scholarly journals Relationship of root canal treatment to C-reactive protein as an inflammatory marker for cardiovascular disease

2010 ◽  
Vol 2 (1) ◽  
pp. 11 ◽  
Author(s):  
Bruce Arroll ◽  
Divya Dhar ◽  
Mary Cullinan
Keyword(s):  
Cardiovascular Disease ◽  
Root Canal ◽  
Periodontal Diseases ◽  
Inflammatory Marker ◽  
Root Canal Treatment ◽  
P Value ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Serum Crp

INTRODUCTION: Periodontal disease and elevated C-reactive protein (CRP) tests both are positively correlated with cardiovascular disease (CVD) in many studies. Some health practitioners have concerns that root canal treatment may provide a source for inflammation and hence increase the risk for CVD. AIM: To explore the relationship between CRP as a marker of inflammation and presence and number of root canal treatments in primary care patients. METHODS: Cross-sectional questionnaire about dental care followed by a blood test for serum CRP in patients from two New Zealand urban family practices. RESULTS: One hundred and 34 patients participated. The study showed no significant association between CRP and root canal treatment on multivariate analysis controlling for socioeconomic status, age, gender and smoking. The CRP level for those with =3 root-treated teeth was 1.68 while the level for those with <3 was 2.36, but the p-value was not statistically significant (p=0.198). Age, missing teeth and smoking were all significantly related to CRP levels so the sample has biological validity. DISCUSSION: Root canal treatment was not associated with higher CRP levels. The CRP levels were non-significantly lower in those with higher numbers of root-treated teeth. While there are a number of potential biases in this paper, the dataset appears to be biologically valid and consistent with known facts. These findings do not support the hypothesis that root canal treatment is associated with higher levels of inflammation. At this point patients should not consider having their root canal teeth removed. KEYWORDS: Periodontal diseases; C-reactive protein; inflammation; cardiovascular diseases; gingivitis; root canal treatment

scholarly journals Gambaran kadar C-reactive protein (CRP) serum pada perokok aktif usia >40 tahun

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Hendrika N. C. Dewi ◽  
Michaela E. Paruntu ◽  
Murniati Tiho
Keyword(s):  
Inflammatory Marker ◽  
Systemic Disease ◽  
Toxic Chemical ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Positive Serum ◽  
Cross Sectional Design ◽  
Serum Crp ◽  
Descriptive Method

Abstract: Cigarette are the most cause of death around the world. Smoking cigarrete is harmful to the organs because it contains many toxic chemical that can stimulate inflammatory process. Smoking cigarrete is a risk factors for heart disease and chronic pulmonary disease (COPD). C-reactive protein (CRP) are a non spesific inflammatory marker that can elevated in both local and systemic disease. Beside biomarker, CRP also use as prognostic marker for inflammation. The purpose of this study was to identify the level of serum CRP of smokers aged >40 years old. Twenty eight smokers were eligible to this criteria and participated in this study. Cross-sectional design with a descriptive method was employed in this study. Sampels were analysed in laboratory for serum CRP levels. The results showed that 23 subjects (82%) had normal (negatif) serum CRP level and five subjects (18%) had positive serum CRP level. It can be concluded that serum CRP level of >40 years old smokers in Kolombo village, west Bitung two were mostly in normal level.Keywords: c-reactive protein (crp), active smoker, at age >40 years oldAbstrak: Rokok menjadi salah satu penyebab kematian terbesar di dunia. Merokok membahayakan hampir semua organ tubuh karena mengandung berbagai bahan kimia berbahaya yang dapat merangsang proses peradangan dan merupakan faktor utama penyakit jantung dan penyakit paru obstruktif kronik (PPOK). C-Reactive Protein (CRP) merupakan petanda inflamasi non-spesifik yang meningkat pada penyakit lokal maupun sistemik. Selain biomarker CRP juga dijadikan sebagai penanda prognostik untuk inflamasi. Tujuan dari penelitian ini untuk mengetahui kadar CRP serum pada perokok berusia >40 tahun. Dua puluh delapan perokok memenuhi syarat untuk kriteria ini dan berpartisipasi dalam penelitian ini. Penelitian ini menggunakan desain cross-sectional dengan metode deskriptif. Kadar CRP serum sampel dianalisis di laboratorium. Hasil penelitian menunjukkan bahwa 23 subyek (82%) memiliki kadar CRP serum normal (negatif) dan lima subjek (18%) memiliki kadar CRP serum positif. Dapat disimpulkan bahwa kadar CRP serum perokok berusia >40 tahun di desa Kolombo, Bitung barat dua kebanyakan dalam kadar normal.Kata kunci: c-reactive protein (crp), perokok aktif, usia >40 tahun.

