Preliminary comparison of grating-based and in-line phase contrast X-ray imaging with synchrotron radiation for mouse kidney at TOMCAT

2013 ◽  
Vol 8 (06) ◽  
pp. C06003-C06003 ◽  
Author(s):  
J Sun ◽  
P Liu ◽  
S Irvine ◽  
B Pinzer ◽  
M Stampanoni ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Phase Contrast ◽  
Mouse Kidney ◽  
X Ray ◽  
Preliminary Comparison ◽  
X Ray Imaging

Phase-Contrast X-Ray Imaging Using Both Vertically and Horizontally Expanded Synchrotron Radiation X-Rays with Asymmetric Bragg Reflection

1999 ◽  
Vol 38 (Part 2, No. 4B) ◽  
pp. L470-L472 ◽  
Author(s):  
Yasushi Kagoshima ◽  
Yoshiyuki Tsusaka ◽  
Kazushi Yokoyama ◽  
Kengo Takai ◽  
Shingo Takeda ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Phase Contrast ◽  
Bragg Reflection ◽  
X Rays ◽  
X Ray ◽  
X Ray Imaging

scholarly journals Visualization of protein crystals by high-energy phase-contrast X-ray imaging

2019 ◽  
Vol 75 (11) ◽  
pp. 947-958 ◽  
Author(s):  
Maxim Polikarpov ◽  
Gleb Bourenkov ◽  
Irina Snigireva ◽  
Anatoly Snigirev ◽  
Sophie Zimmermann ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Data Collection ◽  
Diffraction Data ◽  
Phase Contrast ◽  
High Energy ◽  
Protein Crystals ◽  
Cubic Phase ◽  
Macromolecular Crystallography ◽  
X Ray ◽  
X Ray Imaging

For the extraction of the best possible X-ray diffraction data from macromolecular crystals, accurate positioning of the crystals with respect to the X-ray beam is crucial. In addition, information about the shape and internal defects of crystals allows the optimization of data-collection strategies. Here, it is demonstrated that the X-ray beam available on the macromolecular crystallography beamline P14 at the high-brilliance synchrotron-radiation source PETRA III at DESY, Hamburg, Germany can be used for high-energy phase-contrast microtomography of protein crystals mounted in an optically opaque lipidic cubic phase matrix. Three-dimensional tomograms have been obtained at X-ray doses that are substantially smaller and on time scales that are substantially shorter than those used for diffraction-scanning approaches that display protein crystals at micrometre resolution. Adding a compound refractive lens as an objective to the imaging setup, two-dimensional imaging at sub-micrometre resolution has been achieved. All experiments were performed on a standard macromolecular crystallography beamline and are compatible with standard diffraction data-collection workflows and apparatus. Phase-contrast X-ray imaging of macromolecular crystals could find wide application at existing and upcoming low-emittance synchrotron-radiation sources.

Medical Applications with Synchrotron Radiation in Japan

1998 ◽  
Vol 5 (3) ◽  
pp. 326-332 ◽  
Author(s):  
Tohoru Takeda ◽  
Yuji Itai ◽  
Kazuyuki Hyodo ◽  
Masami Ando ◽  
Takao Akatsuka ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Coronary Arteries ◽  
Phase Contrast ◽  
Coronary Arteriography ◽  
Medical Applications ◽  
Imaging Method ◽  
Two Dimensional ◽  
X Ray ◽  
X Ray Imaging ◽  
X Ray Computed

In Japan, various medical applications of synchrotron X-ray imaging, such as angiography, monochromatic X-ray computed tomography (CT), radiography and radiation therapy, are being developed. In particular, coronary arteriography (CAG) is quite an important clinical application of synchrotron radiation. Using a two-dimensional imaging method, the first human intravenous CAG was carried out at KEK in May 1996; however, further improvements of image quality are required in clinical practice. On the other hand, two-dimensional aortographic CAG revealed canine coronary arteries as clearly as those on selective CAG, and coronary arteries less than 0.2 mm in diameter. Among applications of synchrotron radiation to X-ray CT, phase-contrast X-ray CT and fluorescent X-ray CT are expected to be very interesting future applications of synchrotron radiation. For actual clinical applications of synchrotron radiation, a medical beamline and a laboratory are now being constructed at SPring-8 in Harima.

