scholarly journals The mutational load in natural populations is significantly affected by high primary rates of retroposition

2021 ◽  
Vol 118 (6) ◽  
pp. e2013043118 ◽  
Author(s):  
Wenyu Zhang ◽  
Chen Xie ◽  
Kristian Ullrich ◽  
Yong E. Zhang ◽  
Diethard Tautz
Keyword(s):  
Gene Evolution ◽  
Natural Populations ◽  
Distribution Patterns ◽  
Mutational Load ◽  
Negative Effects ◽  
Single Nucleotide ◽  
Species Comparisons ◽  
The Impact ◽  
Profiling Analysis

Gene retroposition is known to contribute to patterns of gene evolution and adaptations. However, possible negative effects of gene retroposition remain largely unexplored since most previous studies have focused on between-species comparisons where negatively selected copies are mostly not observed, as they are quickly lost from populations. Here, we show for natural house mouse populations that the primary rate of retroposition is orders of magnitude higher than the long-term rate. Comparisons with single-nucleotide polymorphism distribution patterns in the same populations show that most retroposition events are deleterious. Transcriptomic profiling analysis shows that new retroposed copies become easily subject to transcription and have an influence on the expression levels of their parental genes, especially when transcribed in the antisense direction. Our results imply that the impact of retroposition on the mutational load has been highly underestimated in natural populations. This has additional implications for strategies of disease allele detection in humans.

scholarly journals The mutational load in natural populations is significantly affected by high primary rates of retroposition

2020 ◽  
Author(s):  
Wenyu Zhang ◽  
Chen Xie ◽  
Kristian Ullrich ◽  
Yong E. Zhang ◽  
Diethard Tautz
Keyword(s):  
Gene Evolution ◽  
Natural Populations ◽  
Distribution Patterns ◽  
Mutational Load ◽  
Negative Effects ◽  
Genomic Dataset ◽  
Evolutionary Innovation ◽  
Species Comparisons ◽  
The Impact ◽  
Profiling Analysis

AbstractGene retroposition is known to contribute to patterns of gene evolution and adaptations. However, possible negative effects of gene retroposition remain largely unexplored, since most previous studies have focussed on between-species comparisons where negatively selected copies are mostly not observed, as they are quickly lost from the populations. Here, we show for natural house mouse populations that the primary rate of retroposition is orders of magnitude higher than previously thought. Comparisons with SNP distribution patterns in the same populations show that most retroposition events are deleterious. Transcriptomic profiling analysis shows that new retroposed copies become easily subject to transcription and have an influence on the expression level of their parental genes, especially when transcribed in the antisense direction. Our results imply that the impact of retroposition on the mutational load in natural populations has been highly underestimated, which has also implications for strategies of disease allele detection in humans.Significance statementThe phenomenon or retroposition (re-integration of reverse transcribed RNA into the genome), has been well studied in comparisons between genomes and has been identified as a source of evolutionary innovation. However, the negative effects of retroposition have been overlooked so far. Our study makes use of a unique population genomic dataset from natural mouse populations. It shows that the retroposition rate is magnitudes higher than previously suspected. We show that most of the newly transposed retrocopies have a deleterious impact through modifying the expression of their parental genes. In humans, this effect is expected to cause disease alleles and we propose that genetic screening needs to take into account the search for newly transposed retrocopies.

Welfare Use in Japan: Trends and Determinants

2007 ◽  
pp. 88
Author(s):  
Wataru Suzuki ◽  
Yanfei Zhou
Keyword(s):  
Time Series ◽  
Longitudinal Data ◽  
Time Series Data ◽  
Positive Impact ◽  
Series Data ◽  
Negative Effects ◽  
Long Time ◽  
Welfare Use ◽  
The Impact

This article represents the first step in filling a large gap in knowledge concerning why Public Assistance (PA) use recently rose so fast in Japan. Specifically, we try to address this problem not only by performing a Blanchard and Quah decomposition on long-term monthly time series data (1960:04-2006:10), but also by estimating prefecturelevel longitudinal data. Two interesting findings emerge from the time series analysis. The first is that permanent shock imposes a continuously positive impact on the PA rate and is the main driving factor behind the recent increase in welfare use. The second finding is that the impact of temporary shock will last for a long time. The rate of the use of welfare is quite rigid because even if the PA rate rises due to temporary shocks, it takes about 8 or 9 years for it to regain its normal level. On the other hand, estimations of prefecture-level longitudinal data indicate that the Financial Capability Index (FCI) of the local government2 and minimum wage both impose negative effects on the PA rate. We also find that the rapid aging of Japan's population presents a permanent shock in practice, which makes it the most prominent contribution to surging welfare use.

