scholarly journals REVIEW: Organosulphure compound of garlic (Allium sativum L.) and its biological activities

2003 ◽  
Vol 1 (2) ◽  
pp. 65-76 ◽  
Author(s):  
UDHI EKO HERNAWAN ◽  
AHMAD DWI SETYAWAN
Keyword(s):  
Platelet Aggregation ◽  
Side Effects ◽  
Allium Sativum ◽  
Urinary Infection ◽  
Biological Activities ◽  
Bioactive Compound ◽  
Traditional Medicines ◽  
Anti Cancer ◽  
Long Time ◽  
Anti Oxidant

Garlic has been used a long time ago as traditional medicines. The valuable bulb is used to treat hypertension, respiratory infection, headache, hemorrhoids, constipation, bruised injury or slice, insomnia, cholesterol, influenza, urinary infection, etc. Garlic bulbs can be used as anti-diabetic, anti-hypertension, anti-cholesterol, anti-atheroschlerosis, anti-oxidant, anti-cell platelet aggregation, fibrinolyse spur, anti-viral, anti-microbial, and anti-cancer. The ultimate bioactive compound of garlic is organo-sulphure components, i.e. alliin, allicin, ajoene, allyl sulphide groups, and allyl cystein. There was not any report of any side effects or toxicity of garlic.

scholarly journals Mangiferin as New Potential Anti-Cancer Agent and Mangiferin-Integrated Polymer Systems—A Novel Research Direction

Biomolecules ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 79
Author(s):  
Svetlana N. Morozkina ◽  
Thi Hong Nhung Vu ◽  
Yuliya E. Generalova ◽  
Petr P. Snetkov ◽  
Mayya V. Uspenskaya
Keyword(s):  
Molecular Mechanisms ◽  
Biological Activities ◽  
Research Direction ◽  
Biological Action ◽  
The Body ◽  
Biologically Active ◽  
Polymer Systems ◽  
Anti Cancer ◽  
Long Time ◽  
Cancer Agent

For a long time, the pharmaceutical industry focused on natural biologically active molecules due to their unique properties, availability and significantly less side-effects. Mangiferin is a naturally occurring C-glucosylxantone that has substantial potential for the treatment of various diseases thanks to its numerous biological activities. Many research studies have proven that mangiferin possesses antioxidant, anti-infection, anti-cancer, anti-diabetic, cardiovascular, neuroprotective properties and it also increases immunity. It is especially important that it has no toxicity. However, mangiferin is not being currently applied to clinical use because its oral bioavailability as well as its absorption in the body are too low. To improve the solubility, enhance the biological action and bioavailability, mangiferin integrated polymer systems have been developed. In this paper, we review molecular mechanisms of anti-cancer action as well as a number of designed polymer-mangiferin systems. Taking together, mangiferin is a very promising anti-cancer molecule with excellent properties and the absence of toxicity.

A Review on the Anti-Viral Activity of Houttuynia cordata: A Possible Herb for the Management and Treatment of COVID-19

2021 ◽  
Vol 4 (2) ◽  
pp. 3-10
Author(s):  
Emdormi Rymbai ◽  
Keyword(s):  
Vital Role ◽  
Viral Agent ◽  
Houttuynia Cordata ◽  
Traditional Medicines ◽  
Virulent Newcastle Disease Virus ◽  
Wide Range ◽  
Anti Cancer ◽  
The Family ◽  
Anti Oxidant

Plants are an important source of natural products and they play a vital role in the field of medicinal chemistry and pharmaceutical science. Traditional medicines have been practiced and used for thousands of years, mostly in Asian countries, where plants are the main sources of medicine. Houttuynia cordata, a herb that belongs to the family Saururaceae, has a wide range of pharmacological activities and is used traditionally in conditions like anisolobis sores, heatstroke, lung carbuncles, malaria, scrotal abscess, tonsillitis, salammoniac poison and has also been widely accepted to possess anti-cancer, anti-oxidant, anti-hypertension, anti-inflammatory, anti-mutagenic, antibacterial, anti-viral and anti-purulent activity. Moreover, it is one of the herbs that was recognized during pandemic outbreaks, such as Severe Acute Respiratory Syndrome Coronavirus (SARS CoV) in China, virulent Newcastle Disease Virus (VNDV) in Java (Indonesia) and Newcastle (England). In this review, we briefly discuss the role of H. cordata as an anti-viral agent and the possibility of developing a dosage form against Coronavirus disease-19 (COVID-19).

