Mathematical modeling and control for cancer treatment with cold atmospheric plasma jet

2019 ◽  
Vol 52 (18) ◽  
pp. 185202 ◽  
Author(s):  
Yuanwei Lyu ◽  
Li Lin ◽  
Eda Gjika ◽  
Taeyoung Lee ◽  
Michael Keidar
Keyword(s):  
Mathematical Modeling ◽  
Cancer Treatment ◽  
Plasma Jet ◽  
Atmospheric Plasma ◽  
Modeling And Control ◽  
Cold Atmospheric Plasma ◽  
And Control

The Application of the Cold Atmospheric Plasma-Activated Solutions in Cancer Treatment

2018 ◽  
Vol 18 (6) ◽  
pp. 769-775 ◽  
Author(s):  
Dayun Yan ◽  
Jonathan H. Sherman ◽  
Michael Keidar
Keyword(s):  
Cancer Treatment ◽  
Atmospheric Plasma ◽  
Current Status ◽  
Cold Atmospheric Plasma ◽  
Anti Cancer ◽  
Long Time ◽  
Key Topics ◽  
The Common

Background: Over the past five years, the cold atmospheric plasma-activated solutions (PAS) have shown their promissing application in cancer treatment. Similar as the common direct cold plasma treatment, PAS shows a selective anti-cancer capacity in vitro and in vivo. However, different from the direct cold atmospheric plasma (CAP) treatment, PAS can be stored for a long time and can be used without dependence on a CAP device. The research on PAS is gradually becoming a hot topic in plasma medicine. Objectives: In this review, we gave a concise but comprehensive summary on key topics about PAS including the development, current status, as well as the main conclusions about the anti-cancer mechanism achieved in past years. The approaches to make strong and stable PAS are also summarized.

scholarly journals Tiny Cold Atmospheric Plasma Jet for Biomedical Applications

Processes ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 249
Author(s):  
Zhitong Chen ◽  
Richard Obenchain ◽  
Richard E. Wirz
Keyword(s):  
Biomedical Applications ◽  
Plasma Jet ◽  
Discharge Voltage ◽  
Plasma Jets ◽  
Atmospheric Plasma ◽  
Physical Parameters ◽  
Cold Atmospheric Plasma ◽  
Water Metal ◽  
Plasma Probe ◽  
Jet Nozzle

Conventional plasma jets for biomedical applications tend to have several drawbacks, such as high voltages, high gas delivery, large plasma probe volume, and the formation of discharge within the organ. Therefore, it is challenging to employ these jets inside a living organism’s body. Thus, we developed a single-electrode tiny plasma jet and evaluated its use for clinical biomedical applications. We investigated the effect of voltage input and flow rate on the jet length and studied the physical parameters of the plasma jet, including discharge voltage, average gas and subject temperature, and optical emissions via spectroscopy (OES). The interactions between the tiny plasma jet and five subjects (de-ionized (DI) water, metal, cardboard, pork belly, and pork muscle) were studied at distances of 10 mm and 15 mm from the jet nozzle. The results showed that the tiny plasma jet caused no damage or burning of tissues, and the ROS/RNS (reactive oxygen/nitrogen species) intensity increased when the distance was lowered from 15 mm to 10 mm. These initial observations establish the tiny plasma jet device as a potentially useful tool in clinical biomedical applications.

scholarly journals The Cell Activation Phenomena in the Cold Atmospheric Plasma Cancer Treatment

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Dayun Yan ◽  
Wenjun Xu ◽  
Xiaoliang Yao ◽  
Li Lin ◽  
Jonathan H. Sherman ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Cell Activation ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

Human Mononuclear Cell Survival and Proliferation is Modulated by Cold Atmospheric Plasma Jet

2013 ◽  
Vol 10 (8) ◽  
pp. 706-713 ◽  
Author(s):  
Sander Bekeschus ◽  
Kai Masur ◽  
Julia Kolata ◽  
Kristian Wende ◽  
Anke Schmidt ◽  
...  
Keyword(s):  
Cell Survival ◽  
Mononuclear Cell ◽  
Plasma Jet ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma ◽  
Human Mononuclear Cell ◽  
Cell Survival And Proliferation

Promotion of Wound Healing of Genetic Diabetic Mice Treated by a Cold Atmospheric Plasma Jet

2019 ◽  
Vol 47 (11) ◽  
pp. 4848-4860 ◽  
Author(s):  
Donghai Li ◽  
Guiling Li ◽  
Jing Li ◽  
Zhi-Qiang Liu ◽  
Xuman Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Plasma Jet ◽  
Atmospheric Plasma ◽  
Diabetic Mice ◽  
Cold Atmospheric Plasma
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