scholarly journals Total Protein Usual Intake Is Associated With Reduced Risk of All-Cause and Heart Disease Mortality in US Adults

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1079-1079
Author(s):  
Yanni Papanikolaou ◽  
Victor III Fulgoni
Keyword(s):  
Heart Disease ◽  
Mortality Risk ◽  
Total Protein ◽  
Protein Intake ◽  
Animal Protein ◽  
Disease Mortality ◽  
Usual Intake ◽  
Cancer Mortality Risk ◽  
Reduced Risk ◽  
Related Mortality

Abstract Objectives Studies have linked animal protein intake with an increased risk in mortality from all-causes and certain chronic diseases, including cancer and heart disease. The objective of the current analysis was to examine associations between usual intake of total and animal protein from various sources and all-cause, cancer, and heart disease-related mortality risk. Methods Data for adults (≥19 y; N = 54,830) from the Third National Health and Nutrition Examination Survey (NHANES) and NHANES 1999–2014 were linked with mortality data through 2015. Individual protein usual intakes were estimated using the National Cancer Institute method. Hazard ratio (HR) models were fit for mortality types (all cause, cancer, heart disease) and measures of total and animal protein usual intake. Multivariable analysis further adjusted for age, gender, ethnicity, waist circumference, smoking status, education level, chronic condition status (i.e., based on cancer, myocardial infarct, and diabetes/diabetes medication reported), weight loss attempts, and % kcal from total fat. Results Total protein usual intake was associated with 10% and 13% lowered risk of mortality from all-causes [HR = 0.90; CI: 0.82–0.99; P = 0.003] and heart disease [HR = 0.87; CI: 0.72–1.05; P = 0.05], respectively. No associations were observed between total protein intake and cancer mortality risk [HR = 0.98; CI: 0.80–1.21; P = 0.84]. No associations were seen between animal protein intake and mortality risk from all-causes [Quartile trend HR = 0.97; confidence intervals (CI): 0.91–1.04; P = 0.32], cancer [HR = 1.08; CI: 0.95–1.23; P = 0.13] and heart disease [HR = 0.98; CI: 0.85–1.13; P = 0.73]. No associations were seen between total dairy protein intake and all-cause and cancer mortality risk, however, there was an 11% reduced risk in heart disease mortality [HR = 0.89; CI: 0.80–1.00; P = 0.008]. No significant associations were seen between total red meat (beef, pork, lamb) protein usual intake and all-cause, cancer, and heart disease-related mortality risk. Conclusions These results contradict previous findings that have linked animal protein intake to increased mortality risk from all-causes, cancer and heart disease. Further, total protein consumption may help lower all-cause and heart disease-related mortality risk in adults. Funding Sources Funded by the Beef Checkoff.

scholarly journals Dairy Food Consumption Is Associated With Reduced Risk of Heart Disease Mortality, but Not All-Cause and Cancer Mortality in US Adults

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1078-1078
Author(s):  
Yanni Papanikolaou ◽  
Victor III Fulgoni
Keyword(s):  
Heart Disease ◽  
Confidence Intervals ◽  
Food Consumption ◽  
Mortality Risk ◽  
Animal Protein ◽  
Mortality Data ◽  
Dairy Food ◽  
Dairy Foods ◽  
Disease Mortality ◽  
Reduced Risk