scholarly journals Experience with Imaging by Using of Microfocus X-Ray Source

2010 ◽  
Vol 61 (5) ◽  
pp. 287-290 ◽  
Author(s):  
Zdenko Zápražný ◽  
Dušan Korytár ◽  
František Dubecký ◽  
Vladimír Áč ◽  
Zbigniew Stachura ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Phase Contrast ◽  
Ccd Camera ◽  
X Ray ◽  
X Ray Imaging ◽  
Radiation Sources ◽  
Set Up ◽  
High Level ◽  
Very High

Experience with Imaging by Using of Microfocus X-Ray SourceIn this paper we present the current work and experience with using microfocus x-ray generator and commercial CCD camera for x-ray imaging purpose. There is a need in laboratories for the development of imaging methods approaching synchrotron radiation sources, where the brilliance of radiation is on very high-level. Generally, there is no continuous access to synchrotron facilities. Several synchrotron radiation laboratories allocate the access via a proposal system. Thus the time for synchrotron radiation experiments seldom exceeds more than 1-2 weeks per year, which restricts its application to a few selected experiments. Even in future, the routine characterization of samples will be performed mainly at the experimenters home laboratories [10]. In this contribution we show that with the present set-up it is possible to achieve the spatial resolution down to μm and with the appropriate geometry a phase contrast images are observable.

scholarly journals Principles of Different X-ray Phase-Contrast Imaging: A Review

2021 ◽  
Vol 11 (7) ◽  
pp. 2971
Author(s):  
Siwei Tao ◽  
Congxiao He ◽  
Xiang Hao ◽  
Cuifang Kuang ◽  
Xu Liu
Keyword(s):  
Biological Samples ◽  
Phase Contrast ◽  
Recent Progress ◽  
Phase Contrast Imaging ◽  
Contrast Imaging ◽  
X Ray ◽  
X Ray Imaging ◽  
Internal Structures ◽  
X Ray Absorption ◽  
Made In

Numerous advances have been made in X-ray technology in recent years. X-ray imaging plays an important role in the nondestructive exploration of the internal structures of objects. However, the contrast of X-ray absorption images remains low, especially for materials with low atomic numbers, such as biological samples. X-ray phase-contrast images have an intrinsically higher contrast than absorption images. In this review, the principles, milestones, and recent progress of X-ray phase-contrast imaging methods are demonstrated. In addition, prospective applications are presented.

scholarly journals X-ray imaging of silicon die within fully packaged semiconductor devices

2021 ◽  
pp. 1-7
Author(s):  
Brian K. Tanner ◽  
Patrick J. McNally ◽  
Andreas N. Danilewsky
Keyword(s):  
Synchrotron Radiation ◽  
Feasibility Studies ◽  
Monochromatic Radiation ◽  
X Ray Diffraction ◽  
Divergent Beam ◽  
X Ray ◽  
X Ray Imaging ◽  
Setting Process ◽  
Diffraction Imaging ◽  
Lattice Planes

X-ray diffraction imaging (XRDI) (topography) measurements of silicon die warpage within fully packaged commercial quad-flat no-lead devices are described. Using synchrotron radiation, it has been shown that the tilt of the lattice planes in the Analog Devices AD9253 die initially falls, but after 100 °C, it rises again. The twist across the die wafer falls linearly with an increase in temperature. At 200 °C, the tilt varies approximately linearly with position, that is, displacement varies quadratically along the die. The warpage is approximately reversible on cooling, suggesting that it has a simple paraboloidal form prior to encapsulation; the complex tilt and twisting result from the polymer setting process. Feasibility studies are reported, which demonstrate that a divergent beam and quasi-monochromatic radiation from a sealed X-ray tube can be used to perform warpage measurements by XRDI in the laboratory. Existing tools have limitations because of the geometry of the X-ray optics, resulting in applicability only to simple warpage structures. The necessary modifications required for use in situations of complex warpage, for example, in multiple die interconnected packages are specified.

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