scholarly journals Autonomic Activity in Overweight-Obese Children During the Morning Transition in Cardiac Circadian Regulation (P21-065-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
R Pivik ◽  
Y Gu ◽  
H Downs ◽  
A Andres ◽  
K Jarratt ◽  
...  
Keyword(s):  
Nervous System ◽  
Circadian Rhythms ◽  
Energy Homeostasis ◽  
Cardiovascular Health ◽  
Parasympathetic Nervous System ◽  
Negative Impact ◽  
Low Frequency ◽  
Normal Weight ◽  
Obese Children ◽  
Funding Sources

Abstract Objectives Regulation of the autonomic nervous system is disturbed in obese children and adults. This dysregulation—which includes sympathetic nervous system (SNS) over activity and disruption of cardiac circadian rhythms—is of interest because of the negative impact of these effects on cognition, regulation of energy homeostasis, cardiovascular health, and metabolic functions. The present study evaluated heart rate (HR) measures during the first hours following awakening from sleep when circadian cardiac control transitions from an emphasis on parasympathetic nervous system activity (PNS) during sleep to an emphasis on SNS activity during wakefulness. Methods Resting HR recordings (5 min) were obtained from healthy normal weight (NW: BMI < 85th %ile; n = 47; 25 boys) and overweight-obese (OB: BMI > 95th %ile; n = 48; 24 boys) 10 yr olds enrolled in the ACNC's Brain Food study. The first of two recording sessions (T1) took place 2 hrs after awakening (1 hr after a standardized breakfast), and the second (T2) 1 hr later. Recordings were processed for measures of sympathetic [low frequency (LF)] and parasympathetic [high frequency (HF); vagal tone (VT); root mean square of intervals between adjacent heart beats (RMSSD)] activities. Results Separate ANOVAs (recording session by group by sex) were conducted for each measure. Previous reports of higher HR in girls than boys and in OB than NW groups were confirmed (both P ≤ 0.001) HR slowed significantly from T1 to T2 for OB (P = 0.021), but not NW. These effects were associated with T1 to T2 increases in SNS LF activity for both groups (both P ≤ 0.003), but significant increases in PNS measures (HF, RMSSD, VT; all P < 0.05) for only OB children. Increases in PNS activity across recording sessions for OB children attenuated group HR differences during T2 (T1: OB > NW, P = 0.008; T2: OB > NW, P = .051). Gender differences were consistent with faster HR in girls which was maintained across groups and recording sessions. Conclusions The results are the first to show that autonomic dysregulation in obese children modulates the shift in SNS-PNS balance characteristic of the transition from sleep to waking. These findings may inform the development of new early intervention strategies to attenuate obesity that consider the role played by circadian rhythms. Funding Sources Funded by USDA-ARS Project 6026-51000-010-05S.

scholarly journals Comparative analysis of gross motor coordination between overweight/obese and eutrophic children

2020 ◽  
Vol 33 ◽  
Author(s):  
Fabiana do S. da Silva Dias de Andrade ◽  
Josy Davidson ◽  
Amélia Miyashiro Nunes dos Santos
Keyword(s):  
Linear Regression ◽  
Associated Factors ◽  
Motor Coordination ◽  
Linear Regression Analysis ◽  
Low Frequency ◽  
Multiple Linear Regression Analysis ◽  
Normal Weight ◽  
Obese Children ◽  
Cross Sectional ◽  
Gross Motor

Abstract Introduction: Overweight and obese children may have lower motor coordination score than normal-weight children. Objective: To compare gross motor coordination between overweight/obese and normal-weight children and investigate the associated factors with the motor coordination scores. Method: This cross-sectional study involved 169 children of both genders, aged 6-9 years. Children with malformations, bone, muscle, and joint or neurological disorders, and BMI z < -2 were excluded. Gross motor coordination was assessed by the “Körperkoordinationstest für Kinder” (KTK). The associated factors with the motor coordination scores were analyzed by linear regression. Results: The mean scores for balancing backwards (84.2 ± 13.2 vs. 91.0 ± 15.0), hopping over on one foot (127.9 ± 10.1 vs. 132.3 ± 12.1), shifting platforms sidewise (123.5 ± 23.4 vs. 129.8 ± 14.9), as well as the overall motor scores (112.5 ± 14.8 vs. 118.8 ± 11.6) were significantly lower (p < 0.05) in overweight/obese children when compared to normal-weight children. The percentage of poor motor scores (< 85) in balancing backwards was higher in overweight/obese children (60.4% vs. 36.4%, p = 0.004) and was similar for jumping sideways (18.8% vs. 9.9%, p = 0.116), as well as for shifting platforms sidewise (6.3% vs. 0.8%, p = 0.070). By multiple linear regression analysis, the variables overweight/obesity and sports practice for less than 2 times/week decreased significantly (p < 0.05) the motor coordination score by -18.7 and -15.6 points, respectively. Conclusion: The overweight/obese children scored lower in the motor coordination tests compared to the normal-weight children. Overweight/obesity and low frequency of physical activity were associated with lower scores of gross motor coordination.

