The Relation Between Histological, Tumor-Biological and Clinical
Parameters in Deep and Superficial Leiomyosarcoma and Leiomyoma

Purpose: Leiomyosarcomas (LMS) of deep and superficial tissues were examined to identify prognostic markers explaining their different biological behaviour and to define differences between cutaneous and subcutaneous LMS. LMS and leiomyomas (LM) of the skin were compared to and consistent differences that could aid in the (sometimes difficult) diagnosis.Patients: Material was obtained from 27 patients with a deep LMS, 14 with a superficial LMS, and 21 with a LM.Methods: Proliferation markers (mitotic and Ki-67 indices), DNA ploidy, size, grade, and the amount of apoptosis were studied. Statistical analysis was performed and survival curves were constructed by the Kaplan-Meier method and compared by the log-rank test.Results: Superficial LMS were smaller than deep LMS (p < 0.05), and the overall survival of patients with a superficial LMS was better than with a deep LMS (p < 0.05).Within the group of superficial LMS only entirely subcutaneous, and not cutaneous tumors metastasized.No differences were found in the other examined parameters. Proliferation and apoptotic indices were significantly higher in superficial LMS compared to superficial LM.Discussion: The difference in clinical outcome between patients with a superficial and deep LMS, seems to be related to site and size.The metastatic potential of subcutaneous LMS, however, seems to be related to location alone and not to size.The amount of apoptosis and proliferation can be used as additional criteria in the differentiation between superficial LMS and LM.

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Treatment of Recurrent or Metastatic Uterine Adenosarcoma

Sarcoma ◽

10.1155/2017/4680273 ◽

2017 ◽

Vol 2017 ◽

pp. 1-9 ◽

Cited By ~ 5

Author(s):

Michael J. Nathenson ◽

Anthony P. Conley ◽

Heather Lin ◽

Nicole Fleming ◽

Vinod Ravi

Keyword(s):

Hormonal Therapy ◽

Response Rate ◽

Progression Free Survival ◽

Rank Test ◽

Free Survival ◽

Log Rank Test ◽

Recist 1.1 ◽

Kaplan Meier ◽

Study Population ◽

The Difference

Purpose. This study retrospectively evaluated overall survival (OS) by treatment of recurrent or metastatic uterine adenosarcoma including surgery, radiation, chemotherapy, and hormonal therapy and evaluated OS and progression-free survival (PFS) after 1st line systemic chemotherapy. Methods. 78 patients with recurrent or metastatic adenosarcoma comprised the study population. The Kaplan-Meier method was used to estimate OS and PFS. The log-rank test was performed to test the difference in survival between groups. Results. Median OS from diagnosis of recurrent or metastatic disease was 1.8 yrs. OS was influenced by pathology on recurrence, p=0.035. Median OS differed by surgery for 1st recurrence 26.3 months versus 15.1 months. OS was not influenced by chemotherapy, p=0.58, palliative radiation, p=0.58, or hormonal therapy, p=0.15. The response rate (CR + PR) per RECIST 1.1 for chemotherapy was 31.2% for doxorubicin-based regimens and 14.3% for gemcitabine/docetaxel. OS since 1st line chemotherapy was not significantly different among chemotherapy regimens. However, the median PFS was superior for doxorubicin/ifosfamide (15.4 months) compared to gemcitabine/docetaxel (5.0 months), platinum-based regimens (5.7 mo), or other doxorubicin-based regimens (6.5 months). Conclusion. These results suggest that surgery is an important treatment modality for recurrent or metastatic uterine adenosarcoma, and the most effective chemotherapeutics are doxorubicin/ifosfamide and gemcitabine/docetaxel.

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Nonspecific interstitial pneumonia: survival is influenced by the underlying cause

European Respiratory Journal ◽

10.1183/09031936.00148613 ◽

2014 ◽

Vol 45 (3) ◽

pp. 746-755 ◽

Cited By ~ 30

Author(s):

Hilario Nunes ◽

Kirsten Schubel ◽

Diane Piver ◽

Eline Magois ◽

Séverine Feuillet ◽

...

