Psychophysiological Correlates of Emotional- and Alcohol-Related Cues Processing in Offspring of Alcohol-Dependent Patients

2020 ◽  
Vol 55 (4) ◽  
pp. 374-381
Author(s):  
I Dominguez-Centeno ◽  
R Jurado-Barba ◽  
A Sion ◽  
A Martínez-Maldonado ◽  
G Castillo-Parra ◽  
...  
Keyword(s):  
Emotional Reactivity ◽  
Event Related Potentials ◽  
Total Sample ◽  
Event Related Potential ◽  
Control Group ◽  
Theta Power ◽  
Affective Stimuli ◽  
Early Posterior Negativity ◽  
Related Potentials ◽  
Alcohol Dependent

Abstract Aims To determinate if offspring of alcohol-dependent patients (OA) process affective stimuli and alcohol-related cues in a different manner than control subjects do. Methods Event-related potentials (early posterior negativity [EPN]/ late positive potential [LPP]) and event-related oscillations (Theta) were obtained by electroencephalographic (EEG) recording during the viewing of International Affective Picture System (IAPS) images with positive, negative and neutral valence, as well as alcohol-related cues. The total sample was comprised of 60 participants, divided into two groups: one group consisted of OA (30) and the control group of participants with negative family history of alcohol use disorders (30). Results Theta power analysis implies a significant interaction between condition, region and group factors. Post-hoc analysis indicates an increased theta power for the OA at different regions, during pleasant (frontal, central, parietal, occipital, right temporal); unpleasant (frontal, central, occipital); alcohol (frontal, central, parietal, occipital, right and left temporal) and neutral (occipital) cues. There are no group differences regarding any of the event-related potential measurements (EPN/LPP). Conclusions There is evidence of alterations in the processing of affective stimuli and alcohol-related information, evidenced by changes in theta brain oscillations. These alterations are characterized by an increased emotional reactivity, evidenced by increased theta at posterior sites. There is also an increased recruitment of emotion control, which could be a compensation mechanism, evidenced by increased theta power at anterior sites during affective stimuli and alcohol cues.

Startle-elicited Event-Related Potentials to Affective Stimuli are Associated with Recent Illicit Opioid use among Patients Receiving Opioid Agonist Treatment

2021 ◽  
pp. 155005942110701
Author(s):  
Joshua BB Garfield ◽  
Ali Cheetham ◽  
Nicholas B Allen ◽  
Paul G Sanfilippo ◽  
Dan I Lubman
Keyword(s):  
Event Related Potentials ◽  
Event Related Potential ◽  
Control Group ◽  
Opioid Use ◽  
Opioid Agonist ◽  
Opioid Agonist Treatment ◽  
Affective Stimuli ◽  
Related Potentials ◽  
P3 Amplitude ◽  
Illicit Opioid Use

Opioid use disorder (OUD) has been linked to exaggerated attentional, affective, and arousal responses to opioid-related stimuli, as well as altered responses to other affective (eg, naturally rewarding or aversive) stimuli, particularly blunted responses to pleasant/rewarding stimuli. Both exaggerated responses to drug-related stimuli and reduced response to pleasant stimuli may influence the course of OUD and its treatment, however interpretation of studies thus far is limited by methodological issues. In the present study, we examined subjective ratings, and attenuation of the P3 component of the acoustic startle-evoked event-related potential (as a measure of attention), while viewing neutral, pleasant, unpleasant, and drug-related images. Participants prescribed opioid agonist treatment (OAT) for OUD (n = 82) were compared to a carefully-matched control group (n = 33) and to recently-abstinent participants with OUD (n = 22). Relative to controls, participants prescribed OAT gave higher positive valence ratings of drug images, and blunted valence responses to other affective images, but groups did not differ in terms of arousal ratings or P3 amplitude. Within the OAT group, linear modeling of associations between frequency of recent illicit opioid use and startle P3 amplitude found an association between increased recent illicit opioid use and reduced attention to pleasant, relative to unpleasant, images. The latter finding may have implications for interventions targeting cognitive biases in people with substance use disorder. In particular, they suggest that enhancing attention to pleasant stimuli may be as, if not more important, than the typical approach of trying to reduce attentional bias to drug-related stimuli.

scholarly journals Neuronal Correlates of Cognitive Control Are Altered in Women With Endometriosis and Chronic Pelvic Pain