scholarly journals Selective quantification of the cardiac sympathetic and parasympathetic nervous systems by multisignal analysis of cardiorespiratory variability

2008 ◽  
Vol 294 (1) ◽  
pp. H362-H371 ◽  
Author(s):  
Xiaoxiao Chen ◽  
Ramakrishna Mukkamala
Keyword(s):  
Nervous System ◽  
Transfer Function ◽  
Parasympathetic Nervous System ◽  
Transfer Functions ◽  
Low Frequency ◽  
Sympathetic Blockade ◽  
Nervous Systems ◽  
Autonomic Nervous ◽  
Arterial Blood ◽  
The Time Domain

Heart rate (HR) power spectral indexes are limited as measures of the cardiac autonomic nervous systems (CANS) in that they neither offer an effective marker of the β-sympathetic nervous system (SNS) due to its overlap with the parasympathetic nervous system (PNS) in the low-frequency (LF) band nor afford specific measures of the CANS due to input contributions to HR [e.g., arterial blood pressure (ABP) and instantaneous lung volume (ILV)]. We derived new PNS and SNS indexes by multisignal analysis of cardiorespiratory variability. The basic idea was to identify the autonomically mediated transfer functions relating fluctuations in ILV to HR (ILV→HR) and fluctuations in ABP to HR (ABP→HR) so as to eliminate the input contributions to HR and then separate each estimated transfer function in the time domain into PNS and SNS indexes using physiological knowledge. We evaluated these indexes with respect to selective pharmacological autonomic nervous blockade in 14 humans. Our results showed that the PNS index derived from the ABP→HR transfer function was correctly decreased after vagal and double (vagal + β-sympathetic) blockade ( P < 0.01) and did not change after β-sympathetic blockade, whereas the SNS index derived from the same transfer function was correctly reduced after β-sympathetic blockade in the standing posture and double blockade ( P < 0.05) and remained the same after vagal blockade. However, this SNS index did not significantly decrease after β-sympathetic blockade in the supine posture. Overall, these predictions were better than those provided by the traditional high-frequency (HF) power, LF-to-HF ratio, and normalized LF power of HR variability.

scholarly journals Physical Exercise Improves Heart-Rate Variability in Obese Children and Adolescents: A Systematic Review

2021 ◽  
Vol 13 (5) ◽  
pp. 2946
Author(s):  
Santos Villafaina ◽  
Juan Pedro Fuentes-García ◽  
Juan Luis Leon-Llamas ◽  
Daniel Collado-Mateo
Keyword(s):  
Systematic Review ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Physical Exercise ◽  
Children And Adolescents ◽  
Cardiovascular Health ◽  
Exercise Intervention ◽  
Negative Impact ◽  
Obese Children ◽  
Exercise Interventions

Background: Childhood obesity has negative impact on heart-rate variability (HRV) and, thereby, on the cardiovascular health of children and adolescents. Thus, physical-exercise interventions were proposed to increase HRV. The present systematic review aims to provide an up-to-date analysis of research on the effect of physical-exercise interventions on HRV in obese children and adolescents. Methods: An electronic search of the literature was performed, and 10 articles were included. PRISMA guideline methodology was employed. Results: Physical-exercise interventions predominantly involved aerobic training; however, alternative training programs, including judo or recreational soccer, were found. The duration of intervention ranged from 6 to 24 weeks, with a training frequency of between 2 and 7 times per week. The duration of sessions typically ranged from 40 to 60 min. Conclusions: Results of the included articles indicated that physical-exercise intervention increased the HRV and thereby the autonomic modulation of obese children and adolescents. This is significant, as HRV is associated with cardiovascular health. Such physical-exercise interventions are crucial to reduce weight and improve cardiovascular health in children and adolescents, thereby achieving a sustainable future.

