Copper, manganese, zinc, nickel, cadmium and lead in human foetal tissues

1978 ◽  
Vol 39 (3) ◽  
pp. 639-646 ◽  
Author(s):  
Clare E. Casey ◽  
Marion F. Robinson
Keyword(s):  
Skeletal Muscle ◽  
Gestational Age ◽  
Soft Tissues ◽  
Tissue Samples ◽  
Manganese Zinc ◽  
Copper Manganese ◽  
Cadmium And Lead ◽  
The Brain ◽  
Zinc Nickel ◽  
Nickel Cadmium

1. Concentrations of copper, manganese, zinc, nickel, cadmium and lead were measured in samples of liver, kidney, brain, heart, lung, skeletal muscle and vertebral bone from forty foetuses of 22–43 weeks gestation.2. Cu concentrations in the liver were up to 100 times those in other tissues, but only those in the brain showed a significant increase with gestational age.3. Mn concentrations were similar in all tissues; the over-all range was 0.35–9.27 μg/g dry matter (dm).4. Concentrations of Zn in the liver were much higher than in other tissues and decreased with gestational age, whereas levels in skeletal muscle increased.5. In all tissues Ni concentrations were within the range 0.04–2.8 μg/gdmand levels in kidney and muscle decreased significantly with age.6. Cd was detected in most of the tissue samples and concentrations were within the range 0.01–0.58μg/gdm.7. Concentrations of Pb, where it was detected, varied from 0.1 to 2.4 μg/gdmin the soft tissues and from 0.4 to 4.3 μg/gdmin the bone samples.

Endotoxin Alteration of the Mucopolysaccharide Blood Vessel Coating in Rats

1974 ◽  
Vol 32 ◽  
pp. 148-149
Author(s):  
D. E. Philpott ◽  
A. Takahashi
Keyword(s):  
Skeletal Muscle ◽  
Endothelial Cells ◽  
Salivary Gland ◽  
Carotid Artery ◽  
Basement Membrane ◽  
Coronary Vessels ◽  
Ruthenium Red ◽  
E Coli ◽  
Old Rats ◽  
The Brain

Two month, eight month and two year old rats were treated with 10 or 20 mg/kg of E. Coli endotoxin I. P. The eight month old rats proved most resistant to the endotoxin. During fixation the aorta, carotid artery, basil arartery of the brain, coronary vessels of the heart, inner surfaces of the heart chambers, heart and skeletal muscle, lung, liver, kidney, spleen, brain, retina, trachae, intestine, salivary gland, adrenal gland and gingiva were treated with ruthenium red or alcian blue to preserve the mucopolysaccharide (MPS) coating. Five, 8 and 24 hrs of endotoxin treatment produced increasingly marked capillary damage, disappearance of the MPS coating, edema, destruction of endothelial cells and damage to the basement membrane in the liver, kidney and lung.

A Survey on Detection and Classification of Brain Tumor Using Image Processing Techniques

2020 ◽  
pp. 967-973
Author(s):  
V. Deepika ◽  
T. Rajasenbagam
Keyword(s):  
Image Processing ◽  
Brain Tumor ◽  
Soft Tissues ◽  
Tumor Detection ◽  
Tumor Classification ◽  
Normal Brain ◽  
Image Processing Techniques ◽  
Normal Brain Function ◽  
Processing Techniques ◽  
The Brain

A brain tumor is an uncontrolled growth of abnormal brain tissue that can interfere with normal brain function. Although various methods have been developed for brain tumor classification, tumor detection and multiclass classification remain challenging due to the complex characteristics of the brain tumor. Brain tumor detection and classification are one of the most challenging and time-consuming tasks in the processing of medical images. MRI (Magnetic Resonance Imaging) is a visual imaging technique, which provides a information about the soft tissues of the human body, which helps identify the brain tumor. Proper diagnosis can prevent a patient's health to some extent. This paper presents a review of various detection and classification methods for brain tumor classification using image processing techniques.

Heavy metals accumulation in freshwater mussels (Lamellidens marginalis) as a biological monitor inhabiting in Dhanmondi Lake, Dhaka, Bangladesh.