2020 ◽  
Vol 14 ◽  
Author(s):  
Genevieve Z. Steiner ◽  
Robert J. Barry ◽  
Katherine Wassink ◽  
Frances M. De Blasio ◽  
Jack S. Fogarty ◽  
...  
Keyword(s):  
Cognitive Control ◽  
Pelvic Pain ◽  
Chronic Pelvic Pain ◽  
Performance Test ◽  
Event Related Potentials ◽  
Event Related Potential ◽  
Pain Severity ◽  
Control Group ◽  
Severity Scores ◽  
Related Potentials

Endometriosis is a debilitating women's health condition and is the most common cause of chronic pelvic pain. Impaired cognitive control is common in chronic pain conditions, however, it has not yet been investigated in endometriosis. The aim of this study was to explore the neuronal correlates of cognitive control in women with endometriosis. Using a cross-sectional study design with data collected at a single time-point, event-related potentials were elicited during a cued continuous performance test from 20 women with endometriosis (mean age = 28.5 ± 5.2 years) and 20 age- and gender-matched controls (mean age = 28.5 ± 5.2 years). Event-related potential components were extracted and P3 component amplitudes were derived with temporal principal components analysis. Behavioral and ERP outcomes were compared between groups and subjective pain severity was correlated with ERP component amplitudes. No significant behavioral differences were seen in task performance between the groups (all p > 0.094). Target P3b (all p < 0.034) and SW (all p < 0.040), and non-target early P3a (eP3a; all p < 0.023) and late P3a (lP3a; all p < 0.035) amplitudes were smaller for the endometriosis compared to the healthy control group. Lower non-target eP3a (p < 0.001), lP3a (p = 0.013), and SW (p = 0.019) amplitudes were correlated with higher pain severity scores. Findings suggest that endometriosis-associated chronic pelvic pain is linked to alterations in stimulus-response processing and inhibitory control networks, but not impaired behavioral performance, due to compensatory neuroplastic changes in overlapping cognitive control and pain networks.

scholarly journals Mild cognitive impairment in mild brain injury (MBI) patients: An event related potential (ERP) and neuropsychology study.

2019 ◽  
Vol 18 (3) ◽  
pp. 557-566
Author(s):  
Faruque Reza ◽  
Tahamina Begum
Keyword(s):  
Brain Injury ◽  
Medical Science ◽  
Event Related Potentials ◽  
Wisconsin Card Sorting Test ◽  
Event Related Potential ◽  
Auditory Memory ◽  
Control Group ◽  
Significant Group ◽  
Mild Brain Injury ◽  
Related Potentials

Objectives: To evaluate auditory cognitive function in mild brain injury (MBI) patients, which is important to determine for rehabilitation and improve quality of their life. Methods: Participants (n=19/group) were divided into group 1 (G1-control), group 2 (G2/1st test-MBI/within 7 days of road traffic accident-RTA) and group 3 (G3/2nd test-MBI/2-6 months after RTA). Event related potentials (ERPs) were conducted using a 128-sensor net; participants counted silently rare target tone stimuli and ignored standard tones. Several neuropsychology tests like Verbal fluency test (PAS), Wisconsin Card Sorting Test (WCST), Rey Auditory Verbal and Learning Test (RAVLTIM, RAVLTDR and RAVLTTS) and Beck Depression Inventory (BDI) were subsequently administered. Results: Sensory (P50, N100) and cognitive (P300) ERP components were analysed from ERP waveforms. There were no significant group differences in amplitudes or latencies for all components across sites except P300 component amplitudes at T6 location. P50, N100 and P300 ERP components exhibited non-significantly increased amplitudes in G2 and G3 compared with G1 at all sites; non-significantly shorter latencies were identified at various sites. At several locations, G3 evoked non-significantly increased amplitudes and longer latencies with shorter latencies to other sites compared with G2 in all components. The MBI (G3) group exhibited significantly increased WCST, RAVLTIM and RAVLTDR scores compared with G1. Conclusion: These findings indicate MBI patients may have mild auditory, cognitive and executive dysfunctions with good auditory memory. MBI was associated with mild depression. Bangladesh Journal of Medical Science Vol.18(3) 2019 p.557-566

scholarly journals Decline in attentional inhibition among migraine patients: an event‐related potential study using the Stroop task

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Min Su ◽  
Rongfei Wang ◽  
Zhao Dong ◽  
Dengfa Zhao ◽  
Shengyuan Yu
Keyword(s):  
Stroop Task ◽  
Event Related Potentials ◽  
Brain Dysfunction ◽  
Event Related Potential ◽  
Control Group ◽  
Healthy Controls ◽  
Conflict Monitoring ◽  
Related Potentials ◽  
Migraine Group ◽  
Attentional Inhibition