scholarly journals Zoom fatigue wśród nastolatków

2021 ◽  
pp. 167-178
Author(s):  
Ewa Pudłowska
Keyword(s):  
Distance Learning ◽  
School Psychologist ◽  
Social Phenomenon ◽  
Stanford University ◽  
Social Changes ◽  
Negative Effects ◽  
Long Distance ◽  
School Activities ◽  
The Impact

The aim of this study is to analyze a new social phenomenon that appeared during the SARS-CoV-2 pandemic, i.e. zoom fatigue. Zoom fatigue is the result of fatigue from long-term conferences, which can also be related to long-term school lessons during distance learning. The main considerations will focus on teenagers, namely on the impact of zoom fatigue on teenagers in Polish schools and on observation of students from technical secondary schools by a school psychologist. This paper, based on the results of research conducted at Stanford University and by Social Changes, is also an attempt to answer the questions: what risks may arise from the phenomenon of zoom fatigue and the threat posed by distance learning for teenagers in the era of Covid-19. It will also attempt to answer the question of how to help students cope with the fatigue of long distance school activities and find ways to help teens deal with isolation and the negative effects of zoom fatigue and find ways to overcome zoom fatigue.

scholarly journals CONGENITAL ANOMALIES IN CHILDREN OF UKRAINE: 25-YEAR MONITORING OF MORBIDITY AND PREVALENCE

2020 ◽  
Vol 73 (10) ◽  
pp. 2193-2197
Author(s):  
Oleksandr P. Volosovets ◽  
Tetyana O. Kryuchko ◽  
Viktor L. Veselskyi ◽  
Sergii P. Kryvopustov ◽  
Tetiana M. Volosovets ◽  
...  
Keyword(s):  
Congenital Anomalies ◽  
Congenital Defects ◽  
Negative Effects ◽  
Epidemiological Analysis ◽  
Child Population ◽  
Total Incidence ◽  
Industrial Regions ◽  
The Impact ◽  
Long Term Studies

The aim: Of the work was to study 25-year trends in the incidence of congenital anomalies in the child population of Ukraine in order to determine the impact of ecotoxic environmental factors on their development, in particular radiation. Materials and methods: Methods of statistical assessment, epidemiological analysis of materials at the Center for Medical Statistics of the MOH of Ukraine were used. Results: The rate of congenital anomalies growth for the recent 25 years has exceeded the growth rate of the total incidence in the child population of Ukraine by 1.6 times, occupying the leading place in Europe by the level of environment pollution. Over the last 25 years, the growth of the Ukrainian children’s congenital anomalies incidence level by 59.5% is observed, mostly in children from large industrial regions of Ukraine, due to the significant ecotoxic effect of pollutants on the child’s body. Children living permanently in the areas contaminated by the Chernobyl accident had significantly higher rates of congenital anomalies in 1986 than in the early 1990s, but over the recent 25 years the incidence in this contingent has decreased. Conclusions: The results of such long-term studies performed by a group of leading Ukrainian scientists from different regions of Ukraine indicate that in children experiencing negative effects of ecotoxic factors, including radiation, an increase in the detection and prevalence of congenital defects is observed, which requires complex international and intersectoral measures to prevent and reduce child mortality.

scholarly journals The Search of New Distribution Patterns in Digital Media Environment

2011 ◽  
Vol 3 (4) ◽  
pp. 111-117
Author(s):  
Gennady Petrovich Bakulev
Keyword(s):  
New Media ◽  
Digital Media ◽  
Value Chain ◽  
Distribution Patterns ◽  
Media Technologies ◽  
Film Distribution ◽  
On Line ◽  
Radical Revision ◽  
The Impact

