scholarly journals Association of residential distance to coast with myocardial infarction: a prospective cohort study

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
Z X D Zhuang ◽  
X X Liao ◽  
S Z Zhang
Keyword(s):  
Myocardial Infarction ◽  
Reference Group ◽  
Population Based ◽  
High Nitrogen ◽  
Funding Sources ◽  
Residence Location ◽  
Residential Distance ◽  
Using Data ◽  
Offshore Region

Abstract Background Little is known about whether the residential distance to coast is associated with incident myocardial infarction (MI), as well as which mechanisms may explain the association. We aim to explore this association using data from a prospective, population-based cohort with unprecedented sample size and broad geographical coverage. Methods 377,340 participants from the prospective, population-based UK Biobank cohort were included. Residential distance to the coast was defined as participant's residence location to coast. Results 4,059 MI occurred during median 8.0 years follow-up. Using group (<1 km) as reference, group (20–50 km) was associated with lower risk of MI (hazard ratio, HR 0.79, 95% CI 0.64–0.98) and a U-shaped relation between distance to coast and MI was shown with the low risk interval between 32 km and 64 km (Pnonlinear = 0.0012). Using participants of intermediate region (32–64 km) as reference, participants of offshore region (<32 km) and inland region (>64 km) were both associated with a higher risk of incident MI (HR 1.12, 95% CI 1.04–1.21 and HR 1.09, 95% CI 1.01–1.18, respectively). HR for offshore region (<32 km) was larger in subgroup with low total physical activity (<24 hours/week) (HR 1.24, 95% CI 1.09–1.42, Pinteraction = 0.043), whereas HR for inland region (>64 km) was larger in subgroup in urban area (HR 1.12, 95% CI 1.03–1.22, Pinteraction = 0.065) and in subgroup of high nitrogen dioxide air pollution (HR 1.29, 95% CI 1.11–1.50, Pinteraction = 0.021). Conclusions Our findings highlight the complex and diverse associations between residential distance to the coast and incident MI. FUNDunding Acknowledgement Type of funding sources: None. Figure 1

scholarly journals Gender differences in risk of myocardial infarction and stroke in population with sleep disorders in Russia / Siberia: population-based study MONICA-psychosocial

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
V Gafarov ◽  
E Gromova ◽  
D Panov ◽  
I Gagulin ◽  
A Gafarova
Keyword(s):  
Myocardial Infarction ◽  
Gender Differences ◽  
Sleep Disorders ◽  
Univariate Analysis ◽  
Population Based ◽  
Never Married ◽  
Funding Sources ◽  
Open Population ◽  
New Onset

Abstract Funding Acknowledgements Type of funding sources: None. Objectives To determine the gender differences in the effect of sleep disorders on risk of myocardial infarction (MI) and stroke in population 25-64 years over 16 years of follow-up. Methods Under the third screening of WHO program MONICA -Psychosocial a random representative sample of both gender aged 25- 64 years in Novosibirsk was examined in 1994 (n = 1346, male 48.8%, mean age 44,9 ± 0,4 years). The sleep assessment was performed using the Jenkins Sleep Questionnaire. There were 15 cases of new-onset MI in women and 30 in men, new-onset stroke 35 cases in women and 22 in men from 1994 to 2010. Results In an open population aged 25-64 years 48.6% of men and 65.9% of women had sleep disorders (p< 0.001). Univariate analysis showed 2.4-fold risk of MI in those males with SD over 16-year of follow-up (95%CI 1.1-5.3; p< 0.05) but not for women. MI risk was higher in those men who were never married, divorced or widowed (p for all <0.01) compared to married ones. Risk of stroke was higher in men HR = 3 (95%CI 1.2-7.6;p < 0.05) than in women HR = 1.9 (95%CI 1.03-3.7; p < 0.05). Multivariate analysis revealed 2.8-fold risk of stroke (95%CI 1.1-7.1; p < 0.05) in men and HR = 2.7 in women (95%CI 1.4-5.42;p < 0.01) with SD. Stroke risk was higher in men with lower educational level and in women with college degree in those with SD. Conclusions Sleep disorders is a risk factor of MI in men only and stroke for both gender and negative social gradient increases cardiovascular risk.

scholarly journals Association of Tooth Scaling with Acute Myocardial Infarction and Analysis of the Corresponding Medical Expenditure: A Nationwide Population-Based Study

