scholarly journals Pace of arterial aging and its association with cardiovascular risk factors

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
A Akopyan ◽  
I Strazhesko ◽  
I Orlova
Keyword(s):  
Risk Factors ◽  
Regression Analysis ◽  
Augmentation Index ◽  
Linear Regression Analysis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Applanation Tonometry ◽  
Chronological Age ◽  
Age Difference ◽  
Arterial Aging

Abstract Introduction Chronological age is a well-known risk factor of cardiovascular diseases (CVD). In comparison with chronological age, biological arterial age can determine person's individual pace of aging, while difference between biological and chronological arterial age (delta age) can be rated as accelerated or decelerated artery aging. Purpose The aim of this study was to assess the association of risk factors of CVD with accelerated and decelerated arterial aging in almost healthy people. Methods We investigated systolic blood pressure (SBP), blood chemistry (total cholesterol (TC), low- (LDL) and high-density (HDL) lipoproteins, triglycerides (TG), apolipoprotein B (ApoB), fasting glucose (FG), glycated hemoglobin (HbA1c), serum renin levels) and urinary albumine, carotid ultrasonography (presence of atherosclerotic plaques and carotid intima-media thickness), arterial stiffness (AS) and leucocyte telomere length (LTL) in 143 adults (mean age 50.31±12.98 years, 35% male, 29% have hypertension, 15% - type 2 diabetes mellitus (T2DM)). LTL was measured by real-time polymerase chain reaction. AS was measured by pulse wave velocity and augmentation index with applanation tonometry using SphygmoCor device (AtCor, Australia). Biological artery age was estimated according to the age-predicting models, based on arterial wall parameters (A. Fedintsev et al, 2017). All the subjects were divided into groups of “old” and “young” arteries according to the positive or negative delta age – difference between biological and chronological age. The data were analyzed using multivariate logistic and linear regression analysis. Results The main statistically significant results are shown in the table. Arterial pace of aging is closely associated with chronological age, hypertension and glucose metabolism. There were not found any associations of arterial pace of aging with lipid, renin levels, urinary albumin and LTL. Conclusion Hypertension, carbohydrate metabolism are main therapeutic targets for accelerated arterial aging and CVD prevention. FUNDunding Acknowledgement Type of funding sources: None. Results of regression analysis

Fib4 index is a more relevant marker for pulse wave velocity but not for carotid intima-media thickness in a men population

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
S Ojima ◽  
T Kubozono ◽  
S Kawasoe ◽  
T Kawabata ◽  
H Miyahara ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Regression Analysis ◽  
Linear Regression ◽  
Pulse Wave Velocity ◽  
Roc Analysis ◽  
Pulse Wave ◽  
Linear Regression Analysis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
The Other

Abstract Background Carotid intima-media thickness (IMT) and pulse wave velocity (PWV) are useful markers for predicting cardiovascular disease not only in patients with cardiovascular disease but also in the general population. On the other hand, liver disease due to obesity has become a problem and has been reported to be associated with the progression of atherosclerosis. Recently, an indicator of liver stiffness, the Fibrosis-4 index (Fib4 index), has been used to detect the pre-stage liver diseases. However, there is no report to investigate the association between atherosclerotic parameters such as IMT and PWV, and Fib4 index. The Fib4 index is a simple index calculated from age and three blood sample data, and it will be useful for screening for an early stage of atherosclerosis if we can show the association between Fib4 index and these parameters. Purpose To investigate the association between atherosclerotic parameters such as IMT or PWV and Fib4 index Methods We recruited 3, 128 men participants who underwent health checkup. IMT was evaluated by carotid ultrasonography, and branchial-ankle PWV (baPWV) was measured by an automatic device. We analysed the association of IMT or baPWV with Fib4 index and atherosclerotic risk factors such as age, systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C) and fasting blood sugar (FBS). baPWV ≥1,600 cm/s was defined high baPWV and we performed the receiver operating characteristics (ROC) analysis to demonstrate the significance of Fib4 index for baPWV. Results Mean Fib4 index was 1.39±0.68. In the univariate linear regression analysis, all factors such as age, SBP, LDL-C, FBS, Fib4 index were significantly associated with IMT or baPWV. On the other hand, in the multivariate linear regression analysis, Fib4 index was an independent factor for baPWV but not for IMT (IMT, p=0.498; baPWV, p=0.023). Figure 1 showed the result of ROC analysis to predict the high baPWV by Fib4 index. The area under curve (AUC) was 0.73, with the highest discriminating sensitivity and specificity at 0.71 and 0.65, respectively at Fib4 index = 1.27. Conclusions Fib4 index was significantly related to baPWV and could be the useful screening marker for arterial stiffness in a general men population. Figure 1. ROC curve analysis Funding Acknowledgement Type of funding source: None

scholarly journals Impact of Mitochondrial DNA Mutations on Carotid Intima-Media Thickness in the Novosibirsk Region

