Spray Drying of Aqueous Salbutamol Sulfate Solutions Using the Nano Spray Dryer B-90—The Impact of Process Parameters on Particle Size

2013 ◽  
Vol 31 (12) ◽  
pp. 1346-1353 ◽  
Author(s):  
E. M. Littringer ◽  
S. Zellnitz ◽  
K. Hammernik ◽  
V. Adamer ◽  
H. Friedl ◽  
...  
Keyword(s):  
Particle Size ◽  
Spray Drying ◽  
Process Parameters ◽  
Spray Dryer ◽  
Salbutamol Sulfate ◽  
Sulfate Solutions ◽  
The Impact

Optimization of the Spray Drying Operating Conditions for Producing the Powder Mixture of Gum Arabic and Maltodextrin

2017 ◽  
Vol 13 (8) ◽  
Author(s):  
Duc Quang Nguyen ◽  
Sabah Mounir ◽  
Karim Allaf
Keyword(s):  
Spray Drying ◽  
Air Temperature ◽  
Powder Mixture ◽  
Gum Arabic ◽  
Feed Solution ◽  
Operating Conditions ◽  
Operating Parameters ◽  
Spray Dryer ◽  
Optimal Parameters ◽  
The Impact

AbstractThe powder mixture of gum arabic and maltodextrin was produced by spray drying. The inlet air temperature of spray dryer was varied from 160 °C to 260 °C and the maltodextrin content was varied from 0 to 50 % in the feed solution with the concentration of 42.5 % (w/v) total solids by weight. The properties of the finished product were characterized to examine the impact of changes in these operating parameters. The results showed that: the inlet air temperature had a stronger influence on the properties of finished product than the MD/GA ratio, whereas the feed rate was more clearly affected by the MD/GA ratio. Two optimal parameters obtained include MD/GA ratio equal to 0.615 and the inlet air temperature of spray dryer Te = 258 °C.

Synthesis of Nd2Fe14B powders by spray-drying and reduction–diffusion processes

2001 ◽  
Vol 16 (4) ◽  
pp. 1083-1089 ◽  
Author(s):  
X. L. Dong ◽  
B. K. Kim ◽  
C. J. Choi ◽  
K. S. Park ◽  
Z. D. Zhang
Keyword(s):  
Particle Size ◽  
Thermal Properties ◽  
Spray Drying ◽  
Process Parameters ◽  
Diffusion Processes ◽  
Liquid Solution ◽  
Metal Salts ◽  
Mechanochemical Method ◽  
Precursor Powders ◽  
Spray Dried

The magnetic Nd–Fe–B powders were prepared by a mechanochemical method, including the processes of spray drying, debinding, milling, H2 reduction, Ca reduction, and washing. The liquid solution dissolved with various metal salts was first spray-dried to prepare the precursor powders having uniformly dispersed Nd, Fe, and B components. The precursor powders in turn were subjected to the subsequent processes. The particle size of the resultant Nd–Fe–B powders was about 1 μm. Effects of the process parameters on phases, morphologies, microstructures, compositions, and thermal properties of the powders were investigated.

Spray Drying of Mannitol as a Drug Carrier—The Impact of Process Parameters on Product Properties

2012 ◽  
Vol 30 (1) ◽  
pp. 114-124 ◽  
Author(s):  
Eva Maria Littringer ◽  
Axel Mescher ◽  
Susanna Eckhard ◽  
Hartmuth Schröttner ◽  
Christoph Langes ◽  
...  
Keyword(s):  
Spray Drying ◽  
Process Parameters ◽  
Drug Carrier ◽  
The Impact

Encapsulation and In Vitro Release Test of Flavonoid and Phenolic Compounds Extracted from Watermelon (Citrullus lanatus) Rind: Comparison of Oven and Spray Drying Treatments

2021 ◽  
Vol 1033 ◽  
pp. 87-92
Author(s):  
Lilis Kistriyani ◽  
Lutfi Kurniawan ◽  
Fadhli Syaputra ◽  
Achmad Chafidz
Keyword(s):  
Particle Size ◽  
Spray Drying ◽  
Total Flavonoid ◽  
Total Phenolic ◽  
Anthocyanin Content ◽  
In Vitro Test ◽  
Spray Dryer ◽  
Total Anthocyanin ◽  
Watermelon Rind

