scholarly journals Prognostic role of C-reactive protein in acute stroke

1970 ◽  
Vol 10 (1) ◽  
pp. 29-33 ◽  
Author(s):  
MM Rahman ◽  
MA Rabim ◽  
RK Nath ◽  
AK Al-Mahmood ◽  
FH Mollah
Keyword(s):  
Health Hazard ◽  
Medical Science ◽  
Stroke Outcome ◽  
C Reactive Protein ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Post Stroke ◽  
Reactive Protein ◽  
Outcome Score ◽  
Serum Crp

Background & objective: Stroke is a dreadful health hazard all over the world as well as in our country and one of the leading causes of mortality & morbidity. The relationship between serum C-reactive protein (CRP) level and post stroke outcome is not well studied especially in Bangladesh. We were interested to study this relationship in our country. Materials & methods: A cross sectional prospective study was performed on 50-stroke patients. Serum CRP & Lipid profile was determined. Post stroke outcome was measured by modified ranking scale (good outcome, score within 0 – 2 & bad outcome, score within 3 – 6). The subjects were divided in two groups, CRP level above or below 10 mg/L. Statistical analysis was performed by using SPSS software. Chi-square test & Spearman’s rho correlation test was done to see the level of significance. Results: Mean serum CRP level was 9.69 mg/L that was higher than normal subjects. Correlation analysis between serums CRP level of stroke patients with post stroke outcome was found to be positively correlated (r = 0.598/p<0.01). Conclusion: Serum CRP level may be used as a prognostic marker in stroke patients and it helps to make necessary management plan to physician. DOI: 10.3329/bjms.v10i1.7316 Bangladesh Journal of Medical Science Vol.10 No.1 Jan 2010 pp.29-33

scholarly journals Gambaran kadar C-reactive protein (CRP) serum pada perokok aktif usia >40 tahun

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Hendrika N. C. Dewi ◽  
Michaela E. Paruntu ◽  
Murniati Tiho
Keyword(s):  
Inflammatory Marker ◽  
Systemic Disease ◽  
Toxic Chemical ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Positive Serum ◽  
Cross Sectional Design ◽  
Serum Crp ◽  
Descriptive Method

Abstract: Cigarette are the most cause of death around the world. Smoking cigarrete is harmful to the organs because it contains many toxic chemical that can stimulate inflammatory process. Smoking cigarrete is a risk factors for heart disease and chronic pulmonary disease (COPD). C-reactive protein (CRP) are a non spesific inflammatory marker that can elevated in both local and systemic disease. Beside biomarker, CRP also use as prognostic marker for inflammation. The purpose of this study was to identify the level of serum CRP of smokers aged >40 years old. Twenty eight smokers were eligible to this criteria and participated in this study. Cross-sectional design with a descriptive method was employed in this study. Sampels were analysed in laboratory for serum CRP levels. The results showed that 23 subjects (82%) had normal (negatif) serum CRP level and five subjects (18%) had positive serum CRP level. It can be concluded that serum CRP level of >40 years old smokers in Kolombo village, west Bitung two were mostly in normal level.Keywords: c-reactive protein (crp), active smoker, at age >40 years oldAbstrak: Rokok menjadi salah satu penyebab kematian terbesar di dunia. Merokok membahayakan hampir semua organ tubuh karena mengandung berbagai bahan kimia berbahaya yang dapat merangsang proses peradangan dan merupakan faktor utama penyakit jantung dan penyakit paru obstruktif kronik (PPOK). C-Reactive Protein (CRP) merupakan petanda inflamasi non-spesifik yang meningkat pada penyakit lokal maupun sistemik. Selain biomarker CRP juga dijadikan sebagai penanda prognostik untuk inflamasi. Tujuan dari penelitian ini untuk mengetahui kadar CRP serum pada perokok berusia >40 tahun. Dua puluh delapan perokok memenuhi syarat untuk kriteria ini dan berpartisipasi dalam penelitian ini. Penelitian ini menggunakan desain cross-sectional dengan metode deskriptif. Kadar CRP serum sampel dianalisis di laboratorium. Hasil penelitian menunjukkan bahwa 23 subyek (82%) memiliki kadar CRP serum normal (negatif) dan lima subjek (18%) memiliki kadar CRP serum positif. Dapat disimpulkan bahwa kadar CRP serum perokok berusia >40 tahun di desa Kolombo, Bitung barat dua kebanyakan dalam kadar normal.Kata kunci: c-reactive protein (crp), perokok aktif, usia >40 tahun.

scholarly journals Relationship of root canal treatment to C-reactive protein as an inflammatory marker for cardiovascular disease