Keyword(s):

Interstitial Pneumonia ◽

Cox Model ◽

Connective Tissue Diseases ◽

Rank Test ◽

Log Rank Test ◽

Kaplan Meier ◽

Clinical Disorders ◽

Nonspecific Interstitial Pneumonia ◽

Better Than

Idiopathic, nonspecific interstitial pneumonia (NSIP) is most often associated with various clinical disorders, including connective tissue diseases (CTDs) and chronic hypersensitivity pneumonitis (cHP). Emerging evidence also suggests that “idiopathic” NSIP may be the lung manifestation of undifferentiated CTD (UCTD). However, whether or not NSIP outcome is influenced by the underlying cause remains uncertain.This retrospective study included 127 biopsy-proven NSIP patients (65 women, mean±sd age 55±12 years). Survivals were estimated using a Kaplan–Meier curve and compared using the log-rank test. Multivariate analyses were based on a Cox model.15 (11.8%) patients had cHP, 29 (22.8%) had CTD, 32 (25.2%) satisfied the Kinder criteria for UCTD and 51 (40.1%) had idiopathic NSIP. At the end of follow-up (mean±sd 64±54 months), a difference in survival was observed between aetiological groups (p=0.002). Survival was better for UCTD than for idiopathic NSIP (p=0.020) and similar to that observed for CTD. cHP survival tended to be poorer than that of idiopathic NSIP (p=0.087) and was an independent predictor of mortality (hazard ratio 2.17, 95% CI 1.05–4.47; p=0.035).NSIP outcome is influenced by its cause. cHP exhibits the highest mortality. UCTD does not differ from CTD supporting the concept of autoimmune NSIP, with a prognosis that is better than that of idiopathic NSIP.

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RTOG 9804: A prospective randomized trial for “good risk” ductal carcinoma in situ (DCIS), comparing radiation (RT) to observation (OBS)

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.1004 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. 1004-1004 ◽

Cited By ~ 16

Author(s):

Beryl McCormick

Keyword(s):

Ductal Carcinoma ◽

Rank Test ◽

Margin Width ◽

Log Rank Test ◽

Kaplan Meier ◽

Size Grade ◽

To Receive ◽

Good Risk

1004 Background: Whole breast RT following conservation surgery (BCS) for low risk DCIS has remained controversial despite several large trials comparing RT to OBS, all showing significant benefit in local control with RT. RTOG 9804 compares RT to OBS for mammographically detected disease, of low or intermediate nuclear grade, <2.5 cm size, and surgical margins ≥ 3 mm. Tamoxifen (TAM) use for 5 years was allowed but not required. Methods: The primary endpoint was ipsilateral breast local failure (LF). LF and contralateral breast failures (CBF) were estimated by the cumulative incidence method and treatment arms compared by log-rank test. Disease-free (DFS) and overall survival (OS) were estimated by the Kaplan-Meier method and treatment arms compared by log-rank test. Patients were stratified by age, margin width, grade, TAM use, and primary size. With 1790 patients, 80% power and using a 2-sided log rank test at 0.05, the study was designed to detect a reduction in 5-year local recurrence from 6% to 3.5% with RT. Results: Accrual goals for the planned 1790 patients were not met; the study was closed early. From December 1999 to July 2006, 636 women were randomized to receive 50 Gy in 5 weeks vs. OBS. 43 women were ineligible on review and 8 withdrew consent. Median follow-up (F/U) time was 6.46 years. Mean age was 59; TAM was used in 62% of women. There were 2 LF in the RT arm vs. 15 in the OBS arm: at 5 years 0.4% RT vs. 3.2% OBS (p=0.0023, HR [95%CI] = 0.14 [0.03, 0.61]). With limited events, LF is not correlated with size, grade, margin status, or age. The rate of CBF at 5 years was 3.0% for the RT arm vs. 1.9% for the OBS arm (p=0.42, HR [95%CI] = 1.46 [0.59, 3.62]) and does not appear to be influenced by TAM use (3.6 versus 2.7% TAM). The DFS and OS results were excellent. Rate of grade 1-2 toxicity was 76% in the RT arm vs. 30% in the OBS arm, and the rate of ≥ 3 grade toxicities was 4% on both arms. Conclusions: In this “good risk” subset of DCIS, the LF rate was decreased significantly with the addition of RT. Longer follow-up is planned.