Abstract Background As a disorder of brain dysfunction, migraine has been associated with cognitive decline. However, no consistent results with respect to the attention function in migraineurs have been found, and the relationship between attentional inhibition and migraine is also unclear. In this study, the attentional inhibition function was evaluated using event-related potentials (ERPs) while migraine patients and healthy controls were performing the color–word Stroop task. Methods In this study, 75 migraine patients and 41 age-, gender-, and education-matched healthy controls were enrolled. The Stroop task was performed, and both behavioral and ERP data were analyzed. Results As to the behavioral data, the migraine group had a longer reaction time compared to the control group, but no difference in Stroop effect was observed. With respect to ERP components, the amplitudes of both early and late medial frontal negativity (MFN) were decreased in the migraine group. Additionally, obvious differences in the early MFN and sustained potential (SP) amplitudes were found between patients with and without allodynia. Conclusions At the behavioral level, migraine patients exhibited decreased executive ability but no obvious decline in inhibition. By contrast, a decline in attentional inhibition during the migraine interictal phase was confirmed by the analysis of ERP components, mainly those associated with changes in the conflict-monitoring stage, independent of confounding factors such as age, education, medication and mood disorders. Migraine patients with allodynia exhibited some significant differences in early MFN and SP compared to those without, supporting the hypothesis that migraine chronification aggravates the decline in attentional inhibition.

scholarly journals Can ambient odors influence the recognition of emotional words? A behavioral and event-related potentials study

2021 ◽  
Author(s):  
Danyang Li ◽  
Xiaochun Wang
Keyword(s):  
Event Related Potentials ◽  
Event Related Potential ◽  
Emotional Words ◽  
N400 Amplitude ◽  
Early Posterior Negativity ◽  
Unpleasant Odor ◽  
Related Potentials ◽  
Pleasant Odor ◽  
Left And Right ◽  
The Brain

AbstractOdor context can affect the recognition of facial expressions. However, there is no evidence to date that odor can regulate the processing of emotional words conveyed by visual words. An emotional word recognition task was combined with event-related potential technology. Briefly, 49 adults were randomly divided into three odor contexts (pleasant odor, unpleasant odor, and no odor) to judge the valence of emotional words (positive, negative, and neutral). Both behavioral and Electroencephalography (EEG) data were collected. Both the pleasant odor and unpleasant odor contexts shortened the response time of the subjects to emotional words. In addition, negative words induced greater amplitudes of early posterior negativity (EPN) and late positive potential (LPP) than the positive and neutral words. However, the neutral words induced a larger N400 amplitude than the positive and negative words. More importantly, the processing of emotional words was found to be modulated by external odor contexts. For example, during the earlier (P2) processing stages, pleasant and unpleasant odor contexts induced greater P2 amplitudes than the no odor context. In the unpleasant odor context, negative words with the same odor valence induced greater P2 amplitudes than the positive words. During the later (N400) stages, various regions of the brain regions exhibited different results. For example, in the left and right frontal areas of the brain, exposure to positive words in a pleasant odor context resulted in a smaller N400 amplitude than exposure to neutral words in the same context. Meanwhile, in the left and right central regions, emotional words with the same valence as pleasant or unpleasant odor contexts elicited the minimum N400 amplitude. Individuals are very sensitive to emotional information. With deeper processing, different cognitive processes are reflected and they can be modulated by external odors. In the early and late stages of word processing, both pleasant and unpleasant odor contexts exhibited an undifferentiated dominance effect and could specifically modulate affectively congruent words.

scholarly journals Auditory Cognitive Function Assessment during Pregnancy: An Event-Related Potential and Neuropsychological Study

2021 ◽  
Vol 20 (3) ◽  
pp. 608-617
Author(s):  
Tahamina Begum ◽  
Faruque Reza
Keyword(s):  
Cognitive Function ◽  
Medical Science ◽  
Event Related Potentials ◽  
Positive Influence ◽  
Event Related Potential ◽  
Oddball Paradigm ◽  
Control Group ◽  
Hormonal Changes ◽  
Related Potentials ◽  
Function Assessment

