The Relationship between Psychosocial Factors and Breast Cancer: Some Unexpected Results

192 Background: Sleep disturbance negatively impacts quality of life and recovery. Our objective was to evaluate the relationship between individual patient factors (demographic, surgical, pain, opioid use, and psychosocial factors) and greater sleep disturbance. Methods: In this prospective longitudinal study, patients completed validated measures regarding their sleep disturbance, pain, opioid use, and psychological symptoms preoperatively and then 2 weeks, 6 and 12 months postoperatively. Objective pain sensitivity measures were evaluated at baseline using quantitative sensory testing. Univariable and multivariable generalized estimating equations (GEE) evaluated demographic, surgical, pain, and psychological predictors of sleep disturbance during the first year after surgery for breast cancer. Results: Female patients (n = 259) reported varying degrees of sleep disturbance, which were longitudinally associated with pain, psychosocial factors such as anxiety, depression, and affect. While the mean degree of sleep disturbance did not change substantially over time, the link to pain severity appeared to strengthen over the first postoperative year. Independent preoperative predictors of worse sleep disturbance on multivariable longitudinal GEE included younger age (B = -.09, p =.006), opioid use (B = 3.09, p =.02), higher pain (B =.19, p = <.001) and anxiety (B =.45, p = <.001) at baseline. On the other hand, higher basline positive affect (B = -.14, p = <.012) and the surgical category total mastectomy without reconstruction (B = -2.81, p = <.006) were indepently associated with lower sleep disturbance. Those with worse baseline sleep required more opioid analgesics during surgical recovery, and continued use of opioids at 2 weeks post-surgery was associated with disturbed sleep. Conclusions: Sleep disturbance in the first year following surgery for breast cancer varied substantially between individuals. Certain demographic, psychosocial, and pain factors explained more of this variance than surgical procedure, with the exception of total mastectomy without reconstruction that was associated with lower sleep disturbance. Sleep disturbance was associated with increased need for opioids in the perioperative period, and a propensity for more prolonged postoperative opioid use. Pre-surgical interventions in high risk individuals such as anxiety management, boosting positive affect, and controlling pain that have been shown to improve sleep quality could enhance postoperative recovery and decrease opioid use following breast surgery.

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Structural equation modeling of the relationship between posttraumatic growth and psychosocial factors in women with breast cancer

Psycho-Oncology ◽

10.1002/pon.4298 ◽

2016 ◽

Vol 26 (8) ◽

pp. 1198-1204 ◽

Cited By ~ 8

Author(s):

Makiko Tomita ◽

Miyako Takahashi ◽

Nobumi Tagaya ◽

Miyako Kakuta ◽

Ichiro Kai ◽

...

Keyword(s):

Breast Cancer ◽

Structural Equation Modeling ◽

Posttraumatic Growth ◽

Psychosocial Factors ◽

Structural Equation ◽

Equation Modeling ◽

The Relationship

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The relationship between psychosocial, demographic and navigation contact variables in underserved breast cancer patients

PsycEXTRA Dataset ◽

10.1037/e741372011-200 ◽

2010 ◽

Author(s):

Andrea Apodaca

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Breast Cancer Patients ◽

The Relationship

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CASC15：A tumor-associated long non-coding RNA

Current Pharmaceutical Design ◽

10.2174/1381612826666200922153701 ◽

2020 ◽

Vol 26 ◽

Author(s):

Bei Wang ◽

Wen Xu ◽

Yuxuan Cai ◽

Chong Guo ◽

Gang Zhou ◽

...

Keyword(s):

Breast Cancer ◽

Therapeutic Target ◽

Cancer Colorectal ◽

Tumor Development ◽

Pathophysiological Mechanism ◽

Biological Processes ◽

Non Coding Rna ◽

Cancer Côlon ◽

The Relationship ◽

Long Non Coding Rna

Background: CASC15, one of long non-coding RNA, is involved in the regulation of many tumor biological processes, and is expected to become a new biological therapeutic target. This paper aims to elucidate the pathophysiological function of CASC15 in various tumors. Methods: The relationship between CASC15 and tumors was analyzed by searching references, and summarizes the specific pathophysiological mechanism of CASC15. Results: LncRNA CASC15 is closely related to tumor development, and has been shown to be abnormally high expressed in all kinds of tumors, including breast cancer, cervical cancer, lung cancer, hepatocellular carcinoma, gastric cancer, bladder cancer, colon cancer, colorectal cancer, cardiac hypertrophy, intrahepatic cholangiocarcinoma, leukemia, melanoma, tongue squamous cell carcinoma, nasopharyngeal carcinoma. However, CASC15 has been found to be downexpressed abnormally in ovarian cancer, glioma and neuroblastoma. Besides, it is identified that CASC15 can affect the proliferation, invasion and apoptosis of tumors. Conclusion: LncRNA CASC15 has the potential to become a new therapeutic target or marker for a variety of tumors.