The purpose of this study was to determine and compare the effect of oven drying and spray drying treatments on the encapsulation of anthocyanin, flavonoid and phenolic extracted from watermelon rind. The analysis done in this work were as follow: total anthocyanin (TA), total flavonoid (TF) and total phenolic (TPC) content in the supernatant, yield of nanocapsule, Particle Size Analysis, and In Vitro test (test for flavonoid and phenolic release) in the supernatant food. The analysis results showed that the total anthocyanin content in watermelon rind with a spray drying treatment was 0.1113 mg/L, total flavonoid was 0.6159 g/mL, and total phenolic was 0.3410 g/mL. While using the oven, the anthocyanin content was 0.0891 mg/L, total flavonoid was 1.4590 g/mL, and total phenolic was 1.1349 g/mL. As noticed, the total content of anthocyanin resulted by using a spray dryer was greater than by using an oven. However, the total flavonoid and total phenolic resulted by using a spray dryer was smaller than by using an oven. During In Vitro analysis, the results of the release of flavonoid and phenolic resulted by using an oven into the distilled water were much larger and unstable than by using a spray dryer. This is likely because chitosan-Na (TPP) bonds are weak. Additionally, the yield of capsule on the use of spray dryer was 0.6, higher than the use of an oven, which was 0.48. While, the average particle size in the use of a spray dryer was 2.296 μm, smaller than the use of an oven, which was 61.998 μm.

scholarly journals Micro-Sized Particle Production of Momordicas sp Extract Using Spray Dryer

1970 ◽  
Vol 12 (4) ◽  
Author(s):  
Maizirwan Mel ◽  
Emirul Adzhar Yahya ◽  
And Mohd Rushdi Abu Bakar
Keyword(s):  
Particle Size ◽  
Spray Drying ◽  
Particle Production ◽  
Continuous Production ◽  
Industrial Process ◽  
Spray Dryer ◽  
Residual Moisture ◽  
Liquid Feed ◽  
Ideal Process

Spray drying is the most widely used industrial process involving particle formation and drying. It is highly suited for the continuous production of dry solids in either powder, granulate or agglomerate form from liquid feed-stocks as solutions, emulsions and pump able suspensions. Therefore, spray drying is an ideal process where the end-product must comply with precise quality standards regarding particle size distribution, residual moisture content, bulk density, and particle shape. In this study, Momordica sp extract product has been successfully spray dried into micro scale of powder particle and will be used as plant-based insulin. The process optimized using Taguchi method with four factors and three levels has given a good quality of the product. The average of particle size was obtained at about 11 microns.ABSTRAK: Kering sembur digunakan secara meluas dalam proses industri yang melibatkan pembentukan zarah dan pengeringan. Ia amat sesuai dalam penghasilan pepejal kering secara beterusan dalam bentuk serbuk, butiran atau gumpalan daripada simpanan suapan bendalir sebagai larutan, emulsi dan ampaian boleh dipam. Maka, kering sembur adalah proses yang ideal apabila hasil akhir harus mematuhi piawaian kualiti yang tepat berkaitan dengan pengagihan saiz zarah, kandungan kelengsaan sisa, ketumpatan pukal dan bentuk zarah. Dalam kajian ini, produk ekstrak Momordica sp (dikenali juga sebagai peria katak) telah berjaya dikering sembur menjadi serbuk zarah berskala mikro dan akan digunakan sebagai insulin berasaskan tumbuhan. Proses ini dioptimumkan dengan pengunaan kaedah Taguchi empat faktor dan tiga peringkat, agar memberikan hasil produk yang berkualiti. Kadar purata saiz zarah yang terhasil adalah lebih kurang 11 mikron.KEY WORDS: micro-sized, particle, Momordica sp, spray dryer.

scholarly journals β-hexanitrohexaazaisowurtzitane Particles Prepared by Spray Drying and its Characterization

2021 ◽  
Vol 27 (1) ◽  
pp. 119-124
Author(s):  
Wenzheng XU ◽  
Hao LI ◽  
Xin LIANG ◽  
Jie WANG ◽  
Jinyu PENG ◽  
...  
Keyword(s):  
Particle Size ◽  
Spray Drying ◽  
Ultrafine Particles ◽  
Average Particle Size ◽  
Narrow Particle Size Distribution ◽  
Average Particle ◽  
Thermal Stimulus ◽  
Particle Size Analyzer ◽  
Xrd Patterns ◽  
The Impact

In this paper, the ultrafine β-hexanitrohexaazaisowurtzitane (β – CL – 20) particles were prepared by spray drying method. The CL – 20 samples were characterized by scanning electron microscope (SEM), particle size analyzer, X-ray diffraction (XRD), and Differential Scanning Calorimeter (DSC). Furthermore, the safety properties of samples under impact and thermal stimulus were tested and analyzed. The results of SEM showed that the average particle size of ultrafine CL – 20 particles with a narrow particle size distribution, were about 320 nm, and the shape was elliptical. The XRD patterns indicated that the polymorphic phase of ultrafine particles was mainly β-type. Compared with that of raw CL – 20, the impact sensitivity of the ultrafine CL – 20 had been decreased significantly, for the drop height (H50) was increased from 13.0 to 33.5 cm. The critical explosion temperature of the ultrafine CL – 20 decreased from 232.16 ℃ to 227.93 ℃, indicating that the thermal stability of the ultrafine CL – 20 is lower than that of raw CL – 20.

scholarly journals Influence of combined hydrolyzed collagen and maltodextrin as carrier agents in spray drying of cocona pulp