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A Score for Predicting Freedom from Progression of Children and Adolescents with Hodgkin Lymphoma

Hemato ◽

10.3390/hemato2020016 ◽

2021 ◽

Vol 2 (2) ◽

pp. 264-280

Author(s):

Valli De Re ◽

Laura Caggiari ◽

Maurizio Mascarin ◽

Mariangela De Zorzi ◽

Caterina Elia ◽

...

Keyword(s):

Children And Adolescents ◽

Hodgkin Lymphoma ◽

Rank Test ◽

Log Rank Test ◽

Kaplan Meier ◽

Positron Emission ◽

Pet Ct ◽

Risk Patients ◽

Better Than

Several studies have examined the prognostic performance of therapeutic groups (TG) and early responses to therapy on positron emission tomography/computed tomography (PET/CT) in children and adolescents with classical Hodgkin lymphoma (cHL); less research has been performed on molecular parameters at diagnosis. The aim of the present study was to devise a scoring system based on the TG criteria for predicting freedom from progression (FFP) in 133 patients: 63.2% males; 14 years median age (interquartile range (IQR) 11.9–15.1); with cHL (108 nodular sclerosis (NS) subtype) treated according to the AIEOP LH-2004 protocol; and median 5.55 (IQR 4.09–7.93) years of follow-up. CHL progressed or relapsed in 37 patients (27.8%), the median FFP was 0.89 years (IQR = 0.59–1.54), and 14 patients (10.5%) died. The FPR (final prognostic rank) model associates the biological HLA-G SNP 3027C/A (numerical point assigned (pt) = 1) and absolute neutrophil count (>8 × 109/L, pt = 2) as variables with the TG (TG3, pt = 3). Results of FPR score analyses for FFP suggested that FPR model (Kaplan–Meier curves, log-rank test for trends) was better than the TG model. At diagnosis, high-risk patients classified at FPR rank 4 and 5 identified 18/22 patients who relapse during the follow-up.

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Genetic Polymorphism of C-262T Catalase and Susceptibility to Schizophrenia

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2014.013 ◽

2014 ◽

Vol 2 (1) ◽

pp. 74-77 ◽

Cited By ~ 1

Author(s):

Mostafa Saadat ◽

Samane Safaie ◽

Iraj Saadat

Keyword(s):

Oxidative Stress ◽

Significant Interaction ◽

Rank Test ◽

Healthy Controls ◽

Log Rank Test ◽

Kaplan Meier ◽

Integral Role ◽

The Difference ◽

Gender Groups ◽

Cat Gene

Background: Catalase (CAT, OMIM: 115500) plays an integral role in the primary defence against oxidative stress. The T allele of the C-262T CAT polymorphism (rs1001179) is associated with lower activity of CAT. Here we investigated whether polymorphism of C-266T CAT was associated with susceptibility to schizophrenia.Methods: The present study was performed on 363 (267 males, 96 females) in-patients with schizophrenia diagnosis, and a total of 363 (266 males, 97 females) healthy controls. The C-262T CAT genotypes were determined using RFLP-PCR method.Results: Although the association between genotypes and susceptibility was not significant in both genders, there was significant interaction between gender and the TT genotype (P=0.035). The Log-rank test and the Kaplan-Meier survival analysis were used to evaluate the influence of C-262T genotypes on age at diagnosis (AAD) of schizophrenia. Mean AAD of the CC and CT+TT genotypes in males was 22.8 and 24.9 years, respectively. The difference was significant (c2=4.26, P=0.039). Difference of mean AAD of the CC (26.7 years) and CT+TT (27.3 years) genotypes among females was not significant (c2=0.02, P=0.896).Conclusion: Different associations between gender groups might be at least in part interpreted by the effect of gender on the association between C-262T polymorphism and CAT gene expression.

