Lymphatic filariasis in the Southeast Asian region; status and control options.

2020 ◽  
Vol 15 (059) ◽  
Author(s):  
Nilmini T. G. A. Chandrasena
Keyword(s):  
Sri Lanka ◽  
Lymphatic Filariasis ◽  
Disease Burden ◽  
Public Health Problem ◽  
Southeast Asian ◽  
World Health ◽  
Selective Treatment ◽  
Preventive Chemotherapy ◽  
Asian Region ◽  
Health Organization

Abstract The Global Program to Eliminate Lymphatic Filariasis (GPELF) was launched in year 2000 by the World Health Organization (WHO) with the goal set for elimination by 2020. Over half the global disease burden lies in the Southeast Asian region (SEAR). The preventive chemotherapy (PC) programme has been initiated in all the WHO SEAR member states with varying levels of progress. Maldives, Sri Lanka and Thailand have achieved the goal of elimination as a public health problem (EPHP) within the stipulated period with Bangladesh working towards validation in 2021. Both Sri Lanka and Thailand are continuing with post-validation surveillance combined with selective treatment, striving for zero transmission in-parallel with the morbidity management and disability prevention program (MMDP). Timor-Leste appears close to reaching critical transmission thresholds with 100% coverage and triple therapy in the last round of PC. Data on MMDP activities are insufficient to comment on reaching EPHP status. PC coverage and country reports indicate ongoing transmission in Nepal, Myanmar, Indonesia and India requiring further rounds of PC. The PELF has made considerable progress in the SEAR towards elimination but there still remain significant transmission and disease burden in the highly populated countries in SEAR.

scholarly journals Progress towards elimination of lymphatic filariasis in the Eastern Mediterranean Region

2020 ◽  
Vol 13 (Supplement_1) ◽  
pp. S28-S32
Author(s):  
Reda M R Ramzy ◽  
Abdul Samid Al Kubati
Keyword(s):  
Lymphatic Filariasis ◽  
Mediterranean Region ◽  
Disease Burden ◽  
Eastern Mediterranean ◽  
Eastern Mediterranean Region ◽  
Public Health Problem ◽  
World Health ◽  
Prevention Measures ◽  
Control And Prevention ◽  
History Of

Abstract Lymphatic filariasis (LF), a neglected tropical disease, is targeted for global elimination as a public health problem. This article reviews the history of LF control and elimination activities in the countries of the World Health Organization's (WHO) Eastern Mediterranean Region (EMR) over the last 2 decades. In 2000, the estimated at-risk population in EMR countries was 12.6 million people, accounting for approximately 1% of the global disease burden. Of the 22 EMR countries, 3 countries (Egypt, Sudan and Yemen) were LF endemic and the disease was suspected in 4 other countries (Djibouti, Oman, Somalia and Saudi Arabia). After almost 2 decades of implementing sustained control and prevention measures, Egypt and Yemen were successfully validated by the WHO as having achieved the elimination criteria in 2017 and 2019, respectively. In 2018, Sudan completed mapping of LF, reaching 26.2% geographical coverage where mass drug administration (MDA) is required and is scaling-up MDA. Extensive epidemiological assessment indicated the absence of LF transmission in the four suspected countries and no MDA required. Challenges faced during the elimination and post-elimination phases are described and discussed.

scholarly journals Supporting drug development for neglected tropical diseases using mathematical modelling

2021 ◽  
Author(s):  
Martin Walker ◽  
Jonathan I D Hamley ◽  
Philip Milton ◽  
Frédéric Monnot ◽  
Sally Kinrade ◽  
...  
Keyword(s):  
Drug Development ◽  
Mathematical Modelling ◽  
Neglected Tropical Diseases ◽  
Public Health Problem ◽  
World Health ◽  
Tropical Diseases ◽  
Resource Saving ◽  
Preventive Chemotherapy ◽  
Health Organization ◽  
Chemotherapy Strategy

