Structural modification and antihypertensive activity study of formononetin derivatives

Microstructure of epitaxial layers of doped GaAs and its crystal growth dynamics on single crystal GaAs substrate were studied by Raman microspectroscopy with a Dilor OMARS instrument equipped with a 1024 photodiode multichannel detector and a ion-argon laser Spectra-Physics emitting at 514.5 nm.The spatial resolution of this technique, less than 1 μm2, allows the recording of Raman spectra at several spots in function of thickness, from the substrate to the outer deposit, including areas around the interface (Fig.l).The high anisotropy of the LO and TO Raman bands is indicative of the orientation of the epitaxial layer as well as of the structural modification in the deposit and in the substrate at the interface.With Sn doped, the epitaxial layer also presents plasmon in Raman scattering. This fact is already very well known, but we additionally observed that its frequency increases with the thickness of the deposit. For a sample with electron density 1020 cm-3, the plasmon L+ appears at 930 and 790 cm-1 near the outer surface.

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Soft recovery of a ferrous alloy: Structural modification and properties

DYMAT 2009 - 9th International Conferences on the Mechanical and Physical Behaviour of Materials under Dynamic Loading ◽

10.1051/dymat/2009136 ◽

2009 ◽

Author(s):

T. d'Almeida ◽

D. J. Chapman ◽

W. G. Proud ◽

P. J. Gould ◽

P. D. Church ◽

...

Keyword(s):

Structural Modification ◽

Ferrous Alloy

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Efficient Digital Hologram Generation using Position Clustering and FFT-based Structural Modification

TECHART Journal of Arts and Imaging Science ◽

10.15323/techart.2016.11.3.4.35 ◽

2016 ◽

Vol 3 (4) ◽

pp. 35

Author(s):

ChoongSang Cho ◽

Sangkeun Lee

Keyword(s):

Structural Modification ◽

Digital Hologram

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10-step Synthesis of 20-nor-Salvinorin A by Dynamic Strategic Bond Analysis

10.26434/chemrxiv.5318188.v1 ◽

2017 ◽

Author(s):

Jeremy Roach ◽

Yusuke Sasano ◽

Cullen Schmid ◽

Saheem Zaidi ◽

Vsevolod Katritch ◽

...

Keyword(s):

Total Synthesis ◽

Opioid Receptors ◽

Structural Modification ◽

High Selectivity ◽

Therapeutic Potential ◽

Salvinorin A ◽

High Affinity ◽

Plant Metabolite ◽

Complex Architecture ◽

Property Modification

Salvinorin A (SalA) is a plant metabolite that agonizes the human kappa-opioid receptor (κ-OR) with high affinity and high selectivity over mu- and delta-opioid receptors. Its therapeutic potential has stimulated extensive semi-synthetic studies and total synthesis campaigns. However, structural modification of SalA has been complicated by its instability, and efficient total synthesis has been frustrated by its dense, complex architecture. Treatment of strategic bonds in SalA as dynamic and dependent on structural perturbation enabled the identification of an efficient retrosynthetic pathway. Here we show that deletion of C20 simultaneously stabilizes the SalA skeleton, simplifies its synthesis and retains its high affinity and selectivity for the κ-OR. The resulting 10-step synthesis now opens the SalA scaffold to deep-seated property modification.

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Structural Modification in Borosilicate Glass by Use of Femtosecond Fiber Laser at 1.56 µm

Journal of Laser Micro/Nanoengineering ◽

10.2961/jlmn.2007.01.0005 ◽

2007 ◽

Vol 2 (1) ◽

pp. 26-30 ◽

Cited By ~ 2

Author(s):

Takayuki Tamaki

Keyword(s):

Fiber Laser ◽

Borosilicate Glass ◽

Structural Modification ◽

Femtosecond Fiber Laser

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Characterization and functional properties of new everbearing strawberry (Fragaria x ananasa Duch.) cultivar, ‘Summertiara’ berries

Functional Foods in Health and Disease ◽

10.31989/ffhd.v4i1.27 ◽

2014 ◽

Vol 4 (1) ◽

pp. 1 ◽

Cited By ~ 1

Author(s):

Takeshi Nagai ◽

Misuzu Tamai ◽

Masato Sato ◽

Yasuhiro Tanoue ◽

Norihisa Kai ◽

...

Keyword(s):

Vitamin C ◽

Sensory Evaluation ◽

Functional Properties ◽

Active Oxygen Species ◽

Active Oxygen ◽

Antihypertensive Activity ◽

Oxygen Species ◽

Total Anthocyanins ◽

Strawberry Cultivar ◽

The Stability

Background: In recent years, a new everbearing strawberry cultivar, ‘Summertiara’ was cultivated to supply the strawberries in pre-harvest season from July to October in Japan. For highly research and development of processing of this cultivar, ‘Summertiara’ berries, the objective of this study was to characterize these berries, with relation to chemical parameters, total phenols, total flavonoids, total vitamin C, and total anthocyanins, and was to investigate the solubility and the stability of anthocyanins from the berries. Moreover, the functional properties such as antioxidative activity, active oxygen species scavenging activity, and antihypertensive activity were also evaluated.Methods: Chemical analysis, colour measurement, and sensory evaluation of new everbearing strawberry cultivar, ‘Summertiara’ berries were performed. Next, the solubility of anthocyanins from the berries and stability of these against pH, temperature, and an incandescent lighting were investigated. Moreover, functional properties of the extracts prepared from berries were elucidated using 5 different methods.Results: The contents of water, proteins, lipids, carbohydrates, and ash were the same as those of other cultivar berries. The sugar-acid ratio in the berries was low; these were acidulous. By sensory evaluation, the main factors were vivid red colour, aroma, and acidity. The berries were rich in phenols, flavonoids, vitamin C, and anthocyanins. The anthocyanins of the berries became unstable by heat treatment and light exposures such as visible rays. On the other hand, the extracts prepared from the berries showed the functionalities such as antioxidant activity, active oxygen species scavenging activities, and antihypertensive activity. Conclusions: The strawberry cultivar, ‘Summertiara’ berries were the most suitable for processing ingredient of strawberry-derived products with superior health promoting functionalities.Keywords: Summertiara, everbearing strawberry cultivar, characterization, sensory evaluation, color and storage, functional property

