scholarly journals Effect of virgin coconut oil on caecal microbiota composition in alloxan-induced diabetic rats

2019 ◽  
Vol 333 ◽  
pp. 012080 ◽  
Author(s):  
D Mitic-Culafic ◽  
S Djurasevic ◽  
Z Todorovic ◽  
J Knezevic-Vukcevic ◽  
J Djordjevic ◽  
...  
Keyword(s):  
Coconut Oil ◽  
Diabetic Rats ◽  
Microbiota Composition ◽  
Virgin Coconut Oil ◽  
Caecal Microbiota

scholarly journals Evaluation of Kidney Function Parameters in Diabetic Rats Following Virgin Coconut Oil Diet

Folia Medica ◽  
2019 ◽  
Vol 61 (2) ◽  
pp. 249-257 ◽  
Author(s):  
Akinjide M. Akinnuga ◽  
Olubayode Bamidele ◽  
Anthony J. Adewumi
Keyword(s):  
Kidney Function ◽  
Biochemical Analysis ◽  
Coconut Oil ◽  
Diabetic Rats ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Normal Rat ◽  
Group 2 ◽  
Diabetes Control Group ◽  
Group 1

Abstract Background: Diabetes mellitus (DM) leads to disruption of kidney function parameters (KFPs) which are markers of kidney diseases, especially nephropathy. Virgin coconut oil (VCO) has been implicated in playing a significant role in DM management. However, its role on KFPs in DM is scarce. Aim: To evaluate the kidney function parameters following VCO diet in diabetic rats. Materials and methods: : Twenty-five (25) male rats of 150 – 200 g were divided into 5 groups (n=5): Non-diabetic control (Group 1), diabetes control (Group 2), diabetes + metformin (Group 3), diabetes + 10% VCO (Group 4) and diabetes + 20% VCO (Group 5). Apart from Group 1, other groups were given intraperitone-ally 50 mg/kg of streptozotocin to induce diabetes mellitus. After 72 hours, fasting hyperglycaemia was confirmed by glucose oxidase method. All the rats were fed normal rat chow for 8 weeks. At 8th week, serum and urine samples were analysed for biochemical analysis. After 8 weeks, Group 1 and Group 2 continued to be fed on normal rat chow while other groups were treated with diets (VCO) or drug (metformin) for 4 weeks. At 12th week, urine samples were collected for biochemical analysis, the rats were sacrificed, and blood samples were collected by cardiac puncture. Results: There were significant differences in some KFPs in diabetes control (Group 2) compared to other experimental groups. However, there was no significant difference in glomerular filtration rate (GFR) and serum sodium in all the groups. Conclusion: VCO supplementary diet improved the altered KFPs and could be a therapy for kidney problems.

scholarly journals The protective role of virgin coconut oil on the alloxan-induced oxidative stress in the liver, kidneys and heart of diabetic rats

2019 ◽  
Vol 10 (4) ◽  
pp. 2114-2124 ◽  
Author(s):  
Siniša Đurašević ◽  
Nebojša Jasnić ◽  
Marko Prokić ◽  
Ilijana Grigorov ◽  
Vesna Martinović ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Coconut Oil ◽  
Protective Role ◽  
Diabetic Rats ◽  
Toxic Effects ◽  
Virgin Coconut Oil ◽  
Tissue Specific

Our results show that VCO supplementation ameliorates some toxic effects of alloxan induced diabetes, and that the changes are tissue specific.

scholarly journals Distinct effects of virgin coconut oil supplementation on the glucose and lipid homeostasis in non-diabetic and alloxan-induced diabetic rats

2020 ◽  
Vol 64 ◽  
pp. 103601 ◽  
Author(s):  
Siniša Đurašević ◽  
Gorana Nikolić ◽  
Ivan Zaletel ◽  
Ilijana Grigorov ◽  
Lidija Memon ◽  
...  
Keyword(s):  
Coconut Oil ◽  
Diabetic Rats ◽  
Lipid Homeostasis ◽  
Virgin Coconut Oil ◽  
Glucose And Lipid Homeostasis

Modulation of the Lipid Profile, Hepatic and Renal Antioxidant Activities, and Markers of Hepatic and Renal Dysfunctions in Alloxan-Induced Diabetic Rats by Virgin Coconut Oil

2019 ◽  
Vol 19 (7) ◽  
pp. 1032-1040
Author(s):  
Chinedum Eleazu ◽  
Chima E. Ekeleme ◽  
Ademola Famurewa ◽  
Mahaneem Mohamed ◽  
Gabriel Akunna ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coconut Oil ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Distilled Water ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Virgin Coconut Oil