A review on phyto-pharmacology of Oxalis corniculata

2021 ◽  
Vol 24 ◽  
Author(s):  
Iqra Sarfraz ◽  
Azhar Rasul ◽  
Ghulam Hussain ◽  
Muhammad Ajmal Shah ◽  
Bushra Nageen ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Current Effort ◽  
Isolation And Characterization ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Anti Fungal ◽  
Warm Temperate

: Oxalis corniculata (Oxalidaceae) is a small decumbent and delicate appearing medicinal herb flourishing in warm temperate and tropical domains such as Pakistan and India. Main bioactive chemical constituents of Oxalis plant include several alkaloids, flavonoids, terpenoids, cardiac glycosides, saponins, phlobatannins along with steroids. Due to its polyphenolic, glycosides and flavonoid profile, it is proved to be protective in numerous ailments and exhibit various biological activities such as anti-fungal, anti-cancer, anti-oxidant, anti-bacterial, anti-diabetic, and cardioprotective. Moreover, bioactive phytochemicals from this plant possess significant wound healing potential. Our current effort intends to emphasize on the immense significance of this plant species, which have not been the subject matter of clinical trials and effective pharmacological studies, even though its favored usage has been stated. This review proposes that Oxalis corniculata possess potential for the cure of various diseases, however, further researches on isolation and characterization of bioactive compounds along with pre-clinical trials are compulsory to figure out its pharmacological applications.

A review of the mechanisms of anti-cancer activities of some medicinal plants–biochemical perspectives

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Patrick E. Aba ◽  
John I. Ihedioha ◽  
Isaac U. Asuzu
Keyword(s):  
Medicinal Plants ◽  
Adverse Side Effects ◽  
Safety Margins ◽  
Management Procedures ◽  
Anti Cancer ◽  
Long Time ◽  
Cell Cycle Inhibition ◽  
Anti Oxidant ◽  
Induction Of Apoptosis ◽  
Plant Compounds

Abstract Cancer is a disease resulting in unbridled growth of cells due to dysregulation in the balance of cell populations. Various management procedures in handling cases of cancer are not without their adverse side effects on the normal cells. Medicinal plants/herbs have been in use in the management of various ailments, including cancer, for a long time. Medicinal plants have been credited with wide safety margins, cost effectiveness, availability and diverse activities. This study reviewed various mechanisms of anti-cancer activities of some medicinal plants from a biochemical perspective. The mechanisms of anti-cancer activities of plant compounds addressed in this article include induction of apoptosis, anti-angiogenic effects, anti-metastasis, inhibition of cell cycle, inhibition of DNA destruction and effects on key enzymes, cytotoxic and anti-oxidant effects. The anti-cancer activities of some of the plants involve more than one mechanism.

scholarly journals Flavonoids Profile, Taxonomic Data, History of Cosmetic Uses, Anti-Oxidant and Anti-Aging Potential of Alpinia galanga (L.) Willd

Cosmetics ◽  
2020 ◽  
Vol 7 (4) ◽  
pp. 89
Author(s):  
Duangjai Tungmunnithum ◽  
Nobuyuki Tanaka ◽  
Ayumi Uehara ◽  
Tsukasa Iwashina
Keyword(s):  
Medicinal Plant ◽  
Biological Activities ◽  
Taxonomic Status ◽  
Raw Material ◽  
Alpinia Galanga ◽  
Long Time ◽  
History Of ◽  
Data History ◽  
Phytochemical Compounds ◽  
Anti Oxidant

