Predictive value of oxidative stress biomarkers in drug-free patients with bipolar disorder

Aims:Oxidative stress is increased during the acute phases of bipolar disorder (BD). Our aim here was to analyze oxidative stress biomarkers in patients with BD during euthymia and their siblings.Method:A cross-sectional study was performed in euthymic patients with BD-I (n=48), unaffected siblings (n=23) and genetically unrelated healthy controls (n=21). Protein carbonyl content (PCC), total antioxidant capacity (TRAP), lipid peroxidation (TBARS) and uric acid were measured as biomarkers of oxidative stress in blood.Results:The antioxidant capacity (TRAP) was lower (p<0.001) in patients with BD compared to their siblings and controls, whereas no differences were observed in PCC, TBARS or uric acid. In patients, the concentrations of TRAP and TBARS were positively associated with the dose of valproic acid (p<0.05 and p<0.001, respectively). The concentrations of these biomarkers were not significantly associated with any of socio-demographic and clinical variables.Conclusion:A selective reduction in antioxidant capacity is present in BD during euthymia state, whereas other markers of oxidative stress are unaltered during euthymia. Siblings did not show any alterations in oxidative stress biomarkers. Oxidative stress might represent a state-dependent marker in BD. The association between treatment with valproic acid and oxidative stress markers in euthymia deserves further studies.

Download Full-text

Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review

Journal of Pharmaceutical Negative Results ◽

10.4103/jpnr.jpnr_3_19 ◽

2019 ◽

Vol 10 (1) ◽

pp. 6

Author(s):

LaiFong Chan ◽

NurulAin Mohamad Kamal ◽

JiannLin Loo ◽

JoAan Goon ◽

HanafiAhmad Damanhuri ◽

...

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Bipolar Disorder ◽

Suicidal Behavior ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers

Download Full-text

OXIDATIVE STRESS BIOMARKERS IN EXPIRATED AIR OF HEALTHY HUMANS AND PROMISING TECHNIQUES OF THEIR ANALYSIS DURING SPACE FLIGHT

Aerospace and Environmental Medicine ◽

10.21687/0233-528x-2020-54-3-5-21 ◽

2020 ◽

pp. 5-21

Author(s):

L.N. Mukhamedieva ◽

◽

D.S. Tsarkov ◽

D.S. Ozerov ◽

G.Yu. Grigoriev ◽

...

Keyword(s):

Oxidative Stress ◽

Space Flight ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Healthy Humans

Download Full-text

Association between Vitamin D Status, Oxidative Stress Biomarkers and Viral Load in Human Immunodeficiency Virus Type 1 Infection

Current HIV Research ◽

10.2174/1570162x15666171005170227 ◽

2017 ◽

Vol 15 (5) ◽

Cited By ~ 4

Author(s):

Tamires Flauzino ◽

Andrea N.C. Simao ◽

Elaine R.D. de Almeida ◽

Helena K. Morimoto ◽

Sayonara R. Oliveira ◽

...

Keyword(s):

Oxidative Stress ◽

Vitamin D ◽

Human Immunodeficiency Virus ◽

Viral Load ◽

Human Immunodeficiency Virus Type ◽

Vitamin D Status ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Immunodeficiency Virus

Download Full-text

Oxidative Stress Biomarkers in Urine of Metal Carpentry Workers Can Be Diagnostic for Occupational Exposure to Low Level of Welding Fumes from Associated Metals

Cancers ◽

10.3390/cancers13133167 ◽

2021 ◽

Vol 13 (13) ◽

pp. 3167

Author(s):

Flavia Buonaurio ◽

Maria Luisa Astolfi ◽

Daniela Pigini ◽

Giovanna Tranfo ◽

Silvia Canepari ◽

...

Keyword(s):

Oxidative Stress ◽

Occupational Exposure ◽

Oxidation Products ◽

Control Group ◽

Welding Fumes ◽

Oxidative Stress Biomarkers ◽

Limit Values ◽

Stress Biomarkers ◽

Specificity And Sensitivity ◽

The Impact

Urinary concentrations of 16 different exposure biomarkers to metals were determined at the beginning and at the end of a working shift on a group of workers in the metal carpentry industry. Five different oxidative stress biomarkers were also measured, such as the oxidation products of RNA and DNA metabolized and excreted in the urine. The results of workers exposed to metals were compared to those of a control group. The metal concentrations found in these workers were well below the occupational exposure limit values and exceeded the mean concentrations of the same metals in the urine of the control group by a factor of four at maximum. Barium (Ba), mercury (Hg), lead (Pb) and strontium (Sr) were correlated with the RNA oxidative stress biomarker, 8-oxo-7, 8-dihydroguanosine (8-oxoGuo), which was found able to discriminate exposed workers from controls with a high level of specificity and sensitivity. The power of this early diagnostic technique was assessed by means of the ROC curve. Ba, rubidium (Rb), Sr, tellurium (Te), and vanadium (V) were correlated with the level of the protein oxidation biomarker 3-Nitrotyrosine (3-NO2Tyr), and Ba, beryllium (Be), copper (Cu), and Rb with 5-methylcytidine (5-MeCyt), an epigenetic marker of RNA damage. These effect biomarkers can help in identifying those workers that can be defined as “occupationally exposed” even at low exposure levels, and they can provide information about the impact that such doses have on their health.

Download Full-text

Antioxidants, lysosomes and elements status during the life cycle of sea trout Salmo trutta m. trutta L.

Scientific Reports ◽

10.1038/s41598-021-85127-3 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Natalia Kurhaluk ◽

Halyna Tkachenko

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Muscle Tissue ◽

Salmo Trutta ◽

Protein Carbonyl ◽

Oxidative Modification ◽

Oxidative Stress Biomarkers ◽

Development Stages ◽

Stress Biomarkers ◽

Element Contents

AbstractThe aim of our study was to elucidate the effects of both development stages (parr, smolt, adult, spawner), and kelt as a survival form and sex (male, female) on the functional stability of the lysosomal complex, biomarkers of oxidative stress, and element contents in the muscle tissue of the sea trout (Salmo trutta m. trutta L.) sampled in the Pomerania region (northern Poland). We have evaluated the maximal activities of lysosomal enzymes (alanyl aminopeptidase, leucyl aminopeptidase, β-N-acetylglucosaminidase, and acid phosphatase), lipid peroxidation level, and protein carbonyl derivatives as indices of muscle tissue degradation. The relationship between lysosomal activity and oxidative stress biomarkers estimated by the lipid peroxidation level and protein carbonyl derivatives was also assessed, as well as the relationships between element levels and oxidative stress biomarkers. Trends of the main effects (i.e., the development stages and sex alone, the interaction of the sex and development stage simultaneously) on oxidative stress biomarkers, lysosomal functioning, and element contents in the muscle tissue were evaluated. The study has shown sex-related relationships between the pro- and antioxidant balance and the tissue type in the adult stage as well as modifications in the lysosomal functioning induced by long-term environmental stress associated with changing the habitats from freshwater to seawater and intense migrations. The highest level of toxic products generated in oxidative reactions and oxidative modification of proteins was noted in both the spawner stage and the kelt form. The holistic model of analysis of all parameters of antioxidant defense in all development stages and sex demonstrated the following dependencies for the level of lipid peroxidation, oxidative modification of proteins, lysosomal activities, and element contents: TBARS > OMP KD > OMP AD > TAC, AcP > NAG > LAP > AAP and Cu > Fe > Ca > Mn > Zn > Mg, respectively.

Download Full-text