Die Rolle des innate immune systems in der Entwicklung der Lungenerkrankung bei zystischer Fibrose

Pneumologie ◽  
1999 ◽  
Vol 53 (9) ◽  
pp. 464-468
Author(s):  
R Bals ◽  
D J Weiner ◽  
J M Wilson
Keyword(s):  
Innate Immune ◽  
Immune Systems

Immunology of Multiple Sclerosis

2016 ◽  
Author(s):  
Laura Piccio ◽  
Anne H. Cross
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Monoclonal Antibodies ◽  
B Lymphocytes ◽  
Autoimmune Disorder ◽  
Innate Immune ◽  
Immune Systems ◽  
The Central Nervous System ◽  
Multiple Sclerosis Treatment

Multiple sclerosis (MS) is considered to be an autoimmune disease of the central nervous system that targets myelin but affects both white matter and gray matter. Multiple sclerosis is thought to be mediated by cells of the adaptive and innate immune systems. CD4+ T lymphocytes of the Th1 and Th17 subtypes are believed to be critical for the initiation of multiple sclerosis. Treatment with monoclonal antibodies that deplete B lymphocytes has proven that B cells are critical to relapse development in multiple sclerosis. While immunopathophysiology is clearly important in MS, whether multiple sclerosis is truly an autoimmune disorder and the target or targets of the autoimmunity remain unknown.

scholarly journals Effect of Interferon alfa-2a Treatment on Adaptive and Innate Immune Systems in Patients With Behçet Disease Uveitis

2019 ◽  
Vol 60 (1) ◽  
pp. 52 ◽  
Author(s):  
Ozgur Albayrak ◽  
Merih Oray ◽  
Fusun Can ◽  
Gunay Uludag Kirimli ◽  
Ahmet Gul ◽  
...  
Keyword(s):  
Interferon Alfa ◽  
Innate Immune ◽  
Behçet Disease ◽  
Behcet Disease ◽  
Immune Systems

scholarly journals The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Wei Liu ◽  
Lian-jie Shi ◽  
Sheng-guang Li
Keyword(s):  
Autoimmune Diseases ◽  
Lipoic Acid ◽  
Human Body ◽  
Innate Immune ◽  
Immunomodulatory Effect ◽  
Alpha Lipoic Acid ◽  
Immunomodulatory Effects ◽  
Immune Systems ◽  
Beneficial Effects ◽  
Naturally Occurring

Αlpha-lipoic acid is a naturally occurring antioxidant in human body and has been widely used as an antioxidant clinically. Accumulating evidences suggested that α-lipoic acid might have immunomodulatory effects on both adaptive and innate immune systems. This review focuses on the evidences and potential targets involved in the immunomodulatory effects of α-lipoic acid. It highlights the fact that α-lipoic acid may have beneficial effects in autoimmune diseases once the immunomodulatory effects can be confirmed by further investigation.

scholarly journals Do fungi have an innate immune response? An NLR-based comparison to plant and animal immune systems

2017 ◽  
Vol 13 (10) ◽  
pp. e1006578 ◽  
Author(s):  
Jessie Uehling ◽  
Aurélie Deveau ◽  
Mathieu Paoletti
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Immune Systems

scholarly journals Skin infections are eliminated by cooperation of the fibrinolytic and innate immune systems

2017 ◽  
Vol 2 (15) ◽  
pp. eaan2725 ◽  
Author(s):  
William Santus ◽  
Simona Barresi ◽  
Francesca Mingozzi ◽  
Achille Broggi ◽  
Ivan Orlandi ◽  
...  
Keyword(s):  
Innate Immune ◽  
Skin Infections ◽  
Immune Systems

scholarly journals Impact of Microorganisms and Parasites on Neuronally Controlled Drosophila Behaviours

Cells ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2350
Author(s):  
Martina Montanari ◽  
Julien Royet
Keyword(s):  
Immune System ◽  
Animal Behavior ◽  
Innate Immune System ◽  
Adaptive Immune System ◽  
Model System ◽  
Innate Immune ◽  
Pathogenic Microorganisms ◽  
Immune Systems ◽  
Adaptive Immune ◽  
Drosophila Model

Like all invertebrates, flies such as Drosophila lack an adaptive immune system and depend on their innate immune system to protect them against pathogenic microorganisms and parasites. In recent years, it appears that the nervous systems of eucaryotes not only control animal behavior but also cooperate and synergize very strongly with the animals’ immune systems to detect and fight potential pathogenic threats, and allow them to adapt their behavior to the presence of microorganisms and parasites that coexist with them. This review puts into perspective the latest progress made using the Drosophila model system, in this field of research, which remains in its infancy.

Glycosyltransferases and glycan structures contributing to the adhesive activities of L-, E- and P-selectin counter-receptors

2002 ◽  
Vol 69 ◽  
pp. 33-45 ◽  
Author(s):  
John B. Lowe
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Cell Adhesion Molecules ◽  
Innate Immune ◽  
Vascular Tree ◽  
Major Fraction ◽  
Immune Systems ◽  
Cell Adhesive ◽  
Selectin Family ◽  
Vascular Compartment

In mammals, leucocytes of the adaptive and innate immune systems must move from their sites of origin to sites of maturation, or to where they are deployed against the invasion of pathogens. The vascular tree serves as the primary throughfare by which leucocytes move to these various destinations. Adhesion must be established between the leucocyte and the endothelial cells that line the vascular tree to enable leucocytes to escape the vascular compartment and then contribute to extravascular immune processes. A major fraction of these leucocyte endothelial-cell adhesive events initiate with, and require interactions between, the selectin family of cell adhesion molecules and their glycoconjugate counter-receptors. This article will review the structures of the glycan components of these counter-receptors, and the glycosyltransferases that control their expression.

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