Preliminary Results for a New Final Package Test to Assess the Quality of Sterile Package Systems

2004 ◽  
Vol 25 (1) ◽  
pp. 26-29 ◽  
Author(s):  
Hartmut Dunkelberg ◽  
Silke Wedekind
Keyword(s):  
Bacterial Count ◽  
Pressure Change ◽  
Test Method ◽  
Airborne Bacteria ◽  
Mechanical Device ◽  
Mechanical Pressure ◽  
Packaging System ◽  
Laboratory Errors ◽  
Pressure Changes

AbstractObjectives:To develop a microbial test method to ascertain the passage of airborne bacteria through the medical device packaging System after sterilization, and to apply this test method to flexible packages under mechanical pressure changes.Methods:Petri dishes filled with nutrient agar were integrated into the packaging unit prior to sterilization. We examined paper packaging consisting of 1 (single-paper packaging [P]), 2 (double-paper packaging [PP] and textile and paper double packaging [TP]), and 3 (double packaging with transport packaging [TPP]) layers. After sterilization, the test packages were pressed five times per minute for 1 or 3 hours by a mechanical device weighing 1 kg. This exposure took place in rooms with an average airborne bacterial count of 35 (room 1) or 440 (room 2) CFU/m3. The packaging was opened following culture at 37° C for 48 hours to determine the number of colonies formed.Results:The proportion of contaminated packages rose with the duration of mechanical stress and increased airborne bacteria concentration. Thus, mechanical pressure change for 3 hours resulted in the contamination of 60% (P), 15% (PP), 0% (TP), and 0% (TPP) of the packages in room 1, whereas 100% (P), 65% (PP), 73% (TP), and 0% (TPP) of the packages in room 2 were contaminated.Conclusions:This test method allows sterile packaging Systems to be tested for contamination under practical conditions without extensive laboratory preparation. Contamination as a resuit of laboratory errors can be ruled out almost certainly.

scholarly journals Influence of Temperature and Pressure Change on Adiabatic and Isothermal Methanation Processes

2012 ◽  
Vol 9 (1) ◽  
pp. 22-27 ◽  
Author(s):  
Jekaterina Porubova ◽  
Marco Klemm ◽  
Isabel Kiendl ◽  
Karlis Valters ◽  
Darja Markova ◽  
...  
Keyword(s):  
Natural Gas ◽  
Pressure Change ◽  
Theoretical Modelling ◽  
Transport Sector ◽  
Temperature And Pressure ◽  
Pressure Changes ◽  
The Impact ◽  
Different Sources ◽  
Thermodynamic Equilibrium Calculations

Abstract Energy plans of many countries anticipate an increased use of biomethane for energy supply, i.e., in power and heat production as well as in the transport sector. Existing infrastructure of natural gas storage, supply and application provides a good platform to facilitate transfer to biomethane utilization on a larger scale. One key element of the biomethane system is the upgrade of the biomass-derived synthesis gas originating from different sources, to a quality of natural gas (SNG - Synthesis Natural Gas) via the methanation process for further injection into the natural gas grid.. The maximisation of efficiency of the methanation process is of critical importance in order to make biomethane technology viable for wider application. The aim of the study was to improve efficiency of the methanation process by finding the optimum temperatures and pressure. Theoretical modelling of adiabatic and isothermal methanation processes by using thermodynamic equilibrium calculations was introduced as a method for the study. The results show the impact of temperature and pressure changes on the overall efficiency of methane production. It can be concluded from the study that knowledge about the relation between temperature, pressure and the efficiency of the methanation process makes it possible to optimize the process under various biomass synthesized gas input conditions.

