Conditional cancer-specific survival after radical hepatectomy in patients with nonmetastatic intrahepatic cholangiocarcinoma

2022 ◽  
pp. 1-5
Author(s):  
Xia Yan ◽  
Lai Wang ◽  
Zhiqiang Meng
Keyword(s):  
Intrahepatic Cholangiocarcinoma ◽  
Cancer Specific Survival

scholarly journals The Presence of Small Nerve Fibers in the Tumor Microenvironment as Predictive Biomarker of Oncological Outcome Following Partial Hepatectomy for Intrahepatic Cholangiocarcinoma

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3661
Author(s):  
Jan Bednarsch ◽  
Xiuxiang Tan ◽  
Zoltan Czigany ◽  
Dong Liu ◽  
Sven Arke Lang ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Intrahepatic Cholangiocarcinoma ◽  
Cox Regression ◽  
Oncological Outcome ◽  
Nerve Fibers ◽  
Nodal Metastases ◽  
Cancer Specific Survival ◽  
Curative Intent ◽  
Term Outcome ◽  
Long Term Outcome

The oncological role of the density of nerve fibers (NFs) in the tumor microenvironment (TME) in intrahepatic cholangiocarcinoma (iCCA) remains to be determined. Therefore, data of 95 iCCA patients who underwent hepatectomy between 2010 and 2019 was analyzed regarding NFs and long-term outcome. Extensive group comparisons were carried out and the association of cancer-specific survival (CSS) and recurrence-free survival (RFS) with NFs were assessed using Cox regression models. Patients with iCCA and NFs showed a median CSS of 51 months (5-year-CSS = 47%) compared to 27 months (5-year-CSS = 21%) in patients without NFs (p = 0.043 log rank). Further, NFs (hazard ratio (HR) = 0.39, p = 0.002) and N-category (HR = 2.36, p = 0.010) were identified as independent predictors of CSS. Patients with NFs and without nodal metastases displayed a mean CSS of 89 months (5-year-CSS = 62%), while patients without NFs or with nodal metastases but not both showed a median CCS of 27 months (5-year-CSS = 25%) and patients with both positive lymph nodes and without NFs showed a median CCS of 10 months (5-year-CSS = 0%, p = 0.001 log rank). NFs in the TME are, therefore, a novel and important prognostic biomarker in iCCA patients. NFs alone and in combination with nodal status is suitable to identify iCCA patients at risk of poor oncological outcomes following curative-intent surgery.

Better cancer-specific survival in young patients with nonmetastatic intrahepatic cholangiocarcinoma: A retrospective study of SEER database.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15637-e15637
Author(s):  
Zheng Wang ◽  
Lunxiu Qin
Keyword(s):  
Risk Factors ◽  
Lymph Node ◽  
Intrahepatic Cholangiocarcinoma ◽  
Univariate Analysis ◽  
Young Patients ◽  
Elderly Group ◽  
Survival Outcomes ◽  
Seer Database ◽  
Cancer Specific Survival ◽  
Significant Difference

e15637 Background: Intrahepatic cholangiocarcinoma (ICC) is a complicated and fatal malignancy. Aging plays a significant role in the occurrence and development of this liver cancer, but its prognostic role remains unclear. The purpose of this study is to compare the cancer specific survival (CSS) in young patients with elderly ones, and to further establish a nomogram, integrating age and other risk factors, to predict survival outcomes in ICC patients. Methods: Cases of intrahepatic cholangiocarcinoma diagnosed between 2004 and 2013 were extracted from SEER database. Patients were excluded if they had incomplete TNM staging, with distant metastasis (M1) or no evaluation on lymph node. The enrolled cases were divided into young (under 50 years of age) and elderly groups (50 years and over). 1-year and 3-year cancer CSS data were obtained. Kaplan-Meier methods were adopted and multivariable Cox regression models were built for the analysis of survival outcomes and risk factors. A predictive nomogram for prognosis was generated by software R, and the performance of the nomogram was assessed by C-index and validation curves. Results: There were 2385 patients meeting inclusion criteria with median follow up of 17.0 months. Compared with elderly group, young patients showed significantly higher pathological grading (P = 0.006), lower rate of lymph node invasion (P = 0.002), and early TNM stage (P = 0.005). The 1-year and 3-year CSS rates were 57.3% and 19.2% in young group, and 38.2% and 10.8% in elderly group. Both univariate analysis (P = 0.019) and multivariate analysis (P = 0.040) indicated significant difference of CSS between the two groups. The multi-factor, integrative nomogram was established to predict prognosis, whose predictive power was higher than the conventional tumor staging (AJCC 7thedition staging). And the calibration curves for the probability of 1- and 3-year CSS indicated that the nomogram-based prediction was in optimal agreement with actual observed survival. Conclusions: Compared with elderly patients, young patients with non-metastatic ICC appear to have more favorable clinicopathological characteristics and better prognosis.

