scholarly journals Cardiac autonomic neuropathy in diabetic patients

2019 ◽  
Author(s):  
Adriana Robles-Cabrera ◽  
Bruno Estañol ◽  
Ruben Fossion ◽  
Ana Rivera ◽  
Alejandro Frank
Keyword(s):  
Autonomic Neuropathy ◽  
Cardiac Autonomic Neuropathy ◽  
Diabetic Patients

scholarly journals Predictive Value of Cardiac Autonomic Neuropathy in Diabetic Patients With or Without Silent Myocardial Ischemia

Diabetes Care ◽  
2001 ◽  
Vol 24 (2) ◽  
pp. 339-343 ◽  
Author(s):  
P. Valensi ◽  
R.-N. Sachs ◽  
B. Harfouche ◽  
B. Lormeau ◽  
J. Paries ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Autonomic Neuropathy ◽  
Predictive Value ◽  
Silent Myocardial Ischemia ◽  
Cardiac Autonomic Neuropathy ◽  
Diabetic Patients

scholarly journals Cardiovascular Autonomic Neuropathy and Early Atherosclerosis in Adolescent Type 1 Diabetic Patient

2015 ◽  
Vol 3 (4) ◽  
pp. 681-688 ◽  
Author(s):  
Soha M. Abd El Dayem ◽  
Ahmed A. Battah ◽  
Abo El Magd El Bohy
Keyword(s):  
Coronary Artery ◽  
Autonomic Neuropathy ◽  
Clinical Laboratory ◽  
Cardiovascular Autonomic Neuropathy ◽  
Stepwise Multiple Regression ◽  
Cardiac Autonomic Neuropathy ◽  
Diabetic Patients ◽  
Laboratory Assessment ◽  
Early Atherosclerosis

AIM: To evaluate cardiovascular autonomic neuropathy (CAN) in type 1 Diabetics and to detect its relation to coronary artery calcification.PATIENTS AND METHODS: It is a cross sectional study included 62 diabetics and 30 controls. Clinical, laboratory assessment and 24 Hr holter were done for all patients and controls and coronary artery calcium (CAC) scoring by multisclice CT was done for all patients only. T-test, Mann Whitney U test, and stepwise multiple regression were used for statistical analyses.RESULTS: CAC score was positive in 8.1 % of patients. Heart rate variability (HRV) was significantly lower in diabetics. All parameters of HRV were insignificantly lower in diabetics with positive CAC score. Patients with microalbuminuria had a significantly lower HRV. HRV had a significant correlation with age of patients, duration of disease, HbA1, and Qtc in diabetics.CONCLUSION: Percentage of arrhythmia and early atherosclerosis is high in adolescent type 1 diabetic patients. CAN is associated with early atherosclerosis. Cardiac autonomic neuropathy is associated with older age, longer duration, and poor glycemic control and microalbuminuria.

scholarly journals Diabetic Cardiovascular Autonomic Neuropathy

2021 ◽  
Author(s):  
Amira Siddig ◽  
Abbasher Hussien Mohamed Ahmed ◽  
Khabab Abbasher Hussien Mohamed Ahmed ◽  
Mohammed Eltahier Abdalla Omer
Keyword(s):  
Autonomic Neuropathy ◽  
Diabetic Neuropathies ◽  
Cardiovascular Autonomic Neuropathy ◽  
Cardiac Autonomic Neuropathy ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Coronary Syndrome ◽  
Study Population

Abstract Introduction: Diabetic neuropathies are thought to result from diabetic microvascular injury involving small blood vessels that supply nerves. Cardiac autonomic neuropathy (CAN) represents a serious complication associated with Diabetic neuropathies. Objectives: The aim of the study is to investigate the presence of cardiovascular diabetic autonomic neuropathy in a group of adult diabetic Sudanese patients with ischemic heart disease. Methodology: This is a descriptive prospective cross sectional hospital based study. The study population included type 1 and type 2 diabetic patients admitted to the cardiac care unit in ELshaab Teaching Hospital with acute coronary syndrome over a period of two years, from April 2017to April 2019. Results: A total of 49 males (65.33%) and 26 females (34.67%) were included in the study. CAN was detected in 94.67% of the studied group Conclusion: An incidence of 94.67% cardiovascular autonomic neuropathy in our sample indicates a high occurrence of this syndrome among our diabetic patients. Poor glycemic control is a common feature among our studied group. Sub-clinical autonomic neuropathy can be detected early using autonomic function tests.