scholarly journals SUBCLINICAL HYPOTHYROIDISM;

2019 ◽  
Vol 26 (03) ◽  
Author(s):  
Abdul Salam Memon ◽  
Bheesham Kumar ◽  
Altaf Ahmed Talpur ◽  
Afzal Junejo
Keyword(s):  
Subclinical Hypothyroidism ◽  
Venous Blood ◽  
Thyroid Stimulating Hormone ◽  
Atherosclerotic Disease ◽  
P Value ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Serum Crp ◽  
Serum Tsh

Objectives: Analysis of thyroid function test, C-reactive protein (CRP) and lipids profile in subclinical hypothyroidism (SCH) as indicators of vascular atherosclerotic disease. Study Design: Cross sectional (case control) study. Place and Duration: Department of Surgery, Liaquat University of Medical and Health Sciences Hospital from January 2016 to July 2017. Materials and Methods: Subjects for this study were selected by inclusion and exclusion criteria. Sampling technique was non-probability purposive sampling. A case of SCH was defined as Thyroid stimulating hormone (TSH) > 6.2 (μIU /ml) with normal T4 and T3 free levels. 5 ml venous blood was collected from peripheral vein. Blood was centrifuged to extract sera for the detection of serum TSH, T4 and T3, and CRP. 12 hours fasting was mandatory for blood lipid detection. Data was analyzed on software SPSS 22.0 (P-value ≤0.05) at 95% confidence interval (P-value ≤0.05). Results: Cases showed high TC, TAG and LDLc with low HDLc compared to controls (P<0.05). Serum TSH was elevated in cases compared to controls (P=0.0001). Serum CRP in controls was noted as 2.75±1.12 ng/ml compared to 9.41±1.58 ng/ml in cases (P=0.0001). Pearson`s correlation shows serum CRP was negative correlated with serum T3 (r= -0.180, P=0.074), and serum T4 (r= -0.2250, P=0.025), but positive correlated with serum TSH (r= 0.626, P=0.0001). Conclusion: Subclinical hypothyroid is associated with dyslipidemia and raised C-reactive protein and both may be interpreted as indicators of vascular atherosclerotic disease.

scholarly journals Ethnic Differences in C-Reactive Protein Concentrations

2008 ◽  
Vol 54 (6) ◽  
pp. 1027-1037 ◽  
Author(s):  
Alyson Kelley-Hedgepeth ◽  
Donald M Lloyd-Jones ◽  
Alicia Colvin ◽  
Karen A Matthews ◽  
Janet Johnston ◽  
...  
Keyword(s):  
Risk Factors ◽  
African American ◽  
African American Women ◽  
Ethnic Differences ◽  
White Women ◽  
Inflammatory Marker ◽  
C Reactive Protein ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Reactive Protein

Abstract Background: Limited data exist regarding the ethnic differences in C-reactive protein (CRP) concentrations, an inflammatory marker associated with risk of cardiovascular disease (CVD). We hypothesized that known CVD risk factors, including anthropometric characteristics, would explain much of the observed ethnic variation in CRP. Methods: We performed a cross-sectional analysis of 3154 women, without known CVD and not receiving hormone therapy, enrolled in the Study of Women’s Health Across the Nation (SWAN), a multiethnic prospective study of pre- and perimenopausal women. Results: The study population was 47.4% white, 27.7% African-American, 8.5% Hispanic, 7.7% Chinese, and 8.6% Japanese; mean age was 46.2 years. African-American women had the highest median CRP concentrations (3.2 mg/L), followed by Hispanic (2.3 mg/L), white (1.5 mg/L), Chinese (0.7 mg/L), and Japanese (0.5 mg/L) women (all pairwise P &lt; 0.001 compared with white women). Body mass index (BMI) markedly attenuated the association between ethnicity and CRP. After adjusting for age, socioeconomic status, BMI, and other risk factors, African-American ethnicity was associated with CRP concentrations &gt;3 mg/L (odds ratio 1.37, 95% CI 1.07–1.75), whereas Chinese and Japanese ethnicities were inversely related (0.58, 0.35–0.95, and 0.43, 0.26–0.72, respectively). Conclusions: Modifiable risk factors, particularly BMI, account for much but not all of the ethnic differences in CRP concentrations. Further study is needed of these ethnic differences and their implications for the use of CRP in CVD risk prediction.

scholarly journals HUBUNGAN KADAR TRIASILGLISEROL DARAH DENGAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN PADA REMAJA OBES