2021 ◽  
Vol 18 (14) ◽  
pp. 7613
Author(s):  
Yi-Wei Kao ◽  
Ben-Chang Shia ◽  
Huei-Chen Chiang ◽  
Mingchih Chen ◽  
Szu-Yuan Wu
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Periodontal Diseases ◽  
Population Based ◽  
Medical Expenditure ◽  
Control Group ◽  
Proportional Hazard ◽  
Population Based Study ◽  
Scaling Group

Accumulating evidence has shown a significant correlation between periodontal diseases and systemic diseases. In this study, we investigated the association between the frequency of tooth scaling and acute myocardial infarction (AMI). Here, a group of 7164 participants who underwent tooth scaling was compared with another group of 7164 participants without tooth scaling through propensity score matching to assess AMI risk by Cox’s proportional hazard regression. The results show that the hazard ratio of AMI from the tooth scaling group was 0.543 (0.441, 0.670) and the average expenses of AMI in the follow up period was USD 265.76, while the average expenses of AMI in follow up period for control group was USD 292.47. The tooth scaling group was further divided into two subgroups, namely A and B, to check the influence of tooth scaling frequency on AMI risk. We observed that (1) the incidence rate of AMI in the group without any tooth scaling was 3.5%, which is significantly higher than the incidence of 1.9% in the group with tooth scaling; (2) the tooth scaling group had lower total medical expenditures than those of the other group because of the high medical expenditure associated with AMI; and (3) participants who underwent tooth scaling had a lower AMI risk than those who never underwent tooth scaling had. Therefore, the results of this study demonstrate the importance of preventive medicine.

scholarly journals Is Continuous Eruption Related to Periodontal Changes? A 16-Year Follow-up

2021 ◽  
pp. 002203452199936
Author(s):  
C. Wiedemann ◽  
C. Pink ◽  
A. Daboul ◽  
S. Samietz ◽  
H. Völzke ◽  
...  
Keyword(s):  
Tooth Wear ◽  
Total Sample ◽  
Population Based ◽  
Tooth Eruption ◽  
Reference Points ◽  
3 Dimensional ◽  
Probing Depth ◽  
Molar Teeth ◽  
Using Data

The aims of this study were to 1) determine if continuous eruption occurs in the maxillary teeth, 2) assess the magnitude of the continuous eruption, and 3) evaluate the effects of continuous eruption on the different periodontal parameters by using data from the population-based cohort of the Study of Health in Pomerania (SHIP). The jaw casts of 140 participants from the baseline (SHIP-0) and 16-y follow-up (SHIP-3) were digitized as 3-dimensional models. Robust reference points were set to match the tooth eruption stage at SHIP-0 and SHIP-3. Reference points were set on the occlusal surface of the contralateral premolar and molar teeth, the palatal fossa of an incisor, and the rugae of the hard palate. Reference points were combined to represent 3 virtual occlusal planes. Continuous eruption was measured as the mean height difference between the 3 planes and rugae fix points at SHIP-0 and SHIP-3. Probing depth, clinical attachment levels, gingiva above the cementoenamel junction (gingival height), and number of missing teeth were clinically assessed in the maxilla. Changes in periodontal variables were regressed onto changes in continuous eruption after adjustment for age, sex, number of filled teeth, and education or tooth wear. Continuous tooth eruption >1 mm over the 16 y was found in 4 of 140 adults and averaged to 0.33 mm, equaling 0.021 mm/y. In the total sample, an increase in continuous eruption was significantly associated with decreases in mean gingival height ( B = −0.34; 95% CI, −0.65 to −0.03). In a subsample of participants without tooth loss, continuous eruption was negatively associated with PD. This study confirmed that continuous eruption is clearly detectable and may contribute to lower gingival heights in the maxilla.

scholarly journals Oral Antithrombotic Use Among Myocardial Infarction Patients

2003 ◽  
Vol 37 (1) ◽  
pp. 143-146 ◽  
Author(s):  
Menno E van der Elst ◽  
Nelly Cisneros-Gonzalez ◽  
Cornelis J de Blaey ◽  
Henk Buurma ◽  
Anthonius de Boer
Keyword(s):  
Myocardial Infarction ◽  
Record Linkage ◽  
Antithrombotic Therapy ◽  
Past History ◽  
Oral Anticoagulants ◽  
Antiplatelet Agents ◽  
Antithrombotic Treatment ◽  
History Of ◽  
Using Data