Abstract Objectives Previous evidence has linked animal protein intake, including dairy foods, with an increased risk in mortality from all-causes and certain chronic diseases, including cancer and heart disease. The objective of the current analysis was to examine associations between total dairy consumption with mortality from all-causes, cancer, and heart disease. Methods Data for adults (≥19 y; N = 54,830) from the Third National Health and Nutrition Examination Survey (NHANES) and NHANES 1999–2014 were linked with mortality data through 2015. Individual usual intake for dairy foods were estimated using the National Cancer Institute method. Hazard ratio (HR) models were fit for mortality types (all cause, cancer, heart disease) and measures of dairy intake. Multivariable analysis further adjusted for age, gender, ethnicity, waist circumference, smoking status, education level, chronic condition status (i.e., based on cancer, myocardial infarct, and diabetes/diabetes medication reported), weight loss attempts, and %kcal from animal protein. Results No associations were seen between dairy food intake and mortality risk from all-causes [HR = 0.97; confidence intervals (CI): 0.81–1.16; P = 0.67], and cancer [HR = 0.95; CI: 0.70–1.29; P = 0.65] when comparing the lowest quartile to the highest quartile of consumption. Dairy food consumption was associated with a 26% reduced risk for heart disease mortality when comparing the lowest quartile to the highest quartile [HR = 0.74; CI: 0.49–1.11; P = 0.05]. Further analyses in different age groups showed that dairy food consumption was associated with 39% and 31% reduced risk for heart disease mortality in older adults 51–70 and ≥ 51 y, respectively [adults 51–70 y: HR = 0.61; CI: 0.37–1.03; P = 0.01; adults ≥ 51 y: HR = 0.69; CI: 0.50–0.96; P = 0.004]. No associations were seen between total milk intake and mortality risk from all-causes [HR = 1.04; confidence intervals (CI): 0.90–1.20; P = 0.51], cancer [HR = 0.99; CI: 0.72–1.36; P = 0.95] and heart disease [HR = 0.85; CI: 0.61–1.19; P = 0.21] when comparing the lowest quartile to the highest quartile of consumption. Conclusions These results contradict previous findings that have linked dairy foods to increased mortality risk. Further, dairy foods as part of a healthy dietary pattern, may help lower heart disease mortality risk. Funding Sources Supported by National Dairy Council.

Abstract P510: Association of Animal and Plant Protein Intake With Mortality Among US Adults: A Prospective Cohort Study

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Zhilei Shan ◽  
Danielle E Haslam ◽  
Colin D Rehm ◽  
Mingyang Song ◽  
Frank B Hu ◽  
...  
Keyword(s):  
Heart Disease ◽  
Cancer Mortality ◽  
Protein Intake ◽  
Total Mortality ◽  
Cox Proportional Hazards ◽  
Animal Protein ◽  
Plant Protein ◽  
Food Sources ◽  
Processed Meat ◽  
Disease Mortality

Introduction: Animal protein sources, especially red and processed meat, have been associated with adverse health outcomes. Epidemiological evidence on the isocaloric substitution of plant for animal protein on mortality risk remains limited. Hypothesis: We hypothesized that substituting plant protein for carbohydrates and animal protein would be associated with lower mortality. Method: We included a nationally representative sample of 37 233 US adults ≥20 years with 24-h dietary recall data from eight National Health and Nutrition Examination Survey (NHANES) cycles (1999-2014). Mortality from all causes, heart disease, and cancer were identified through National Death Index linkage (until December 31, 2015). We used Cox proportional hazards regression to estimate the association between plant and animal protein intake and mortality after adjustment for potential confounding factors. Results: During 297 768 person-years of follow-up, 4 866 total deaths occurred, including 849 deaths from heart disease and 1 068 deaths from cancer. After multivariable adjustment, higher intake of total animal protein was not associated with total mortality. Plant protein was associated with lower total mortality; when comparing the lowest with highest quintiles of plant protein intake, the multivariable adjusted HR (95% CIs) of total mortality was 0.73 (0.61, 0.88); P for trend <0.001. The HRs (95% CIs) comparing extreme quintiles were 0.71 (0.48, 1.05) for heart disease mortality, and 0.74 (0.53, 1.04) for cancer mortality. When isocalorically replacing 5% of energy from total animal protein with plant protein, the multivariable HRs were 0.49 (0.32, 0.74) for total mortality, 0.51 (0.28, 0.95) for heart disease mortality, and 0.53 (0.28, 1.00) for cancer mortality. For different food sources of animal protein, isocaloric substitution of 2% of energy from plant protein for protein in unprocessed red meat (0.74, 95% CI: 0.63, 0.87), processed meat (0.68, 95% CI: 0.53, 0.89), total dairy (0.74, 95% CI: 0.58, 0.94), and 1% of energy from plant protein for seafood (0.86, 95% CI: 0.79, 0.93) was each associated with a lower risk of total mortality. Conclusions: Higher plant protein intake was associated with lower total mortality. Isocalorically replacing animal protein with plant protein was associated with lower total mortality.