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Expression of E-cadherin, Ki-67, and p53 in urinary bladder cancer in relation to progression, survival, and recurrence

European Journal of Histochemistry ◽

10.4081/ejh.2020.3098 ◽

2020 ◽

Vol 64 (2) ◽

Author(s):

Stanislav Ziaran ◽

Stefan Harsanyi ◽

Katarina Bevizova ◽

Zuzana Varchulova Novakova ◽

Branislav Trebaticky ◽

...

Keyword(s):

Bladder Cancer ◽

Urinary Bladder ◽

Cox Regression ◽

Urinary Bladder Cancer ◽

Rank Test ◽

Ki 67 ◽

Free Survival ◽

Log Rank Test ◽

Kaplan Meier ◽

E Cadherin

Although the incidence varies with age and gender, urothelial bladder cancer is a relatively frequently occurring malignancy with variable clinical behavior that often has high recurrence rates. In this study, we analyzed the tumor tissues of 224 patients with pTa, pT1, and pT2 urinary bladder cancer. We performed a histomorphologic analysis and immunohistochemistry for p53, Ki-67, and E-cadherin, which were selected as markers of the malignant process. For pTa and pT1, univariate analyses of cancer-specific survival (CSS), progression-free survival (PFS), and recurrence-free survival (RFS) were calculated using the Kaplan-Meier method, the log-rank test and Cox regression. Multivariate analysis was performed by a Cox regression analysis. Ki-67 (P<0.001) was significantly associated with CSS, but the highest association was shown for E-cadherin (P<0.001). For pT1 and pTa, the Kaplan-Meier analysis and the log-rank test revealed significantly worse PFS for patients with higher levels of Ki-67 (P<0.001) and lower levels of E-cadherin (P<0.001). Based on these obtained results, it can be clearly stated that Ki-67 and E-cadherin expression levels are associated with CSS, PFS and RFS. The clinical utility of these markers is valuable for pTa and pT1 urinary bladder cancer and should be further verified with prospective multi-center trials.

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Colorectal Liver Metastases - Does the Number of Lesions Determine the Sensibility of Resection?

Swiss Surgery ◽

10.1024/1023-9332.6.1.6 ◽

2000 ◽

Vol 6 (1) ◽

pp. 6-10

Author(s):

Knoefel ◽

Brunken ◽

Neumann ◽

Gundlach ◽

Rogiers ◽

...

Keyword(s):

Liver Metastases ◽

Colorectal Liver Metastases ◽

Rank Test ◽

Log Rank Test ◽

Kaplan Meier ◽

Chirurgische Entfernung

Die komplette chirurgische Entfernung von Lebermetastasen bietet Patienten nach kolorektalem Karzinom die einzige kurative Chance. Es gibt jedoch eine, anscheinend unbegrenzte, Anzahl an Parametern, die die Prognose dieser Patienten bestimmen und damit den Sinn dieser Therapie vorhersagen können. Zu den am häufigsten diskutierten und am einfachsten zu bestimmenden Parametern gehört die Anzahl der Metastasen. Ziel dieser Studie war es daher die Wertigkeit dieses Parameters in der Literatur zu reflektieren und unsere eigenen Patientendaten zu evaluieren. Insgesamt konnte von 302 Patienten ein komplettes Follow-up erhoben werden. Die gebildeten Patientengruppen wurden mit Hilfe einer Kaplan Meier Analyse und konsekutivem log rank Test untersucht. Die Literatur wurde bis Dezember 1998 revidiert. Die Anzahl der Metastasen bestätigte sich als ein prognostisches Kriterium. Lagen drei oder mehr Metastasen vor, so war nicht nur die Wahrscheinlichkeit einer R0 Resektion deutlich geringer (17.8% versus 67.2%) sondern auch das Überleben der Patienten nach einer R0 Resektion tendenziell unwahrscheinlicher. Das 5-Jahres Überleben betrug bei > 2 Metastasen 9% bei > 2 Metastasen 36%. Das 10-Jahres Überleben beträgt bislang bei > 2 Metastasen 0% bei > 2 Metastasen 18% (p < 0.07). Die Anzahl der Metastasen spielt in der Prognose der Patienten mit kolorektalen Lebermetastasen eine Rolle. Selbst bei mehr als vier Metastasen ist jedoch gelegentlich eine R0 Resektion möglich. In diesen Fällen kann der Patient auch langfristig von einer Operation profitieren. Das wichtigere Kriterium einer onkologisch sinnvollen Resektabilität ist die Frage ob technisch und funktionell eine R0 Resektion durchführbar ist. Ist das der Fall, so sollte auch einem Patienten mit mehreren Metastasen die einzige kurative Chance einer Resektion nicht vorenthalten bleiben.

