scholarly journals The Gly460Trp polymorphism and the overnight sodium potassium excretion in hypertensives

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
C Delgado ◽  
M Delgado-Lelievre ◽  
D Lelievre ◽  
A Delgado-Almeida
Keyword(s):  
Blood Pressure ◽  
Strong Association ◽  
Inverse Association ◽  
Sodium Potassium ◽  
Blood Institute ◽  
Urine Creatinine ◽  
National Heart Lung ◽  
Strong Inverse Association ◽  
K Concentration ◽  
The Relationship

Abstract Introduction The Gly460Trp polymorphism is associated to hypertension and renal sodium (Na) potassium (K) exchange. This study explores the relationship between blood pressure (BP) and urinary overnight Na/K ratio (UONaK) in patients genotyped for Gly460Trp polymorphism, from a cohort of hypertensive (HT) and normotensive (NT) subjects from National Heart, Lung and Blood Institute funded, Family Blood Pressure Program (FBPP). Hypothesis Abnormal renal K and Na excretion is associated to the Trp allele of Gly460Trp polymorphism. Methods 3,545 subjects genotyped for Gly460Trp polymorphism were analyzed from FBPP. Subjects with diastolic BP (DBP) ≥80 or systolic BP (SBP) ≥130 mmHg were classified HTN; subjects with SBP <130 and DBP <80 mmHg were classified as NT. UONAK was calculated by dividing overnight Na by K concentration. Correlation analysis done with partial variables (body mass index, waist hip ratio, overnight urine creatinine). Results In HTN group (n=1,464), 75% had Gly/Gly, 22% Gly/Trp and 3% Trp/Trp. HTN with Gly/Gly showed strong associations between UONaK and DBP (r=0.191 p<0.0001) and SBP (r=0.06, p=0.04); HTN with Gly/Trp showed strong association for DBP (r=0.123 p=0.025) but not for SBP (r=0.07, p=0.188); while HTN with Trp/Trp there was strong inverse association with SBP (r=−0.399, p=0.010; Fig. 1) and none with DBP (r=0.215 p=0.18). In NT group (n=2,081), 69% had Gly/Gly, 28% Gly/Trp and 3% Trp/Trp; NT with Gly/Gly showed strong associations between UONaK and DBP (r=0.104 p<0.0001) and SBP (r=0.09, p=0.0002); NT with Gly/Trp showed strong association for DBP (r=0.146, p=0.0004) but not for SBP (r=0.05, p=0.18); while NT with Trp/Trp showed no association with DBP (r=−0.003 p=97), or SBP (r=0.06, p=0.61). Conclusions Hypertensives with Trp/Trp showed strong correlation between systolic blood pressure and UONaK, indicating abnormal K excretion in hypertensives, and possible subgroup targeted to potassium sparing drugs. Funding Acknowledgement Type of funding source: None

Genetic variations of SCNA7 and blood pressure potassium interaction

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
C Delgado ◽  
M Delgado-Lelievre ◽  
D Lelievre ◽  
A Delgado-Almeida
Keyword(s):  
Blood Pressure ◽  
Strong Correlation ◽  
Genetic Variations ◽  
Sodium Potassium ◽  
Blood Institute ◽  
Urine Creatinine ◽  
National Heart Lung ◽  
Gated Channel ◽  
K Concentration ◽  
The Relationship

Abstract Introduction The sodium voltage-gated channel alpha subunit 7 (SCN7A) has been associated to renal Na regulation and hypertension. This study explores the relationship between blood pressure (BP) and urinary overnight Na/K ratio (UONaK) in hypertensives (HT) and normotensive (NT) subjects from from National Heart, Lung and Blood Institute funded, Family Blood Pressure Program (FBPP) that were genotyped for 3 SNPs for SCN7A: CV2161217, CV 356958 and CV433036. Hypothesis Genetic variations in the SCNA7 are differently associated to BP and UONaK in HT and NT. Methods 1,749 subjects genotyped for SCN7A SNPs CV2161217, CV 356958 and CV433036 were analyzed from FBPP. Subjects with diastolic BP (DBP) ≥80 or systolic BP (SBP) ≥130 mmHg were classified HTN; subjects with SBP <130 and DBP <80 mmHg were classified as NT. UONAK was calculated by dividing overnight Na by K concentration. Correlation analysis done with partial variables (use of antihypertensive drug, use of diuretics, overnight urine creatinine). Results For the CV2161217, HTN group (n=1,030), 52% had C/C, 39% C/T and 9% T/T. In NT group (n=719), 52% had C/C, 38% C/T and 10% T/T. In the HT group, subjects with CC genotype showed strong correlation between DBP and UONaK (Fig 1a) while no significant correlation with SBP. Those with CT genotype maintained the correlation between SBP and UONaK (r=0.10, p=0.03) with no correlation with SBP. The TT showed no correlation between UONaK and SBP or DBP. In the NT, subjects with TT genotype showed strong correlation between DBP and UONaK (Fig 1b) and with SB (r=0.256, p=0.03). Those with CT or TT genotypes showed no correlation between UONaK and SBP or DBP. Similar finding were obtained for CV356958 SNP; no similar association was observed in the CV433036 SNP. Conclusions Subjects with the genetic variations in the SCNA7, such as CV2161217 and CV 356958 SNPs, showed significant correlation between blood pressure and overnight urinary sodium potassium. This finding could have important implications in non dipping status observed in some hypertensive patients. Funding Acknowledgement Type of funding source: None

