scholarly journals Identification of bioactive compound from Nigella sativa, Allium sativum, propolis and Oleaeuropaea mixture as antibacterial and antifungal agent

2018 ◽  
Vol 196 ◽  
pp. 012041
Author(s):  
M Bintang ◽  
F H Pasaribu ◽  
U M Safira ◽  
T Sidhartha
Keyword(s):  
Antifungal Agent ◽  
Allium Sativum ◽  
Nigella Sativa ◽  
Bioactive Compound ◽  
Antibacterial And Antifungal

Synthesis of Grafted Biodegradable Poly(ε-caprolactone) as Antibacterial and Antifungal Agent

2020 ◽  
Vol 62 (6) ◽  
pp. 697-705
Author(s):  
Sarra Benguella ◽  
Aicha Hachemaoui ◽  
Ahmed Yahiaoui ◽  
Abdelkader Dehbi
Keyword(s):  
Antifungal Agent ◽  
Biodegradable Poly ◽  
Antibacterial And Antifungal

scholarly journals REVIEW: Organosulphure compound of garlic (Allium sativum L.) and its biological activities

2003 ◽  
Vol 1 (2) ◽  
pp. 65-76 ◽  
Author(s):  
UDHI EKO HERNAWAN ◽  
AHMAD DWI SETYAWAN
Keyword(s):  
Platelet Aggregation ◽  
Side Effects ◽  
Allium Sativum ◽  
Urinary Infection ◽  
Biological Activities ◽  
Bioactive Compound ◽  
Traditional Medicines ◽  
Anti Cancer ◽  
Long Time ◽  
Anti Oxidant

Garlic has been used a long time ago as traditional medicines. The valuable bulb is used to treat hypertension, respiratory infection, headache, hemorrhoids, constipation, bruised injury or slice, insomnia, cholesterol, influenza, urinary infection, etc. Garlic bulbs can be used as anti-diabetic, anti-hypertension, anti-cholesterol, anti-atheroschlerosis, anti-oxidant, anti-cell platelet aggregation, fibrinolyse spur, anti-viral, anti-microbial, and anti-cancer. The ultimate bioactive compound of garlic is organo-sulphure components, i.e. alliin, allicin, ajoene, allyl sulphide groups, and allyl cystein. There was not any report of any side effects or toxicity of garlic.

Garlic: A Miraculous Herb for Oral Diseases – A Review

2014 ◽  
Vol 8 (1) ◽  
pp. 51-54
Author(s):  
S Yadav ◽  
A Ahuja ◽  
V Ahuja
Keyword(s):  
Traditional Medicine ◽  
Antifungal Agent ◽  
Antibacterial Agent ◽  
Clinical Applications ◽  
Review Article ◽  
Systemic Diseases ◽  
Oral Diseases ◽  
Dental Diseases ◽  
Pungent Odor ◽  
Antibacterial And Antifungal

ABSTRACT Garlic is a member of lily family that has been used worldwide as an incredible herb in the array of medicine. In Indian traditional medicine, garlic holds a special place and is used to cure variety of diseases. It has got the reputation of a powerful healing, antibacterial and antifungal agent. It has proved beneficial in treating systemic diseases like diabetes, hypertension etc in medicine. But it has got less importance in dentistry due to lack of clinical data assuring its safe usage in curing dental diseases. Drawback of garlic is its pungent odor which restricts its oral usage as an antibacterial agent, but now a days odor less garlic preparations are available which can be utilized in treating oral diseases. This review article throws a light on the clinical applications of garlic in the field of dentistry.

scholarly journals Assessment of Quinone Enriched Fraction in Nigella sativa Seed Extracts

2020 ◽  
Vol 11 (2) ◽  
pp. 1505-1510
Author(s):  
Durga B ◽  
Durga B ◽  
Dass Prakash M V ◽  
Julius A
Keyword(s):  
High Performance ◽  
Nigella Sativa ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Bioactive Compound ◽  
New Drugs ◽  
Natural Sources ◽  
Ethanolic Extracts ◽  
Nigella Sativa Seed ◽  
Seed Extracts