Effects of Excitative and Sedative Music on Subjective and Physiological Relaxation

1997 ◽  
Vol 85 (1) ◽  
pp. 287-296 ◽  
Author(s):  
Makoto Iwanaga ◽  
Maki Tsukamoto
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
High Frequency ◽  
Parasympathetic Nervous System ◽  
Low Frequency ◽  
Adjective Checklist ◽  
Major Activity ◽  
Sedative Effects ◽  
Sympathetic Nervous

Previous investigations using heart rate as a measure have not clarified the excitative-sedative effects of music. One of the sources of this failure was considered to be use of the index of heart rate. The present purpose was to examine the excitative-sedative effect of music on indices of the sympathetic and the parasympathetic nervous activities through spectral analysis of heart rate. The presented stimuli were three excitative musical pieces and three sedative ones. Subjective feelings about music were measured by an adjective checklist concerning musical activity. Heart-rate variabilities divided into two components of Low Frequency, mainly affected by the sympathetic nervous system and of High Frequency, mainly affected by the parasympathetic nervous system. Six types of heart-rate indices were employed: (1) mean increments from posttrial base, (2) coefficient of variances of heart rate, (3) mean powers of Low Frequency, (4) coefficient of component variances of Low Frequency, (5) mean powers of High Frequency, and (6) coefficient of component variances of High Frequency. From the factor analysis based on responses to an adjective checklist, there was a single major activity factor. Activity scores showed some were high during excitative pieces and others low during sedative ones. For heart rate, excitative-sedative effects of music were observed only in indices related to High Frequency. This result suggests that musical effect was observed in measures of the parasympathetic nervous system but not in the sympathetic nervous system.

Assessment of autonomic function in humans by heart rate spectral analysis

1985 ◽  
Vol 248 (1) ◽  
pp. H151-H153 ◽  
Author(s):  
B. Pomeranz ◽  
R. J. Macaulay ◽  
M. A. Caudill ◽  
I. Kutz ◽  
D. Adam ◽  
...  
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Spectral Analysis ◽  
High Frequency ◽  
Autonomic Function ◽  
Parasympathetic Nervous System ◽  
Low Frequency ◽  
Parasympathetic System ◽  
Heart Rate Fluctuations ◽  
Frequency Fluctuations

Spectral analysis of spontaneous heart rate fluctuations were assessed by use of autonomic blocking agents and changes in posture. Low-frequency fluctuations (below 0.12 Hz) in the supine position are mediated entirely by the parasympathetic nervous system. On standing, the low-frequency fluctuations increase and are jointly mediated by the sympathetic and parasympathetic nervous systems. High-frequency fluctuations, at the respiratory frequency, are decreased by standing and are mediated solely by the parasympathetic system. Heart rate spectral analysis is a powerful noninvasive tool for quantifying autonomic nervous system activity.

Effects of Qi-Training on Heart Rate Variability

2002 ◽  
Vol 30 (04) ◽  
pp. 463-470 ◽  
Author(s):  
Myeong Soo Lee ◽  
Hwa Jeong Huh ◽  
Byung Gi Kim ◽  
Hoon Ryu ◽  
Ho-Sub Lee ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
High Frequency ◽  
Parasympathetic Nervous System ◽  
Low Frequency ◽  
Autonomic Nervous ◽  
Nervous Function ◽  
Young Subjects

This study investigates changes in autonomic nervous function through Qi-training. The power spectrum of heart rate variability (HRV) was examined in 20 sedentary healthy subjects and 20 Qi-trainees. It was found that Qi-training in healthy young subjects during controlled respiration increases the high frequency (HF) power and decreases the low frequency / high frequency (LF/HF) power ratio of HRV. These results support the hypothesis that Qi-training increases cardiac parasympathetic tone. In addition, Qi-trainees were found to have higher parasympathetic heart modulation compared with their age-matched, sedentary counterparts. This augmented HRV in Qi-trainees provides further support for long-term Qi-training as a possible non-pharmacological cardio-protective maneuver. In conclusion, Qi-training may stabilize the autonomic nervous system by modulating the parasympathetic nervous system.

scholarly journals The Evaluation of Horizontal Whole-Body Vibration in the Low Frequency Range

2002 ◽  
Vol 21 (1) ◽  
pp. 29-36
Author(s):  
Masashi Uchikune
Keyword(s):  
Nervous System ◽  
Parasympathetic Nervous System ◽  
Whole Body Vibration ◽  
Low Frequency ◽  
Psychological Effects ◽  
Whole Body ◽  
Frequency Range ◽  
Horizontal Vibration ◽  
Public Transport System ◽  
Iso 2631

