Tolerability of long-term temperature controlled whole-body thermal treatment in advanced cancer-bearing dogs

We aimed to evaluate the brain hypometabolic signature of persistent isolated olfactory dysfunction after SARS-CoV-2 infection. Twenty-two patients underwent whole-body [18F]-FDG PET, including a dedicated brain acquisition at our institution between May and December 2020 following their recovery after SARS-Cov2 infection. Fourteen of these patients presented isolated persistent hyposmia (smell diskettes olfaction test was used). A voxel-wise analysis (using Statistical Parametric Mapping software version 8 (SPM8)) was performed to identify brain regions of relative hypometabolism in patients with hyposmia with respect to controls. Structural connectivity of these regions was assessed (BCB toolkit). Relative hypometabolism was demonstrated in bilateral parahippocampal and fusiform gyri and in left insula in patients with respect to controls. Structural connectivity maps highlighted the involvement of bilateral longitudinal fasciculi. This study provides evidence of cortical hypometabolism in patients with isolated persistent hyposmia after SARS-Cov2 infection. [18F]-FDG PET may play a role in the identification of long-term brain functional sequelae of COVID-19.

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Bone mineral density and explanatory factors in children and adults with juvenile dermatomyositis at long term follow-up; a cross sectional study

Pediatric Rheumatology ◽

10.1186/s12969-021-00543-z ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Henriette Schermacher Marstein ◽

Kristin Godang ◽

Berit Flatø ◽

Ivar Sjaastad ◽

Jens Bollerslev ◽

...

Keyword(s):

Bone Turnover ◽

Inflammatory Markers ◽

Juvenile Dermatomyositis ◽

Inflammatory Myopathy ◽

Disease Onset ◽

Whole Body ◽

Mineral Density ◽

Z Scores

Abstract Background Juvenile dermatomyositis (JDM) is the most common idiopathic inflammatory myopathy in children and adolescents. Both the disease and its treatment with glucocorticoids may negatively impact bone formation. In this study we compare BMD in patients (children/adolescence and adults) with long-standing JDM with matched controls; and in patients, explore how general/disease characteristics and bone turnover markers are associated with BMD. Methods JDM patients (n = 59) were examined median 16.8y (range 6.6–27.0y) after disease onset and compared with 59 age/sex-matched controls. Dual-energy X-ray absorptiometry (DXA) was used to measure BMD of the whole body and lumbar spine (spine) in all participants, and of ultra-distal radius, forearm and total hip in participants ≥20y only. Markers of bone turnover were analysed, and associations with outcomes explored. Results Reduced BMD Z-scores (<−1SD) were found in 19 and 29% of patients and 7 and 9% of controls in whole body and spine, respectively (p-values < 0.05). BMD and BMD Z-scores for whole body and spine were lower in all patients and for < 20y compared with their respective controls. In participants ≥20y, only BMD and BMD Z-score of forearm were lower in the patients versus controls. In patients, BMD Z-scores for whole body and/or spine were found to correlate negatively with prednisolone use at follow-up (yes/no) (age < 20y), inflammatory markers (age ≥ 20y) and levels of interferon gamma-induced protein 10 (IP-10) (both age groups). In all patients, prednisolone use at follow-up (yes/no) and age ≥ 20y were independent correlates of lower BMD Z-scores for whole body and spine, respectively. Conclusion In long-term JDM, children have more impairment of BMD than adults in spine and whole-body. Associations with BMD were found for both prednisolone and inflammatory markers, and a novel association was discovered with the biomarker of JDM activity, IP-10.

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Personalized management of differentiated thyroid cancer in real life – practical guidance from a multidisciplinary panel of experts

Endocrine ◽

10.1007/s12020-020-02418-x ◽

2020 ◽

Vol 70 (2) ◽

pp. 280-291

Author(s):

Alfredo Campennì ◽

Daniele Barbaro ◽

Marco Guzzo ◽

Francesca Capoccetti ◽

Luca Giovanella

Keyword(s):

