scholarly journals ABO groups can play a role in susceptibility and severity of COVID-19

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
S. Samra ◽  
M. Habeb ◽  
R. Nafae
Keyword(s):  
Blood Group ◽  
Abo Blood Group ◽  
Infection Group ◽  
Mechanically Ventilated ◽  
Blood Group A ◽  
Group A ◽  
Study Population ◽  
Group B ◽  
The Relationship ◽  
Seriously Ill

Abstract Background A few people infected by the coronavirus become seriously ill, while others show little to no signs of the symptoms, or are asymptomatic. Recent researches are pointing to the fact that the ABO blood group might play an important role in a person’s susceptibility and severity of COVID-19 infection. Aim of the study: try to understand the relationship between ABO groups and COVID-19 (susceptibility and severity). Results A total of (507) patients were included in this study. The study population was divided based on the ABO blood group into types A+, A−, B+, AB, O+, and O−. Blood group A was associated with high susceptibility of infection: group A, 381 (75.1%); and less common in group O, 97 (19.2%), group B, 18 (3.5%), and group AB, 11 (2.2%). The severity of COVID-19 infection was common in non-blood group O where (20 (7.1%), 4 (26.7%), 2 (11%), and 1 (9%) in type A+, A−, B+, and AB, respectively), while in type O 3.1%. And mechanically ventilated patients were 22 (5.9%), 2 (13.4%), 2 (11.1%), and 1 (1%). Mortality was high in blood groups A and B, 16 (4.37%) and 1 (5.5%), respectively, while in blood group O, it was 1%. Conclusion The incidence, severity, and mortality of COVID-19 were common in non-blood group O. While blood group O was protected against COVID-19.

scholarly journals Correlation of ABO Blood Groups and Rh Factor with The Severity of Generalized Chronic Periodontitis: Across Sectional Study in Riyadh, Saudi Arabia

2019 ◽  
Vol 7 (4) ◽  
pp. 617-622 ◽  
Author(s):  
Diana Mostafa ◽  
Essam I. Elkhatat ◽  
Pradeep Koppolu ◽  
Muna Mahgoub ◽  
Esam Dhaifullah ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Blood Group ◽  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Blood Groups ◽  
Blood Group Antigens ◽  
Abo Blood Groups ◽  
Sectional Study ◽  
Cross Sectional ◽  
Group I

BACKGROUND: The development of periodontal diseases depends on the presence of causative microorganisms, host immunity and risk factors. Although variability present among the types of periodontal diseases, all are represented to a shared interaction between host and bacteria. ABO blood groups are the most investigated erythrocyte antigen system. However, limited investigations have been conducted to explore the alliance between ABO blood groups and periodontal diseases. AIM: Our purpose was to explore any possible association between the severity of chronic periodontitis with ABO blood groups and Rh factor. METHODS: A cross-sectional study was carried out on 205 patients out of 1126 generalised chronic periodontitis patients (GCP) who were referred to Al-Farabi Colleges, Riyadh, Saudi Arabia. They were categorized into; group I (mild), group II (moderate) and group III (sever). RESULTS: The patients with blood group O were at a greater risk to develop GCP irrespective of its severity, followed by those with blood group A, B, and AB. The dispensation of the Rh factor in all groups exhibited a significantly greater distribution of Rh positive. CONCLUSION: Genetic factors such as ABO blood group antigens may act as a risk influencer that affects the progression and severity of the chronic periodontitis.

scholarly journals Comparative Evaluation of C-reactive Proteins in Pregnant Women with and without Periodontal Pathologies: A Prospective Cohort Analysis

2016 ◽  
Vol 17 (6) ◽  
pp. 480-483
Author(s):  
Padmakanth Mannava ◽  
Sunil Gokhale ◽  
Sudarshan Pujari ◽  
Krishna P Biswas ◽  
Satish Kaliappan ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Prospective Cohort ◽  
Comparative Evaluation ◽  
Periodontal Diseases ◽  
Cohort Analysis ◽  
Study Groups ◽  
Periodontal Index ◽  
The Mean ◽  
Adverse Pregnancy ◽  
Two Parameters

ABSTRACT Introduction Inflammation of tooth supporting structures is referred to as periodontitis. C-reactive proteins (CRP) levels are usually increased in case of chronic inflammatory process like periodontitis. Association of CRP with pregnancy has been observed in the past, which includes most commonly preterm delivery, preeclampsia, etc. Therefore, it can be hypothesized that CRP may act as a link between periodontitis and adverse pregnancy outcomes. Hence, we aim to evaluate the plasma CRP levels in pregnant women with and without periodontal pathologies. Materials and methods The study included 210 pregnant women who reported to the hospital with periodontal problems and for routine checkups. All the patients were divided into three groups based on the presence and absence of periodontal pathologies. Russell's Periodontal Index Score was used for the evaluation of periodontal status of the subjects. Results While comparing the mean CRP levels in all the three study groups, statistically significant results were obtained. Statistically significant results were obtained while comparing the mean CRP levels in group C patients before treatment and after treatment therapy. The CRP levels were estimated by taking blood samples. Paired t-test and one-way analysis of variance was used to assess the correlation between the two parameters. Conclusion Casual association might exist between the CRP levels and periodontal diseases in pregnant women and the CRP levels may also get elevated in pregnant women. How to cite this article Mannava P, Gokhale S, Pujari S, Biswas KP, Kaliappan S, V Shashank. Comparative Evaluation of C-reactive Proteins in Pregnant Women with and without Periodontal Pathologies: A Prospective Cohort Analysis. J Contemp Dent Pract 2016;17(6):480-483.

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