Digital technologies and the Internet in particular are causing deep changes in film industry. The development of the VoD service is enhancing the tendency for digitalization and disintermediation. Consequently, there is a considerable cost reduction in the value chain. In the long term future there can be a radical revision of the existing system of distribution “windows”. To understand the principles of the on-line distribution the author tries to estimate the impact of new media technologies on film distribution and the strategy of its main participants

The impact of food aid on world malnutrition

1981 ◽  
Vol 35 (2) ◽  
pp. 329-354 ◽  
Author(s):  
James N. Schubert
Keyword(s):  
Nutritional Status ◽  
Food Production ◽  
Developed Countries ◽  
Food Aid ◽  
Control Group ◽  
Negative Effects ◽  
Alternative Hypotheses ◽  
Long Term Impact ◽  
The Impact

Does food aid enhance or diminish the nutritional status of recipient populations in less developed countries? In proposing that the long-term impact is negative, critics have argued that aid depresses local food production, is maldistributed and mismanaged such that it does not reach the needy in sufficient quantities, or, where effective, that aid merely reduces the death rate relative to the birth rate, permitting more people to survive at the margin of existence. This study explores the long-term impact of U.S. Public Law 480 food aid through a crossnational analysis of aggregate data on aid receipts and change in nutritional status over the period from 1962 through 1974. Alternative hypotheses are tested through least squares methods and.mean difference tests in the framework of a nonequivalent control group, quasi-experimental design. This study supports the following generalizations: food aid is significantly related with improved nutritional status; the greater the aid, the greater the improvement in nutrition; higher aid recipients do not have significantly lower rates of growth in domestic food production; higher aid recipients do not have higher rates of population growth; and food aid may lead to greater meat consumption among higher aid recipients. Negative effects, experienced in some countries at some times, are not systematically incurred by all food aid recipients over time. In general, food aid does improve nutrition.

scholarly journals Demographic and genetic consequences of disturbed sex determination

2017 ◽  
Vol 372 (1729) ◽  
pp. 20160326 ◽  
Author(s):  
Claus Wedekind
Keyword(s):  
Population Growth ◽  
Sex Determination ◽  
Sex Ratios ◽  
Natural Populations ◽  
Gonad Development ◽  
Empirical Work ◽  
Sex Reversal ◽  
Negative Effects ◽  
Population Extinction

During sex determination, genetic and/or environmental factors determine the cascade of processes of gonad development. Many organisms, therefore, have a developmental window in which their sex determination can be sensitive to, for example, unusual temperatures or chemical pollutants. Disturbed environments can distort population sex ratios and may even cause sex reversal in species with genetic sex determination. The resulting genotype–phenotype mismatches can have long-lasting effects on population demography and genetics. I review the theoretical and empirical work in this context and explore in a simple population model the role of the fitness v yy of chromosomally aberrant YY genotypes that are a consequence of environmentally induced feminization. Low v yy is mostly beneficial for population growth. During feminization, low v yy reduces the proportion of genetic males and hence accelerates population growth, especially at low rates of feminization and at high fitness costs of the feminization itself (i.e. when feminization would otherwise not affect population dynamics much). When sex reversal ceases, low v yy mitigates the negative effects of feminization and can even prevent population extinction. Little is known about v yy in natural populations. The available models now need to be parametrized in order to better predict the long-term consequences of disturbed sex determination. This article is part of the themed issue ‘Adult sex ratios and reproductive decisions: a critical re-examination of sex differences in human and animal societies’.

scholarly journals The Impact of Uncertainty on State-Level Housing Markets of the United States: The Role of Social Cohesion

2021 ◽  
Vol 13 (6) ◽  
pp. 3065
Author(s):  
Linyan Dai ◽  
Xin Sheng
Keyword(s):  
United States ◽  
Social Cohesion ◽  
Housing Markets ◽  
State Level ◽  
The United States ◽  
Negative Effects ◽  
Housing Returns ◽  
The Impact

While considering the role of social cohesion, we analyse the impact of uncertainty on housing markets across the 50 states of the United States, plus the District of Columbia, using the local projection method for panel data. We find that both short-term and long-term measurements of macroeconomic and financial uncertainties reduce real housing returns, with the strongest effect originated from the macro-economic uncertainty over the long term. Moreover, the degree of social cohesion does not change the nature of the impact of uncertainty on real housing returns dramatically, but the size of the negative effects is relatively large for states with low social cohesion.