scholarly journals The Relationship between Adult Height and Blood Pressure

Cardiology ◽  
2021 ◽  
pp. 1-6
Author(s):  
John Michael Cochran ◽  
Vincent R. Siebert ◽  
Jeffrey Bates ◽  
Djenita Butulija ◽  
Anna Kolpakchi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Adult Height ◽  
Augmentation Index ◽  
Epidemiological Data ◽  
Systemic Review ◽  
Inverse Association ◽  
Literature Evidence ◽  
Artery Disease ◽  
The Relationship

Background: Identification and modification of cardiovascular risk factors is paramount to reducing cardiovascular disease morbidity and mortality. Hypertension is a major risk factor for cardiovascular disease, but its association with height remains largely underrecognized. Objectives: The objective of this manuscript is to review the evidence examining the association between blood pressure and human stature and to summarize the plausible pathophysiological mechanisms behind such an association. Methods: A systematic review of adult human height and its association with hypertension and coronary artery disease was undertaken. The literature evidence is summarized and tabulated, and an overview of the pathophysiological basis for this association is presented. Results: Shorter arterial lengths found in shorter individuals may predispose to hypertension in a complex hemodynamic interplay, which is explained predominantly by summated arterial wave reflections and an elevated augmentation index. Our systemic review suggests that an inverse relationship between adult height and blood pressure exists. However, differences in the studied populations and heterogeneity in the methods applied across the various studies limit the generalizability of these findings and their clinical application. Conclusion: Physiological studies and epidemiological data suggest a potential inverse association between adult height and blood pressure. Further research is required to define the relationship more clearly between adult height and blood pressure and to assess whether antihypertensive therapeutic approaches and goals should be modified according to patients’ heights.

Blood Pressure

PEDIATRICS ◽  
1987 ◽  
Vol 80 (3) ◽  
pp. 459-460
Author(s):  
MYUNG K. PARK
Keyword(s):  
Blood Pressure ◽  
Laboratory Testing ◽  
Normative Data ◽  
Task Force ◽  
Pressure Control ◽  
Proper Treatment ◽  
Blood Institute ◽  
National Heart Lung ◽  
Standards And Guidelines

To the Editor.— Recently the National Heart, Lung, and Blood Institute Task Force on Blood Pressure Control in Children published revised normal BP standards and guidelines for children.1 I welcome this effort, as reliable normative data have been unavailable but are prerequisite for the early detection of hypertension and its proper treatment. The guidelines published by the Task Force for the detection of hypertension, the diagnostic evaluation, follow-up laboratory testing, and treatment are, in my opinion, excellent.

scholarly journals Prevalence and Factors Associated with Hypertension among Adolescents in Malaysia

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Liew JK ◽  
Cheong XP ◽  
Law L ◽  
Teo WH ◽  
Eng SS ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Weight ◽  
Statistical Analysis ◽  
Strong Association ◽  
Lifestyle Factors ◽  
Factors Associated ◽  
High Prevalence ◽  
The Relationship ◽  
Malaysian Adolescents

Introduction: Evidence has shown an increase in paediatric hypertension globally and this could give rise to increase prevalence of adult hypertension. The purpose of this paper was to determine the prevalence of hypertension among adolescents in Malaysia as well as the association between hypertension and lifestyle factors selected based on published literature. Methods: Adolescents aged 13-17 years old were selected randomly from two secondary schools to have their blood pressure measured. Their lifestyle information was obtained through completed bilingual questionnaires based on validated instruments, as well as anthropometry measurements. The relationship between hypertension and lifestyle factors was determined through statistical analysis. Results: A total of 273 students were included in the study with 120 (44%) males and 153 (56%) females. The prevalence of hypertension was 24.5% among the respondents with the highest being recorded among Malays (28.7%). Generally, hypertension was associated with an increased Body Mass Index (BMI) (AOR=4.053, 95%CI=1.677-9.795, p=0.002) and waist circumference (WC) (AOR=2.918, 95%CI=1.171-7.269, p=0.021) in all respondents. Similar associations were noted in females (BMI: AOR=7.707, 95%CI=2.043-29.072, p=0.003; WC: AOR=3.690, 95%CI=1.011-13.464, p=0.048) but not in males. Conclusion: Hypertension recorded high prevalence among Malaysian adolescents in our study. The strong association between elevated body weight, BMI and WC with hypertension may require further study to evaluate the need for screening