2010 ◽  
Vol 2 (1) ◽  
pp. 11 ◽  
Author(s):  
Bruce Arroll ◽  
Divya Dhar ◽  
Mary Cullinan
Keyword(s):  
Cardiovascular Disease ◽  
Root Canal ◽  
Periodontal Diseases ◽  
Inflammatory Marker ◽  
Root Canal Treatment ◽  
P Value ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Serum Crp

INTRODUCTION: Periodontal disease and elevated C-reactive protein (CRP) tests both are positively correlated with cardiovascular disease (CVD) in many studies. Some health practitioners have concerns that root canal treatment may provide a source for inflammation and hence increase the risk for CVD. AIM: To explore the relationship between CRP as a marker of inflammation and presence and number of root canal treatments in primary care patients. METHODS: Cross-sectional questionnaire about dental care followed by a blood test for serum CRP in patients from two New Zealand urban family practices. RESULTS: One hundred and 34 patients participated. The study showed no significant association between CRP and root canal treatment on multivariate analysis controlling for socioeconomic status, age, gender and smoking. The CRP level for those with =3 root-treated teeth was 1.68 while the level for those with <3 was 2.36, but the p-value was not statistically significant (p=0.198). Age, missing teeth and smoking were all significantly related to CRP levels so the sample has biological validity. DISCUSSION: Root canal treatment was not associated with higher CRP levels. The CRP levels were non-significantly lower in those with higher numbers of root-treated teeth. While there are a number of potential biases in this paper, the dataset appears to be biologically valid and consistent with known facts. These findings do not support the hypothesis that root canal treatment is associated with higher levels of inflammation. At this point patients should not consider having their root canal teeth removed. KEYWORDS: Periodontal diseases; C-reactive protein; inflammation; cardiovascular diseases; gingivitis; root canal treatment

scholarly journals CORRELATION BETWEEN NEUTROPHIL-TO-LYMPHOCYTE RATIO AND HIGH SENSITIVITY C REACTIVE PROTEIN WITH SEVERITY AND OUTCOME IN ACUTE ISCHEMIC STROKE PATIENT

2020 ◽  
Vol 7 (8) ◽  
pp. 75-80
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
High Sensitivity ◽  
Neutrophil To Lymphocyte Ratio ◽  
C Reactive Protein ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Acute Ischemic Stroke Patient ◽  
Lymphocyte Ratio ◽  
Reactive Protein

Background: Inflammation plays a role in the pathophysiology of cerebral ischemic and also an initial response to brain injury. Inflammation involving Blood and Brain Barrier disturbance, leukocyte infiltration, endothelial cells activation, oxidant and inflammatory mediator buildups which can develop rapidly within hours and can cause secondary injury to brain tissues Objectives: To determine the correlation between Neutrophil-to-Lymphocyte Ratio (NLR) and High Sensitivity C Reactive Protein (hsCRP) with severity and outcome in acute ischemic stroke patients Methods: This study used a cross-sectional design approach. Sampling was done at H. Adam Malik General Hospital Medan and taken as many as 38 subjects. NLR and hsCRP were examined on the first day of admission. Severity was assessed by using the National Institutes of Health Stroke Scale and the outcome was assessed by using the Modified Ranking Scale on the first and fourteenth day of admission. The data analysis used the contingency coefficient correlation test and gamma test. Results: Demographic characteristics of the subjects are; the average age is 62 years old, the highest educational level is high school graduate, and the most occupation is unemployed. There is a positive, moderate, and significant correlation between NLR and severity of acute ischemic stroke (r=0.511; p=0.001). There is a positive, moderate, and significant correlation between NLR and the outcome of acute ischemic stroke (r=0.463; p=0.001). There is a positive, very strong, and significant correlation between hsCRP and severity of acute ischemic stroke (r=0.896; p=0.001). There is a positive, strong, and significant correlation between hsCRP and outcome of acute ischemic stroke (r=0.624; p=0.001) Conclusions: There is a positive and significant correlation between NLR and hsCRP with severity and outcome in acute ischemic stroke patients.

scholarly journals Antioxidant intake from diet and supplements and elevated serum C-reactive protein and plasma homocysteine concentrations in US adults: a cross-sectional study

2011 ◽  
Vol 14 (11) ◽  
pp. 2055-2064 ◽  
Author(s):  
Anna Floegel ◽  
Sang-Jin Chung ◽  
Anne von Ruesten ◽  
Meng Yang ◽  
Chin E Chung ◽  
...  
Keyword(s):  
Elevated Serum ◽  
Cross Sectional Study ◽  
Elevated Blood ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Antioxidant Intake ◽  
The Mean ◽  
Serum Crp