Abstract Drug-based interventions are at the heart of global efforts to reach elimination as a public health problem (trachoma, soil-transmitted helminthiases, schistosomiasis, lymphatic filariasis) or elimination of transmission (onchocerciasis) for five of the most prevalent neglected tropical diseases tackled via the World Health Organization preventive chemotherapy strategy. While for some of these diseases there is optimism that currently available drugs will be sufficient to achieve the proposed elimination goals, for others—particularly onchocerciasis—there is a growing consensus that novel therapeutic options will be needed. Since in this area no high return of investment is possible, minimizing wasted money and resources is essential. Here, we use illustrative results to show how mathematical modelling can guide the drug development pathway, yielding resource-saving and efficiency payoffs, from the refinement of target product profiles and intended context of use, to the design of clinical trials.

scholarly journals African regional progress and status of the programme to eliminate lymphatic filariasis: 2000–2020

2020 ◽  
Vol 13 (Supplement_1) ◽  
pp. S22-S27
Author(s):  
Kebede Deribe ◽  
Didier K Bakajika ◽  
Honorat Marie-Gustave Zoure ◽  
John O Gyapong ◽  
David H Molyneux ◽  
...  
Keyword(s):  
Vector Control ◽  
Lymphatic Filariasis ◽  
Neglected Tropical Diseases ◽  
Public Health Problem ◽  
World Health ◽  
Malaria Vector Control ◽  
Tropical Diseases ◽  
Significant Progress ◽  
African Region ◽  
Preventive Chemotherapy

Abstract To eliminate lymphatic filariasis (LF) by 2020, the World Health Organization (WHO) has launched a campaign against the disease. Since the launch in 2000, significant progress has been made to achieve this ambitious goal. In this article we review the progress and status of the LF programme in Africa through the WHO neglected tropical diseases preventive chemotherapy databank, the Expanded Special Project for Elimination of Neglected Tropical Diseases (ESPEN) portal and other publications. In the African Region there are 35 countries endemic for LF. The Gambia was reclassified as not requiring preventive chemotherapy in 2015, while Togo and Malawi eliminated LF as a public health problem in 2017 and 2020, respectively. Cameroon discontinued mass drug administration (MDA) and transitioned to post-MDA surveillance to validate elimination. The trajectory of coverage continues to accelerate; treatment coverage increased from 0.1% in 2000 to 62.1% in 2018. Geographical coverage has also significantly increased, from 62.7% in 2015 to 78.5% in 2018. In 2019, 23 of 31 countries requiring MDA achieved 100% geographic coverage. Although much remains to be done, morbidity management and disability prevention services have steadily increased in recent years. Vector control interventions conducted by other programmes, particularly malaria vector control, have had a profound effect in stopping transmission in some endemic countries in the region. In conclusion, significant progress has been made in the LF programme in the region while we identify the key remaining challenges in achieving an Africa free of LF.

scholarly journals Evolution of the monitoring and evaluation strategies to support the World Health Organization's Global Programme to Eliminate Lymphatic Filariasis

2020 ◽  
Vol 13 (Supplement_1) ◽  
pp. S65-S70
Author(s):  
Patrick J Lammie ◽  
Katherine M Gass ◽  
Jonathan King ◽  
Michael S Deming ◽  
David G Addiss ◽  
...  
Keyword(s):  
Lymphatic Filariasis ◽  
Public Health Problem ◽  
Monitoring And Evaluation ◽  
World Health ◽  
National Programmes ◽  
Evaluation Strategies ◽  
The World ◽  
Practical Experiences ◽  
Health Organization ◽  
Elimination Goal

Abstract The Global Programme to Eliminate Lymphatic Filariasis (GPELF) was established with the ambitious goal of eliminating LF as a public health problem. The remarkable success of the GPELF over the past 2 decades in carrying out its principal strategy of scaling up and scaling down mass drug administration has relied first on the development of a rigorous monitoring and evaluation (M&E) framework and then the willingness of the World Health Organization and its community of partners to modify this framework in response to the practical experiences of national programmes. This flexibility was facilitated by the strong partnership that developed among researchers, LF programme managers and donors willing to support the necessary research agenda. This brief review summarizes the historical evolution of the GPELF M&E strategies and highlights current research needed to achieve the elimination goal.

scholarly journals PENGARUH DUKUNGAN KELUARGA TERHADAP SIKAP KEPALA KELUARGA TENTANG PENYAKIT FILARIASIS DI RW 02 KAMPUNG DUSUN PUSAKA KECAMATAN PUSAKO KABUPATEN SIAK