scholarly journals Nomograms for predicting overall survival and cancer-specific survival in patients with surgically resected intrahepatic cholangiocarcinoma

2019 ◽  
Vol Volume 11 ◽  
pp. 6907-6929 ◽  
Author(s):  
Kexin Ma ◽  
Bing Dong ◽  
Liming Wang ◽  
Chongyu Zhao ◽  
Zhaoyu Fu ◽  
...  
Keyword(s):  
Overall Survival ◽  
Intrahepatic Cholangiocarcinoma ◽  
Cancer Specific Survival

scholarly journals Primary tumor resection improves survival in patients with multifocal intrahepatic cholangiocarcinoma based on a population study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Linlin Yin ◽  
Si Zhao ◽  
Hanlong Zhu ◽  
Guozhong Ji ◽  
Xiuhua Zhang
Keyword(s):  
Intrahepatic Cholangiocarcinoma ◽  
Proportional Hazards ◽  
Tumor Resection ◽  
Original Data ◽  
Cox Proportional Hazards ◽  
Surgical Patients ◽  
Cancer Specific Survival ◽  
Surgery Group ◽  
The Difference ◽  
Cox Analysis

AbstractThe purpose of our study was to evaluate the effect of surgery on the survival and prognosis of patients with multifocal intrahepatic cholangiocarcinoma (ICCA). Patients with multifocal ICCA were selected from the SEER (Surveillance, Epidemiology, and End Results) database between 2010 and 2016. Kaplan–Meier analyses and log-rank tests were used to evaluate the difference in survival between the surgery group and the non-surgery group. We applied the Cox proportional hazards regression model to identify prognostic factors of overall survival (OS) and cancer-specific survival (CSS). In total, 580 patients were enrolled in our study, including 151 patients who underwent surgery and 429 patients who did not. The median survival time of surgical patients was longer than non-surgical patients (OS: 25 months vs. 8 months, p < 0.001; CSS: 40 months vs. 25 months, p < 0.001). Similarly, the 5-year survival rate in the surgery group was significantly higher than those in the non-surgery group (5-year OS rate: 12.91% vs. 0%; p < 0.001; 5-year CSS rate:26.91% vs. 0%; p < 0.001). Multivariate Cox analysis showed that the OS (HR:0.299, 95% CI: 0.229–0.390, p < 0.001) and CSS (HR:0.305, 95% CI:0.222–0.419, p < 0.001) of patients undergoing surgical resection were significantly improved. Meanwhile, after propensity score matching (PSM) of the original data, we come to the same conclusion.

Vascular endothelial growth factor-C (VEGF-C) overexpression is correlated with poor prognosis in intrahepatic cholangiocarcinoma (CCC)

2001 ◽  
Vol 120 (5) ◽  
pp. A261-A261 ◽  
Author(s):  
Y PAIK ◽  
Y KIM ◽  
S PARK ◽  
J CHUNG ◽  
J CHUNG ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Intrahepatic Cholangiocarcinoma ◽  
Poor Prognosis ◽  
Vascular Endothelial ◽  
Factor C ◽  
Endothelial Growth Factor

1111: External Validation of the Mayo Clinic SSIGN Score to Predict Cancer-Specific Survival Using a European Series of Conventional Renal Cell Carcinoma

2006 ◽  
Vol 175 (4S) ◽  
pp. 357-358
Author(s):  
Vincenzo Ficarra ◽  
Christine M. Lohse ◽  
Giacomo Novara ◽  
Antonio Galfano ◽  
Stefano Cavalleri ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Mayo Clinic ◽  
Renal Cell ◽  
External Validation ◽  
Cancer Specific Survival ◽  
Conventional Renal Cell Carcinoma

458: Nomogram Predictive of Cancer-Specific Survival in Patients Undergoing Partial or Total Amputation for Squamous Cell Carcinoma of the Penis

2006 ◽  
Vol 175 (4S) ◽  
pp. 148-149
Author(s):  
Vincenzo Ficarra ◽  
Walter Artibani ◽  
Sergio Cosciani Cunico ◽  
Giuseppe Anselmo ◽  
Filiberto Zattoni ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cancer Specific Survival

An umbrella concept for patients with advanced intrahepatic cholangiocarcinoma

2020 ◽  
Author(s):  
T Longerich ◽  
KH Weiss ◽  
C Springfeld ◽  
A Stenzinger ◽  
P Schirmacher
Keyword(s):  
Intrahepatic Cholangiocarcinoma
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