Heart Rate Signal Decomposition

2000 ◽  
Vol 39 (02) ◽  
pp. 200-203
Author(s):  
H. Mizuta ◽  
K. Yana
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Pressure Change ◽  
Normal Subjects ◽  
Signal Decomposition ◽  
Large Individual ◽  
Heart Rate Fluctuations ◽  
Type Pattern ◽  
Signal Cancellation ◽  
Pressure Changes

Abstract:This paper proposes a method for decomposing heart rate fluctuations into background, respiratory and blood pressure oriented fluctuations. A signal cancellation scheme using the adaptive RLS algorithm has been introduced for canceling respiration and blood pressure oriented changes in the heart rate fluctuations. The computer simulation confirmed the validity of the proposed method. Then, heart rate fluctuations, instantaneous lung volume and blood pressure changes are simultaneously recorded from eight normal subjects aged 20-24 years. It was shown that after signal decomposition, the power spectrum of the heart rate showed a consistent monotonic 1/fa type pattern. The proposed method enables a clear interpretation of heart rate spectrum removing uncertain large individual variations due to the respiration and blood pressure change.

Customer’s satisfaction on service quality at Vietnam Technological and Commercial Joint Stock Bank – An Giang Branch

2020 ◽  
Vol 4 (3) ◽  
pp. First
Author(s):  
Tran Minh Hieu ◽  
Nguyen Duong Ngoc Mai Chi
Keyword(s):  
Customer Satisfaction ◽  
Service Quality ◽  
Test Method ◽  
Quality Of Services ◽  
Factors Affecting ◽  
Factors Influencing ◽  
Alpha Reliability ◽  
Survey Results ◽  
Development Orientation

This study applied SERVQUAL scale of Parasuraman et al to measure factors affecting customer satisfaction on service quality at Vietnam Technological and Commercial Joint Stock Bank - An Giang Branch (Techcombank An Giang). The study was conducted to survey 207 customers who have been using the service at Techcombank An Giang. The survey results were analyzed by the Cronbach's Alpha reliability test method, then used Exploratory factor analysis (EFA) to verify and evaluate the scale of service quality. The results of the regression analysis show that customer's satisfaction about service quality at Techcombank An Giang includes four factors: The factor with the highest level is the Empathy with Beta = 0.253, the second of factor is the Responsibility with Beta = 0.248, ranked third in the influence level is the Tangible with Beta = 0.235, and the lowest impact level is the Reliability with Beta = 0.144. The research also uses statistical methods to describe and test the differences of demographic factors with customer's satisfactionon service quality.The analysis results show that there is no difference between customer's satisfaction on service quality and factors such as gender, age, income, number of transaction banks, regular transaction banks, and time to use the service at Techcombank An Giang. Through the research results, the author would like to propose some ideas to improve the quality of services, thereby attracting new customers and importantly, keeping traditional customers because the development orientation of Techcombank is to take care of old customers to cross sell other products of the bank. The Stud results offer a basis for the branch to identify the factors influencing customer satisfaction on their service quality, thereby having an appropriate strategy to improve customer satisfaction.

scholarly journals Physical Characteristics and Microbial Quality of Ostrich Meat in Relation to the Type of Packaging and Refrigerator Storage Time

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3445
Author(s):  
Olaf K. Horbańczuk ◽  
Artur Jóźwik ◽  
Jarosław Wyrwisz ◽  
Joanna Marchewka ◽  
Agnieszka Wierzbicka
Keyword(s):  
Storage Time ◽  
Modified Atmosphere Packaging ◽  
Physical Characteristics ◽  
Modified Atmosphere ◽  
Packaging System ◽  
Initial Ph ◽  
Viable Bacteria ◽  
L Value ◽  
Meat Samples

The aim of this study was to evaluate the effect of the packaging system type on the physical characteristics and microbial changes in ostrich meat during refrigerated storage. The applied packaging systems were vacuum packaging (VP) and modified atmosphere packaging (MAP) using two combinations of gases: MAP1 (40% O2/40% CO2/20% N2) and MAP2 (60% O2/30% CO2/10% N2). Eight meat samples were obtained in three replicates for all parameters, except for pH, for which six replicates were obtained from the M. ilifibularis (IF) muscle, and were stored in a refrigerator at 2 °C and analyzed at 0, 4, 8, 12 and 16 days for the effect of packaging methods on physical meat quality. The initial pH (5.99) decreased at the end of the storage time for MAP1 to 5.81, whereas VP was stable from day 0 to 12 and increased up to 6.08 on day 16. Regarding meat color, the L* value increased during storage for MAP1 and MAP2 from 36.99 to 40.75 and 41.60, respectively, whereas it declined for VP to 34.22. The same tendencies were reported for redness (a*) and yellowness (b*). Drip loss was the lowest in MAP1 and highest in VP. The lowest total viable bacteria counts were identified in VP, as compared to MAP1 and MAP2.

