Mathematical modeling and control for cancer treatment with cold atmospheric plasma jet

2019 ◽  
Vol 52 (18) ◽  
pp. 185202 ◽  
Author(s):  
Yuanwei Lyu ◽  
Li Lin ◽  
Eda Gjika ◽  
Taeyoung Lee ◽  
Michael Keidar
2018 ◽  
Vol 18 (6) ◽  
pp. 769-775 ◽  
Author(s):  
Dayun Yan ◽  
Jonathan H. Sherman ◽  
Michael Keidar

Background: Over the past five years, the cold atmospheric plasma-activated solutions (PAS) have shown their promissing application in cancer treatment. Similar as the common direct cold plasma treatment, PAS shows a selective anti-cancer capacity in vitro and in vivo. However, different from the direct cold atmospheric plasma (CAP) treatment, PAS can be stored for a long time and can be used without dependence on a CAP device. The research on PAS is gradually becoming a hot topic in plasma medicine. Objectives: In this review, we gave a concise but comprehensive summary on key topics about PAS including the development, current status, as well as the main conclusions about the anti-cancer mechanism achieved in past years. The approaches to make strong and stable PAS are also summarized.


Processes ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 249
Author(s):  
Zhitong Chen ◽  
Richard Obenchain ◽  
Richard E. Wirz

Conventional plasma jets for biomedical applications tend to have several drawbacks, such as high voltages, high gas delivery, large plasma probe volume, and the formation of discharge within the organ. Therefore, it is challenging to employ these jets inside a living organism’s body. Thus, we developed a single-electrode tiny plasma jet and evaluated its use for clinical biomedical applications. We investigated the effect of voltage input and flow rate on the jet length and studied the physical parameters of the plasma jet, including discharge voltage, average gas and subject temperature, and optical emissions via spectroscopy (OES). The interactions between the tiny plasma jet and five subjects (de-ionized (DI) water, metal, cardboard, pork belly, and pork muscle) were studied at distances of 10 mm and 15 mm from the jet nozzle. The results showed that the tiny plasma jet caused no damage or burning of tissues, and the ROS/RNS (reactive oxygen/nitrogen species) intensity increased when the distance was lowered from 15 mm to 10 mm. These initial observations establish the tiny plasma jet device as a potentially useful tool in clinical biomedical applications.


2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Dayun Yan ◽  
Wenjun Xu ◽  
Xiaoliang Yao ◽  
Li Lin ◽  
Jonathan H. Sherman ◽  
...  

2013 ◽  
Vol 10 (8) ◽  
pp. 706-713 ◽  
Author(s):  
Sander Bekeschus ◽  
Kai Masur ◽  
Julia Kolata ◽  
Kristian Wende ◽  
Anke Schmidt ◽  
...  

2019 ◽  
Vol 47 (11) ◽  
pp. 4848-4860 ◽  
Author(s):  
Donghai Li ◽  
Guiling Li ◽  
Jing Li ◽  
Zhi-Qiang Liu ◽  
Xuman Zhang ◽  
...  

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