International Standard ISO 2631 gives the reaction to horizontal vibration for the occupant of a building, a public transport system, the oscillations of the ocean and so on. These effects have not yet been evaluated by physiological methods as the criterion curves in the Standard are based on psychological evaluations of comfort and discomfort, rather than physiological investigations. Physiological and psychological effects of low frequency horizontal vibration on the whole-body were as follows: Changes in the autonomic nervous system were observed, in which the system tended to change from the state of predominance of the parasympathetic nervous system to that of the sympathetic nervous system, when the frequency exceeded the range 0.2 to 0.4Hz, typically around 0.3Hz.

scholarly journals Interplay Between Systemic Metabolic Cues and Autonomic Output: Connecting Cardiometabolic Function and Parasympathetic Circuits

2021 ◽  
Vol 12 ◽  
Author(s):  
Liliana Espinoza ◽  
Stephanie Fedorchak ◽  
Carie R. Boychuk
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Cardiac Function ◽  
Energy Homeostasis ◽  
Metabolic Diseases ◽  
Parasympathetic Nervous System ◽  
Cardiac Activity ◽  
Motor Output ◽  
Sympathetic Nervous

There is consensus that the heart is innervated by both the parasympathetic and sympathetic nervous system. However, the role of the parasympathetic nervous system in controlling cardiac function has received significantly less attention than the sympathetic nervous system. New neuromodulatory strategies have renewed interest in the potential of parasympathetic (or vagal) motor output to treat cardiovascular disease and poor cardiac function. This renewed interest emphasizes a critical need to better understand how vagal motor output is generated and regulated. With clear clinical links between cardiovascular and metabolic diseases, addressing this gap in knowledge is undeniably critical to our understanding of the interaction between metabolic cues and vagal motor output, notwithstanding the classical role of the parasympathetic nervous system in regulating gastrointestinal function and energy homeostasis. For this reason, this review focuses on the central, vagal circuits involved in sensing metabolic state(s) and enacting vagal motor output to influence cardiac function. It will review our current understanding of brainstem vagal circuits and their unique position to integrate metabolic signaling into cardiac activity. This will include an overview of not only how metabolic cues alter vagal brainstem circuits, but also how vagal motor output might influence overall systemic concentrations of metabolic cues known to act on the cardiac tissue. Overall, this review proposes that the vagal brainstem circuits provide an integrative network capable of regulating and responding to metabolic cues to control cardiac function.

scholarly journals Lifestyle modifications result in alterations in the gut microbiota in obese children

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ky Young Cho
Keyword(s):  
Gut Microbiota ◽  
Normal Weight ◽  
Rrna Gene ◽  
Weight Changes ◽  
Obese Children ◽  
Lifestyle Modifications ◽  
Cross Sectional ◽  
Fat Loss ◽  
Link Type ◽  
Firmicutes Phylum

Abstract Background The association between the gut microbiota and pediatric obesity was analyzed in a cross-sectional study. A prospective study of obese children was conducted to assess the gut microbial alterations after a weight change. We collected fecal samples from obese children before and after a 2-month weight reduction program that consisted of individual counseling for nutritional education and physical activity, and we performed 16S rRNA gene amplicon sequencing using an Illumina MiSeq platform. Results Thirty-six participants, aged 7 to 18 years, were classified into the fat loss (n = 17) and the fat gain (n = 19) groups according to the change in total body fat (%) after the intervention. The baseline analysis of the gut microbiota in the preintervention stages showed dysbiotic features of both groups compared with those of normal-weight children. In the fat loss group, significantly decreased proportions of Bacteroidetes phylum, Bacteroidia class, Bacteroidales order, Bacteroidaceae family, and Bacteroides genus, along with increased proportions of Firmicutes phylum, Clostridia class, and Clostridiales order, were observed after intervention. The microbial richness was significantly reduced, without a change in beta diversity in the fat loss group. The fat gain group showed significantly deceased proportions of Firmicutes phylum, Clostridia class, Clostridiales order, Lachnospiraceae family, and Eubacterium hallii group genus, without a change in diversity after the intervention. According to the functional metabolic analysis by the Phylogenetic Investigation of Communities by Reconstruction of Unobserved States 2, the “Nitrate Reduction VI” and “Aspartate Superpathway” pathways were predicted to increase significantly in the fat loss group. The cooccurring networks of genera were constructed and showed the different microbes that drove the changes between the pre- and postintervention stages in the fat loss and fat gain groups. Conclusions This study demonstrated that lifestyle modifications can impact the composition, richness, and predicted functional profiles of the gut microbiota in obese children after weight changes. Trial registration ClinicalTrials.govNCT03812497, registration date January 23, 2019, retrospectively registered.

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