scholarly journals Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance

Hematology ◽  
2007 ◽  
Vol 12 (6) ◽  
pp. 511-517 ◽  
Author(s):  
Yusuf Baran ◽  
Bala Gür ◽  
Pelin Kaya ◽  
Ali Uğur Ural ◽  
Ferit Avcu ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Resistance Genes ◽  
Leukemia Cells ◽  
Multi Drug Resistance ◽  
Acute Myelogeneous Leukemia

scholarly journals Detection of Antibiotic Resistance Genes in Some Multiple Antibiotic Resistant E. coli from Apparently Healthy Pregnant Women

2020 ◽  
pp. 23-31
Author(s):  
O. C. Adekunle ◽  
A. J. Falade- Fatila ◽  
R. Ojedele ◽  
G. Odewale
Keyword(s):  
Escherichia Coli ◽  
Drug Resistance ◽  
Antibiotic Resistance ◽  
Pregnant Women ◽  
Resistance Genes ◽  
Antibiotic Resistance Genes ◽  
Multi Drug Resistance ◽  
Antibiotic Resistant ◽  
E Coli ◽  
Apparently Healthy

The emerging drug resistance, especially among the Escherichia coli (E.coli) isolates from pregnant women, spread rapidly within the community. Urinary tract infection (UTI) is a well-known bacterial infection posing serious health problem in pregnant women. Also, multi-drug resistance is becoming rampant, and it is of serious public health concern. Treatment of E. coli is now a challenge due to continuous increase in resistance towards commonly prescribed antibiotics, thus posing a threat to treatment. Hence, the aim of the study is to determine antibiotic resistance genes in some multiple antibiotic resistant E.coli from apparently healthy pregnant women in Osun State. A cross-sectional study design was used to collect 150 mid-stream urine samples from apparently healthy pregnant women from March, 2018 to September, 2018. A well structured questionnaire and informed consent were used for data collection. Standard loop technique was used to place 0.001 ml of urine on Cysteine Lactose Electrolyte Deficient (CLED) medium, Blood agar, MacConkey agar and incubated at 37 °C for 24 h. A standard agar disc diffusion method was used to determine antimicrobial susceptibility pattern of the isolates. The molecular detection of the resistant genes was done using PCR techniques. The ages of women enrolled in this study ranges from 22 to 42 years (mean ± standard deviation = 31 ± 4.7 years). Escherichia coli showed high percentage of resistance to ampicillin and low resistance to ciprofloxacin and penicillin. All the E. coli isolates were sensitive to levofloxacin, and most were resistant to Meropenem. Multiple drug resistance was observed in all the isolates. Resistance genes in VIM 390bp, bla ctx-M 585bp and TEM 517bp were detected in some of the representative E. coli isolates profiled. This study identified the presence of Multi-drug resistance genes in E. coli associated UTI among pregnant women in Osogbo.

Nitric Oxide Control of MYCN Expression and Multi Drug Resistance Genes in Tumours of Neural Origin

2010 ◽  
Vol 16 (4) ◽  
pp. 431-439 ◽  
Author(s):  
Antonio Porro ◽  
Christophe Chrochemore ◽  
Francesco Cambuli ◽  
Nunzio Iraci ◽  
Antonio Contestabile ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Drug Resistance ◽  
Resistance Genes ◽  
Multi Drug Resistance ◽  
Neural Origin ◽  
Mycn Expression

Local differentiation in Plasmodium falciparum drug resistance genes in Sudan

Parasitology ◽  
2003 ◽  
Vol 126 (5) ◽  
pp. 391-400 ◽  
Author(s):  
A. A. ABDEL-MUHSIN ◽  
M. J. MACKINNON ◽  
P. AWADALLA ◽  
E. ALI ◽  
S. SULEIMAN ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Plasmodium Falciparum ◽  
Population Structure ◽  
Resistance Genes ◽  
Microsatellite Loci ◽  
Balancing Selection ◽  
Dry Season ◽  
Chloroquine Resistance ◽  
Multi Drug Resistance ◽  
Eastern Region