scholarly journals A population-based study of cardiovascular disease mortality risk in US cancer patients

2019 ◽  
Vol 40 (48) ◽  
pp. 3889-3897 ◽  
Author(s):  
Kathleen M Sturgeon ◽  
Lei Deng ◽  
Shirley M Bluethmann ◽  
Shouhao Zhou ◽  
Daniel M Trifiletti ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Heart Disease ◽  
General Population ◽  
Cancer Diagnosis ◽  
Mortality Risk ◽  
First Year ◽  
Cardiovascular Disease Mortality ◽  
Disease Mortality ◽  
Cvd Mortality

Abstract Aims This observational study characterized cardiovascular disease (CVD) mortality risk for multiple cancer sites, with respect to the following: (i) continuous calendar year, (ii) age at diagnosis, and (iii) follow-up time after diagnosis. Methods and results The Surveillance, Epidemiology, and End Results program was used to compare the US general population to 3 234 256 US cancer survivors (1973–2012). Standardized mortality ratios (SMRs) were calculated using coded cause of death from CVDs (heart disease, hypertension, cerebrovascular disease, atherosclerosis, and aortic aneurysm/dissection). Analyses were adjusted by age, race, and sex. Among 28 cancer types, 1 228 328 patients (38.0%) died from cancer and 365 689 patients (11.3%) died from CVDs. Among CVDs, 76.3% of deaths were due to heart disease. In eight cancer sites, CVD mortality risk surpassed index-cancer mortality risk in at least one calendar year. Cardiovascular disease mortality risk was highest in survivors diagnosed at &lt;35 years of age. Further, CVD mortality risk is highest (SMR 3.93, 95% confidence interval 3.89–3.97) within the first year after cancer diagnosis, and CVD mortality risk remains elevated throughout follow-up compared to the general population. Conclusion The majority of deaths from CVD occur in patients diagnosed with breast, prostate, or bladder cancer. We observed that from the point of cancer diagnosis forward into survivorship cancer patients (all sites) are at elevated risk of dying from CVDs compared to the general US population. In endometrial cancer, the first year after diagnosis poses a very high risk of dying from CVDs, supporting early involvement of cardiologists in such patients.

scholarly journals Prognostic significance of nocturnal dipping for stroke and heart disease mortality risk: The Ohasama study

2005 ◽  
Vol 18 (5) ◽  
pp. A259-A259
Author(s):  
H METOKI ◽  
T OHKUBO ◽  
M KIKUYA ◽  
K ASAYAMA ◽  
T OBARA ◽  
...  
Keyword(s):  
Heart Disease ◽  
Mortality Risk ◽  
Prognostic Significance ◽  
Nocturnal Dipping ◽  
Disease Mortality

scholarly journals Validation of an FFQ to assess dietary protein intake in type 2 diabetic subjects attending primary health-care services in Mali

2009 ◽  
Vol 12 (5) ◽  
pp. 644-650 ◽  
Author(s):  
A Coulibaly ◽  
H Turgeon O’Brien ◽  
I Galibois
Keyword(s):  
Dietary Protein ◽  
Total Protein ◽  
Protein Intake ◽  
Animal Protein ◽  
Plant Protein ◽  
Animal Origin ◽  
Dietary Protein Intake ◽  
Men And Women ◽  
Type 2 Diabetic