Research on the V/H Inspection of Spiral Bevel Gear before Heat Treatment

2013 ◽  
Vol 483 ◽  
pp. 166-169
Author(s):  
Jia Lun Qiu ◽  
Rui Rong Zhao ◽  
Ying Jie Wang ◽  
Wei Zhao ◽  
Jing Cai Li
Keyword(s):  
Heat Treatment ◽  
Contact Region ◽  
Bevel Gear ◽  
Test Method ◽  
Spiral Bevel Gear ◽  
Basic Definition ◽  
Technical Process ◽  
Inspection Method ◽  
Spiral Bevel

The V / H inspection method is analyzed, including its basic definition, purpose and V / H inspection technical process of Gleason Company. In order to improve the quality of the contact region, Gleasons V / H test method is conducted for V/H inspection of spiral bevel gear before heat treatment, and analysis of experimental data is given.

Analysis of the Test Method of Quartz Glass Optical Homogeneity

2017 ◽  
Vol 726 ◽  
pp. 414-418
Author(s):  
Bo Fu ◽  
Hui Wang ◽  
Zhu Feng Shao
Keyword(s):  
Quartz Glass ◽  
Measurement Accuracy ◽  
Test Methods ◽  
Test Method ◽  
Wavefront Aberration ◽  
Optical Homogeneity ◽  
Advantages And Disadvantages ◽  
Interference Measurement ◽  
Optical Quartz Glass

The optical quartz glass is widely applied in optical system , photo communications，inertial navigation，etc.It must have high optical homogeneity. Optical homogeneity of the optical quartz glass directly affects the wavefront quality of the optical transmission system, and changes the wavefront aberration of the system. How to accurately determine the optical homogeneity of the quartz glass is especially important. Currently，the method of test for optical homogeneity mainly used by interference principle. This paper analyzes various existing interference measurement method and test equipment. Summarized the advantages and disadvantages of various test methods，using range and measurement accuracy.

Study of Toynbee Phenomenon by Combined Intranasopharyngeal and Tympanometric Measurements

1988 ◽  
Vol 97 (2) ◽  
pp. 199-206 ◽  
Author(s):  
Yehuda Finkelstein ◽  
Yuval Zohar ◽  
Yoav P. Talmi ◽  
Nelu Laurian
Keyword(s):  
Middle Ear ◽  
Negative Pressure ◽  
Pressure Change ◽  
Positive Pressure ◽  
New Information ◽  
Pressure Changes ◽  
Rapid Pressure

The Toynbee maneuver, swallowing when the nose is obstructed, leads in most cases to pressure changes in one or both middle ears, resulting in a sensation of fullness. Since first described, many varying and contradictory comments have been reported in the literature concerning the type and amount of pressure changes both in the nasopharynx and in the middle ear. In our study, the pressure changes were determined by catheters placed into the nasopharynx and repeated tympanometric measurements. New information concerning the rapid pressure variations in the nasopharynx and middle ear during deglutition with an obstructed nose was obtained. Typical individual nasopharyngeal pressure change patterns were recorded, ranging from a maximal positive pressure of + 450 to a negative pressure as low as −320 mm H2O.

Airborne bacteria concentrations and related factors at university laboratories, hospital diagnostic laboratories and a biowaste site

2011 ◽  
Vol 64 (3) ◽  
pp. 261-264 ◽  
Author(s):  
Sung Ho Hwang ◽  
Dong Uk Park ◽  
Kwon Chul Ha ◽  
Hyun Woo Cho ◽  
Chung Sik Yoon
Keyword(s):  
Sampling Site ◽  
Ventilation System ◽  
Airborne Bacteria ◽  
Gram Negative Bacteria ◽  
Indoor Environments ◽  
Related Factors ◽  
P Values ◽  
Regular Control ◽  
Number Of Bacteria