Nuclear Medicine ◽

Thyroid Cancer ◽

Clinical Practice ◽

Molecular Imaging ◽

Routine Clinical Practice ◽

Whole Body ◽

Neck Ultrasound ◽

Long Term Follow Up

Abstract Purpose The standard of care for differentiated thyroid carcinoma (DTC) includes surgery, risk-adapted postoperative radioiodine therapy (RaIT), individualized thyroid hormone therapy, and follow-up for detection of patients with persistent or recurrent disease. In 2019, the nine Martinique Principles for managing thyroid cancer were developed by the American Thyroid Association, European Association of Nuclear Medicine, Society of Nuclear Medicine and Molecular Imaging, and European Thyroid Association. In this review, we present our clinical practice recommendations with regard to implementing these principles in the diagnosis, treatment, and long-term follow-up of patients with DTC. Methods A multidisciplinary panel of five thyroid cancer experts addressed the implementation of the Martinique Principles in routine clinical practice based on clinical experience and evidence from the literature. Results We provide a suggested approach for the assessment and diagnosis of DTC in routine clinical practice, including the use of neck ultrasound, measurement of serum thyroid-stimulating hormone and calcitonin, fine-needle aspiration, cytology, and molecular imaging. Recommendations for the use of surgery (lobectomy vs. total thyroidectomy) and postoperative RaIT are also provided. Long-term follow-up with neck ultrasound and measurement of serum anti-thyroglobulin antibody and basal/stimulated thyroglobulin is standard, with 123/131I radioiodine diagnostic whole-body scans and 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography suggested in selected patients. Management of metastatic DTC should involve a multidisciplinary team. Conclusions In routine clinical practice, the Martinique Principles should be implemented in order to optimize clinical management/outcomes of patients with DTC.

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Transitional Cell Carcinomas of the Urinary Tract in a Colony of Beagle Dogs

Veterinary Pathology ◽

10.1177/030098588902600601 ◽

1989 ◽

Vol 26 (6) ◽

pp. 455-461 ◽

Cited By ~ 11

Author(s):

K. J. Nikula ◽

S. A. Benjamin ◽

G. M. Angleton ◽

A. C. Lee

Keyword(s):

Urinary Tract ◽

Transitional Cell ◽

Clinical Signs ◽

Conclusive Evidence ◽

Whole Body ◽

Beagle Dogs ◽

Long Term Effects ◽

Significant Difference ◽

Microscopic Features

Gross and light microscopic features of transitional cell carcinomas (TCC) of the urinary tract were examined in Beagle dogs used for the study of the long-term effects of low-dose, whole-body, 60Co gamma radiation. Thirty-eight cases of TCC occurred among 990 dogs that were from 0 to 14 years of age. There was no conclusive evidence of a radiation effect. The 38 TCC were equally divided between male and female dogs, but there was a significant difference in the sex distribution of urethra-origin TCC. Eleven males had a primary urethral TCC compared to only two females. There was no significant difference between the urethra-origin and bladder-origin TCCs in the number of tumors that caused clinical signs, metastasized, or that contributed to the death of the dog. All cases of urethral TCC in male dogs occurred in the prostatic urethra. The majority of these cases were not recognized to be neoplasms at gross necropsy, but microscopic examination revealed the TCC. Our findings differ from previous reports stating that TCC occurs more frequently in female than male dogs, and they especially differ from reports claiming that urethra-origin TCC is predominately a disease of female dogs.

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Temperature-controlled MPa-pressure ultrasonic cell manipulation in a microfluidic chip

Lab on a Chip ◽

10.1039/c5lc00490j ◽

2015 ◽

Vol 15 (16) ◽

pp. 3341-3349 ◽

Cited By ~ 31

Author(s):

Mathias Ohlin ◽

Ida Iranmanesh ◽

Athanasia E. Christakou ◽

Martin Wiklund

Keyword(s):

Lung Cancer ◽

High Pressure ◽

Cancer Cells ◽

Microfluidic Chip ◽

Acoustic Streaming ◽

Cell Manipulation ◽

Wave Trapping ◽

Ultrasonic Standing Wave ◽

Temperature Controlled

We study the effect of 1 MPa-pressure ultrasonic-standing-wave trapping of cells during one hour in a fully temperature- and acoustic streaming-controlled microfluidic chip, and conclude that the viability of lung cancer cells are not affected by this high-pressure, long-term acoustophoresis treatment.

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Effect of Long-Term Whole Body Vibration Training on Visceral Adipose Tissue: A Preliminary Report

Obesity Facts ◽

10.1159/000301785 ◽

2010 ◽

Vol 3 (2) ◽

pp. 7-7 ◽

Cited By ~ 49

Author(s):

Dirk Vissers ◽

An Verrijken ◽

Ilse Mertens ◽

Caroline Van Gils ◽

Annemie Van de Sompel ◽

...