OBJECTIVE To examine the use of oral antithrombotics (i.e., antiplatelet agents, oral anticoagulants) after myocardial infarction (MI) in the Netherlands from 1988 to 1998. METHODS Retrospective follow-up of 3800 patients with MI, using data from the PHARMO Record Linkage System. RESULTS From 1988 to 1998, oral antithrombotic treatment increased significantly from 54.0% to 88.9%. In 1998, only 75.8% of patients who experienced a MI in the late 1980s received oral antithrombotic treatment compared with 94.4% of those who experienced a recent MI. CONCLUSIONS Oral antithrombotics were considerably underused in patients with a past history of MI. Therefore, these patients should be reviewed for antithrombotic therapy to assess whether their failure to use oral antithrombotics was right or wrong, and whether treatment should be initiated if possible.

scholarly journals Association between faecal haemoglobin concentration and the risk of cardiovascular diseases among Taiwanese adults in a community-based screening cohort

BMJ Open ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. e032633 ◽  
Author(s):  
Kuo-Liong Chien ◽  
Ting-Yu Lin ◽  
Chen-Yang Hsu ◽  
Chang-Chuan Chan ◽  
Tony Hsiu-Hsi Chen ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Cardiovascular Events ◽  
Reference Group ◽  
Haemoglobin Concentration ◽  
Population Based ◽  
Trend Test ◽  
Cohort Study Design

ObjectivesThe role of faecal haemoglobin as a colorectal cancer screening tool has been demonstrated. However, the association between the faecal haemoglobin concentration and the risk of cardiovascular disease events and deaths is still unclear.DesignCohort study design.SettingPopulation-based organised integrated service screening in Keelung City, TaiwanParticipantsA total of 33 355 healthy individuals aged over 40 years who were free of cardiovascular disease at study entry were followed up.Main outcomes and measuresNewly diagnosed cardiovascular disease events and deaths.ResultsAfter a median follow-up of 2.39 years, a total of 2768 participants developed cardiovascular events, and after a median follow-up of 8.43 years, 317 cases of cardiovascular deaths occurred. The risk of cardiovascular disease increased with baseline faecal haemoglobin in a dose–response manner, yielding a significant elevated risk of cardiovascular disease in parallel with the incremental concentration of faecal haemoglobin (adjusted HRs=1.04, 1.10, 1.40 and 1.23 for faecal haemoglobin concentrations of 1–19, 20–49, 50–99 and ≥100 ng/mL, trend test, p<0.0001, as compared with the reference group with undetectable faecal haemoglobin concentrations). A similar pattern was observed for the risk of cardiovascular disease deaths. In addition, the faecal haemoglobin improved the prediction performance of the model for the risk of cardiovascular diseases; the integrated discrimination improvement was 0.3% (p<0.001) for cardiovascular events and 0.1% (p=0.020) for cardiovascular deaths.ConclusionsOur data support that faecal haemoglobin concentrations may be associated with the risk of cardiovascular diseases. The biological mechanisms underlying the role of faecal haemoglobin as health outcomes should be investigated.

scholarly journals Dyspnea, a high-risk symptom in patients suspected of myocardial infarction in the ambulance? A population-based follow-up study

2016 ◽  
Vol 24 (1) ◽  
Author(s):  
Morten Thingemann Bøtker ◽  
Carsten Stengaard ◽  
Mikkel Strømgaard Andersen ◽  
Hanne Maare Søndergaard ◽  
Karen Kaae Dodt ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
High Risk ◽  
Population Based ◽  
Follow Up Study ◽  
Risk Symptom

Abstract P285: Frequency of Sexual Activity the Year before Myocardial Infarction and Risk for Subsequent Cardiovascular Adverse Events: Results of a Long-Term Follow-Up Study

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Dietrich Rothenbacher ◽  
Dhayana Dallmeier ◽  
Ute Mons ◽  
Wayne D Rosamond ◽  
Wolfgang Koenig ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Sexual Activity ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Reference Group ◽  
Smoking Status ◽  
Multivariable Analysis ◽  
Left Ventricular ◽  
Cox Proportional Hazards Model