AbstractObjectiveTo investigate the association of antioxidant intakes from diet and supplements with elevated blood C-reactive protein (CRP) and homocysteine (Hcy) concentrations.DesignA cross-sectional study. The main exposures were vitamins C and E, carotene, flavonoid and Se intakes from diet and supplements. Elevated blood CRP and Hcy concentrations were the outcome measures.SettingThe US population and its subgroups.SubjectsWe included 8335 US adults aged ≥19 years from the National Health and Nutrition Examination Survey 1999–2002.ResultsIn this US population, the mean serum CRP concentration was 4·14 (95 % CI 3·91, 4·37) mg/l. Intakes of vitamins C and E and carotene were inversely associated with the probability of having serum CRP concentrations >3 mg/l in multivariate logistic regression models. Flavonoid and Se intakes were not associated with the odds of elevated serum CRP concentrations. The mean plasma Hcy concentration was 8·61 (95 % CI 8·48, 8·74) μmol/l. Intakes of vitamins C, E, carotenes and Se were inversely associated with the odds of plasma Hcy concentrations >13 μmol/l after adjusting for covariates. Flavonoid intake was not associated with the chance of elevated plasma Hcy concentrations.ConclusionsThese results suggest that high antioxidant intake is associated with lower blood concentrations of CRP and Hcy. These inverse associations may be among the potential mechanisms for the beneficial effect of antioxidant intake on CVD risk mediators in observational studies.

scholarly journals The Association of Plasma Fractalkine and Inflammation After Ischemic Stroke

2016 ◽  
Vol 8 (2) ◽  
pp. 109
Author(s):  
Lucia Herminawati ◽  
Andi Wijaya ◽  
Mansyur Arief ◽  
Suryani As'ad
Keyword(s):  
Ischemic Stroke ◽  
Tissue Injury ◽  
Cross Sectional Study ◽  
Stroke Onset ◽  
C Reactive Protein ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Reactive Protein ◽  
The Brain ◽  
Sensitive Marker

BACKGROUND: Inflammation affects the brain after stroke with main functions to rapidly eliminate the source of the disturbance, remove damaged tissue and then restore tissue homeostasis. High sensitive C-reactive protein (hsCRP) is a sensitive marker of inflammation and tissue injury in the arterial wall, while fractalkine is a distinct chemokine that promotes inflammatory signaling after neuronal death on ischemic stroke. We aim to investigate the association of fractalkine with hsCRP as a marker of inflammation in ischemic stroke patients.METHODS: This study was designed as a cross-sectional study. Soon after patients with ischemic stroke admitted to hospital, plasma fractalkine and hsCRP concentrations were assesed. Subjects had to be at least 30 years old and maximum 30 days of stroke onset. High inflammation was defined as hsCRP value >3 mg/L.RESULTS: High fractalkine levels were found on 24 ischemic stroke patients (49%) and mean of fractalkine 0.719 ng/mL on patients with stroke onset <7 days was higher than patients with stroke onset 7-30 days. Low fractalkine levels (<0.527 ng/mL) were found on ischemic stroke patients with onset 7-30 days accompanied by high inflammation (hsCRP >3 mg/L), but no significant correlation between fractalkine and hsCRP (p=0.613).CONCLUSION: High inflammation and low plasma fractalkine profile was found after 7 days of onset in ischemic stroke patients. No significant correlation between fractalkine and hsCRP in ischemic stroke patients.KEYWORDS: CRP, fractalkine, inflammation, ischemic stroke

scholarly journals Evaluating serum C-reactive protein level in patients with chronic obstructive pulmonary disease – A cross-sectional study

2019 ◽  
pp. 1-4
Author(s):  
Karthika M ◽  
Prakash Chandra Bhardwaj ◽  
Laimayum Amarnath Sharma ◽  
Laimayum Amarnath Sharma ◽  
W Kanan ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Cross Sectional Study ◽  
Chronic Obstructive ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Reactive Protein ◽  
Copd Patients ◽  
Serum Crp