Alpinia galanga is a well-known medicinal plant in Southeast Asia and has been used for a long time as food and medicine. A large number of flavonoid phytochemical compounds have been identified in various parts of this medicinal herb. Flavonoids are commonly known as attractive compounds that can be applied to cosmetic or cosmeceutical product development because of their antioxidant, anti-aging and many other potential biological activities. This recent review aims to illustrate and update the taxonomic status as well as the species description that will be helpful for a rigorous identification and authenticate the raw material or living specimen from A. galanga. The flavonoid phytochemical compounds and the bioactivity of this medicinal plant are also provided. The future perspectives and research directions of A. galanga and its flavonoids are pointed out in this study as well.

scholarly journals Economic Value of Agarwood and Its Prospects of Cultivation

2021 ◽  
Vol 9 (1) ◽  
pp. 23-31
Author(s):  
Suraj Raj Adhikari ◽  
Kusum Pokhrel ◽  
Sunil Dutta Baral
Keyword(s):  
New Technology ◽  
Economic Value ◽  
Traditional Medicines ◽  
Hill Country ◽  
The Past ◽  
Northern India ◽  
Anti Cancer ◽  
Pharmacological Studies ◽  
Anti Oxidant ◽  
The Hill

Aquilaria are genera of tropical trees that produces a valuable resinous wood called agarwood. Agarwood plant have been widely used as traditional medicines and Ayurvedic medicine. They are used for the treatment of arthritis, asthma, diarrhoea etc effects. It contains bioactive phytochemical sesquiterpenoids, 2 (-2-phenylethyl)-4H-chromen-4-one derivatives, genkwanins, mangiferins, cucurbitacins, other terpenoids and phenolic acids. Many pharmacological studies have been performed on anti-allergic, anti-cancer, anti-inflammatory, anti-microbial, anti-diabetic, anti-oxidant, etc. The aromatic properties of agarwood when burned or distilled are extraordinary and there is high demand for the resinous wood to make incense, perfume and as traditional medicine. Aquilaria are native to northern India but over harvesting of this tree as well as other forest trees in the past has ravaged the hill country. With new technology that has been developed to induce agarwood in trees, it is now possible to produce a sustainable high valued agarwood in young plantation trees. The growing of Aquilaria in the hill agro-ecosystems of Nepal and cultivation of agarwood as a crop using new technology could provide a new economy for the region. Int. J. Appl. Sci. Biotechnol. Vol 9(1): 23-31

scholarly journals Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 872 ◽  
Author(s):  
Gaber El-Saber Batiha ◽  
Amany Magdy Beshbishy ◽  
Lamiaa G. Wasef ◽  
Yaser H. A. Elewa ◽  
Ahmed A. Al-Sagan ◽  
...  
Keyword(s):  
Allium Sativum ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Biological Properties ◽  
Herbaceous Plant ◽  
Anticancer Activities ◽  
Active Constituent ◽  
Pharmacological Activities ◽  
Traditional Medicines ◽  
Traditional Remedy

Medicinal plants have been used from ancient times for human healthcare as in the form of traditional medicines, spices, and other food components. Garlic (Allium sativum L.) is an aromatic herbaceous plant that is consumed worldwide as food and traditional remedy for various diseases. It has been reported to possess several biological properties including anticarcinogenic, antioxidant, antidiabetic, renoprotective, anti-atherosclerotic, antibacterial, antifungal, and antihypertensive activities in traditional medicines. A. sativum is rich in several sulfur-containing phytoconstituents such as alliin, allicin, ajoenes, vinyldithiins, and flavonoids such as quercetin. Extracts and isolated compounds of A. sativum have been evaluated for various biological activities including antibacterial, antiviral, antifungal, antiprotozoal, antioxidant, anti-inflammatory, and anticancer activities among others. This review examines the phytochemical composition, pharmacokinetics, and pharmacological activities of A. sativum extracts as well as its main active constituent, allicin.

