scholarly journals The impact of laser-induced thermocoagulation effects on the optical spectra of brain tissues

2021 ◽  
Vol 2103 (1) ◽  
pp. 012045
Author(s):  
E Kh Israpov ◽  
K M Giraev ◽  
N A Ashurbekov ◽  
K M Rabadanov ◽  
M A Magomedov
Keyword(s):  
Optical Properties ◽  
Spatial Distribution ◽  
Grey Matter ◽  
Laser Radiation Intensity ◽  
Structural Elements ◽  
Optical Studies ◽  
Biological Objects ◽  
Laser Hyperthermia ◽  
The Impact ◽  
The Brain

Abstract In this work, the results of spectral and optical studies of the grey matter tissues of the brain by a laser hyperthermia action are presented. The coefficients of optical absorption and transport scattering in the spectral range of 250-1500 nm are determined, and the features of the spatial distribution of the laser radiation intensity in the studied objects are identified. It is shown that the coagulation effects lead to compaction and an increase in the concentration of endogenous chromophores and structural elements, which is reflected in the optical properties of biological objects.

scholarly journals Brain imaging before and after COVID-19 in UK Biobank

2021 ◽  
Author(s):  
Gwenaëlle Douaud ◽  
Soojin Lee ◽  
Fidel Alfaro-Almagro ◽  
Christoph Arthofer ◽  
Chaoyue Wang ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Grey Matter ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Uk Biobank ◽  
Hospitalised Patients ◽  
Imaging Results ◽  
Before And After ◽  
The Impact ◽  
The Brain

There is strong evidence for brain-related pathologies in COVID-19, some of which could be a consequence of viral neurotropism. The vast majority of brain imaging studies so far have focused on qualitative, gross pathology of moderate to severe cases, often carried out on hospitalised patients. It remains unknown however whether the impact of COVID-19 can be detected in milder cases, in a quantitative and automated manner, and whether this can reveal a possible mechanism for the spread of the disease. UK Biobank scanned over 40,000 participants before the start of the COVID-19 pandemic, making it possible to invite back in 2021 hundreds of previously-imaged participants for a second imaging visit. Here, we studied the effects of the disease in the brain using multimodal data from 782 participants from the UK Biobank COVID-19 re-imaging study, with 394 participants having tested positive for SARS- CoV-2 infection between their two scans. We used structural and functional brain scans from before and after infection, to compare longitudinal brain changes between these 394 COVID- 19 patients and 388 controls who were matched for age, sex, ethnicity and interval between scans. We identified significant effects of COVID-19 in the brain with a loss of grey matter in the left parahippocampal gyrus, the left lateral orbitofrontal cortex and the left insula. When looking over the entire cortical surface, these results extended to the anterior cingulate cortex, supramarginal gyrus and temporal pole. We further compared COVID-19 patients who had been hospitalised (n=15) with those who had not (n=379), and while results were not significant, we found comparatively similar findings to the COVID-19 vs control group comparison, with, in addition, a greater loss of grey matter in the cingulate cortex, central nucleus of the amygdala and hippocampal cornu ammonis (all |Z|>3). Our findings thus consistently relate to loss of grey matter in limbic cortical areas directly linked to the primary olfactory and gustatory system. Unlike in post hoc disease studies, the availability of pre- infection imaging data helps avoid the danger of pre-existing risk factors or clinical conditions being mis-interpreted as disease effects. Since a possible entry point of the virus to the central nervous system might be via the olfactory mucosa and the olfactory bulb, these brain imaging results might be the in vivo hallmark of the spread of the disease (or the virus itself) via olfactory and gustatory pathways.

Influence of the distribution of the shear walls on the seismic response of the buildings

2020 ◽  
Vol 15 (1) ◽  
pp. 37-44
Author(s):  
El Mehdi Echebba ◽  
Hasnae Boubel ◽  
Oumnia Elmrabet ◽  
Mohamed Rougui
Keyword(s):  
Structural Analysis ◽  
Seismic Response ◽  
Natural Frequency ◽  
Structural Design ◽  
Structural Response ◽  
Shear Walls ◽  
Structural Elements ◽  
Analysis Software ◽  
Ansys Apdl ◽  
The Impact

Abstract In this paper, an evaluation was tried for the impact of structural design on structural response. Several situations are foreseen as the possibilities of changing the distribution of the structural elements (sails, columns, etc.), the width of the structure and the number of floors indicates the adapted type of bracing for a given structure by referring only to its Geometric dimensions. This was done by studying the effect of the technical design of the building on the natural frequency of the structure with the study of the influence of the distribution of the structural elements on the seismic response of the building, taking into account of the requirements of the Moroccan earthquake regulations 2000/2011 and using the ANSYS APDL and Robot Structural Analysis software.

What's Left of the Law of Integration?