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Cohort study of the overall survival of patients with pancreatic cancer in a hospital of specialties of Quito-Ecuador in the period 2007–2017

Innovative Surgical Sciences ◽

10.1515/iss-2020-0030 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Andrés Moreno Roca ◽

Luciana Armijos Acurio ◽

Ruth Jimbo Sotomayor ◽

Carlos Céspedes Rivadeneira ◽

Carlos Rosero Reyes ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cohort Study ◽

Survival Time ◽

Univariate Analysis ◽

Rank Test ◽

Kaplan Meier ◽

Significant Difference ◽

Icd 10 ◽

The Difference ◽

Clinical Records

Abstract Objectives Pancreatic cancers in most patients in Ecuador are diagnosed at an advanced stage of the disease, which is associated with lower survival. To determine the characteristics and global survival of pancreatic cancer patients in a social security hospital in Ecuador between 2007 and 2017. Methods A retrospective cohort study and a survival analysis were performed using all the available data in the electronic clinical records of patients with a diagnosis of pancreatic cancer in a Hospital of Specialties of Quito-Ecuador between 2007 and 2017. The included patients were those coded according to the ICD 10 between C25.0 and C25.9. Our univariate analysis calculated frequencies, measures of central tendency and dispersion. Through the Kaplan-Meier method we estimated the median time of survival and analyzed the difference in survival time among the different categories of our included variables. These differences were shown through the log rank test. Results A total of 357 patients diagnosed with pancreatic cancer between 2007 and 2017 were included in the study. More than two-thirds (69.9%) of the patients were diagnosed in late stages of the disease. The median survival time for all patients was of 4 months (P25: 2, P75: 8). Conclusions The statistically significant difference of survival time between types of treatment is the most relevant finding in this study, when comparing to all other types of treatments.

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Sarcomas de alto grau: estudo retrospectivo de 131 casos

Revista do Colégio Brasileiro de Cirurgiões ◽

10.1590/s0100-69912008000200004 ◽

2008 ◽

Vol 35 (2) ◽

pp. 83-87 ◽

Cited By ~ 1

Author(s):

Wilmar José Manoel ◽

Bruno José de Queiroz Sarmento ◽

Luiz de Paula Silveira Júnior ◽

Deidimar Cássia Batista de Abreu ◽

Iron Pires de Abreu Neto ◽

...

Keyword(s):