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A New Paradigm in the Relationship between Melatonin and Breast Cancer: Gut Microbiota Identified as a Potential Regulatory Agent

Cancers ◽

10.3390/cancers13133141 ◽

2021 ◽

Vol 13 (13) ◽

pp. 3141

Author(s):

Aurora Laborda-Illanes ◽

Lidia Sánchez-Alcoholado ◽

Soukaina Boutriq ◽

Isaac Plaza-Andrades ◽

Jesús Peralta-Linero ◽

...

Keyword(s):

Breast Cancer ◽

Gut Microbiota ◽

Bacterial Population ◽

Kynurenine Pathway ◽

New Paradigm ◽

Bacterial Composition ◽

Glucuronidase Activity ◽

The One ◽

The Relationship ◽

Melatonin Production

In this review we summarize a possible connection between gut microbiota, melatonin production, and breast cancer. An imbalance in gut bacterial population composition (dysbiosis), or changes in the production of melatonin (circadian disruption) alters estrogen levels. On the one hand, this may be due to the bacterial composition of estrobolome, since bacteria with β-glucuronidase activity favour estrogens in a deconjugated state, which may ultimately lead to pathologies, including breast cancer. On the other hand, it has been shown that these changes in intestinal microbiota stimulate the kynurenine pathway, moving tryptophan away from the melatonergic pathway, thereby reducing circulating melatonin levels. Due to the fact that melatonin has antiestrogenic properties, it affects active and inactive estrogen levels. These changes increase the risk of developing breast cancer. Additionally, melatonin stimulates the differentiation of preadipocytes into adipocytes, which have low estrogen levels due to the fact that adipocytes do not express aromatase. Consequently, melatonin also reduces the risk of breast cancer. However, more studies are needed to determine the relationship between microbiota, melatonin, and breast cancer, in addition to clinical trials to confirm the sensitizing effects of melatonin to chemotherapy and radiotherapy, and its ability to ameliorate or prevent the side effects of these therapies.

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Disparities in access to mobile devices and e-health literacy among breast cancer survivors

Supportive Care in Cancer ◽

10.1007/s00520-021-06407-2 ◽

2021 ◽

Author(s):

Zoe Moon ◽

Mira Zuchowski ◽

Rona Moss-Morris ◽

Myra S. Hunter ◽

Sam Norton ◽

...

Keyword(s):

Breast Cancer ◽

Health Literacy ◽

Cancer Survivors ◽

Mobile Devices ◽

Breast Cancer Survivors ◽

Social Deprivation ◽

Logistic Regressions ◽

Widespread Access ◽

The Relationship ◽

Questionnaire Pack

Abstract Background The number of e-health interventions developed for breast cancer survivors continues to increase. However, issues with engagement and retention are common. This study aimed to explore e-health literacy rates and access to smartphones and tablets in a large sample of breast cancer survivors. Methods In study 1, women were recruited from outpatient breast clinics across England and Wales. Eligible women were asked to complete a questionnaire pack to assess their access to devices and their e-health literacy. Multiple regression analyses were run to assess the relationship between technology access and e-health literacy with sociodemographic variables such as age, social deprivation, and education. Study 2 presents a smaller sample recruited through social media who answered a questionnaire relating to use of mobile devices and e-health, and apps. Results Two thousand nine women participated in the study. Seventy-one percent had access to a smartphone, 54% had access to a tablet, and 20% did not have access to either device. Multiple logistic regressions showed that women who were younger, had higher levels of education, and who were from less deprived areas were more likely to have access to either device. Poorer e-health literacy was associated with being older, having less education, and not having access to a mobile device. Conclusions Whilst the results show relatively widespread access to mobile devices, there is evidence of a digital divide across some groups. Online interventions should be developed with consideration of individuals who are less e-health-literate and less technologically adept in order to increase the likelihood of engagement.

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