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Antineoplastic Activity, Structural Modification, Synthesis and Structure-activity Relationship of Dammarane-type Ginsenosides: An Overview

Current Organic Chemistry ◽

10.2174/1385272823666190401141138 ◽

2019 ◽

Vol 23 (5) ◽

pp. 503-516 ◽

Cited By ~ 1

Author(s):

Qiang Zhang ◽

Xude Wang ◽

Liyan Lv ◽

Guangyue Su ◽

Yuqing Zhao

Keyword(s):

Structural Modification ◽

Gastrointestinal Disease ◽

Structure Activity Relationship ◽

Cerebrovascular Diseases ◽

Activity Relationship ◽

Cycle Arrest ◽

Structure Activity ◽

Wide Range ◽

Structural Association ◽

Relationship Of

Dammarane-type ginsenosides are a class of tetracyclic triterpenoids with the same dammarane skeleton. These compounds have a wide range of pharmaceutical applications for neoplasms, diabetes mellitus and other metabolic syndromes, hyperlipidemia, cardiovascular and cerebrovascular diseases, aging, neurodegenerative disease, bone disease, liver disease, kidney disease, gastrointestinal disease and other conditions. In order to develop new antineoplastic drugs, it is necessary to improve the bioactivity, solubility and bioavailability, and illuminate the mechanism of action of these compounds. A large number of ginsenosides and their derivatives have been separated from certain herbs or synthesized, and tested in various experiments, such as anti-proliferation, induction of apoptosis, cell cycle arrest and cancer-involved signaling pathways. In this review, we have summarized the progress in structural modification, shed light on the structure-activity relationship (SAR), and offered insights into biosynthesis-structural association. This review is expected to provide a preliminary guide for the modification and synthesis of ginsenosides.

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Combinatorial Synthesis of Novel 9R-Acyloxyquinine Derivatives as Insecticidal Agents

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207323666200120112714 ◽

2020 ◽

Vol 23 (2) ◽

pp. 111-118

Author(s):

Zhiping Che ◽

Jinming Yang ◽

Di Sun ◽

Yuee Tian ◽

Shengming Liu ◽

...

Keyword(s):

Natural Products ◽

Double Bond ◽

Insecticidal Activity ◽

Structural Modification ◽

Combinatorial Synthesis ◽

Hydroxyl Group ◽

Botanical Insecticide ◽

Mythimna Separata ◽

Lead Compounds

Background: It is one of the effective ways for pesticide innovation to develop new insecticides from natural products as lead compounds. Quinine, the main alkaloid in the bark of cinchona tree as well as in plants in the same genus, is recognized as a safe and potent botanical insecticide to many insects. The structural modification of quinine into 9R-acyloxyquinine derivatives is a potential approach for the development of novel insecticides, which showed more toxicity than quinine. However, there are no reports on the insecticidal activity of 9Racyloxyquinine derivatives to control Mythimna separata. Methods: Endeavor to discover biorational natural products-based insecticides, 20 novel 9Racyloxyquinine derivatives were prepared and assessed for their insecticidal activity against M. separata in vivo by the leaf-dipping method at 1 mg/mL. Results: Among all the compounds, especially derivatives 5i, 5k and 5t exhibited the best insecticidal activity with final mortality rates of 50.0%, 57.1%, and 53.6%, respectively. Conclusion: Overall, a free 9-hydroxyl group is not a prerequisite for insecticidal activity and C9- substitution is well tolerated; modification of out-ring double-bond is acceptable, and hydrogenation of double-bond enhances insecticidal activity; Quinine ring is essential and open of it is not acceptable. These preliminary results will pave the way for further modification of quinine in the development of potential new insecticides.

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Exploring the Chemistry and Therapeutic Potential of Triazoles: A Comprehensive Literature Review

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557519666190312162601 ◽

2019 ◽

Vol 19 (16) ◽

pp. 1298-1368 ◽

Cited By ~ 4

Author(s):

Ankit Jain ◽

Poonam Piplani

Keyword(s):

Oxidative Stress ◽

Drug Discovery ◽

Literature Review ◽

Structural Modification ◽

Therapeutic Potential ◽

Pharmacological Properties ◽

Pharmacological Activities ◽

Triazole Derivatives ◽

Comprehensive Literature Review ◽

The Common

: Triazole is a valuable platform in medicinal chemistry, possessing assorted pharmacological properties, which could play a major role in the common mechanisms associated with various disorders like cancer, infections, inflammation, convulsions, oxidative stress and neurodegeneration. Structural modification of this scaffold could be helpful in the generation of new therapeutically useful agents. Although research endeavors are moving towards the growth of synthetic analogs of triazole, there is still a lot of scope to achieve drug discovery break-through in this area. Upcoming therapeutic prospective of this moiety has captured the attention of medicinal chemists to synthesize novel triazole derivatives. The authors amalgamated the chemistry, synthetic strategies and detailed pharmacological activities of the triazole nucleus in the present review. Information regarding the marketed triazole derivatives has also been incorporated. The objective of the review is to provide insights to designing and synthesizing novel triazole derivatives with advanced and unexplored pharmacological implications.

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