Rank Test ◽

Log Rank Test ◽

Kaplan Meier

OBJETIVO: Relatar as características clínicas dos sarcomas de partes moles de alto grau e apresentar a experiência do Hospital Araújo Jorge no tratamento destes sarcomas. MÉTODO: Análise retrospectiva dos casos de sarcoma de alto grau em adultos admitidos no Hospital Araújo Jorge (HAJ) entre 1996 e 2000. Idade, sexo, características anátomo-patológicas (tamanho e tipo histológico), localização, tratamentos oncológicos realizados (cirurgias de preservação de órgãos e membros, margens, quimioterapia, radioterapia), recorrência local, recorrência distante e sobrevida foram estudados. Análise descritiva, curvas de Kaplan-Meier, log-rank test e teste ÷² foram usados quando pertinentes. RESULTADOS: Foram registrados 235 pacientes com sarcomas de partes moles entre 1996 - 2000, sendo que 131 eram de alto grau. A média de idade foi de 47,2 anos. O tipo histológico não foi determinado em 23,7% dos casos. O tipo mais freqüente foi o leiomiossarcoma (13,7%), seguido do sarcoma sinovial (10,7%) e rabdomiossarcoma (9,2%). O tamanho mediano foi de 10 cm (2-48 cm). A distribuição nos estádios II,III e IV foi de 15%, 55% e 30%, respectivamente. Nos pacientes com estádios II e III, a margem cirúrgica adequada foi obtida em 51,9% dos pacientes. Radioterapia e quimioterapia adjuvantes foram indicadas em 33,7% e 26,1% dos casos, respectivamente. As recorrências locais e distantes ocorreram em 31,5% e 34,8% dos pacientes, respectivamente. A sobrevida global em 5 anos foi 61,8%. CONCLUSÃO: A maioria dos pacientes atendidos no HAJ é portadora de lesões localmente avançadas, volumosas ou com metástase ao diagnóstico. Os pacientes apresentaram evolução adversa, com altas taxas de recorrência local e distante.

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P850Clinical difference of recent myocardial infarction compared with acute myocardial infarction - Insights from Tokyo CCU network multicenter registry

European Heart Journal ◽

10.1093/eurheartj/ehz747.0448 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

R Ito ◽

M Takayama ◽

J Yamashita ◽

K Yahagi ◽

T Shinke ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Cardiogenic Shock ◽

Cause Of Death ◽

Rank Test ◽

Mechanical Complication ◽

Recent Myocardial Infarction ◽

Log Rank Test ◽

Kaplan Meier ◽

Multicenter Registry

Abstract Background Although the patient's characteristics and outcome of acute myocardial infarction (AMI) have been sufficiently investigated and primary percutaneous coronary intervention (PCI) has been recognized as established treatment strategy, those of recent myocardial infarction (RMI) have not been fully evaluated. Purpose The purpose of the present study was to clarify clinical characteristics and in-hospital outcomes of RMI patients from the database of the Tokyo CCU network multicenter registry. Methods In Tokyo CCU network multicenter registry database from 2013 to 2016, 15788 consecutive patients were registered as AMI (within 24 hours from onset) and RMI (within 2–30 days from onset). However 1246 patients were excluded because of inadequate data. And we excluded 66 cases because of out of onset period and 129 cases that strongly suspected of involvement of vasospastic events. Therefore, remaining 14347 patients were categorized to RMI group (n=1853) and AMI group (n=12494), and analyzed. Results Compared with AMI group, average age was older (70.4±12.9 vs 68.0±13.4 years, p<0.001), male was less (72.4 vs 76.4%, p<0.001), chest pain as chief complaint was less (75.2 vs 83.6%, p<0.001), prevalence of diabetes mellitus was higher (35.9 vs 31.0%, p<0.001), multi-vessel coronary disease was more (54.7 vs 44.6%, p<0.001), patients undergoing PCI was less (79.0 vs 91.2%, p<0.001), and the incidence of mechanical complication was more in RMI group (3.0 vs 1.5%, p<0.001). Although 30-day mortality was equivalent between 2 groups (5.3 vs 5.8%, p=0.360), the major cause of death in AMI group was cardiogenic shock, while in the RMI group it was a mechanical complication. On Kaplan-Meier analysis, the 2 groups had significantly different cumulative incidence of death due to cardiogenic shock (p=0.006, Log-rank test) and mechanical complication (p=0.021, Log-rank test). Furthermore death due to mechanical complication in AMI group was plateau after about 1 week from hospitalization, whereas in RMI group it continued to increase. Kaplan-Meier analysis Conclusions RMI patients had distinctive clinical features in backgrounds and treatment strategies compared with AMI patients, and the major cause of death of RMI patients was different from that of AMI patients. Furthermore, even though treatment during hospitalization of RMI patients was well done, death due to mechanical complications continued to increase.

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