scholarly journals 288 The effects of cardiovascular diseases and treatment on clinical course of hospitalized COVID-19 patients

2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Silvia Prosperi ◽  
Lucia Ilaria Birtolo ◽  
Mia Yarden Revivo ◽  
Sara Monosilio ◽  
Sara Cimino ◽  
...  

Abstract Aims Significant concern has been raised about the effect of pre-existing cardiovascular diseases (CVD), cardiovascular (CV) risk factors and CV therapies on COVID-19 course. On the other hand, COVID-19 could worse pre-existing CVD or trigger the development of new-onset CVD. The aim of this study was to evaluate the relationship between pre-existing CVD, CV risk factors, and CV therapy with the clinical course of hospitalized COVID-19 patients. Methods and results Consecutive hospitalized COVID-19 patients admitted to the Cardiovascular COVID-19 Unit at Policlinico Umberto I of Rome between December 2020 and April 2021 were enrolled. All patients underwent a cardiovascular evaluation including troponin, electrocardiogram (ECG), and echocardiogram. Data on medical history, pre-existing CVD, CV risk factors, and therapy were collected. Admission to the Intensive Care Unit (ICU) or Cardiac Intensive Care Unit (CICU), as well as the development of new-onset CVD, were considered as endpoint of the study. Among n = 229 patients enrolled, 22 (10%) died. Nearly half of patients (112, 49%) were admitted to the ICU/CICU. The presence of prior ischaemic heart disease nearly doubled the probability of hospitalization in the ICU/CICU (HR: 2.09, 95% CI: 1.132–3.866, P 0.018). In regards of therapy, beta blockers reduced the likelihood of admission in the ICU/CICU (HR: −1016, 95% CI: 0.192–10.682, P 0.002). However, neither the use of RAAS blockers, heparin or dexamethasone influenced the risk of ICU/CICU admission (respectively, HR: 0.85, 95% CI: 0.498–1.450, P 0.551; HR: 0.768, 95% CI: 0.435–1.356, P 0.363; HR: 0.861, 95% CI: 0.453–1.635, P 0.647). N = 89 patients (39%) experienced a new onset CVD including arrythmias (18.3%) with nearly half experiencing atrial fibrillation, acute coronary syndrome (10.9%), acute pulmonary embolism (5.3%), heart failure (HF) (3%), and myocarditis and pericarditis (1.3%). A pre-existing diagnosis of HF substantially increased the likelihood of new onset CVD (HR: 2.380, 95% CI: 1.004–5.638, P 0.049). However, treatment with heparin or dexamethasone reduced the risk of new onset CVD (HR: 0.482 95% CI: 0.268–0.867, P 0.015; HR: 0.487, 95% CI: 0.253–0.937, P 0.031, respectively). Conclusions Our study found that hospitalized COVID-19 patients who have at least one CV risk factor or pre-existing CVD had a greater likelihood of being admitted to the ICU/CICU and experiencing new onset CVD.

Author(s):  
Slađana Pavić ◽  
Jelena Raković-Radivojević ◽  
Radmila Sparić ◽  
Ivan Janković ◽  
Aleksandra Andrić ◽  
...  