Background:Research studies that holistically investigated the effect of administration of Virgin Coconut Oil (VCO) on diabetic humans or animals are limited in literature.Objective:To investigate the effect of administration of VCO on lipid profile, markers of hepatic and renal dysfunction, and hepatic and renal antioxidant activities of alloxan induced diabetic rats.Methods:Twenty-four male albino rats were used, and they were divided into four groups of six rats each. Group 1 (Normal Control, NC) received distilled water (1 mL/kg); Group 2 (VCO Control) received VCO (5 mL/kg); Group 3 (Diabetic Control, DC) received distilled water (1 mL/kg); Group 4 (Test Group, TG) received 5 ml/kg of VCO.Results:There were no significant differences in blood glucose, body weights, relative liver weights, relative kidney weights, hepatic and renal Superoxide Dismutase (SOD) activities, Malondialdehyde (MDA), albumin, aspartate Amino Transaminase (AST), alanine Amino Transaminase (ALT), Alkaline Phosphatase (ALP), urea, creatinine, uric acid, total cholesterol, triacylglycerol, Very Low Density Lipoprotein cholesterol (VLDL) and Low Density Lipoprotein cholesterol (LDL) concentrations; significant increases in renal Glutathione (GSH), hepatic catalase, Glutathione Peroxidase (GPx) and GSH but significant reduction in renal GPx and catalase activities of VCO control group compared with NC group. There were significant increases in blood glucose, relative liver and kidney weights, hepatic GPx, hepatic and renal MDA concentration, ALP, AST, ALT, urea, creatinine, uric acid, triacylglycerol, total cholesterol, LDL and VLDL concentrations; and significant decreases in body weight, hepatic SOD and GSH activities and albumin concentration but no significant difference in hepatic catalase activity of DC group compared with NC group. Administration of VCO to diabetic rats positively modulated these parameters compared with the diabetic control.Conclusion:The study showed the potentials of VCO in the management of hyperlipidemia, renal and hepatic dysfunctions imposed by hyperglycemia and by oxidative stress in diabetic rats.

scholarly journals Hypoglycaemic Activity of Extra Virgin Avocado (Persea americana) Oil and Extra Virgin Coconut (Cocos nucifera) Oil on Alloxan-induced Diabetic Rats

2021 ◽  
pp. 241-250
Author(s):  
Samuel J. Offor ◽  
Adedayo A. Tologbonse ◽  
Uduak P. Iseh ◽  
Deborah E. Okoh ◽  
SifonObong Akpan
Keyword(s):  
Diabetes Mellitus ◽  
Normal Saline ◽  
Cocos Nucifera ◽  
Coconut Oil ◽  
Saline Group ◽  
Diabetic Rats ◽  
Persea Americana ◽  
Normal Saline Group ◽  
Virgin Coconut Oil ◽  
Avocado Oil

Diabetes mellitus is a chronic, metabolic disorder characterized by abnormal elevation of blood glucose levels (hyperglycaemia). Despite significant milestones achieved using conventional drugs in managing the disease, there are some drawbacks associated with their use such as drug resistance, adverse drug effects, high cost, and sometimes outright therapeutic failure. The urgent need to bridge this therapeutic lacuna calls for further exploration and investigation of other treatment options. This study therefore aims at evaluating the antidiabetic potentials of virgin avocado oil and virgin coconut oil in alloxan-induced diabetic rats. Animals were divided into 5 groups of five rats each. Group 1 (negative control) received 10 ml /kg/day of normal saline, group 2 (diabetic control) -10 ml/kg/day of normal saline; group 3 received extra virgin avocado oil (1 ml/250 g) body weight, group 4 received extra virgin coconut oil (2 ml/kg) bodyweight, and group 5 received 10 mg/kg/day of metformin. Treatments were administered orally for 15 days. Extra virgin avocado oil and extra virgin coconut oil respectively showed significant antidiabetic activities, and may be beneficial for management of diabetes mellitus.

Beneficial Effect of Virgin Coconut Oil on Alloxan-Induced Diabetes and Microbiota Composition in Rats

2018 ◽  
Vol 73 (4) ◽  
pp. 295-301 ◽  
Author(s):  
Sinisa Djurasevic ◽  
Svetlana Bojic ◽  
Biljana Nikolic ◽  
Ivica Dimkic ◽  
Zoran Todorovic ◽  
...  
Keyword(s):  
Beneficial Effect ◽  
Coconut Oil ◽  
Microbiota Composition ◽  
Virgin Coconut Oil

scholarly journals Virgin Coconut Oil: Remedial Effects on Renal Dysfunction in Diabetic Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
A. M. Akinnuga ◽  
S. O. Jeje ◽  
O. Bamidele ◽  
E. E. Amaku ◽  
F. O. Otogo ◽  
...  
Keyword(s):  
Renal Dysfunction ◽  
Coconut Oil ◽  
Diabetic Rats ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
Control Group Group