Life ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 160
Author(s):  
Tatiana V. Kirichenko ◽  
Anastasia I. Ryzhkova ◽  
Vasily V. Sinyov ◽  
Marina D. Sazonova ◽  
Varvara A. Orekhova ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Regression Analysis ◽  
Linear Regression Analysis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Mtdna Mutations ◽  
Media Thickness ◽  
Dna Mutations ◽  
Novosibirsk Region ◽  
Atherosclerosis Development

The search for markers of predisposition to atherosclerosis development is very important for early identification of individuals with a high risk of cardiovascular disease. The aim of the present study was to investigate the association of mitochondrial DNA mutations with carotid intima-media thickness and to determine the impact of mitochondrial heteroplasmy measurements in the prognosis of atherosclerosis development. This cross-sectional, population-based study was conducted in 468 subjects from the Novosibirsk region. It was shown that the mean (carotid intima-media thickness) cIMT correlated with the following mtDNA mutations: m.15059G>A (r = 0.159, p = 0.001), m.12315G>A (r = 0.119; p = 0.011), m.5178C>A (r = 0.114, p = 0.014), and m.3256C>T (r = 0.130, p = 0.011); a negative correlation with mtDNA mutations m.14846G>A (r = −0.111, p = 0.042) and m.13513G>A (r = −0.133, p = 0.004) was observed. In the linear regression analysis, the addition of the set of mtDNA mutations to the conventional cardiovascular risk factors increased the ability to predict the cIMT variability from 17 to 27%. Multi-step linear regression analysis revealed the most important predictors of mean cIMT variability: age, systolic blood pressure, blood levels of total cholesterol, LDL and triglycerides, as well as the mtDNA mutations m.13513G>A, m.15059G>A, m.12315G>A, and m.3256C>T. Thus, a high predictive value of mtDNA mutations for cIMT variability was demonstrated. The association of mutation m.13513G>A and m.14846G>A with a low value of cIMT, demonstrated in several studies, represents a potential for the development of anti-atherosclerotic gene therapy.

The associations of body composition and anthropometric measures with carotid intima-media thickness in obese and non-obese schoolchildren: A possible predictor for cardiovascular diseases

Vascular ◽  
2017 ◽  
Vol 26 (3) ◽  
pp. 285-290 ◽  
Author(s):  
Alaa Al-Shorman ◽  
Hayder Al-Domi ◽  
Muatasem Al-Atoum
Keyword(s):  
Body Composition ◽  
Regression Analysis ◽  
Cardiovascular Risk ◽  
Waist Circumference ◽  
Linear Regression Analysis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Fat Free Mass ◽  
Anthropometric Measures ◽  
Media Thickness

Background Increased carotid intima-media thickness is one of the predictors of future cardiovascular diseases. However, it is still unknown which body composition parameter or anthropometric measure is the best predictor for carotid intima-media thickness change among children and young adolescents. Objective To investigate the associations of body composition and anthropometric measures with carotid intima-media thickness among a group of obese and normal bodyweight schoolchildren. Methods A total of 125 schoolchildren (10–15 years) were recruited from four public schools in Amman, Jordan. Of them, 60 (29 boys and 31 girls) were normal bodyweight students and 65 (35 boys and 30 girls) were obese students. Anthropometric measures, fat mass and fat-free mass were determined. Carotid intima-media thickness of the common artery was measured using high-resolution B-mode ultrasound. Results Compared to normal bodyweight students, obese participants exhibited greater carotid intima-media thickness (mm) (0.45 ± 0.10 vs. 0.38 ± 0.08, p = 0.002) and fat-free mass (kg) (48.01 ± 11.39 vs. 32.65 ±7.65, p < 0.001). Pearson’s correlation coefficient and linear regression analysis revealed significant associations ( p≤0.05) between mean carotid intima-media thickness and body mass index, waist circumference, hip circumference, waist-to-hip ratio, fat mass and fat-free mass. Stepwise linear regression analysis revealed that waist circumference was the only measure that was statistically significant ( p ≤ 0.05) with mean carotid intima-media thickness (r2 = 0.129, p = 0.002). Conclusions Obesity is related to greater carotid intima-media thickness and other cardiovascular risk factors among schoolchildren. Waist circumference is more sensitive in predicting increased carotid intima-media thickness than other body composition or anthropometric measures. Waist circumference measurement in the analysis of future studies assessing the cardiovascular risk among obese children is warranted.