2020 ◽  
Vol 23 ◽  
Author(s):  
Diana Patricia Vargas-Muñoz ◽  
Louise Emy Kurozawa
Keyword(s):  
Particle Size ◽  
Spray Drying ◽  
Chemical Structure ◽  
Particle Diameter ◽  
Spray Dryer ◽  
Drying Process ◽  
Hydrolyzed Collagen ◽  
Bioactive Properties ◽  
Encapsulation Process ◽  
Mean Particle Diameter

Abstract This work aimed to evaluate the effect of carrier agents containing maltodextrin and protein, represented by hydrolyzed collagen on the spray drying process of cocona (Solanum sessiliflorum Dunal), and on the properties of the resulting powders. We used pre-established proportions between the solids of cocona pulp and the carrier agents (P:CA), and among carrier agents themselves, maltodextrin and hydrolyzed collagen, (MD:HC). The process was carried out in a spray dryer at an inlet air temperature of 120 ºC. We prepared twelve feed solutions containing 20% of total solids, with P:CA ratios of 1:3, 1:4, 1:5 and 1:6, and MD:HC ratios of 0:100, 50:50, and 100:0. Solids recovery was obtained for the evaluation of the spray drying process. The cocona pulp powders were analyzed for moisture content, water activity, particle size distribution, mean particle diameter, chemical structure (FTIR) and color. For a P:CA of 1:6, for the sample formulated with hydrolyzed collagen only, solids recovery (96.2%) was much higher than that of the sample with maltodextrin only (39.2%). The chemical structure of cocona powders can be considered a sign of a good encapsulation process. The color of the cocona pulp powder was similar to that of the carrier agents. The formulation with highest content of hydrolyzed collagen improved the recovery of solids, guaranteed the cocona pulp encapsulation, and obtained fruit powders with bioactive properties.

scholarly journals Advantages of Utilizing Population Balance Modeling of Crystallization Processes for Particle Size Distribution Prediction of an Active Pharmaceutical Ingredient

Processes ◽  
2019 ◽  
Vol 7 (6) ◽  
pp. 355
Author(s):  
Tamar Rosenbaum ◽  
Li Tan ◽  
Joshua Engstrom
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Process Parameters ◽  
Crystallization Process ◽  
Population Balance ◽  
Active Pharmaceutical Ingredient ◽  
Population Balance Modeling ◽  
The Impact

Active pharmaceutical ingredient (API) particle size distribution is important for both downstream processing operations and in vivo performance. Crystallization process parameters and reactor configuration are important in controlling API particle size distribution (PSD). Given the large number of parameters and the scale-dependence of many parameters, it can be difficult to design a scalable crystallization process that delivers a target PSD. Population balance modeling is a useful tool for understanding crystallization kinetics, which are primarily scale-independent, predicting PSD, and studying the impact of process parameters on PSD. Although population balance modeling (PBM) does have certain limitations, such as scale dependency of secondary nucleation, and is currently limited in commercial software packages to one particle dimension, which has difficulty in predicting PSD for high aspect ratio morphologies, there is still much to be gained from applying PBM in API crystallization processes.

scholarly journals Optimization of Chitosan Microspheres Spray Drying via 32 Full Factorial Design

Folia Medica ◽  
2017 ◽  
Vol 59 (3) ◽  
pp. 310-317 ◽  
Author(s):  
Plamen D. Katsarov ◽  
Bissera A. Pilicheva ◽  
Hristo M. Manev ◽  
Paolina K. Lukova ◽  
Margarita I. Kassarova
Keyword(s):  
Particle Size ◽  
Factorial Design ◽  
Size Distribution ◽  
Spray Drying ◽  
Process Parameters ◽  
Polymer Concentration ◽  
Production Yield ◽  
Nasal Administration ◽  
Chitosan Microspheres ◽  
Pump Rate

AbstractBackground:Generally, the preparation of spray-dried microspheres is strongly affected by the process parameters. Particle size and production yield are mainly influenced by the spraying solution concentration and the pump rate of the spray dryer.Aim:The aim of this study was to assess optimum spray drying parameters - polymer concentration and pump rate required for the production of chitosan microspheres with high production yield and targeted for nasal administration particle size.Materials and methods:Full 32factorial design was used to study the investigated parameters. Three different concentrations of the chitosan solution were selected: a low concentration of 1%, average concentration of 1.5% and high concentration of 2%. The rate of the peristaltic pump was also varied at three levels: low rate of 10%, medium rate of 14% and high rate of 18%.Results:Nine models of chitosan microspheres were formulated and characterized in terms of shape, surface morphology, size, particle size distribution and production yield. The particles obtained from 2% chitosan solutions, sprayed at 10% pump rate were of the highest yield (64.33%) and appropriate for nasal administration median diameter (3,434 μm).Conclusion:The two investigated spray-drying parameters interact with each other and their influence on the production yield and the size of the chitosan microspheres should be evaluated together, instead of one at a time. The assessed process parameters allow the production of chitosan microparticles with high yield and desirable characteristics (size, size distribution and shape) for intranasal delivery.

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