scholarly journals Omega-3 Polyunsaturated Fatty Acids Improved Arterial Stiffness Parameters in Type 2 Diabetic Patients with Cardiac Autonomic Neuropathy

2018 ◽  
Vol 25 (4) ◽  
pp. 363-368
Author(s):  
Victoria Serhiyenko ◽  
Ludmila Serhiyenko ◽  
Alexandr Serhiyenko
Keyword(s):  
Fatty Acids ◽  
Arterial Stiffness ◽  
Polyunsaturated Fatty Acids ◽  
Autonomic Neuropathy ◽  
Augmentation Index ◽  
Cardiac Autonomic Neuropathy ◽  
Control Group ◽  
Diabetic Patients ◽  
Omega 3

Abstract Background and Aims: Diabetic cardiac autonomic neuropathy (DCAN) in type 2 diabetes (T2D) is among the strongest and independent risk markers for future global and cardiac mortality. Material and Methods: Thirty-six patients suffering from T2D and confirmed DCAN were enrolled in this investigation. Depending on the prescribed therapy, patients were allocated into two groups: group 1 was comprised of 15 patients to whom standard hypoglycemic treatment was prescribed (control group), the second received standard hypoglycemic treatment and omega-3 polyunsaturated fatty acids (ω-3 PUFAs, n = 21). The duration of the study was three month. Results: In subjects with T2D and DСAN prescription of ω-3 PUFAs was associated with a significant decrease of aorta augmentation index (AIxao), pulse wave velocity (PWV) during the active period of the day and decrease of AIxao, brachial augmentation index and PWV during the passive period of the day compared with the control group. Therefore, three month of ω-3 PUFAs supplementation to patients with confirmed DCAN and T2D promotes to improvement of arterial stiffness indices. Conclusions: In patients with T2D and СAN treatment with ω-3 PUFAs improved arterial stiffness parameters. The effectiveness of ω-3 PUFAs is not connected with optimization of glycemic control, but is rather the result of a direct drug action on the studied parameters.

scholarly journals The relationship between QT interval indices with cardiac autonomic neuropathy in diabetic patients: a case control study

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Maryam Vasheghani ◽  
Farzaneh Sarvghadi ◽  
Mohammad Reza Beyranvand ◽  
Habib Emami
Keyword(s):  
Autonomic Neuropathy ◽  
Qt Interval ◽  
High Specificity ◽  
Qt Dispersion ◽  
Cardiac Autonomic Neuropathy ◽  
P Value ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Significant Difference ◽  
The Relationship

Abstract Background Long QT interval (QT) and abnormal QT dispersion (QTd) are associated with sudden death. The relationship between cardiac autonomic neuropathy (CAN) and QT indices in type 2 diabetic patients were investigated. Methods Totally 130 diabetic subjects (mean age 50.87 ± 13.9 years) were included (70 individuals with and 60 individuals without CAN). All participants had sinus cardiac rhythm. The patients who had diseases or take drugs that cause orthostatic hypotension (OH), cardiac arrhythmia and QT prolongation were excluded. After interview and examination, standard and continuous ECG was taken in supine position with deep breathing and standing up position. CAN diagnosis was based on Ewing’s tests. QT, QT corrected (QTc), minimum QT (QT min), maximum QT (QT max) and mean ± SD of QT (QT mean) and QTd were assessed from standard ECG. QTc was calculated by Bazett’s formula from V2 lead. QTc > 440 ms in men and QTc > 460 ms in women and QTd > 80 ms were considered abnormal. Results In patients with CAN, 21.5% were symptomatic. The prevalence of abnormal QTc and QTd was 11.3% and 28.7%, respectively. There was no significant difference between the patients with or without CAN in terms of long QTc and abnormal QTd. However, the mean ± SD of QT max, QT mean and QTd was higher in the patients with CAN (P value < 0.03). The used cut points for QTc and QTd have high specificity (79% for both) and low sensitivity (30% and 37%, respectively). To use QTc and QTd as screening test for CAN in T2DM patients, the cutoff points 380 and 550 ms are suggested, respectively. Conclusion The prevalence of asymptomatic CAN was 3.7 times that of symptomatic CAN. In patients with CAN the QT max, QT mean and QTd were higher than those without CAN. There was no association between CAN and long QTc and abnormal QTd.