Introduction: Sexual activity (SA) is an important component of quality of life and of concern for many patients with myocardial infarction (MI). Available data showed that the frequency of SA decreased one year after an MI, however, the general patterns were relatively stable overall. Although SA may be a trigger of an MI in very few cases, the association between SA before MI and the onset of a subsequent adverse cardiovascular disease event (CVD-event) has not been evaluated so far. Hypothesis: Frequency of SA during the 12-months prior to an MI is not associated with risk of subsequent adverse CVD-event. Methods: Prospective cohort study in CHD patients aged 30-70 years undergoing an in-patient rehabilitation program after an incident MI due to CHD. SA frequency (including masturbation) during the 12-months prior to the MI was evaluated by means of a standardized questionnaire. A Cox-proportional hazards model was used to determine the association of frequency of SA on subsequent adverse CVD-events (nonfatal and fatal MI, stroke, cardiovascular death) during ten-year follow-up after adjustment for age, gender, school education, rehabilitation clinic, smoking status, history of diabetes mellitus, left-ventricular function HDL-cholesterol. Results and Conclusions: The mean age of the included 536 patients with an incident MI was 57.1 years (SD 8.6) at baseline, 85.8% were men. Self-reported SA in the 12-months before the MI was none for n=80, less than 1 time per month for n=25 (both grouped in one category), less than 1 time per week for n=136, and one or more times per week for n=295. Sexual more active patients were on average younger, more often men, had less often diabetes and a less severe coronary vessel disease. They were also more often physical active in leisure time compared to others. During ten-year follow up (median 9.97 years) n=100 adverse CVD-events occurred (overall 23.9 events per 1000 patient years). When compared to patients with less than one time SA per week (reference group) patients with at least one SA per week had a Hazard ratio (HR) of 0.49 (95% confidence interval (CI) 0.31-0.77) in the multivariable analysis; adding leisure time physical activity practiced 12-months prior to the MI into this final model did not change the results. Additional adjustment for Nt-proBNP level at baseline did not alter the result. In conclusion, a weekly SA activity pattern in the year prior to an acute MI is not associated with a higher risk for subsequent adverse cardiovascular events.

Increased Risk of Cardiovascular Events Associated with TKI Treatment in Chronic Phase Chronic Myeloid Leukemia. Data from Swedish Population-Based Registries

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 3134-3134 ◽  
Author(s):  
Torsten Dahlén ◽  
Gustaf Edgren ◽  
Martin Höglund ◽  
Mats Lambe ◽  
Magnus Björkholm ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Events ◽  
Research Funding ◽  
Chronic Phase ◽  
Population Based ◽  
Swedish Population ◽  
2Nd Generation ◽  
Increased Risk ◽  
Tki Treatment