2018 ◽  
Author(s):  
Julio Baquero Cruz
Keyword(s):  
International Law ◽  
Fundamental Rights ◽  
Structural Elements ◽  
The European Union ◽  
Difficult Situation ◽  
Court Of Justice ◽  
Structural Connections ◽  
The Law ◽  
Constitutional Pluralism ◽  
The Impact

This book discusses the impact of the difficult situation the European Union is currently going through on some structural elements of its legal order, looking for symptoms of decay, exploring examples of resistance, and assessing its overall state of health. The original choices made by the drafters of the Treaties and by the Court of Justice are put in their proper historical perspective, understanding Union law as a tool of civilization, and explaining its current problems, at least in part, as a consequence of the waning of the initial impetus behind integration. The concrete themes to be explored are the following: primacy, the national resistance to it and constitutional pluralism; the preliminary rulings procedure; Union citizenship, equality, and human dignity; the scope of the Charter and the standard of protection of fundamental rights; and the rigidity and fragmentation of the Union system in connection with the recent occasional use of international law as an alternative to Union law. The book looks at the development of the law throughout the decades, inevitably losing much detail, but hopefully also uncovering structural connections and continuities.

Modelling Agricultural Controls for Flooding and Soil Erosion

2018 ◽  
pp. 776-796
Author(s):  
Roger Moussa ◽  
Bruno Cheviron
Keyword(s):  
Spatial Distribution ◽  
Model Structure ◽  
Land Uses ◽  
Research Challenges ◽  
Water And Sediment ◽  
Flow Processes ◽  
Cultivation Practices ◽  
Modelling Strategies ◽  
The Impact ◽  
Significant Factors

Floods are the highest-impact natural disasters. In agricultural basins, anthropogenic features are significant factors in controlling flood and erosion. A hydrological-hydraulic-erosion diagnosis is necessary in order to choose the most relevant action zones and to make recommendations for alternative land uses and cultivation practices in order to control and reduce floods and erosion. This chapter first aims to provide an overview of the flow processes represented in the various possible choices of model structure and refinement. It then focuses on the impact of the spatial distribution and temporal variation of hydrological soil properties in farmed basins, representing their effects on the modelled water and sediment flows. Research challenges and leads are then tackled, trying to identify the conditions in which sufficient adequacy exists between site data and modelling strategies.

scholarly journals Synthesis of PVA/CeO2 Based Nanocomposites with Tuned Refractive Index and Reduced Absorption Edge: Structural and Optical Studies

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1570
Author(s):  
Shujahadeen B. Aziz ◽  
Elham M. A. Dannoun ◽  
Dana A. Tahir ◽  
Sarkawt A. Hussen ◽  
Rebar T. Abdulwahid ◽  
...  
Keyword(s):  
Refractive Index ◽  
Optical Properties ◽  
Absorption Edge ◽  
Ceo2 Nanoparticles ◽  
Poly Vinyl Alcohol ◽  
Optical Parameters ◽  
Single Oscillator Model ◽  
Vis Spectroscopy ◽  
The Impact ◽  
Host Polymer

In the current study, polymer nanocomposites (NCPs) based on poly (vinyl alcohol) (PVA) with altered refractive index and absorption edge were synthesized by means of a solution cast technique. The characterization techniques of UV–Vis spectroscopy and XRD were used to inspect the structural and optical properties of the prepared films. The XRD patterns of the doped samples have shown clear amendments in the structural properties of the PVA host polymer. Various optical parameters were studied to get more insights about the influence of CeO2 on optical properties of PVA. On the insertion of CeO2 nanoparticles (NPs) into the PVA matrix, the absorption edge was found to move to reduced photon energy sides. It was concluded that the CeO2 nanoparticles can be used to tune the refractive index (n) of the host polymer, and it reached up to 1.93 for 7 wt.% of CeO2 content. A detailed study of the bandgap (BG) was conducted using two approaches. The outcomes have confirmed the impact of the nanofiller on the BG reduction of the host polymer. The results of the optical BG study highlighted that it is crucial to address the ɛ” parameter during the BG analysis, and it is considered as a useful tool to specify the type of electronic transitions. Finally, the dispersion region of n is conferred in terms of the Wemple–DiDomenico single oscillator model.

scholarly journals The impact of fluence dependent 120 MeV Ag swift heavy ion irradiation on the changes in structural, electronic, and optical properties of AgInSe2 nano-crystalline thin films for optoelectronic applications

RSC Advances ◽  
2021 ◽  
Vol 11 (42) ◽  
pp. 26218-26227
Author(s):  
R. Panda ◽  
S. A. Khan ◽  
U. P. Singh ◽  
R. Naik ◽  
N. C. Mishra
Keyword(s):  
Thin Films ◽  
Optical Properties ◽  
Ion Irradiation ◽  
Heavy Ion ◽  
Swift Heavy Ion Irradiation ◽  
Heavy Ion Irradiation ◽  
Swift Heavy Ion ◽  
Nano Crystalline ◽  
Shi Irradiation ◽  
The Impact