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Melda Melatunan
Keyword(s):  
Cardiovascular Disease ◽  
High Sensitivity ◽  
Nonparametric Test ◽  
Inflammatory Factors ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Reactive Protein ◽  
Triacylglycerol Level ◽  
Hs Crp

Abstract: Obesity is one of the health problem in the world, also in Indonesia. Obesity is caused by an increased amount of fat that stored in the form triacylglycerol ( TAG ) which is acquired from food. Increase of triacylglycerol level may cause higher risk of cardiovascular disease. High Sensitivity C-Reactive Protein (hs-CRP) is a marker of inflammatory factors that can be used as a marker for cardiovascular disease. This study aimed to determine the correlations between TAG levels on blood and hs-CRP levels on obese adolescents. This study performed by observational analytic study design with the cross-sectional approach. The number of sample in this study were 17 sample who was willing to join. Analysis of bivariate using Spearman nonparametric test. The results showed a significance value ( p ) 0.272 which indicates that the correlation between TAG levels and hs-CRP levels were not significant. Spearman value showed 0.282 that indicates that the direction of a positive correlation with the strength of the correlation is weak. It can be concluded that there is no correlations between TAG levels in blood with hs-CRP levels on obese adolescents. Keyword: Obesity, TAG, hs-CRP, Adolescents    Abstrak: Obesitas merupakan masalah kesehatan di seluruh dunia, termasuk di Indonesia. Obesitas disebabkan akibat peningkatan jumlah lemak yang disimpan dalam bentuk triasilgliserol (TAG) yang diperoleh dari makanan. Peningkatan triasilgliserol ini akan meningkatkan risiko penyakit kardiovaskuler. High Sensitivity C-Reactive Protein (hs-CRP) merupakan faktor penanda inflamasi yang dapat digunakan sebagai penanda risiko penyakit kardiovaskuler. Penelitian ini bertujuan untuk mengetahui hubungan kadar TAG darah dengan kadar hs-CRP pada remaja obes. Penelitian ini menggunakan desain penelitian analitik observasional dengan pendekatan cross-sectional. Sampel pada penelitian ini berjumlah 17 sampel yang diambil dari seluruh populasi yang bersedia. Analisis bivariat menggunakan uji nonparametrik Spearman. Hasil penelitian didapatkan nilai signifikansi (p) 0,272 yang menunjukkan bahwa korelasi antara kadar TAG dan kadar hs-CRP tidak signifikan. Nilai Spearman sebesar 0,282 menunjukkan bahwa arah korelasi positif dengan kekuatan korelasi yang lemah. Dapat disimpulkan bahwa tidak terdapat hubungan antara kadar TAG darah dengan kadar hs-CRP pada remaja obes. Kata Kunci : Obesitas, TAG, hs-CRP, Remaja

scholarly journals Prognostic role of C-reactive protein in acute stroke

1970 ◽  
Vol 10 (1) ◽  
pp. 29-33 ◽  
Author(s):  
MM Rahman ◽  
MA Rabim ◽  
RK Nath ◽  
AK Al-Mahmood ◽  
FH Mollah
Keyword(s):  
Health Hazard ◽  
Medical Science ◽  
Stroke Outcome ◽  
C Reactive Protein ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Post Stroke ◽  
Reactive Protein ◽  
Outcome Score ◽  
Serum Crp

Background & objective: Stroke is a dreadful health hazard all over the world as well as in our country and one of the leading causes of mortality & morbidity. The relationship between serum C-reactive protein (CRP) level and post stroke outcome is not well studied especially in Bangladesh. We were interested to study this relationship in our country. Materials & methods: A cross sectional prospective study was performed on 50-stroke patients. Serum CRP & Lipid profile was determined. Post stroke outcome was measured by modified ranking scale (good outcome, score within 0 – 2 & bad outcome, score within 3 – 6). The subjects were divided in two groups, CRP level above or below 10 mg/L. Statistical analysis was performed by using SPSS software. Chi-square test & Spearman’s rho correlation test was done to see the level of significance. Results: Mean serum CRP level was 9.69 mg/L that was higher than normal subjects. Correlation analysis between serums CRP level of stroke patients with post stroke outcome was found to be positively correlated (r = 0.598/p<0.01). Conclusion: Serum CRP level may be used as a prognostic marker in stroke patients and it helps to make necessary management plan to physician. DOI: 10.3329/bjms.v10i1.7316 Bangladesh Journal of Medical Science Vol.10 No.1 Jan 2010 pp.29-33

scholarly journals Antioxidant intake from diet and supplements and elevated serum C-reactive protein and plasma homocysteine concentrations in US adults: a cross-sectional study