Abstract Introduction: The introduction of continuous tyrosine kinase inhibitor (TKI) treatment has dramatically improved progression-free survival for chronic phase chronic myeloid leukaemia (CML) patients. This success, however, has put the issue of long-term drug toxicity and safety into focus. Recent data from clinical studies have indicated an increased risk of cardiovascular events (CVE), including peripheral arterial occlusive disease, in CML patients receiving treatment with the TKIs nilotinib or ponatinib, as compared to imatinib (Giles et al, Leukemia 2013; Kim et al, Leukemia 2013; Cortes et al, New England Journal of Medicine 2013; FDA communication 2013). This study used data retrieved from Swedish population-based registries to estimate the frequency of CVE in CML patients, particularly those treated with imatinib and the 2nd generation TKIs nilotinib and dasatinib. Methods: We identified all incident cases between 2002 and 2012 in the Nationwide Swedish CML register. All patients who were in blast crisis or accelerated phase at time of diagnosis were excluded. All patients were followed untill death, emigration or 31st December 2012. For all CML patients a comparison cohort was established, matched to be of the same age and sex as the CML cohort, with 5 control subjects per CML patient. By means of record linkage with the nationwide Swedish patient register both cohorts were followed for the occurrence of adverse cardiovascular outcomes. Two sets of relative risks (expressed as incidence rate ratios; IRRs) of cardiovascular and venous thromboembolic disease were computed. In a first step CML patients were compared to the control population. In a second step, restricted to CML patients ever treated with TKIs, CML patients on different TKI treatments were compared. Patients could be treated with several TKIs during their follow-up, and events would only be attributable to the TKI used during the time period. Both analyses were adjusted for age, sex and calendar period. The second analysis was also adjusted for Sokal risk score. Results: A total of 896 CML patients were included and followed during a median of 4.2 years (Table I). The main outcome data are presented in Table II. A total of 23 venous thrombotic events (VTE) and 60 arterial thrombotic events were detected in the CML patient cohort during follow-up. Compared with the general population, this corresponded to significantly increased risks. In particular, deep venous thrombosis and “other arterial thromboses” were more common among CML patients (IRR 2.41 95% CI 1.29-4.52 and IRR 3.50 95% CI 1.36-9.04, respectively). Assessing risks associated with particular TKIs, we noted that treatment with any of the 2nd generation TKIs nilotinib or dasatinib, as compared to imatinib, was associated with a significantly increased occurrence of myocardial infarction (IRR 2.98 95% CI 1.05-8.49 and IRR 2.89 95% CI 1.20-7.00, respectively). Notably, there were no differences in the occurrence of CVE between the different patient groups before CML diagnosis. Conclusion: These data, derived from a large population-based Swedish cohort, provide evidence of an increased risk of both venous and arterial thrombotic events among CML patients and that patients on 2nd generation TKIs, as compared to imatinib, may be at increased risk of myocardial infarction. Further analyses will assess whether these differences may reflect patient selection and characterstics, rather than drug-related factors. Meanwhile, risk factors for CVE should be observed and considered in the TKI treatment of CML. Figure 1 Figure 1. Figure 2 Figure 2. * Footnote: the number of events may not add up because of occurrence of more than one type of vascular event in one subject. The number of events in the analysis within the CML cohort is lower than in the comparison with the general population because of exclusion of patients who were never treated with TKIs in the former analysis. Disclosures Björkholm: Novartis: Research Funding; Shire: Research Funding; Merck: Research Funding; Amgen: Honoraria, Research Funding; Pfizer: Research Funding; Bristol-Myers Squibb: Honoraria; Celgene: Honoraria; Akinon: Honoraria; Nordic Nanovector: Honoraria. Själander:Novartis: Honoraria. Richter:Ariad: Honoraria; Bristol-Myers Squibb: Honoraria; Novartis: Honoraria.

scholarly journals Whether inflammatory disorders matter for long-term prognosis after myocardial infarction?

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
I Leonova ◽  
S Boldueva ◽  
E Bykova ◽  
M Ivanova
Keyword(s):  
Myocardial Infarction ◽  
Prognostic Significance ◽  
Cardiac Insufficiency ◽  
Inflammatory Factors ◽  
Inflammatory Disorders ◽  
Risk Of Death ◽  
Funding Sources ◽  
Heart Failure Progression ◽  
Cox Analysis

Abstract Funding Acknowledgements Type of funding sources: None. Introduction In the acute period of myocardial infarction (MI) inflammatory disorders of blood are registered, but data of prognostic significance of these disorders is multiple-valued. Purpose Research of manifestation of the inflammatory response in patients who suffered MI, and estimation of its prognostic significance. Materials and methods 772 patients with myocardial infarction were examined. Prospective follow-up from 1 to 7 years was performed. Results The death rate during all years of follow-up was 14,2 % of all included in the study. 61% of patients died suddenly, but 26% of them died as a consequence of the progression of chronic cardiac insufficiency. In patients died suddenly lower level of lymphocytes in the first 24 hours: 1,30 ± 0,47 * 109/l vs 1,80 ± 0,73*109/l, (p = 0,03) was registered. In patients who died due to heart failure progression, authentically registered higher leukocytosis in the first 24 hours, in comparison to survived ones, reached 13,83 ± 6,00*109/l (vs 11,9 ± 3,12*109/l; p = 0,005), but to 5th day in the compared groups leukocytes levels had practically the same values (7,36 ± 1,89*109/l vs 7,47 ± 1,99*109/l; accordingly p = 0,8). In the compared groups the number of lymphocytes, expressing CD 95 did not differ authentically, but in died abruptly patients this index was rather lower.  There were not authentic differences detected among groups of dead and survived patients, in terms of interleukins 1β,2, and 6, whereas TNF-α was almost twice as high in patients who died due to CHF progression. Studying inflammatory markers were not included in the number of independent indexes, connected with the risk of death when conducting multivariate regressive Cox-analysis. Conclusion In our opinion, inflammatory factors were displaced from the prognostic model for assessing the risk of death, both sudden and due to heart progression, by more powerful structural-functional predictors.

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