Objectives: We investigated the auditory cognitive and behavioral functions during 2nd and 3rd trimesters of pregnancy using event-related potentials (ERPs) and different neuropsychology tests, respectively. Methods: The ERPs were studied by using a 128-sensor net, and PAS/COWA, WCST, ZCT, RAVLTIM/RAVLTDR/RAVLTTS, and BDI were tested for neuropsychology assessment. Total 39 subjects were recruited for control group (G1, n=15, non-pregnant), 2nd trimester group (G2, n=12, 13-26 weeks gestation), and 3rd trimester group (G3, n=12, 26- 40 weeks gestation). Auditory oddball paradigm was used during ERP study. Subjects silently counted only the target stimuli with attention by ignoring standard stimuli. Value of the mean differences of the target and standard stimuli were measured across groups in 10-20 electrode systems. Results: The P50, N100, and P300 ERP components were analyzed. The G3 (at F7 and C3) and G2 (at T4) groups evoked the highest significant amplitudes in P50, and G3 (at Cz and Pz) and G1 (at F8 and T4) evoked the highest significant amplitudes of N100 with significantly prolonged latencies at Cz and O1 (in G1) and F8 (in G2). However, significantly higher amplitudes of P300 were found at Fz (in G3) and FP1 (G2) (G2>G3). On the other hand, neuropsychology tests revealed that G2 possessed the highest significant score in WCST and G1 in ZCT. The G3 performed poorly in all tests. Conclusion: We concluded that pregnant groups performed better in auditory (attention/memory) and executive function assessment. Moreover, the 2nd trimester group has better auditory cognitive function compared to the 3rd trimester group due to the effect of hormonal changes during pregnancy, which might be a positive influence during the pregnancy period. Bangladesh Journal of Medical Science Vol.20(3) 2021 p.608-617

scholarly journals Abnormal Habituation of the Auditory Event-Related Potential P2 Component in Patients With Schizophrenia

2021 ◽  
Vol 12 ◽  
Author(s):  
Prune Mazer ◽  
Inês Macedo ◽  
Tiago O. Paiva ◽  
Fernando Ferreira-Santos ◽  
Rita Pasion ◽  
...  
Keyword(s):  
Auditory Processing ◽  
Event Related Potentials ◽  
Event Related Potential ◽  
Diagnostic Tools ◽  
First Episode ◽  
Control Group ◽  
Bird Songs ◽  
Auditory Event ◽  
Complex Sounds ◽  
Related Potentials

Auditory event-related potentials (ERP) may serve as diagnostic tools for schizophrenia and inform on the susceptibility for this condition. Particularly, the examination of N1 and P2 components of the auditory ERP may shed light on the impairments of information processing streams in schizophrenia. However, the habituation properties (i.e., decreasing amplitude with the repeated presentation of an auditory stimulus) of these components remain poorly studied compared to other auditory ERPs. Therefore, the current study used a roving paradigm to assess the modulation and habituation of N1 and P2 to simple (pure tones) and complex sounds (human voices and bird songs) in 26 first-episode patients with schizophrenia and 27 healthy participants. To explore the habituation properties of these ERPs, we measured the decrease in amplitude over a train of seven repetitions of the same stimulus (either bird songs or human voices). We observed that, for human voices, N1 and P2 amplitudes decreased linearly from stimulus 1–7, in both groups. Regarding bird songs, only the P2 component showed a decreased amplitude with stimulus presentation, exclusively in the control group. This suggests that patients did not show a fading of neural responses to repeated bird songs, reflecting abnormal habituation to this stimulus. This could reflect the inability to inhibit irrelevant or redundant information at later stages of auditory processing. In turn schizophrenia patients appear to have a preserved auditory processing of human voices.

Deficits in Processing of Lexical Tones in Mandarin-Speaking Children With Developmental Language Disorder: Electrophysiological Evidence

2021 ◽  
pp. 1-13
Author(s):  
Ying-Ying Cheng ◽  
Hsin-Chi Wu ◽  
Hsin-Yi Shih ◽  
Pei-Wen Yeh ◽  
Huei-Ling Yen ◽  
...  
Keyword(s):  
Mismatch Negativity ◽  
Event Related Potentials ◽  
Event Related Potential ◽  
Oddball Paradigm ◽  
Control Group ◽  
Lexical Tone ◽  
Data Set ◽  
Lexical Tones ◽  
Related Potentials ◽  
Neural Marker