Apolipoprotein(a), Fibrinopeptide A and Carotid Atherosclerosis in Middle-Aged Men

1994 ◽  
Vol 72 (04) ◽  
pp. 563-566 ◽  
Author(s):  
Tuomo Rankinen ◽  
Sari Väisänen ◽  
Michele Mercuri ◽  
Rainer Rauramaa
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Carotid Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Bifurcation ◽  
Carotid Intima Media Thickness ◽  
Fibrinopeptide A ◽  
Carotid Imt ◽  
Apolipoprotein A ◽  
The Difference

SummaryThe association between apolipoprotein(a) [apo(a)], fibrinogen, fibrinopeptide A (FPA) and carotid intima-media thickness (IMT) was analyzed in Eastern Finnish men aged 50 to 60 years. Apo(a) correlated directly with carotid bifurcation (r = 0.26, p = 0.001), but not with common carotid IMT. Men in the lowest quartile of apo(a) had thinner (p = 0.013) IMT in bifurcation [1.59 mm (95% Cl 1.49; 1.68)] compared to the men in the highest [1.91 mm (95% Cl 1.73; 2.09)] apo(a) quartile. The difference remained (p=0.038) after adjusting for confounders. Plasma fibrinogen was not related to carotid IMT, whereas FPA correlated with common carotid (r = 0.21, p = 0.016) and carotid bifurcation (r = 0.21, p = 0.018) IMT. These associations abolished after adjusting for the confounders. The data suggest that apo(a) associate with carotid atherosclerosis independent of other risk factors for ischemic cardiovascular diseases.

scholarly journals Carotid intima–media thickness and cardiovascular risk factors in healthy volunteers

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Birgit-Christiane Zyriax ◽  
Kira Dransfeld ◽  
Eberhard Windler
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Risk Prediction ◽  
Framingham Risk Score ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Continuous Variables ◽  
Framingham Risk ◽  
Low Cardiovascular Risk

Abstract Background Assessment of cardiovascular risk by scores lacks sensitivity and leaves the majority of future cardiovascular patients unidentified particularly individuals at low cardiovascular risk. The present analysis investigates into the correlation of carotid intima–media thickness (CIMT) and cardiovascular risk factors and derived scores as to the potential of improved cardiovascular risk prediction by combining the two. Methods The Stress, Atherosclerosis and ECG Study (STRATEGY) is a cross-sectional study of selectively healthy 107 women and 106 men without diagnosed and treated cardiovascular risk factors evenly distributed between 30 and 70 years. CIMT was determined by evaluating B-mode ultrasonograms offline according to a standardized protocol. The unpaired t-test was used to compare normal-distributed continuous variables, the Chi-squared test for normal-distributed categorical variables and the Mann–Whitney U test for non-normal distributed continuous variables. The association between risk prediction scores and CIMT was calculated by the Spearman rank correlation coefficient. Pearson correlation coefficient was used for the correlation between cardiovascular risk factors and CIMT. A multiple linear regression analysis was executed for the association of cardiovascular risk factors and CIMT. Results Age, systolic blood pressure, fasting glucose, total, LDL- and non-HDL-cholesterol and waist circumference were significantly associated with CIMT (each P ≤ 0.03). The Framingham Risk Score, the Prospective Cardiovascular Münster Study Score and the European Society of Cardiology Score correlated significantly but only moderately with CIMT. The Framingham Risk Score considering BMI correlated most strongly and predicted 27% of the CIMT variance in men and 20% in women. Conclusion In individuals without overt cardiovascular risk factors and thus at low cardiovascular risk, CIMT and cardiovascular risk factors correlated only partially suggesting that combining CIMT and conventional risk factors or common derived scores may improve risk prediction in individuals at low cardiovascular risk. The clinical benefit as to cardiovascular events of such combined risk prediction needs to be explored in large prospective cohorts of still healthy low-risk volunteers. DRKS ID DRKS00015209 07/02/2019 retrospectively registered https://www.drks.de/drks_web/navigate.do?navigationId=resultsExt

Subclinical atherosclerosis in children and adolescents with congenital heart disease

2020 ◽  
pp. 1-8
Author(s):  
Silvia M. Cardoso ◽  
Michele Honicky ◽  
Yara M. F. Moreno ◽  
Luiz R. A. de Lima ◽  
Matheus A. Pacheco ◽  
...  
Keyword(s):  
Risk Factors ◽  
Congenital Heart Disease ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Clinical Characteristics ◽  
Congenital Heart ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