2011 ◽  
Vol 14 (11) ◽  
pp. 2055-2064 ◽  
Author(s):  
Anna Floegel ◽  
Sang-Jin Chung ◽  
Anne von Ruesten ◽  
Meng Yang ◽  
Chin E Chung ◽  
...  
Keyword(s):  
Elevated Serum ◽  
Cross Sectional Study ◽  
Elevated Blood ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Antioxidant Intake ◽  
The Mean ◽  
Serum Crp

AbstractObjectiveTo investigate the association of antioxidant intakes from diet and supplements with elevated blood C-reactive protein (CRP) and homocysteine (Hcy) concentrations.DesignA cross-sectional study. The main exposures were vitamins C and E, carotene, flavonoid and Se intakes from diet and supplements. Elevated blood CRP and Hcy concentrations were the outcome measures.SettingThe US population and its subgroups.SubjectsWe included 8335 US adults aged ≥19 years from the National Health and Nutrition Examination Survey 1999–2002.ResultsIn this US population, the mean serum CRP concentration was 4·14 (95 % CI 3·91, 4·37) mg/l. Intakes of vitamins C and E and carotene were inversely associated with the probability of having serum CRP concentrations >3 mg/l in multivariate logistic regression models. Flavonoid and Se intakes were not associated with the odds of elevated serum CRP concentrations. The mean plasma Hcy concentration was 8·61 (95 % CI 8·48, 8·74) μmol/l. Intakes of vitamins C, E, carotenes and Se were inversely associated with the odds of plasma Hcy concentrations >13 μmol/l after adjusting for covariates. Flavonoid intake was not associated with the chance of elevated plasma Hcy concentrations.ConclusionsThese results suggest that high antioxidant intake is associated with lower blood concentrations of CRP and Hcy. These inverse associations may be among the potential mechanisms for the beneficial effect of antioxidant intake on CVD risk mediators in observational studies.

scholarly journals Serum C-reactive protein and Pro-Calcitonin as an Indicator in Post-Operative Infection after Hepatobiliary Surgery

2020 ◽  
Vol 3 (1) ◽  
pp. 64-70
Author(s):  
Joshua CC ◽  
Sreejith V ◽  
A. Sreekumar
Keyword(s):  
Serum Albumin ◽  
P Value ◽  
Specific Marker ◽  
Hepatobiliary Surgery ◽  
C Reactive Protein ◽  
Biliary Surgery ◽  
Reactive Protein ◽  
Operative Complications ◽  
Serum Crp ◽  
Post Operative Complications

Background: Major hepato-biliary surgeries carry a high risk for post-operative sepsis. Recent therapeutic advances both medical and surgical have improved early post-operative outcome. Considering the difficulties in diagnosis of infection in critically ill patients an early sensitive  and specific marker for sepsis would be of interest. Studies have shown that C - reactive protein (CRP) and pro calcitonin (PCT) are acute phase reactants and good independent early markers of post-operative sepsis, severe or septic shock. This aspect has not been evaluated in     the hepatobiliary surgeries. More over there is no data available from the Indian sub-continent in this aspect. This study aims to evaluate the efficacy of serum CRP and PCT levels after hepatobiliary surgery for diagnosis of postoperative complication. Subjects and Methods: This is a cross-sectional diagnostic study has conducted in 42 patients who all are satisfying the inclusion criteria. Study duration was From August 2017 to July 2019, conducted on patients between 18-80yrs of age undergoing hepato-biliary surgery, in surgical wards of PK Das Institute     of Medical Sciences. Study variables include age, sex, pre-operative serum albumin level, pre and post-operative S.CRP AND S.PCT levels. On post-operative day 4 and day 7 S.CRP and S.PCT are monitored and its predictability also measured. . Descriptive statistical analysis will be carried out using SPSS (IBM). The p-value of less than 0.05 will be taken as significant. Results: out of 42 patients studied, 30 patients developed post-operative complications. Pre-operative serum C - reactive protein and serum procalcitonin measured compared with pre-operative serum albumin was significant identifying post-operative complications (P-value 0.02). On post-operative day 4 and 7value was significant in post-operative patients with P-value of 0.04 vs. 0.046 respectively. Similarly serum procalcitonin values also were significant on postoperative day (POD) 4 and 7 with P-value of 0.02 and 0.03. Sensitivity and specificity of S.PCT was more compared to S.CRP (92 vs 90% in sensitivity and 100% vs 80% in specificity respectively. This study shows those who were clinically septic post operatively have statistically elevated levels of serum CRP and Procalcitonin. Conclusion: S.PCT is more sensitive and specific as a marker of post operative infection following hepato biliary surgery. Early identification of patients with insidious septic illness allows early therapeutic intervention which may favorably influence outcome.

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