AbstractObjectiveTo validate a 53-item quantitative FFQ (QFFQ) for the assessment of dietary protein intake in type 2 diabetic outpatients in Bamako, Mali.DesignConsumption of protein-containing foods over the week preceding the interview was measured with a 7d QFFQ and compared with intakes measured with 48-h recalls.SettingCentre National de Lutte contre le Diabète.SubjectsSeventeen male and forty female adults with type 2 diabetes.ResultsCorrelation between protein intakes estimated using the QFFQ and 48h recalls was 0·63 (P< 0·0001). There was no significant difference between the two methods concerning the total protein daily intakes and intakes per kilogram of body weight. The QFFQ indicated that foods of animal origin were a lesser source of protein. Animal protein intake did not differ between men and women but sources did. In men, the main sources were beef (54 % of total animal protein), fish (15 %) and milk powder (8 %). In women, the principal sources were fish (28 %), beef (20 %) and birds (13 %). In contrast, plant protein intake was significantly higher in men than in women (P= 0·01), but the same plant foods contributed in similar proportions for both genders, rice being by far the greatest source (47 % of plant protein in men, 53 % in women).ConclusionThe QFFQ developed in this study is a valid tool to evaluate dietary protein intakes in Malian diabetic subjects. While the total protein intakes were low in both men and women, differences in choices and amounts of protein food sources were shown.

scholarly journals Rapidly upsloping ST-segment on exercise ECG: a marker of reduced coronary heart disease mortality risk

2012 ◽  
Vol 20 (4) ◽  
pp. 541-548 ◽  
Author(s):  
Christian Hodnesdal ◽  
Erik Prestgaard ◽  
Gunnar Erikssen ◽  
Knut Gjesdal ◽  
Sverre E Kjeldsen ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Mortality Risk ◽  
Coronary Heart Disease Mortality ◽  
Disease Mortality ◽  
St Segment ◽  
Exercise Ecg

scholarly journals Association of engagement in cultural activities with cause-specific mortality determined through an eight-year follow up: The HUNT Study, Norway

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248332
Author(s):  
Bente I. Løkken ◽  
Dafna Merom ◽  
Erik R. Sund ◽  
Steinar Krokstad ◽  
Vegar Rangul
Keyword(s):  
Cardiovascular Disease ◽  
Cancer Mortality ◽  
Cardiovascular Disease Mortality ◽  
Cultural Activities ◽  
Disease Mortality ◽  
Specific Mortality ◽  
Risk Of Cancer ◽  
Reduced Risk ◽  
Related Mortality

Participation in cultural activities may protect against cause-specific mortality; however, there is limited knowledge regarding this association. The present study examines the association between participation in a range of receptive and creative cultural activities and risk of cardiovascular disease- and cancer-related mortality. We also examined whether participation in such activities and influence by gender have on this association. We followed 35,902 participants of the Nord-Trøndelag Health Study (HUNT3) of Cardiovascular-Disease and Cancer Mortality from 2006–08 to 2016. Cox proportional-hazards regression was used to estimate the risk of specific mortality based on baseline cultural participation. During the eight-year follow-up, there were 563 cardiovascular-disease- and 752 cancer-related deaths among the sample (292,416 person years). Risk of cardiovascular-disease mortality was higher among non-participants in associations/club meetings (22%) and outdoor activities (23%), respectively, as well as non-attendees of art exhibitions (28%). People who engaged in music, singing, and theatre had a 27% reduced risk of cancer-related mortality when compared to non-participants. Among women, participating in associations/club meetings reduced the risk of cardiovascular-disease mortality by 36%. Men who participated in music, singing, and theatre had a 33% reduced risk of cancer mortality. Overall, a reduced risk of cardiovascular-disease mortality was associated with engaging in creative activities on weekly basis to less than twice per week. For both genders, participating in creative activities less than once a week reduced cardiovascular-disease mortality risk by 40% and 33%, respectively. For the overall sample, participating > 2 times per week in combined receptive and creative activities reduced cancer-related mortality by 29%. Participating frequently in both receptive and creative activities cultural activities was associated with lower risks of CVD and cancer-related mortality. Our data suggest that, to counteract the public health burden of cardiovascular disease- and cancer mortality, policies and initiatives to increase citizens’ participation in cultural activities should be considered.