Abstract P470: Cardiac Autonomic Neuropathy Develops As A Result Of Mild Hypercaloric Intake In Absence Of Signs Of Diabetes: Modulation By Anti-diabetic Drugs.

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Ahmed El-Yazbi ◽  
Ola Al-Assi ◽  
Rana Ghali ◽  
Abdullah Kaplan ◽  
Nahed Mougharbil ◽  
...  
Keyword(s):  
Heart Rate ◽  
Autonomic Neuropathy ◽  
Pressor Response ◽  
Fold Increase ◽  
Cardiovascular Complications ◽  
Frequency Domain Analysis ◽  
Cardiac Autonomic Neuropathy ◽  
Oral Glucose ◽  
Diabetic Patients ◽  
Risk Predictor

Cardiac autonomic neuropathy (CAN) represents a major cause of morbidity and mortality in diabetes. It is usually seen early in the course of diabetes as an impaired heart rate variability (HRV) and baroreflex sensitivity (BRS), and represents an independent risk predictor of cardiac mortality. CAN development is linked to hyperglycemia; however, current understanding extends cardiovascular risk to pre-diabetic patients with slight glycemic changes. As well, recent evidence suggests that anti-diabetic drugs (metformin and pioglitazone) reduced the risk of cardiovascular complications in pre-diabetic patients. Here, we assessed whether CAN develops independent of hyperglycemia and whether metformin or pioglitazone modify this process. Rats were fed a hypercaloric (HC) diet (4.035 KCal/g vs. 3 KCal/g for control rats) composed of: weight (calories) 18.06 % fat (38.68%), 15.8% protein (15.66%), and 46.13% carbohydrates (45.73%). Stable fasting hyperglycemia developed by 16 weeks of feeding. However, at 12 weeks of feeding, there was no elevation in body weight, fasting or random blood glucose, and no difference in oral glucose tolerance, yet an increase in adipose inflammatory cytokines was observed (4- and 40- fold increase in IL-1β and TGF-β expression). No change in systolic blood pressure was observed over the course of feeding. At 12 weeks, carotid and jugular access were established. Mean arterial pressure (MAP) and heart rate (HR) were recorded, and BRS was assessed using Oxford method. HC-fed rats had a higher pressor response to increasing i.v. doses of phenylephrine vs. control rats. BRS sensitivity was blunted (slope of the ΔMAP vs. ΔHR line, -1.018 ± 0.1217 vs. -0.3379 ± 0.04135) indicating reduced parasympathetic feedback. A 2-week treatment with pioglitazone (2.5 mg/Kg) or metformin (100 mg/Kg) normalized the adipose cytokine profile, yet only pioglitazone improved BRS (-0.7463 ± 0.05775). Parasympathetic dysfunction in HC fed rats was further demonstrated by a decreased high frequency power upon frequency domain analysis of HRV data (3098 ± 233 vs. 89 ± 88 μs 2 ). To our knowledge, this is the first report that CAN occurs prior to any glycemic alterations with a potential role for adipose inflammation and modification by antidiabetic drugs.

scholarly journals Altered cerebral regulation in type 2 diabetic patients with cardiac autonomic neuropathy

Diabetologia ◽  
2006 ◽  
Vol 49 (10) ◽  
pp. 2481-2487 ◽  
Author(s):  
H. Marthol ◽  
C. M. Brown ◽  
U. Zikeli ◽  
D. Ziegler ◽  
N. Dimitrov ◽  
...  
Keyword(s):  
Autonomic Neuropathy ◽  
Cardiac Autonomic Neuropathy ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic
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