2018 ◽  
Vol 7 (2) ◽  
pp. 9-14
Author(s):  
Rifa Yanti ◽  
Fitra Mayenti
Keyword(s):  
Public Health ◽  
World Health Organization ◽  
Lymphatic Filariasis ◽  
Health Problem ◽  
Public Health Problem ◽  
World Health ◽  
Cross Sectional ◽  
Global Goal ◽  
Health Organization

Latar Belakang : Filariasis salah satu jenis penyakit yang mendapat perhatian khusus di dunia kesehatan, lebih dari 1(satu) miliar penduduk dunia memiliki risiko menderita filariasis dan lebih dari 120 juta orang dari 80 negara telah terinfeksi filariasis. WHO (World Health Organization) mencanangkan kesepakatan global untuk memberantas penyakit filariasis dengan The Global Goal of Elimination of Lymphatic Filariasis as Public Health Problem by the Year 2020       (WHO, 2010). Pada tahun 2003, penyakit filariasis di Indonesia dilaporkan sebanyak 6.571 kasus. Pada tahun 2007 dijumpai 11.473 kasus dan pada tahun 2008 terdapat 11.699 kasus kemudian meningkat menjadi 11.914 kasus pada tahun 2009. Hampir ribuan desa di 26 provinsi di Indonesia dinyatakan endemis. (Kemenkes  RI,  2010). Tujuan penelitian ini mengetahui pengaruh dukungan keluarga dengan sikap kepala keluarga tentang penyakit filariasis di RW 02 Kampung Dusun Pusaka Kecamatan Pusako Kabupaten Siak. Metode penelitian kuantitatif observational dengan pendekatan cross sectional. Pengumpulan data dilakukan dengan cara menyebarkan angket dan dianalisis secara univariat dan bivariat. Hasil penelitian didapatkan dari 116 repsonden, 62.1% dukungan keluarga baik dan 37.9% dukungan keluarga kurang baik, dan sikap kepala keluarga 60,3% positif dan 39,7%  sikap responden negatif. Hasil uji statistik didapatkan ada pengaruh yang signifikan antara dukungan keluarga terhadap sikap kepala keluarga tentang penyakit filariasis (p.Value = 0,00). Diharapkan kepada petugas kesehatan agar lebih aktif menggiatkan serta memberikan penyuluhan tentang penyakit filariasis khususnya di RW 02.

scholarly journals The role of medicine donations in the global programme for the elimination of lymphatic filariasis

2020 ◽  
Vol 13 (Supplement_1) ◽  
pp. S39-S43
Author(s):  
Tijana Williams ◽  
Rachel Taylor ◽  
Minne Iwamoto ◽  
Takayuki Hida ◽  
Fabian Gusovsky
Keyword(s):  
Lymphatic Filariasis ◽  
Public Health Problem ◽  
Lessons Learned ◽  
World Health ◽  
Public And Private ◽  
Global Partnership ◽  
World Health Assembly Resolution ◽  
Trade Name ◽  
Main Components ◽  
Health Organization

Abstract World Health Assembly Resolution 50.29, adopted in 1997, committed the World Health Organization (WHO) and its member states to eliminate lymphatic filariasis (LF) as a public health problem. In 2000, to support this ambitious goal and the health ministries in the >70 LF-endemic countries, the Global Programme to Eliminate Lymphatic Filariasis (GPELF) was created. The resulting WHO elimination strategy consists of two main components: to stop the spread of infection by interrupting transmission and to alleviate the suffering of affected populations (by controlling morbidity). The GPELF has brought together a broad global partnership of public and private actors, including three pharmaceutical companies with headquarters in three different continents. The medicine donations programmes from GlaxoSmithKline, MSD (trade name of Merck & Co., Kenilworth, NJ, USA) and Eisai have enabled significant achievements during the first 20 y of the GPELF and are positioned to provide essential contributions to the GPELF's goals for the next decade. As we celebrate the progress towards LF elimination during the GPELF's first 20 y, this article reflects on the factors that led to the creation of the three donation programmes, the contributions these programmes have made and some lessons learned along the way. We close by emphasizing our continued commitments to LF elimination and perspectives on the next decade.

scholarly journals Control and elimination of schistosomiasis as a public health problem thresholds fail to differentiate schistosomiasis morbidity prevalence in children