Abstract Patients with the chronic obstructive pulmonary disease have ongoing systemic inflammation, which can be assessed by measuring serum  C- reactive protein. Objective: To explore whether CRP could be used as an independent predictor of disease outcome in COPD. Methods: A cross-sectional study was conducted among 50 COPD patients attending Respiratory Medicine outpatient services in the Regional Institute of Medical Sciences (RIMS), Imphal from January 2015 to September 2016. Patients aged 18-67 were included in the study after obtaining Ethical approval from the Research Ethics Board, RIMS, Imphal. Computerized Spirometer Helios 401 was the instrument used to measure lung volumes and capacities. BeneSpheraTM CRP Latex Slide test kit was used to estimate serum c-reactive protein. Results and observation: The present study was conducted on fifty COPD patients in which serum CRP level showed positive correlation with COPD (p=0.002) but serum CRP level with spirometric parameters showed significant negative correlation;FEV1 (r=-0.451, p=0.001), FEV1/FVC (r=-0.617, p<0.001) and PEFR (r=-0.398, p=0.004). Conclusion: In our study, we found an association between serum CRP level and severity of COPD and Plasma CRP may be used as a marker of prognosis in COPD as the small increase is associated with poorer prognosis in COPD. Keywords: CRP; Chronic obstructive pulmonary disease (COPD); Imphal.

scholarly journals Dietary B Vitamins and Serum C-Reactive Protein in Persons With Human Immunodeficiency Virus Infection

2016 ◽  
Vol 37 (4) ◽  
pp. 517-528 ◽  
Author(s):  
Kalpana Poudel-Tandukar ◽  
Ram Krishna Chandyo
Keyword(s):  
Geometric Mean ◽  
Latex Agglutination ◽  
B Vitamins ◽  
C Reactive Protein ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Reactive Protein ◽  
The Mean ◽  
Serum Crp

Background: B vitamins may have beneficial roles in reducing inflammation; however, research on the role of B vitamins in inflammation among HIV-infected persons is lacking. Objective: This study assessed the association between B vitamins and serum C-reactive protein (CRP) concentrations in HIV-infected persons. Methods: A cross-sectional survey was conducted among 314 HIV-infected persons (180 men and 134 women) aged 18 to 60 years residing in the Kathmandu, Nepal. High-sensitive and regular serum CRP concentrations were measured by the latex agglutination nephelometry and latex agglutination turbidimetric method, respectively. Dietary intake was assessed using 2 nonconsecutive 24-hour dietary recalls. The relationships between B vitamins and serum CRP concentrations were assessed using multiple regression analysis. Results: The multivariate-adjusted geometric mean of serum CRP concentrations was significantly decreased with an increasing B vitamins intake across quartiles of niacin ( P for trend = .007), pyridoxine ( P for trend = .042), and cobalamin ( P for trend = .037) in men. In men, the mean serum CRP concentrations in the highest quartiles of niacin, pyridoxine, and cobalamin were 63%, 38%, and 58%, respectively, lower than that in the lowest quartile. In women, the mean serum CRP concentrations in the highest quartiles of riboflavin ( P for trend = .084) and pyridoxine ( P for trend = .093) were 37% and 47%, respectively, lower than that in the lowest quartile. Conclusion: High intake of niacin, pyridoxine, or cobalamin was independently associated with decreased serum CRP concentrations among HIV-infected men. Further prospective studies are warranted to confirm the role of B vitamins in inflammation among HIV-infected persons.

scholarly journals Ringworm: Evaluation of C-reactive Protein and Lipid Profile as well as Their Correlation with the Patients Age and Body Mass Index

2020 ◽  
Vol 19 (4) ◽  
pp. 673-677
Author(s):  
Md Shafiul Hossen ◽  
Auditi Kar ◽  
Hasan Moinul Haque
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol Level ◽  
Medical Science ◽  
Control Group ◽  
Healthy Individuals ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Significant Difference ◽  
Serum Crp ◽  
And Control

Objectives: Ringworm is a common cutaneous fungal disease with worldwide distribution.It may lead to the abnormal c-reactive protein levels and metabolism of lipid. Thus this study has been designed for determining serum CRP and also evaluating the Lipid profile in patients associated with ringworm. Materials and methods: This study recruited 25 patients with ringworm (cases) and 25 healthy individuals (controls). A questionnaire of personal characteristics was completed for each patient and control. Inflammatory marker (CRP) and Serum lipid profile (total, lowdensity lipoprotein (LDL), high-density lipoprotein (HDL) cholesterol and triglyceride) was recorded for each case and control. The test of significance was applied for statistical analysis. Results and discussion: The mean serum CRP were 1.608±0.14 and 0.648±0.03 mg/dl and total cholesterol level were 175.09±3.26 and 182.09±3.01 mg/dl in ringworm patients and control subject respectively. It was also observed that the serum TG; HDL; LDL levels were 131.76±3.07 and 139.84±3.47 mg/dl; 80.79±1.79 and 73.35±4.14 mg/dl; 67.95±4.64 and 86.55±3.70 mg/dl in patients and control group respectively. The value of CRP was significantly increased in patients compared to control group (p <0.05). There was no significant difference of lipid profile study between patients and control Conclusion: Findings of this study indicate increased concentrations of CRP in patients affected to ringworm and its role in this infection. Patients should thus be routinely screened for such abnormalities Probably observation of lipid profile in healthy individuals in compare with patients group indicates that it has no relationship in case of ringworm. Bangladesh Journal of Medical Science Vol.19(4) 2020 p.673-677

scholarly journals Inverse association linking serum levels of potential antioxidant vitamins with C-reactive protein levels using a novel analytical approach