Purpose This study explored the neural marker indexing deficits in discriminating lexical tone changes in Mandarin-speaking children with developmental language disorders (DLDs) using mismatch negativity, an event-related potential component for auditory change detection. Mandarin has four lexical tones characterized by a high-level tone (T1), high-rising tone (T2), low-dipping tone (T3), and high-falling tone (T4), in which the T2/T3 contrast is acoustically less discriminable in developmental groups. Therefore, this study further examined how deficits in children with DLD would vary with tonal contrasts' acoustic saliency. Method Event-related potentials were measured using the multideviant oddball paradigm described by Lee et al. (2012), who used Mandarin syllables [i] in T3 as the standard sound (80%), T1 as the large deviant (10%), and T2 as the small deviant (10%). Twelve children with DLD aged between 4 and 6 years participated in this study, and 12 age-matched children with typical development were selected from the data set of Lee et al. (2012) as the controls. Results The T1/T3 change elicited adultlike mismatch negativity in both the DLD and control groups, while no group difference was revealed. The T2/T3 change elicited a robust positive mismatch response (P-MMR) in children with DLD, while the P-MMR was less significant in the control group. The group comparisons revealed a larger P-MMR in children with DLD than in the control group. Furthermore, children with lower scores in language assessments tend to reveal larger P-MMRs. Conclusions This study demonstrated that deficits in children with DLD in discriminating subtle lexical tone changes reflect greater positivity of P-MMR to T2/T3 change. This implies that MMR to T2/T3 may serve as a neural marker for evaluating language delay in preschoolers.

EEG Measurement of Emotion Processing in Children with Daytime Urinary Incontinence

2018 ◽  
Vol 46 (4) ◽  
pp. 336-341
Author(s):  
Justine Niemczyk ◽  
Monika Equit ◽  
Katja Rieck ◽  
Mathias Rubly ◽  
Catharina Wagner ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Patient Group ◽  
Imaging Techniques ◽  
Emotion Processing ◽  
Event Related Potentials ◽  
Oddball Paradigm ◽  
Control Group ◽  
Central Processing ◽  
Daytime Urinary Incontinence ◽  
Related Potentials

Abstract. Objective: Daytime urinary incontinence (DUI) is common in childhood. The aim of the study was to neurophysiologically analyse the central emotion processing in children with DUI. Method: In 20 children with DUI (mean age 8.1 years, 55 % male) and 20 controls (mean age 9.1 years, 75 % male) visual event-related potentials (ERPs) were recorded after presenting emotionally valent (80 neutral, 40 positive, and 40 negative) pictures from the International Affective Picture System (IAPS) as an oddball-paradigm. All children received a full organic and psychiatric assessment. Results: Children with DUI did not differ significantly from controls regarding responses to emotional pictures in the frontal, central, and parietal regions and in the time intervals 250–450 ms, 450–650 ms, and 650–850 ms after stimulus onset. The patient group had more psychological symptoms and psychiatric comorbidities than the control group. Conclusions: EEG responses to emotional stimuli are not altered in children with DUI. Central emotion processing does not play a major role in DUI. Further research, including a larger sample size, a more homogeneous patient group (regarding subtype of DUI) or brain imaging techniques, could reveal more about the central processing in DUI.

Age does not necessarily influence latency of event-related potentials

2014 ◽  
Vol 33 (10) ◽  
pp. 723-727
Author(s):  
M. Westermann ◽  
I. W. Husstedt ◽  
A. Okegwo ◽  
S. Evers
Keyword(s):  
Normal Values ◽  
Rank Correlation ◽  
Event Related Potentials ◽  
Intrinsic Property ◽  
Total Sample ◽  
Oddball Paradigm ◽  
Age Dependent ◽  
Related Potentials ◽  
The Mean ◽  
P3 Component

SummaryEvent-related potentials (ERP) are regarded as age dependent. However, it is not known whether this is an intrinsic property of ERP or an extrinsic factor. We designed a setting in which ERP were evoked using a modified oddball paradigm with highly differentiable and detectable target and non-target stimuli. A total of 98 probands were enrolled in this study. We evaluated the latency and amplitude of the P3 component of visually evoked ERP. The mean P3 latency was 294 ± 28 ms and was not related to age (r = –0.089; p = 0.382; Spearman-rank-correlation). The P3 amplitude was related to age in the total sample (r = –0.323; p = 0.001; Spearmanrank-correlation) but not in the probands under the age of 60 years. There were no significant differences regarding sex. Our findings suggest that ERP are not age dependent if highly differentiable and detectable stimuli are used. This should be considered when normal values of ERP are created for clinical use.

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