Studies of population genetic structure of parasites can be used to infer which parasite genes are under selection. Here, the population structure of 4 genes associated with drug resistance of Plasmodium falciparum (the chloroquine resistance transporter, pfcrt, dihydrofolate reductase, dhfr, dihydropteroate synthase, dhps, and multi-drug resistance, pfmdr-1) were examined in parasite populations in 3 villages in eastern Sudan and in an urban area of Khartoum, the capital. In order to differentiate the effects of drug selection from neutral influences on population structure, parasites were also genotyped for 3 putatively neutral microsatellite loci (polyα, TA81 and pfg377), and for 2 antigenic loci that are either under balancing selection or neutral, merozoite surface protein 1 and 2, (MSP-1 and MSP-2). Cross-sectional surveys were carried out during the peak transmission (wet) season and in the ensuing dry season. No significant variation in frequencies of MSP-1 and MSP-2 alleles was seen among villages in the eastern region and between the villages and Khartoum, nor between the wet and dry season. However, the drug resistance genes, pfmdr-1, pfcrt and dhfr and to a lesser extent the microsatellite loci showed high FST values when comparing villages with Khartoum, indicating strong geographical differentiation at these loci. Moreover, variation in frequencies of the drug resistance genes, pfmdr-1, pfcrt and dhfr, was observed between the wet and dry season. These differences most probably reflect the variation in drug pressure between each region, and in drug usage between the wet and dry season in a given region.

scholarly journals Re-Emergence of Salmonellosis in Hog Farms: Outbreak and Bacteriological Characterization

2021 ◽  
Vol 9 (5) ◽  
pp. 947
Author(s):  
Mariana Meneguzzi ◽  
Caroline Pissetti ◽  
Raquel Rebelatto ◽  
Julian Trachsel ◽  
Suzana Satomi Kuchiishi ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antimicrobial Resistance ◽  
Resistance Genes ◽  
High Rate ◽  
Multi Drug Resistance ◽  
Marker Genes ◽  
Genotypic Resistance ◽  
Clonal Group ◽  
Hog Farms

Clinical salmonellosis has been increasing significantly in Brazil in recent years. A total of 130 outbreaks distributed among 10 swine-producing states were investigated. One representative Salmonella isolate from each outbreak was characterized through serotyping, antimicrobial resistance profiles, PFGE, and WGS. From 130 outbreaks: 50 were enteric, 48 were septicemic, 17 cases were characterized as hepato-biliary invasive, 13 as nodal and two were not classified. The most prevalent serovars were a monophasic variant of S. typhimurium (55/130), Choleraesuis (46/130), and Typhimurium (14/130). Most of the strains (86.92%) demonstrated a high rate of multi-drug resistance. The identification of a major Choleraesuis clonal group in several Brazilian states sharing the same resistance genes suggested that these strains were closely related. Six strains from this clonal group were sequenced, revealing the same ST-145 and 11 to 47 different SNPs. The detected plasmid type showed multiple marker genes as RepA_1_pKPC-CAV1321, the first to be reported in Salmonella. All AMR genes detected in the genomes were likely present on plasmids, and their phenotype was related to genotypic resistance genes. These findings reveal that salmonellosis is endemic in the most important pig-producing states in Brazil, emphasizing the need to make data available to aid in reducing its occurrence.

scholarly journals Identification of Multi-Drug Resistance Genes (MDRG) in Stool Samples of Hospitalized Patients

2015 ◽  
Vol 2 (suppl_1) ◽  
Author(s):  
Ali Hassoun ◽  
Khushdeep Chahal ◽  
Esmeralda Asis ◽  
Donald Stalons ◽  
Stefan Brzezinski ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Resistance Genes ◽  
Hospitalized Patients ◽  
Multi Drug Resistance ◽  
Stool Samples

Assessment of effects of multi drug resistance on dielectric properties of K562 leukemic cells using electrorotation

RSC Advances ◽  
2014 ◽  
Vol 4 (85) ◽  
pp. 44879-44887 ◽  
Author(s):  
Garsha Bahrieh ◽  
Murat Erdem ◽  
Ebru Özgür ◽  
Ufuk Gündüz ◽  
Haluk Külah
Keyword(s):  
Drug Resistance ◽  
Multidrug Resistant ◽  
Leukemic Cells ◽  
Leukemia Cells ◽  
Multi Drug Resistance ◽  
Human Leukemia ◽  
Dielectric Characterization ◽  
Human Leukemia Cells ◽  
3D Electrodes

In this study, dielectric characterization of multidrug resistant (MDR) K562 human leukemia cells was carried out using a MEMS based electrorotation (ER) device with 3D electrodes.

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