2016 ◽  
Vol 116 (7) ◽  
pp. 1256-1264 ◽  
Author(s):  
Hui G. Cheng ◽  
Omayma Alshaarawy ◽  
Marven D. Cantave ◽  
James C. Anthony
Keyword(s):  
Structural Equations ◽  
Composite Indicator ◽  
Inverse Association ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Summary Estimate ◽  
Reactive Protein ◽  
Measurement Models ◽  
Indicator Approach ◽  
Serum Crp

AbstractExposures to antioxidants (AO) are associated with levels of C-reactive protein (CRP), but the pattern of evidence is mixed, due in part to studying each potential AO, one at a time, when multiple AO exposures might affect CRP levels. By studying multiple AO via a composite indicator approach, we estimate the degree to which serum CRP level is associated with serum AO level. Standardised field survey protocols for the US National Health and Nutrition Examination Survey (NHANES) 2003–2006 yielded nationally representative cross-sectional samples of adults aged 20 years and older (n8841). NHANES latex-enhanced nephelometry quantified serum CRP levels. Liquid chromatography quantified serum concentrations of vitamins A, E and C and carotenoids. Using structural equations, we regressed CRP level on AO levels, and derived a summary estimate for a composite of these potential antioxidants (CPA), with covariates held constant. The association linking CPA with CRP was inverse, stronger for slightly elevated CRP (1·8≤CRP<10 mg/l; slope= −1·08; 95 % CI −1·39, −0·77) and weaker for highly elevated CRP (≥10 mg/l; slope= −0·52; 95 % CI −0·68, −0·35), with little change when covariates were added. Vitamins A and C, as well as lutein+zeaxanthin, were prominent contributors to the composite. In these cross-sectional data studied via a composite indicator approach, the CPA level and the CRP level were inversely related. The stage is set for more confirmatory longitudinal or intervention research on multiple vitamins. The composite indicator approach might be most useful in epidemiology when several exposure constructs are too weakly inter-correlated to be studied via formal measurement models for underlying latent dimensions.

scholarly journals Serum C-reactive protein levels in severe and very severe pneumonia in children

2012 ◽  
Vol 52 (3) ◽  
pp. 161
Author(s):  
Ni Putu Sucita Wahyu Dewi ◽  
Putu Siadi Purniti ◽  
Roni Naning
Keyword(s):  
Severe Pneumonia ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Pneumonia Severity ◽  
Protein Levels ◽  
Reactive Protein ◽  
Median Serum ◽  
Serum Crp

Background Pneumonia is a major cause of death in children fromdeveloping countries. It is difficult to assess pneumonia severity ifclinical symptoms of pneumonia are unclear, co-morbidities occursimultaneously, or there is an absence of consolidation or infiltrateson chest radiograph. Examination of C-reactive protein (CRP)levels can help to determine the severity of pneumonia.Objective To compare serum CRP levels in severe and very severepneumonia cases.Methods This was a cross-sectional study on pediatric patientsaged> 28 days up to 60 months v.ith a diagnosis of severe or verysevere pneumonia. Subjects were hospitalized at the Departmentof Child Health, Udayana University Medical SchooliSanglahHospital, Denpasar from May 2010 to January 2011. There were30 subjects in each group, severe or very severe pneumonia. Datawere analyzed using Mann-Whitney and ANCOVA tests withstatistical significance set at P < 0.05.Results There were significant differences in median serum CRPlevels in the severe and very severe pneumonia groups. The verysevere pneumonia group had a median CRP level of 54.75 mgiL(lQrange 0.22 to 216.00) and the severe pneumonia group had amedian CRP level ofl6.06 mgiL (IQ range 0.97 to 89.35). SerumCRP levels were influenced by the severity of pneumonia (P =0.002) and the timing of the CRP examination (P = 0.001).Conclusion Subjects with very severe pneumonia hadsignificantly higher median CRP level compared to that of subjectswith severe pneumonia. [Paediatr Indones. 2012;52:161A].

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