Keyword(s):

Adipose Tissue ◽

Visceral Adipose Tissue ◽

Preliminary Report ◽

Whole Body Vibration ◽

Whole Body ◽

Body Vibration ◽

Vibration Training ◽

Whole Body Vibration Training ◽

Visceral Adipose

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Position Paper: The Concept of Whole Body Autoregulation and the Dominant Role of the Kidneys for Long-term Blood Pressure Regulation

Frontiers in Hypertension Research ◽

10.1007/978-1-4612-5899-5_24 ◽

1981 ◽

pp. 125-134 ◽

Cited By ~ 6

Author(s):

Arthur C. Guyton ◽

John E. Hall ◽

Thomas E. Lohmeier ◽

R. Davis Manning ◽

Thomas E. Jackson

Keyword(s):

Blood Pressure ◽

Dominant Role ◽

Blood Pressure Regulation ◽

Position Paper ◽

Whole Body ◽

Pressure Regulation

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Homozygous Protein C Deficiency: Description of a New Mutation and Successful Treatment with Low Molecular Weight Heparin

Thrombosis and Haemostasis ◽

10.1055/s-0037-1615060 ◽

1998 ◽

Vol 79 (04) ◽

pp. 756-761 ◽

Cited By ~ 38

Author(s):

Paul Monagle ◽

Maureen Andrew ◽

Jacqueline Halton ◽

Richard Marlar ◽

Lawrence Jardine ◽

...

Keyword(s):

Molecular Weight ◽

Bone Density ◽

Skin Necrosis ◽

Protein C ◽

Low Molecular Weight Heparin ◽

Whole Body ◽

Term Therapy ◽

Low Molecular Weight ◽

New Mutation

SummaryWe present a kindred with a new mutation of the protein C gene, in which the proband had an unusual clinical presentation. The relationship between warfarin induced skin necrosis and level of anticoagulation was investigated. The pharmacokinetics of protein C concentrate was assessed to determine frequency of replacement therapy. The clinical and biochemical efficacy of therapy with low molecular weight heparin (LMWH) was assessed. The effect of long-term LMWH on bone density in the growing child was monitored using whole body densitometry.Warfarin therapy required an INR of greater than 3.5 to avoid skin necrosis. If protein C replacement was to be used, doses of 100 U/kg/day would have been required to maintain protein C levels consistently at or above 0.20 U/ml. While receiving prophylactic therapy with LMWH for almost 3 years, there were no episodes of recurrent thrombosis, no skin necrosis and no bleeding. Biochemical markers of in vivo thrombin generation were suppressed and within the normal range. Bone density continued to increase at the normal rate throughout the treatment period.LMWH is an effective form of long-term therapy for homozygous protein C deficient patients with measurable protein C levels.

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The Burden of Survivorship on Hematological Patients—Long-Term Analysis of Toxicities after Total Body Irradiation and Allogeneic Stem Cell Transplantation

Cancers ◽

10.3390/cancers13225640 ◽

2021 ◽

Vol 13 (22) ◽

pp. 5640

Author(s):

Michael Oertel ◽

Jonas Martel ◽

Jan-Henrik Mikesch ◽

Sergiu Scobioala ◽

Christian Reicherts ◽

...

Keyword(s):

Stem Cell ◽

Side Effects ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Allogeneic Stem Cell Transplantation ◽

Total Body Irradiation ◽

Whole Body ◽

Total Body

Total body irradiation is an effective conditioning modality before autologous or allogeneic stem cell transplantation. With the whole body being the radiation target volume, a diverse spectrum of toxicities has been reported. This fact prompted us to investigate the long-term sequelae of this treatment concept in a large patient cohort. Overall, 322 patients with acute leukemia or myelodysplastic syndrome with a minimum follow-up of one year were included (the median follow-up in this study was 68 months). Pulmonary, cardiac, ocular, neurological and renal toxicities were observed in 23.9%, 14.0%, 23.6%, 23.9% and 20.2% of all patients, respectively. The majority of these side effects were grades 1 and 2 (64.9–89.2% of all toxicities in the respective categories). The use of 12 Gray total body irradiation resulted in a significant increase in ocular toxicities (p = 0.013) and severe mucositis (p < 0.001). Renal toxicities were influenced by the age at transplantation (relative risk: 1.06, p < 0.001) and disease entity. In summary, total body irradiation triggers a multifaceted, but manageable, toxicity profile. Except for ocular toxicities and mucositis, a 12 Gray regimen did not lead to an increase in long-term side effects.

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