Renal dysfunction is now a prevalent complication of diabetes mellitus. Therefore, this study was carried out to evaluate the remedial effects of virgin coconut oil (VCO) on renal dysfunction in diabetic rats. Fifteen albino Wistar rats were divided into 3 groups that comprise normal control group (Group I) and diabetic control group (Group II) fed with normal rat chows and a diabetic test group (Group III) fed with 10% VCO diet. Group II and Group III were made diabetic by single intraperitoneal injection of 150 mg/kg of freshly prepared alloxan monohydrate. After 72 hours of alloxan injection, fasting blood glucose was tested to confirm diabetes mellitus. After 3 weeks, the animals were anaesthetized and sacrificed to collect blood samples for renal function analysis. The creatinine, urea, and blood urea nitrogen values of Group II were significantly different from those of Group I and Group III at P<0.001. Also, there was significant difference (P<0.05) in total protein value between Group II (4.42  ±  0.47 mg/dL) and Group I (5.78  ±  0.12 mg/dL) as well as Group III (5.86  ±  0.19 mg/dL), but there was no significant difference between that of Group I and Group III (5.78  ±  0.12 mg/dL and 5.86  ±  0.19 mg/dL, resp.). Thus, VCO is effective in preventing renal damage in diabetic patients.

PENGARUH VIRGIN COCONUT OIL (VCO) TERHADAP KARAKTERISTIK DAN UMUR SIMPAN ROTI MANIS

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Aulia Alfi
Keyword(s):  
Moisture Content ◽  
Shelf Life ◽  
Coconut Oil ◽  
Temperature Treatment ◽  
Ash Content ◽  
Virgin Coconut Oil ◽  
Food Ingredients ◽  
Life Analysis ◽  
Antibacterial And Antifungal ◽  
Physical And Chemical

Virgin Coconut Oil (VCO) adalah bahan alami yang memiliki sifat antimikroba (antivirus, antibakteri, dan antijamur). Sehingga VCO dapat memberikan efek pengawet pada bahan makanan, salah satunya adalah roti manis. Penelitian ini dilakukan untuk mengevaluasi pengaruh VCO terhadap karakteristik (fisik dan kimia) dan umur simpan roti manis. Roti manis dianalisis secara fisik (tekstur dan porositas) dan kimia (kadar air, kadar abu, kadar lemak, kadar protein, dan kandungan karbohidrat), dan analisis umur simpan dengan FFA, uji organoleptik dan jamur setiap dua hari selama delapan hari penyimpanan di suhu ruang. Variasi perlakuan roti manis adalah dari rasio konsentrasi VCO: margarin: mentega, K (0%: 8%: 8%); A (4%: 6%: 6%); B (8%: 4%: 4%), C (12%: 2%: 2%); D (16%: 0%: 0%). Hasil penelitian menunjukkan bahwa VCO tidak memiliki pengaruh yang signifikan terhadap karakteristik fisik dan karakteristik kimia roti manis. Namun, VCO berpengaruh signifikan terhadap kadar air roti manis yang dihasilkan, roti manis K memiliki kadar air tertinggi (22,36%) dan berbeda dengan sampel roti manis lainnya. VCO secara efektif menghambat pertumbuhan jamur di roti manis pada konsentrasi 8%, 12%, dan 16%. Roti manis K dan A memiliki masa simpan 4 hari, sedangkan roti manis B, C, dan D memiliki masa simpan 6 hari.Kata kunci: VCO, roti manis, karakteristik, umur simpanABSTRACTVirgin Coconut Oil (VCO) is a natural ingredient that has antimicrobial (antiviral, antibacterial, and antifungal) properties. So that VCO can provide a preservative effect on food ingredients, one of which is sweet bread. This research was conducted to evaluate the effect of VCO on characteristics (physical and chemical) and shelf life of sweet bread. Sweet bread was analyzed physically (texture and porosity) and chemistry (moisture content, ash content, fat content, protein content, and carbohydrate content), and shelf life analysis with FFA, organoleptic and mold tests every two days for eight days of storage at ambient temperature. Treatment variations of sweet breads is from the ratio of the concentration of VCO: margarine: butter, K (0%: 8%: 8%); A (4%: 6%: 6%); B (8%: 4%: 4%), C (12%: 2%: 2%); D (16%: 0%: 0%). The results showed that VCO did not have a significant effect on the physical characteristics and chemical characteristics of sweet bread. However, the VCO has a significant effect on the water content of the sweet bread produced, sweet bread K has the highest moisture content (22,36%) and it is different from other sweet bread samples. VCO effectively inhibits the growth of sweet bread mold at concentrations of 8%, 12%, and 16%. K and A sweet bread has a shelf life of 4 days, while sweet breads B, C, and D have a shelf life of 6 days.Keywords: VCO, sweet bread, characteristics, shelf life

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