Osmotic fragility in essential hypertension revisited: A correlation with Iron status and lipid profile

Background: Essential hypertension is a major public health associated with increase pressure on the vascular walls and red blood cells (RBCs). In the present work, osmotic fragility (OF) of RBCs was reexamined in the means of its correlation with two risk factor; iron status and lipid profile. Experimental: OF, iron status parameters, and lipid profile components were measured in 60 patients and compared with the results of 30 controls. Results: The results showed a significant increase in all iron indices of hypertensive patients in comparing with healthy control group except TIBC, UIBC, and transferrin concentrations, which decrease in these patients in comparing with control group. Serum TGs, total cholesterol, VLDLc, and LDLc were increased while there is no significant in serum HDLc in patients to comparing with control group. There is no significant change in OF between patients and controls where p=0.173. The iron status parameters and lipid profile components were dependent on sex and smoking state. Hemoglobin and PCV were correlated significantly with total cholesterol and LDLc. Transferrin saturation showed a positive correlation with cholesterol, LDLc, and TGs, but negatively correlated with HDLc. No significant correlation between all the measured parameters and OF in HT patients. There is a significant correlation between serum ferritin and systolic BP and between Hb and systolic BP. Conclusion: No significant effect on the OF in HT patients. HT patients have elevated level of iron parameters in comparing with controls. OD has no correlation with iron status parameters or with lipid profile components.

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OP-027 Effects of Newly Begun Carvedilol and Nebivolol Treatment on Insulin Resistance and Lipid Profile in Patients with Essential Hypertension

The American Journal of Cardiology ◽

10.1016/j.amjcard.2015.01.073 ◽

2015 ◽

Vol 115 ◽

pp. S12

Author(s):

Ali Gökhan Özyıldız ◽

Serpil Eroğlu ◽

Uğur Abbas Bal ◽

Ilyas Atar ◽

Kaan Okyay ◽

...

Keyword(s):

Insulin Resistance ◽

Essential Hypertension ◽

Lipid Profile

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Association of Hypertensive Retinopathy with different serum lipid parameters in patients of Essential Hypertension: A Hospital Based Study

Journal of Nobel Medical College ◽

10.3126/jonmc.v7i2.22308 ◽

2018 ◽

Vol 7 (2) ◽

pp. 50-57

Author(s):

Bishwa Nath Adhikari ◽

Pramod Sharma Gautam ◽

Binod Bekoju ◽

Sadhana Basnet ◽

Himlal Bhandari

Keyword(s):

Essential Hypertension ◽

Lipid Profile ◽

Serum Lipid ◽

Cross Sectional Study ◽

Serum Lipid Profile ◽

Hypertensive Retinopathy ◽

Cross Sectional ◽

Hypertensive Patients ◽

Medical College ◽

Department Of Ophthalmology

Introduction: Abnormalities in serum lipid and lipoprotein levels are recognized as major modifiable risk factors for cardiovascular disease and essential hypertension and retinopathy. So this study was conducted to evaluate the role of dyslipidemia on development of retinopathy in hypertensive patients and to establish the association of parameters of serum lipid profile with hypertensive retinopathy. Materials and Methods: A cross-sectional study was conducted in Ophthalmology Department among 135 patients in Nobel Medical College and Teaching Hospital (NoMCTH), Biratnagar who were diagnosed with essential hypertension. Patients having diabetes mellitus, myopia, hazy ocular media and other posterior segment disorders were excluded from the study. The detailed ophthalmic examination was carried out in department of ophthalmology, NoMCTH, Biratnagar and all the study population were investigated for fasting serum lipid profile. Result: Out of 135 patients with essential hypertension, 65.44% had retinopathy and remaining had no signs of retinopathy. Mean age of patients were 60.24 (±15.14) years. Although no gender preponderance was found with retinopathy but this study showed that hypertensive retinopathy increases significantly with increase in age and its incidence increases after the age of 60 years. Conclusion: The duration of hypertension was found to be strongly associated with development of hypertensive retinopathy. The increase in all the lipid profile parameters (Serum TG, TC, and LDL and LDL:HDL) and the obesity were found to be strongly associated with retinopathy in hypertensive patients.

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Optimized dosage of vegan source blended omega3 and omega 6 fatty acids improves circadian variability of blood pressure and lipid profile in patients with essential hypertension and coronary artery disease

Atherosclerosis ◽

10.1016/j.atherosclerosis.2020.10.499 ◽

2020 ◽

Vol 315 ◽

pp. e161

Author(s):

K. Bhardwaj ◽

N. Verma ◽

R. Trivedi ◽

R.B. Singh ◽

S. Bhardwaj

Keyword(s):

Blood Pressure ◽

Coronary Artery Disease ◽

Fatty Acids ◽

Essential Hypertension ◽

Coronary Artery ◽

Lipid Profile ◽

Omega 6 ◽

Artery Disease

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Effects of Carvedilol Compared to Nebivolol on Insulin Resistance and Lipid Profile in Patients With Essential Hypertension

Journal of Cardiovascular Pharmacology and Therapeutics ◽

10.1177/1074248416644987 ◽

2016 ◽

Vol 22 (1) ◽

pp. 65-70 ◽

Cited By ~ 6

Author(s):

Ali Gokhan Ozyıldız ◽

Serpil Eroglu ◽

Ugur Bal ◽

Ilyas Atar ◽

Kaan Okyay ◽

...