A Review on Himalayan Medicinal Plants against Cancer

2021 ◽  
Vol 07 ◽  
Author(s):  
Bhuwan Chandra Joshi ◽  
Piyush Verma ◽  
Vijay Juyal ◽  
Archana N. Sah
Keyword(s):  
Side Effects ◽  
Medicinal Plants ◽  
Web Of Science ◽  
Chemical Constituents ◽  
Traditional Medicines ◽  
Natural Agents ◽  
Active Chemical ◽  
Anti Cancer ◽  
Synthetic Agents ◽  
Pharmaceutical Industries

Background: Plants contributed numerous novel compounds for prophylactic and curative medicine to modern science.They are the important source of natural agents used in various pharmaceutical industries. Himalayan plants are abundant in various secondary metabolites such as anthraquinones, flavonoids, tannins, alkaloids and terpenes. The Himalayan plants grown in high altitude and have around 6500 years old history as traditional medicines. Aim: This review article systematically presents information onHimalayan medicinal plants having anti-cancer potentials. Methodology: Around 160 articles were reviewed by using online search engines like PubMed, Scopus, Google Scholar, Web of Science, and floras of different Himalayan countries. Results: An attempt has been made to review anticancer plants and active constituents isolated from several anti-cancerous plants of Himalayan regions. Eighty three anticancer plants are reported in this review and total twenty two active chemical constituents including phenolic compounds, glycosides, terpenoidsand alkaloids from the plants were reported active against various cancer cell lines. Conclusion: Several synthetic agents are used to cure cancer but number of undesired side effects occurs during chemotherapy. Hence, the research is going on to investigate natural therapies, such as the use of the plant derived productsin cancer treatment. They may reduce adverse side effects.

Medicinal Properties of Cinchona Alkaloids - A Brief Review

2021 ◽  
Vol 11 (3) ◽  
pp. 224-228
Author(s):  
Anubhav Dubey ◽  
Yatendra Singh
Keyword(s):  
Toxic Effect ◽  
Antimalarial Activity ◽  
Biological Activities ◽  
Folk Medicine ◽  
Modern Medicine ◽  
Cinchona Alkaloids ◽  
Literature Study ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Medicinal Properties

Cinchona which belongs to family Rubiaceae, got its importance from the centuries because of its anti- malarial activity. Alkaloids present in this herb, Quinine, Chichonine, Quinidine and Cinchonidine are the main, but percentage may vary in species to species. Since the early 17th century, these alkaloid are frequently used in Indian ayurvedic, sidha and traditional folk medicine to treating fever and Still now in modern medicine cinchona alkaloids are used for the treatment of malaria as well as for other diseases and became the well-known drug after the treatment of malaria caused by Plasmodium Sp. Literature study revealed that along with the antimalarial activity the cinchona alkaloids has other potentiality like anti-obesity, anti-cancer, anti-oxidant, anti-inflammatory, anti-microbial activity. These article reviews the biological activities of cinchona alkaloids along with its toxic effect.

scholarly journals Purification, Structural Characteristics, and Biological Activities of Exopolysaccharide Isolated From Leuconostoc mesenteroides SN-8

2021 ◽  
Vol 12 ◽  
Author(s):  
Junrui Wu ◽  
Danli Yan ◽  
Yumeng Liu ◽  
Xue Luo ◽  
Yang Li ◽  
...  
Keyword(s):  
Leuconostoc Mesenteroides ◽  
Biological Activities ◽  
Structural Characteristics ◽  
Molecular Weights ◽  
Cycle Arrest ◽  
Glycosidic Bonds ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Inhibitory Potential ◽  
Cancer Agent

In this study, a novel exopolysaccharide (EPS) was extracted from Leuconostoc mesenteroides Shen Nong’s (SN)-8 which can be obtained from Dajiang. After the purification step, EPS-8-2 was obtained with molecular weights of 1.46 × 105 Da. The structural characterization of EPS indicated that the EPS belonged to the class polysaccharide, mainly composed of glucan and also contained certain mannose residues that were found to be connected by α-1,6 glycosidic bonds. Moreover, the results demonstrated that EPS displayed a significant capacity to scavenge free radical to some extent, and this anti-oxidant potential was found to be concentration dependent. The results further revealed that EPS displayed a significant inhibitory potential on the growth of HepG2 cells by promoting apoptosis and induced cell cycle arrest in G1 and G2 phases. Overall, these results suggested that EPS can be explored as a possible anti-cancer agent.

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