2021 ◽  
Author(s):  
Ryan E Wiegand ◽  
W Evan Secor ◽  
Fiona M Fleming ◽  
Michael D French ◽  
Charles H King ◽  
...  
Keyword(s):  
Public Health ◽  
Health Problem ◽  
Public Health Problem ◽  
Monitoring And Evaluation ◽  
World Health ◽  
Preventive Chemotherapy ◽  
Schistosomiasis Control ◽  
Gates Foundation ◽  
Health Organization ◽  
The Relationship

Abstract Background Current World Health Organization guidelines utilize prevalence of heavy-intensity infections (PHI), i.e., ≥50 eggs per 10ml of urine for Schistosoma haematobium and ≥400 eggs per gram of stool for S. mansoni, to determine whether a targeted area has controlled schistosomiasis morbidity or eliminated schistosomiasis as a public health problem. The relationship between these PHI categories and morbidity is not well understood. Methods School-aged participants enrolled in schistosomiasis monitoring and evaluation cohorts from 2003-2008 in Burkina Faso, Mali, Niger, Uganda, Tanzania, and Zambia were surveyed for infection and morbidity at baseline and after 1 and 2 rounds of preventive chemotherapy. Logistic regression was used to compare morbidity prevalence among participants based on their school’s PHI category. Findings Microhematuria levels were associated with the S. haematobium PHI categories at all three time points. For any other S. haematobium or S. mansoni morbidity that was measured, PHI categories did not differentiate morbidity prevalence levels consistently. Interpretation These analyses suggest that current PHI categorizations do not differentiate the prevalence of standard morbidity markers. A reevaluation of the criteria for schistosomiasis control is warranted. Funding The Schistosomiasis Control Initiative (now the SCI Foundation) was supported by the Bill and Melinda Gates Foundation (grant 13122).

scholarly journals The roadmap towards elimination of lymphatic filariasis by 2030: insights from quantitative and mathematical modelling

2019 ◽  
Vol 3 ◽  
pp. 1538 ◽  
Author(s):  
Keyword(s):  
Public Health ◽  
Lymphatic Filariasis ◽  
Health Problem ◽  
Neglected Tropical Diseases ◽  
Public Health Problem ◽  
World Health ◽  
Basic Care ◽  
The World ◽  
Health Organization ◽  
Initial Target

The Global Programme to Eliminate Lymphatic Filariasis was launched in 2000 to eliminate lymphatic filariasis (LF) as a public health problem by 1) interrupting transmission through mass drug administration (MDA) and 2) offering basic care to those suffering from lymphoedema or hydrocele due to the infection. Although impressive progress has been made, the initial target year of 2020 will not be met everywhere. The World Health Organization recently proposed 2030 as the new target year for elimination of lymphatic filariasis (LF) as a public health problem. In this letter, LF modelers of the Neglected Tropical Diseases (NTDs) Modelling Consortium reflect on the proposed targets for 2030 from a quantitative perspective. While elimination as a public health problem seems technically and operationally feasible, it is uncertain whether this will eventually also lead to complete elimination of transmission. The risk of resurgence needs to be mitigated by strong surveillance after stopping interventions and sometimes perhaps additional interventions.

Drinking-Water Quality and Intestinal Infectious Diseases in a Colombian Department, 2010-2016

2020 ◽  
pp. 21-29
Author(s):  
Dora Cardona Rivas ◽  
Militza Yulain Cardona Guzmán ◽  
Olga Lucía Ocampo López
Keyword(s):  
Water Quality ◽  
Drinking Water ◽  
Infectious Diseases ◽  
Disease Burden ◽  
Social Protection ◽  
Drinking Water Quality ◽  
World Health ◽  
The Social ◽  
Etiological Agents ◽  
Health Organization

Objective: To characterize the burden of intestinal infectious diseases attributable to drinking-water quality in 27 municipalities in the central region of Colombia. Materials and methods: A time-trend ecological study. The drinking-water quality of the National Institute of Health and the Institute of Hydrology, Meteorology and Environmental Studies was identified. The disease burden was calculated based on the mortality registered in the National Department of Statistics and the records of morbidity attended by the Social Protection Integrated Information System. The etiological agents reported in morbidity records and the observation of environmental conditions in the municipalities of the study were included. The disease burden was determined according to the methodology recommended by the World Health Organization (WHO).

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