scholarly journals Is birth weight associated with blood pressure among African children and adolescents? A systematic review

2018 ◽  
Vol 9 (3) ◽  
pp. 270-280 ◽  
Author(s):  
S. A. Lule ◽  
A. M. Elliott ◽  
L. Smeeth ◽  
E. L. Webb
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Birth Weight ◽  
Children And Adolescents ◽  
Low Income ◽  
Later Life ◽  
Low Income Countries ◽  
Inverse Association ◽  
African Children ◽  
The Relationship

There is substantial evidence of an inverse association between birth weight and later blood pressure (BP) in populations from high-income countries, but whether this applies in low-income countries, where causes of low birth weight are different, is not certain. Objective: We conducted a review of the evidence on the relationship between birth weight and BP among African children and adolescents. Medline, EMBASE, Global Health and Web of Science databases were searched for publications to October 2016. Papers reporting the relationship between birth weight and BP among African children and adolescents were assessed. Bibliographies were searched for further relevant publications. Selected papers were summarized following the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. In total, 16 papers from 13 studies conducted in nine African countries (Nigeria, Republic of Seychelles, Gambia, Democratic Republic of Congo, Cameroon, South Africa, Algeria, Zimbabwe and Angola) were reviewed. Eight studies were cohorts, while five were cross-sectional. The relationship between birth weight and later BP varied with age of the participants. Studies in neonates showed a consistently positive association, while predominantly inverse associations were seen among children, and studies in adolescents were inconsistent. Based on the limited number of studies identified, the relationship between birth weight and later BP may vary with age in African children and adolescents. Not all studies adequately controlled for confounding, notably gender or age. Whether the inverse relationship between birth weight and BP in later life observed in Western settings is also seen in Africa remains unclear.

scholarly journals 100% Fruit juice intake and cardiovascular risk: a systematic review and meta-analysis of prospective and randomised controlled studies

2020 ◽  
Author(s):  
Lanfranco D’Elia ◽  
◽  
Monica Dinu ◽  
Francesco Sofi ◽  
Massimo Volpe ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Dose Response ◽  
Prospective Studies ◽  
Fruit Juice ◽  
Meta Analysis ◽  
Inverse Association ◽  
Non Linear ◽  
Randomised Controlled ◽  
The Relationship

Abstract Purpose The relationship between 100% fruit juice (100%FJ) consumption and cardiovascular risk is object of debate: indeed, recently published investigations provided new but discrepant evidence on this important question and International dietary guidelines are not in agreement on recommendations about fruit juice consumption. Therefore, we performed a meta-analysis of the prospective studies and the randomised controlled trials (RCTs) that explored the relationship between 100%FJ intake, cardiovascular risk profile and risk of cardiovascular events. Methods We performed a systematic search of publications up to August 2019. Summary relative risks and exploration of linearity of the association were estimated for prospective studies and summary mean differences (MDs) calculated for RCTs. Results A total of 21 prospective studies and 35 RCTs met the inclusion criteria. Dose–response analysis detected a significant inverse association between low-moderate 100%FJ consumption and risk of stroke (up to 200 ml/day) or total CV events (up to 170 ml/day) compared with no consumption, with a non-linear relationship (p for non-linearity < 0.05). No significant association was found for coronary heart disease and diabetes risk. In RCTs, a favorable and significant effect of 100%FJ intake was detected on blood pressure (systolic, MD: − 3.14 mmHg; diastolic, MD: − 1.68 mmHg), arterial compliance (carotid-femoral pulse wave velocity, − 0.38 m/s) and endothelial function (flow-mediated dilation, 2.10%). Neutral effects were found on body weight, blood lipids and glucose metabolism. Conclusions The results of these analyses indicate that 100%FJ consumption is not associated with higher CV risk. A non-linear inverse dose–response relationship occurs between 100%FJ consumption and CV disease, in particular for risk of stroke, probably mediated by the decrease in blood pressure. Trial registration PROSPERO registration number (CRD42019135577).

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