Keyword(s):

Insulin Resistance ◽

Blood Pressure ◽

Essential Hypertension ◽

Lipid Profile ◽

Total Cholesterol ◽

Apolipoprotein B ◽

Beta Blockers ◽

Density Lipoprotein ◽

Apolipoprotein Ai ◽

New Generation

Background and aim: Beta-blockers have unfavorable effects on metabolic parameters in hypertensive treatment. New generation beta-blockers with vasodilatory capabilities are superior to traditional beta-blockers, but studies examining their effects on metabolic parameters are still lacking. This study aimed to compare the effects of 2 new generation beta-blockers, carvedilol and nebivolol, on insulin resistance (IR) and lipid profiles in patients with essential hypertension. Methods: This was a prospective, randomized, open-label, single-center clinical trial. A total of 80 patients were randomized into 2 groups: the carvedilol group (n = 40, 25 mg of carvedilol daily) and the nebivolol group (n = 40, 5 mg of nebivolol daily). Follow-up was performed for 4 months. Fasting plasma glucose, insulin levels, and the lipid profile (high-density lipoprotein [HDL], low-density lipoprotein [LDL], total cholesterol, triglyceride, apolipoprotein AI, and apolipoprotein B levels) were measured and IR was calculated by the homeostasis model assessment (HOMA) index. These variables were compared before and 4 months after treatment. Results: Blood pressure and heart rate were significantly and similarly reduced in the carvedilol and nebivolol groups after treatment compared to those before treatment (both P < .001). Serum glucose ( P < .001), insulin ( P < .01), HOMA-IR (P < .01), HDL ( P < .001), LDL ( P < .001), total cholesterol ( P < .001), and apolipoprotein B ( P < .05) levels decreased in a similar manner in the carvedilol and nebivolol groups after treatment compared to those before treatment. Serum triglyceride and apolipoprotein AI levels did not change after treatment with both drugs. Conclusion: New generation beta-blockers, carvedilol and nebivolol, efficiently and similarly decrease blood pressure. They have similar favorable effects on glucose, insulin, IR, and the lipid profile.

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Enhanced calcium-sensitivity of erythrocytes in hypertension. Calcium-induced changes of erythrocyte osmotic fragility in essential hypertension.

Japanese Circulation Journal ◽

10.1253/jcj.50.1158 ◽

1986 ◽

Vol 50 (11) ◽

pp. 1158-1164 ◽

Cited By ~ 3

Author(s):

Kazushi TSUDA ◽

Yohsuke MINATOGAWA ◽

Seiko FURUYA ◽

Eizo UEDA ◽

Yoshio KUSUYAMA ◽

...

Keyword(s):

Essential Hypertension ◽

Osmotic Fragility ◽

Calcium Sensitivity ◽

Erythrocyte Osmotic Fragility ◽

Induced Changes

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The Effects of Dietary Polyphenols on Circulating Cardiovascular Disease Biomarkers and Iron Status: A Systematic Review

Nutrition and Metabolic Insights ◽

10.1177/1178638819882739 ◽

2019 ◽

Vol 12 ◽

pp. 117863881988273 ◽

Cited By ~ 5

Author(s):

Hollie Speer ◽

Nathan M D’Cunha ◽

Michal Botek ◽

Andrew J McKune ◽

Domenico Sergi ◽

...

Keyword(s):

Systematic Review ◽

Cardiovascular Disease ◽

Lipid Profile ◽

Inflammatory Markers ◽

Iron Status ◽

Iron Bioavailability ◽

Current Status ◽

Cochrane Library ◽

Dietary Polyphenols ◽

The Relationship

The prevalence of cardiovascular disease (CVD) is rising worldwide, remaining the major cause of death in developed countries. Polyphenols have been shown to have cardioprotective properties; however, their impact on iron bioavailability and potential impact on other aspects of health is unclear. A systematic review was undertaken to evaluate the current status of the relationship between habitual polyphenol consumption, iron status, and circulating biomarkers of CVD. Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2009 guidelines, searches were performed across 5 electronic databases (PubMed, Cochrane Library, Scopus, Web of Science, and CINAHL) to identify randomized controlled trials which investigated the effects of polyphenol consumption on inflammatory markers, serum lipid profile, and iron absorption and bioavailability. In total, 1174 records were identified, with only 7 studies meeting the inclusion criteria. The selected studies involved 133 participants and used a variety of foods and supplements, including olive oil and cherries, rich in polyphenols including hydroxytyrosol, quercetin, and resveratrol, as well as catechin enriched drinks. The duration of the studies ranged from between 56 and 145 days, with total polyphenolic content of the food items and supplements ranging from 45 to 1015 mg (per 100 g). Polyphenols did not appear to interfere with iron status, and most studies reported improvements in inflammatory markers and lipid profile. While these results are promising, the limited number of studies and considerable heterogeneity across the interventions support the need for more extensive trials assessing the relationship between polyphenol intake, iron bioavailability, and CVD risk.

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