Swift heavy ion (SHI) irradiation in thin films significantly modifies the structure and related properties in a controlled manner.

scholarly journals Miniaturization and Automation of a Human In Vitro Blood–Brain Barrier Model for the High-Throughput Screening of Compounds in the Early Stage of Drug Discovery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 892
Author(s):  
Elisa L. J. Moya ◽  
Elodie Vandenhaute ◽  
Eleonora Rizzi ◽  
Marie-Christine Boucau ◽  
Johan Hachani ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Blood Brain Barrier ◽  
Early Stage ◽  
Molecular Transport ◽  
Brain Barrier ◽  
Blood Brain ◽  
Cns Drugs ◽  
The Impact ◽  
The Brain

Central nervous system (CNS) diseases are one of the top causes of death worldwide. As there is a difficulty of drug penetration into the brain due to the blood–brain barrier (BBB), many CNS drugs treatments fail in clinical trials. Hence, there is a need to develop effective CNS drugs following strategies for delivery to the brain by better selecting them as early as possible during the drug discovery process. The use of in vitro BBB models has proved useful to evaluate the impact of drugs/compounds toxicity, BBB permeation rates and molecular transport mechanisms within the brain cells in academic research and early-stage drug discovery. However, these studies that require biological material (animal brain or human cells) are time-consuming and involve costly amounts of materials and plastic wastes due to the format of the models. Hence, to adapt to the high yields needed in early-stage drug discoveries for compound screenings, a patented well-established human in vitro BBB model was miniaturized and automated into a 96-well format. This replicate met all the BBB model reliability criteria to get predictive results, allowing a significant reduction in biological materials, waste and a higher screening capacity for being extensively used during early-stage drug discovery studies.

scholarly journals Measuring spatial allocative efficiency in basketball

2020 ◽  
Vol 16 (4) ◽  
pp. 271-289
Author(s):  
Nathan Sandholtz ◽  
Jacob Mortensen ◽  
Luke Bornn
Keyword(s):  
Spatial Distribution ◽  
Hierarchical Model ◽  
Opportunity Cost ◽  
Allocative Efficiency ◽  
Bayesian Hierarchical Model ◽  
National Basketball Association ◽  
Spatial Context ◽  
Bayesian Hierarchical ◽  
The Impact

AbstractEvery shot in basketball has an opportunity cost; one player’s shot eliminates all potential opportunities from their teammates for that play. For this reason, player-shot efficiency should ultimately be considered relative to the lineup. This aspect of efficiency—the optimal way to allocate shots within a lineup—is the focus of our paper. Allocative efficiency should be considered in a spatial context since the distribution of shot attempts within a lineup is highly dependent on court location. We propose a new metric for spatial allocative efficiency by comparing a player’s field goal percentage (FG%) to their field goal attempt (FGA) rate in context of both their four teammates on the court and the spatial distribution of their shots. Leveraging publicly available data provided by the National Basketball Association (NBA), we estimate player FG% at every location in the offensive half court using a Bayesian hierarchical model. Then, by ordering a lineup’s estimated FG%s and pairing these rankings with the lineup’s empirical FGA rate rankings, we detect areas where the lineup exhibits inefficient shot allocation. Lastly, we analyze the impact that sub-optimal shot allocation has on a team’s overall offensive potential, demonstrating that inefficient shot allocation correlates with reduced scoring.

scholarly journals The Impact of Bone on the Biology of Aging

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 740-740
Author(s):  
Gerard Karsenty
Keyword(s):  
Muscle Function ◽  
Male Fertility ◽  
Leydig Cells ◽  
Memory Loss ◽  
Age Related ◽  
Systematic Exploration ◽  
Biology Of Aging ◽  
The Impact ◽  
The Brain ◽  
Regulate Energy Metabolism

Abstract We hypothesized that bone may secrete hormones that regulate energy metabolism and reproduction. Testing this hypothesis revealed that the osteoblast-specific secreted protein osteocalcin is a hormone regulating glucose homeostasis and male fertility by signaling through a GPCR, Gprc6a, expressed in pancreatic β bells and Leydig cells of the testes. The systematic exploration of osteocalcin biology, revealed that it regulates an unexpectedly large spectrum of physiological functions in the brain and peripheral organs and that it has most features of an antigeromic molecule. As will be presented at the meeting, this body of work suggests that harnessing osteocalcin for therapeutic purposes may be beneficial in the treatment of age-related diseases such as depression, age-related memory loss and the decline in muscle function seen in sarcopenia.

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