In recent days, the thirst for the identification of the potential bioactive compounds from the natural sources like medicinal plants is on continuous demand. Among scientists and academicians, it has created many interdisciplinary platforms for research in establishing new drugs from the natural sources. According to many recent studies, Nigella sativa is believed to be the rich source of quinone, an effective bioactive compound with lots of medicinal values. The purpose of this study was to isolate and estimate the quinone in Nigella sativa seed extracts (aqueous and ethanol). Based on the qualitative and quantitative determination, the extracts were further focused for isolation of quinone from both aqueous and ethanolic  extracts of Nigella sativa. The isolated compound is identified by thin layer chromatography and purity is analyzed in High performance liquid chromatography. From the results we obtained, it was very clear that among the aqueous and ethanolic extracts of Nigella sativa, the ethanolic extract has been found with the highest quantity of quinine. This would be predicting that the ethanol extract of Nigella sativa may have good efficacy of pharmacological and therapeutic potentials like antidiabetic, anticancer, antimicrobial, anti-inflammatory properties when compared with the aqueous extract due to the presence of more quinone.

scholarly journals Effect of Nigella sativa and its bioactive compound on type 2 epithelial to mesenchymal transition: a systematic review

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Abid Nordin ◽  
Haziq Kamal ◽  
Muhammad Dain Yazid ◽  
Aminuddin Saim ◽  
Ruszymah Idrus
Keyword(s):  
Systematic Review ◽  
Wound Healing ◽  
Epithelial To Mesenchymal Transition ◽  
Nigella Sativa ◽  
Bioactive Compound ◽  
Research Articles ◽  
Pathological Changes ◽  
Mesenchymal Transition ◽  
Organ Fibrosis

Abstract Background Nigella sativa or commonly known as black seed or black cumin is one of the most ubiquitous complementary medicine. Epithelial to mesenchymal transition (EMT) of type 2 is defined by the balance between wound healing and tissue fibrosis, which is dependent to the state of inflammation. This systematic review is conducted to provide an overview regarding the reported effect of Nigella sativa and its bioactive compound on the type 2 EMT. Methods A search was done in EBSCOHOST, OVID and SCOPUS database to obtain potentially relevant articles that were published between 1823 and August 2019. This review includes studies that focus on the effect of Nigella sativa and its bioactive compound on the events related to type 2 EMT. Results A total of 1393 research articles were found to be potentially related to the effect of Nigella sativa and its bioactive compound, thymoquinone on Type 2 EMT. After screening was done, 22 research articles met inclusion criteria and were included in this review. Majority of the studies, reported better wound healing rate or significant prevention of tissue inflammation and organ fibrosis following Nigella sativa or thymoquinone treatments. In terms of wound healing, studies included reported progression of EMT related pathological changes after treatment with Nigella sativa or thymoquinone. Alternatively, in terms of fibrosis and inflammation, studies included reported reversal of pathological changes related to EMT after treatment with Nigella sativa or thymoquinone. Conclusion Through this review, Nigella sativa and thymoquinone have been associated with events in Type 2 EMT. They have been shown to promote wound healing, attenuate tissue inflammation, and prevent organ fibrosis via regulation of the EMT process.

Lactaran Sesquiterpen Velleral Dari Kulit Batang Tumbuhan Drymis beccariana Gibbs. (Winteraceae) yang Bersifat Sitotoksik dan Antimikroba

2012 ◽  
Vol 8 (1) ◽  
Author(s):  
Bimo Budi Santoso ◽  
Darma Santi ◽  
Markus H. Langsa ◽  
Rina Mogea
Keyword(s):  
Bioactive Compound ◽  
Stem Bark ◽  
Artemia Salina ◽  
Leukemia Cells ◽  
Antibacterial And Antifungal Activity ◽  
H Nmr ◽  
Potential Source ◽  
Staphyloccocus Aureus ◽  
Antibacterial And Antifungal ◽  
C Nmr

<em>Isolation guided by brine-shrimp ( Artemia salina) bioassay from the stem bark of .Drymis beccariana Gibbs. led to isolate a bioactive compound called Velleral (<strong>1</strong>) ((3aS,8aS)-2,2,8-trimethyl-3,3a.6.8a-tetrahydro-1H-azulene-5,6-dicarbaldehyde).The structure of this compound was elucidated based on physical and spectroscopic data (UV, IR, , <sup>1</sup>H NMR, <sup>13</sup>C-NMR and&nbsp; GC-MS). This compound showed significant active in the&nbsp; A. salina bioassay with IC<sub>50</sub> 2.92 &micro;g/mL and &nbsp;exhibited siginificant cytotoxicity against&nbsp; murine P-388 leukemia cells with IC<sub>50</sub> 3,39 &mu;g /mL.Moreover, the compound exhibited antibacterial and antifungal activity especially against&nbsp; Staphyloccocus aureus&nbsp; ATCC 25923 and Candida albians respectively. This result indicates that stem bark of D. beccariana is a potential source of bioactive compounds</em><em>.</em>

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