scholarly journals Help in controlling pain in children: pediatrician’s tips

2021 ◽  
pp. 263-268
Author(s):  
Lada S. Starostina
Keyword(s):  
Adverse Reactions ◽  
Invasive Procedures ◽  
Negative Effects ◽  
Oil Emulsion ◽  
Surgical Manipulations ◽  
Social Components ◽  
The Impact ◽  
Receptor Apparatus

The problem of anesthesia includes mainly the treatment of pre-existing pain or surgical manipulations with the use of anesthesia. However, the problems of pain prevention during traumatic (invasive) procedures are also actively solved, methods of prevention are improved and expanded, taking into account the impact of pain on the quality of life. Pain is not a simple physiological process of conducting stimulation from the receptor apparatus to the CNS structures, but a complex phenomenon that includes biological, emotional, psychological and social components. Pain is one of the earliest formed psychophysical functions; by the 30 th week of fetal development all pathways of pain conduction and perception are already formed, so both fetus and child are already capable of perceiving pain, and the intensity is often even higher than in adults. Many believe that: young children do not feel pain because their central nervous system is immature; children remember themselves from the age of 4–5 years, so they do not remember the pain they suffered, so all surgical problems that cause pain should be addressed as early as possible; if the child is sleeping or playing, he or she has no pain, etc. Current research has demonstrated significant short-term adverse reactions and long-term negative effects in children in response to pain-related manipulations. Anesthesia of intact skin was previously impossible without prior painful anesthetic injection. Today, other ways of administering anesthetics are used as alternatives: oral, in enemas or suppositories, locally as sprays, ointments, or by application. To address the pain associated with invasive procedures, the effectiveness of a 5% local anesthetic cream based on a water-oil emulsion of lidocaine and prilocaine (1:1), which has good absorption properties, has been studied. Using local anesthesia can prevent and/or reduce the risk of pain-induced stress. Considering the results of these studies, the use of a local combined anesthetic containing 2.5% lidocaine and 2.5% prilocaine may be suggested.

scholarly journals RELATIONSHIP OF ADOLESCENTS BEHAVIOR TO CONSUMPTION OF SOFT DRINKS IN SMPN 5 PEKANBARU YEAR 2016

1930 ◽  
Vol 7 (02) ◽  
pp. 53-60
Author(s):  
Alhidayati ◽  
Nurhapipa ◽  
Rahma Putri
Keyword(s):  
Negative Impact ◽  
Calcium Deficiency ◽  
Soft Drinks ◽  
The Body ◽  
P Value ◽  
Negative Effects ◽  
Chi Square ◽  
Cross Sectional ◽  
The Impact

Behavior consumption of soft drinks are the actions or deeds regarding how often consume soft drinks per week is calculated. Carbonated drinks consumption habits will have a negative impact when it accumulates in the long term. Have been many studies that explain the negative effects of soft drinks, including carcinogenic benzene in soft drinks is very high, high phosphate content of vital minerals in the body that can trigger heart disease (magnesiumdeficiency), osteoporosis (calcium deficiency) and more. Based on the survey results of the sale of soft drinks in the cafeteria, 5 schools with the highest sales level, is SMP N 5 Pekanbaru selling 6-7 boxes per month. This type of research is quantitative with cross sectional design which was held on 16-18 May 2016 in SMP N 5 Pekanbaru. The population of this research is all student grades 7 and 8 SMP N 5 Pekanbaru which amounted to 541 people, with a sample size of 115 people. Data collected technique by stratified random sampling use questionnaire measuring instrument. Univariate data analysis and use your bivariate chi-square test. The results showed that there was a relationship between the knowledge obtained value (p value = 0.001 value POR = 2.14), Effect of friends (p value = 0.006 value POR = 3.45), Access (p value = 0.029 value POR = 2.70), And advertisement (p value = 0:01 value POR = 3.20) with the consumption of soft drinks. Suggested to the relevant instance, that is SMP N 5 Pekanbaru to provide education and information to as many students on the impact of consuming soft drinks for health when consumed in the long term and excessive, and form healthy canteen, or supervise the beverage products , to minimize the beverage products are bad for health.

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