2016 ◽  
Vol 5 (10) ◽  
pp. 4933
Author(s):  
Sabia Sultana ◽  
A. K. M. Nur Alam Siddiki ◽  
Md. Rokonujjaman ◽  
M. Niamul Naser ◽  
Abdus Salam ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Heavy Metal ◽  
Soft Tissues ◽  
Freshwater Mussels ◽  
Heavy Metal Concentration ◽  
Heavy Metal Concentrations ◽  
Heavy Metals Accumulation ◽  
Manganese Zinc ◽  
Metals Accumulation ◽  
Test Level

The heavy metal concentration (e.g., Mn, Zn, Pb and Ni) were determined in soft tissues and shells of freshwater mussels (Lamellidens marginalis) at the various sites of Dhanmondi lake, Dhaka, Bangladesh between the period April, 2010 and March 2011. The heavy metal concentrations in shells and soft tissues of freshwater mussels were tended to vary significantly among sampling points and seasons in Dhanmondi Lake. Distribution of heavy metals in shell and soft tissue of Lamellidens marginalis followed the order Mn>Zn>Pb>Ni, respectively. According to the t-test, level of manganese, zinc and lead under investigation between shell and tissue showed statistically significant differences [Mn: t=-11.387; df=16; P=0.000; Zn: t=-2.590; df=16; P=0.020 and Pb: t=-2.8679; df=16; P=0.011].

scholarly journals Distribution of Melanin Pigmentation in 33 Organs of Thai Black-Bone Chickens (Gallus gallus domesticus)

Animals ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 777
Author(s):  
Korakot Nganvongpanit ◽  
Piyatida Kaewkumpai ◽  
Varankpicha Kochagul ◽  
Kidsadagon Pringproa ◽  
Veerasak Punyapornwithaya ◽  
...  
Keyword(s):  
Gallus Gallus ◽  
Gallus Domesticus ◽  
Melanin Pigment ◽  
Gallus Gallus Domesticus ◽  
Tissue Samples ◽  
Melanin Pigmentation ◽  
Chicken Breed ◽  
Brachial Vein ◽  
The Brain ◽  
Pigment Accumulation

The black-bone chicken (Gallus gallus domesticus) is a breed of chicken that is commonly found in Thailand. This breed is known for having a number of black colored organs. Consumers have been notably attracted to the black-bone chicken breed for the characteristic darkness that is observed in many of its organs. However, the degree of darkness in all organs of the black-bone chicken is still in question. Importantly, there have not yet been any published reports on the distribution of melanin pigment in the organs of the black-bone chicken. This research study aims to examine the distribution of the melanin pigment in 33 organs of the Thai black-bone chicken. Ten black-bone chickens (five male, five female) were included in this study. Thirty-two organs including the brain, spinal cord, sciatic nerve, larynx, trachea, syrinx, lungs, heart, pericardium, aorta, brachial vein, kidney, cloaca, oviduct, testis, gastrocnemius muscle, femur, tongue, esophagus, crop, proventriculus, gizzard, duodenum, jejunum, ileum, cecum, pancreas, liver, gall bladder, omentum, abdominal fat, spleen, and skin were examined in this study. Histological sections taken from tissue samples of each of these organs were studied. The findings revealed that the presence of the melanin pigment was not significantly different (p > 0.005) between male and female specimens. Notably, the liver was the only organ in which the melanin pigment had not accumulated. Consequently, there was not a uniform pattern of melanin pigment accumulation throughout the organs of the chickens. The melanin pigment was present in all of the tissue layers of most organs, while the melanin pigment was found in only specific layers of some of the organs. In conclusion, the distribution of melanin pigmentation in the organs of each of the animals in this study was found to be different. However, in some tissue samples, such as those obtained from the liver, no accumulation of the melanin pigment was observed.

scholarly journals Safety profile of the transcription factor EB (TFEB)-based gene therapy through intracranial injection in mice