Abstract Background: Subclinical atherosclerosis in childhood can be evaluated by carotid intima-media thickness, which is considered a surrogate marker for atherosclerotic disease in adulthood. The aims of this study were to evaluate carotid intima-media thickness and, to investigate associated factors. Methods: Cross-sectional study with children and adolescents with congenital heart disease (CHD). Socio-demographic and clinical characteristics were assessed. Subclinical atherosclerosis was evaluated by carotid intima-media thickness. Cardiovascular risk factors, such as physical activity, screen time, passive smoke, systolic and diastolic blood pressure, waist circumference, dietary intake, lipid parameters, glycaemia, and C-reactive protein, were also assessed. Factors associated with carotid intima-media thickness were analysed using multiple logistic regression. Results: The mean carotid intima-media thickness was 0.518 mm and 46.7% had subclinical atherosclerosis (carotid intima-media thickness ≥ 97th percentile). After adjusting for confounding factors, cyanotic CHD (odds ratio: 0.40; 95% confidence interval: 0.20; 0.78), cardiac surgery (odds ratio: 3.17; 95% confidence interval: 1.35; 7.48), and be hospitalised to treat infections (odds ratio: 1.92; 95% confidence interval: 1.04; 3.54) were associated with subclinical atherosclerosis. Conclusion: Clinical characteristics related to CHD were associated with subclinical atherosclerosis. This finding suggests that the presence of CHD itself is a risk factor for subclinical atherosclerosis. Therefore, the screen and control of modifiable cardiovascular risk factors should be made early and intensively to prevent atherosclerosis.

scholarly journals Meta-analysis of epigenome-wide association studies of carotid intima-media thickness

2021 ◽  
Author(s):  
Eliana Portilla-Fernández ◽  
Shih-Jen Hwang ◽  
Rory Wilson ◽  
Jane Maddock ◽  
W. David Hill ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Dna Methylation ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Association Studies ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

AbstractCommon carotid intima-media thickness (cIMT) is an index of subclinical atherosclerosis that is associated with ischemic stroke and coronary artery disease (CAD). We undertook a cross-sectional epigenome-wide association study (EWAS) of measures of cIMT in 6400 individuals. Mendelian randomization analysis was applied to investigate the potential causal role of DNA methylation in the link between atherosclerotic cardiovascular risk factors and cIMT or clinical cardiovascular disease. The CpG site cg05575921 was associated with cIMT (beta = −0.0264, p value = 3.5 × 10–8) in the discovery panel and was replicated in replication panel (beta = −0.07, p value = 0.005). This CpG is located at chr5:81649347 in the intron 3 of the aryl hydrocarbon receptor repressor gene (AHRR). Our results indicate that DNA methylation at cg05575921 might be in the pathway between smoking, cIMT and stroke. Moreover, in a region-based analysis, 34 differentially methylated regions (DMRs) were identified of which a DMR upstream of ALOX12 showed the strongest association with cIMT (p value = 1.4 × 10–13). In conclusion, our study suggests that DNA methylation may play a role in the link between cardiovascular risk factors, cIMT and clinical cardiovascular disease.

scholarly journals Rheumatoid Arthritis Impacts on the Independent Relationships between Circulating Adiponectin Concentrations and Cardiovascular Metabolic Risk

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Patrick H. Dessein ◽  
Gavin R. Norton ◽  
Margaret Badenhorst ◽  
Angela J. Woodiwiss ◽  
Ahmed Solomon
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Hdl Cholesterol ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Metabolic Risk ◽  
Black African ◽  
Pressure Independent

Adiponectin and leptin are likely involved in the pathophysiology of rheumatoid arthritis (RA) and therefore potential new therapeutic targets. Adiponectin inhibition could be expected to enhance cardiovascular metabolic risk. However, it is unknown whether RA changes the influence of adipokines on cardiovascular metabolic risk. We determined whether RA impacts on the independent relationships of circulating leptin and adiponectin concentrations with cardiovascular risk factors and carotid intima-media thickness (cIMT) in 277 black African subjects from a developing population; 119 had RA. RA impacted on the relationships of adiponectin concentrations with lipid concentrations and blood pressure, independent of confounders including adiposity (interactionP<0.05). This translated into an association of adiponectin concentrations with more favorable lipid variables including HDL cholesterol (P=0.0005), non-HDL cholesterol (P=0.007), and triglyceride (P=0.005) concentrations, total cholesterol-HDL cholesterol (P=0.0002) and triglycerides-HDL cholesterol (P=0.0003) ratios, and higher systolic (P=0.0006), diastolic (P=0.0004), and mean blood pressure (P=0.0007) in RA but not non-RA subjects. Leptin was not associated with metabolic risk after adjustment for adiposity. The cIMT did not differ by RA status, and adipokine concentrations were unrelated to atherosclerosis. This study suggests that leptin and adiponectin inhibition may not alter overall cardiovascular risk and disease in RA.

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