Abstract P089: Total, Plant and Animal Protein Intake and Blood Pressure: A Meta-analysis of Observational and Intervention Studies

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Susanne M Tielemans ◽  
Wieke Altorf - van der Kuil ◽  
Mariëlle F Engberink ◽  
Elizabeth J Brink ◽  
Marleen A van Baak ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Prospective Studies ◽  
Dietary Protein ◽  
Total Protein ◽  
Protein Intake ◽  
Meta Analysis ◽  
Animal Protein ◽  
Plant Protein ◽  
Cross Sectional ◽  
Cross Sectional Studies

Background: Dietary protein may beneficially influence blood pressure (BP), but evidence is not conclusive. Objective: To quantify the association of total protein, plant protein, and animal protein intake with BP and incident hypertension by means of meta-analysis. Methods: A systematic literature search for eligible studies was conducted until January 2012, using MEDLINE and manual search. Of >3,000 titles evaluated, 29 met the inclusion criteria. Dose-response meta-analyses were performed using STATA 11.0. We included 8 cross-sectional studies (total of 48,985 participants), 4 prospective studies (11,761 participants), and 17 randomized controlled trials (1,449 subjects). Results: Total protein intake was significantly inversely associated with systolic BP ([[Unable to Display Character: &#8209;]]0.20 mmHg per SD, 95%-CI: [[Unable to Display Character: &#8209;]]0.39 to [[Unable to Display Character: &#8209;]]0.01) in cross-sectional studies, but no relation was found with incident hypertension in prospective studies (HR of 0.99 per SD, 95%-CI: 0.96 to 1.02). Trials showed an overall reduction of [[Unable to Display Character: &#8209;]]2.1 mmHg in systolic BP (95%-CI:[[Unable to Display Character: &#8209;]]2.9 to [[Unable to Display Character: &#8209;]]1.4) for a weighed difference in protein intake of 41 g/d, compared to carbohydrates. Plant protein, but not animal protein, was weakly inversely associated with BP in cross-sectional studies. Plant protein and animal protein showed similar associations in prospective studies (non-significant HR of 0.96 and 0.98 per SD, respectively) and randomized trials (-2.0 vs -2.2 mmHg, P<0.05, respectively). Conclusion: Dietary protein may have a beneficial effect on BP if consumed instead of carbohydrates. No clear difference was observed between plant and animal protein, but data on protein from different sources and BP is scarce and more research is needed to draw conclusions.

scholarly journals A prospective study on total protein, plant protein and animal protein in relation to the risk of incident chronic kidney disease

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Sevda Alvirdizadeh ◽  
Emad Yuzbashian ◽  
Parvin Mirmiran ◽  
Shahryar Eghtesadi ◽  
Fereidoun Azizi
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Total Protein ◽  
Protein Intake ◽  
Protective Role ◽  
Animal Protein ◽  
Plant Protein ◽  
Total Protein Content ◽  
Inverse Association ◽  
Incident Chronic Kidney Disease

Abstract Background The link between dietary protein intake and the risk of kidney dysfunction is always a challenging issue. This study aimed to investigate the relationship between total protein, plant protein, and animal protein intake with the risk of incident chronic kidney disease (CKD). Methods This study was performed on 1639 adults aged ≥27 years who participated in the Tehran Lipid and Glucose Study. Dietary data were evaluated using a valid and reliable semi-quantitative food frequency questionnaire (FFQ). Total protein content, plant protein, and animal protein of each participant were calculated. Glomerular filtration rate (GFR) less than 60 mL / min / 1.73 m2 has been considered as the definition of CKD. Odds Ratio (OR) was calculated using logistic regression to show the association between the risk of incident CKD and dietary exposures. Results After adjusting for age, sex, body mass index, smoking, total energy intake, total fiber intake, dietary fat, physical activity, diabetes, and hypertension, there was no significant association of total protein and animal protein consumptions with the incidence of CKD. After adjustment for confounders, compared with the lowest tertile of plant protein consumption, OR of incident CKD in the highest tertile was 0.29 (95% confidence interval [95% CI] 0.15 to 0.55) with a significant trend (P for trend < 0.001). Conclusion The results of this study confirmed an inverse association between plant protein intake and the risk of incident CKD, which demonstrates the protective role of plant-based protein in a diet on kidney function.

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