2020 ◽  
Vol 11 (1) ◽  
pp. 241-250
Author(s):  
Zhenyu Li ◽  
Guangqian Ding ◽  
Yudi Wang ◽  
Zelong Zheng ◽  
Jianping Lv
Keyword(s):  
Gene Therapy ◽  
Transcription Factor ◽  
Neurodegenerative Diseases ◽  
Brain Tissue ◽  
Inflammatory Responses ◽  
Tissue Samples ◽  
Protein Levels ◽  
Virus Serotype ◽  
Transcription Factor Eb ◽  
The Brain

AbstractTranscription factor EB (TFEB)-based gene therapy is a promising therapeutic strategy in treating neurodegenerative diseases by promoting autophagy/lysosome-mediated degradation and clearance of misfolded proteins that contribute to the pathogenesis of these diseases. However, recent findings have shown that TFEB has proinflammatory properties, raising the safety concerns about its clinical application. To investigate whether TFEB induces significant inflammatory responses in the brain, male C57BL/6 mice were injected with phosphate-buffered saline (PBS), adeno-associated virus serotype 8 (AAV8) vectors overexpressing mouse TFEB (pAAV8-CMV-mTFEB), or AAV8 vectors expressing green fluorescent proteins (GFPs) in the barrel cortex. The brain tissue samples were collected at 2 months after injection. Western blotting and immunofluorescence staining showed that mTFEB protein levels were significantly increased in the brain tissue samples of mice injected with mTFEB-overexpressing vectors compared with those injected with PBS or GFP-overexpressing vectors. pAAV8-CMV-mTFEB injection resulted in significant elevations in the mRNA and protein levels of lysosomal biogenesis indicators in the brain tissue samples. No significant changes were observed in the expressions of GFAP, Iba1, and proinflammation mediators in the pAAV8-CMV-mTFEB-injected brain compared with those in the control groups. Collectively, our results suggest that AAV8 successfully mediates mTFEB overexpression in the mouse brain without inducing apparent local inflammation, supporting the safety of TFEB-based gene therapy in treating neurodegenerative diseases.

scholarly journals Practical application of synthetic head models in real ballistic cases

2021 ◽  
Author(s):  
F. Riva ◽  
T. Fracasso ◽  
A. Guerra ◽  
P. Genet
Keyword(s):  
Soft Tissues ◽  
Spherical Model ◽  
Brain Parenchyma ◽  
Human Bone ◽  
Shape Model ◽  
The Difference ◽  
Open Shape ◽  
The Brain ◽  
Synthetic Models ◽  
Representative Material

AbstractIn shooting crimes, ballistics tests are often recommended in order to reproduce the wound characteristics of the involved persons. For this purpose, several “simulants” can be used. However, despite the efforts in the research of “surrogates” in the field of forensic ballistic, the development of synthetic models needs still to be improved through a validation process based on specific real caseworks. This study has been triggered by the findings observed during the autopsy performed on two victims killed in the same shooting incident, with similar wounding characteristics; namely two retained head shots with ricochet against the interior wall of the skull; both projectiles have been recovered during the autopsies after migration in the brain parenchyma. The thickness of the different tissues and structures along the bullets trajectories as well as the incident angles between the bullets paths and the skull walls have been measured and reproduced during the assemblage of the synthetic head models. Two different types of models (“open shape” and “spherical”) have been assembled using leather, polyurethane and gelatine to simulate respectively skin, bone and soft tissues. Six shots have been performed in total. The results of the models have been compared to the findings of post-mortem computed tomography (PMCT) and the autopsy findings.Out of the six shots, two perforated the models and four were retained. When the projectile was retained, the use of both models allowed reproducing the wounds characteristics observed on both victims in terms of penetration and ricochet behaviour. However, the projectiles recovered from the models showed less deformation than the bullets collected during the autopsies. The “open shape” model allowed a better controlling on the shooting parameters than the “spherical” model. Finally, the difference in bullet deformation could be caused by the choice of the bone simulant, which might under-represent either the strength or the density of the human bone. In our opinion, it would be worth to develop a new, more representative material for ballistic which simulates the human bone.

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