AimsTo evaluate concentrations of airborne bacteria in university laboratories, hospital diagnostic laboratories, and a biowaste site in Seoul, Korea. To measure total airborne bacteria (TAB), the authors assessed sampling site, type of ventilation system, weather and detection of Gram-negative bacteria (GNB), indoors and outdoors.MethodAn Andersen one-stage sampler (Quick Take 30; SKC Inc) was used to sample air at a flow rate of 28.3 l/min for 5 min on nutrient medium in Petri dishes located on the impactor. A total of 236 samples (TAB, 109 indoor and nine outdoor; GNB, 109 indoor and nine outdoor) were collected three times in each spot from the 11 facilities to compare airborne bacteria concentrations.ResultsTAB concentrations ranged from undetectable to 3451 CFU/m3 (mean 384 CFU/m3), and GNB concentrations from undetectable to 394 CFU/m3 (mean 17 CFU/m3). TAB concentrations were high in window-ventilated facilities and facilities in which GNB were detected; concentrations were also high when it was rainy (all p values <0.05). TAB concentrations correlated significantly with GNB (r=0.548, p<0.01), number of bacteria species (r=0.351, p<0.01) and temperature (r=0.297, p<0.01). The presence of heating, ventilating, and air conditioning (HVAC), the number of TAB species and the detection of GNB affect TAB concentrations in laboratories.ConclusionsIt is recommended that special attention be given to regular control of indoor environments to improve the air quality of university and hospital laboratories.

Quality of Airborne Bacteria in Operating Theaters in Several Hospitals in Jakarta and Its Surrounding Areas in 2018-2019

2020 ◽  
Vol 14 (4) ◽  
pp. 140-148
Author(s):  
CONNY RIANA TJAMPAKASARI ◽  
◽  
NABILA NAURA ◽  
TJAHJANI MIRAWATI SUDIRO ◽  
◽  
...  
Keyword(s):  
Airborne Bacteria ◽  
Surrounding Areas

Association between ibrutinib treatment and hypertension

Heart ◽  
2021 ◽  
pp. heartjnl-2021-319110
Author(s):  
Dae Hyun Lee ◽  
Fahad Hawk ◽  
Kieun Seok ◽  
Matthew Gliksman ◽  
Josephine Emole ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Repeated Measures ◽  
Treatment Initiation ◽  
Kinase Inhibitor ◽  
Pressure Change ◽  
Exact Test ◽  
N 93 ◽  
Pressure Changes ◽  
Over Time

BackgroundIbrutinib is a tyrosine kinase inhibitor most commonly associated with atrial fibrillation. However, additional cardiotoxicities have been identified, including accelerated hypertension. The incidence and risk factors of new or worsening hypertension following ibrutinib treatment are not as well known.MethodsWe conducted a retrospective study of 144 patients diagnosed with B cell malignancies treated with ibrutinib (n=93) versus conventional chemoimmunotherapy (n=51) and evaluated their effects on blood pressure at 1, 2, 3 and 6 months after treatment initiation. Descriptive statistics were used to compare baseline characteristics for each treatment group. Fisher’s exact test was used to identify covariates significantly associated with the development of hypertension. Repeated measures analyses were conducted to analyse longitudinal blood pressure changes.ResultsBoth treatments had similar prevalence of baseline hypertension at 63.4% and 66.7%, respectively. There were no differences between treatments by age, sex and baseline cardiac comorbidities. Both systolic and diastolic blood pressure significantly increased over time with ibrutinib compared with baseline, whereas conventional chemoimmunotherapy was not associated with significant changes in blood pressure. Baseline hypertensive status did not affect the degree of blood pressure change over time. A significant increase in systolic blood pressure (defined as more than 10 mm Hg) was noted for ibrutinib (36.6%) compared with conventional chemoimmunotherapy (7.9%) at 1 month after treatment initiation. Despite being hypertensive at follow-up, 61.2% of patients who were treated with ibrutinib did not receive adequate blood pressure management (increase or addition of blood pressure medications). Within the ibrutinib group, of patients who developed more than 20 mm Hg increase in systolic blood pressure, only 52.9% had hypertension management changes.ConclusionsIbrutinib is associated with the development of hypertension and worsening of blood pressure. Cardiologists and oncologists must be aware of this cardiotoxicity to allow timely management of blood pressure elevations.

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