Introduction: Influenza A H1N1 occurs worldwide sporadically or epidemically. There have been several epidemics of this disease in recent decades. Millions of people fell ill and hundreds of thousands died. The clinical picture varies from asymptomatic to lethal outcome. Older age, male gender and obesity are the most common risk factors for adverse disease. The aim of the research was to examine the clinical course and outcome of the disease of patients with pneumonia during the epidemic of influenza A H1N1 in 2019 in the Zlatibor district. Methods: Epidemiological, clinical, microbiological and radiographic data of patients with influenza A H1N1 treated at the Department of Infectious and Tropical Diseases and the Intensive Care Unit of the General Hospital of Uzice were retrogradely collected and analyzed. Virological and serological analyzes were performed at the Institute of Immunology and Virology "Torlak" in Belgrade. The diagnosis of acute respiratory distress syndrome (ARDS) was made according to the Berlin definition. Statistical analysis was performed using the Statistical Package for Social Sciences SPSS (version 16.0). Results: Out of a total of 274 patients, women accounted for 52.9%. The most common age was 61 to 70 years. 55.4% of patients had comorbidities, 61.8% of that had cardiovascular disease. C reactive protein was elevated in 79.2% of patients. Pneumonia confirmed by radiographic findings was present in 82.8% of patients, 51.5% of that had bilateral pneumonia. Four patients were pregnant, GML 5-9. Two of them had a mild clinical course of infection, one moderate with unilateral pneumonia. All three had a favorable disease outcome. A fourth pregnant woman was admitted in a severe clinical condition and was immediately referred to a tertiary health institution where the disease ended in death. 10.2% of patients were treated in the intensive care unit. Complications occurred in 23.7% of patients, ARDS in 52.3% of that. 55.9% of patients with ARDS were aged 61 to 70 years, and 58.8% were male. Among patients with ARDS, 94.1% had associated diseases, most often CVD (85.3%). C reactive protein was elevated in 85.3% of patients with ARDS. In 8.4% of patients, the disease had an unfavorable course and ended in death. Among these patients, 65.2% were women, and 73.9% were over 65 years of age. Associated diseases were present in 95.6% of these patients, cardiovascular diseases was present in 87% of that. Conclusion: During the influenza epidemic in 2019 in the Zlatibor district, pneumonia, most often bilateral, was most often in patients aged 61-70 with associated cardiovascular diseases. These were also the main risk factors for complications and adverse disease outcome. ARDS was the most common comlication and risk factor for the lethal outcome of the diseases.


2021 ◽  
Vol 25 (71) ◽  
pp. 1-174
Author(s):  
Jonathan Bedford ◽  
Laura Drikite ◽  
Mark Corbett ◽  
James Doidge ◽  
Paloma Ferrando-Vivas ◽  
...  

Background New-onset atrial fibrillation occurs in around 10% of adults treated in an intensive care unit. New-onset atrial fibrillation may lead to cardiovascular instability and thromboembolism, and has been independently associated with increased length of hospital stay and mortality. The long-term consequences are unclear. Current practice guidance is based on patients outside the intensive care unit; however, new-onset atrial fibrillation that develops while in an intensive care unit differs in its causes and the risks and clinical effectiveness of treatments. The lack of evidence on new-onset atrial fibrillation treatment or long-term outcomes in intensive care units means that practice varies. Identifying optimal treatment strategies and defining long-term outcomes are critical to improving care. Objectives In patients treated in an intensive care unit, the objectives were to (1) evaluate existing evidence for the clinical effectiveness and safety of pharmacological and non-pharmacological new-onset atrial fibrillation treatments, (2) compare the use and clinical effectiveness of pharmacological and non-pharmacological new-onset atrial fibrillation treatments, and (3) determine outcomes associated with new-onset atrial fibrillation. Methods We undertook a scoping review that included studies of interventions for treatment or prevention of new-onset atrial fibrillation involving adults in general intensive care units. To investigate the long-term outcomes associated with new-onset atrial fibrillation, we carried out a retrospective cohort study using English national intensive care audit data linked to national hospital episode and outcome data. To analyse the clinical effectiveness of different new-onset atrial fibrillation treatments, we undertook a retrospective cohort study of two large intensive care unit databases in the USA and the UK. Results Existing evidence was generally of low quality, with limited data suggesting that beta-blockers might be more effective than amiodarone for converting new-onset atrial fibrillation to sinus rhythm and for reducing mortality. Using linked audit data, we showed that patients developing new-onset atrial fibrillation have more comorbidities than those who do not. After controlling for these differences, patients with new-onset atrial fibrillation had substantially higher mortality in hospital and during the first 90 days after discharge (adjusted odds ratio 2.32, 95% confidence interval 2.16 to 2.48; adjusted hazard ratio 1.46, 95% confidence interval 1.26 to 1.70, respectively), and higher rates of subsequent hospitalisation with atrial fibrillation, stroke and heart failure (adjusted cause-specific hazard ratio 5.86, 95% confidence interval 5.33 to 6.44; adjusted cause-specific hazard ratio 1.47, 95% confidence interval 1.12 to 1.93; and adjusted cause-specific hazard ratio 1.28, 95% confidence interval 1.14 to 1.44, respectively), than patients who did not have new-onset atrial fibrillation. From intensive care unit data, we found that new-onset atrial fibrillation occurred in 952 out of 8367 (11.4%) UK and 1065 out of 18,559 (5.7%) US intensive care unit patients in our study. The median time to onset of new-onset atrial fibrillation in patients who received treatment was 40 hours, with a median duration of 14.4 hours. The clinical characteristics of patients developing new-onset atrial fibrillation were similar in both databases. New-onset atrial fibrillation was associated with significant average reductions in systolic blood pressure of 5 mmHg, despite significant increases in vasoactive medication (vasoactive-inotropic score increase of 2.3; p < 0.001). After adjustment, intravenous beta-blockers were not more effective than amiodarone in achieving rate control (adjusted hazard ratio 1.14, 95% confidence interval 0.91 to 1.44) or rhythm control (adjusted hazard ratio 0.86, 95% confidence interval 0.67 to 1.11). Digoxin therapy was associated with a lower probability of achieving rate control (adjusted hazard ratio 0.52, 95% confidence interval 0.32 to 0.86) and calcium channel blocker therapy was associated with a lower probability of achieving rhythm control (adjusted hazard ratio 0.56, 95% confidence interval 0.39 to 0.79) than amiodarone. Findings were consistent across both the combined and the individual database analyses. Conclusions Existing evidence for new-onset atrial fibrillation management in intensive care unit patients is limited. New-onset atrial fibrillation in these patients is common and is associated with significant short- and long-term complications. Beta-blockers and amiodarone appear to be similarly effective in achieving cardiovascular control, but digoxin and calcium channel blockers appear to be inferior. Future work Our findings suggest that a randomised controlled trial of amiodarone and beta-blockers for management of new-onset atrial fibrillation in critically ill patients should be undertaken. Studies should also be undertaken to provide evidence for or against anticoagulation for patients who develop new-onset atrial fibrillation in intensive care units. Finally, given that readmission with heart failure and thromboembolism increases following an episode of new-onset atrial fibrillation while in an intensive care unit, a prospective cohort study to demonstrate the incidence of atrial fibrillation and/or left ventricular dysfunction at hospital discharge and at 3 months following the development of new-onset atrial fibrillation should be undertaken. Trial registration Current Controlled Trials ISRCTN13252515. Funding This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 25, No. 71. See the NIHR Journals Library website for further project information.


Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Heidi T May ◽  
Joseph B Muhlestein ◽  
Benjamin D Horne ◽  
Kirk U Knowlton ◽  
Tami L Bair ◽  
...  

Background: Treatment for COVID-19 has created surges in hospitalizations, intensive care unit (ICU) admissions, and the need for advanced medical therapy and equipment, including ventilators. Identifying patients early on who are at risk for more intensive hospital resource use and poor outcomes could result in shorter hospital stays, lower costs, and improved outcomes. Therefore, we created clinical risk scores (CORONA-ICU and -ICU+) to predict ICU admission among patients hospitalized for COVID-19. Methods: Intermountain Healthcare patients who tested positive for SARS-CoV-2 and were hospitalized between March 4, 2020 and June 8, 2020 were studied. Derivation of CORONA-ICU risk score models used weightings of commonly collected risk factors and medicines. The primary outcome was admission to the ICU during hospitalization, and secondary outcomes included death and ventilator use. Results: A total of 451 patients were hospitalized for a SARS-CoV-2 positive infection, and 191 (42.4%) required admission to the ICU. Patients admitted to the ICU were older (58.2 vs. 53.6 years), more often male (61.3% vs. 48.5%), and had higher rates of hyperlipidemia, hypertension, diabetes, and peripheral arterial disease. ICU patients more often took ACE inhibitors, beta-blockers, calcium channel blockers, diuretics, and statins. Table 1 shows variables that were evaluated and included in the CORONA-ICU risk prediction models. Models adding medications (CORONA-ICU+) improved risk-prediction. Though not created to predict death and ventilator use, these models did so with high accuracy (Table 2). Conclusion: The CORONA-ICU and -ICU+ models, composed of commonly collected risk factors without or with medications, were shown to be highly predictive of ICU admissions, death, and ventilator use. These models can be efficiently derived and effectively identify high-risk patients who require more careful observation and increased use of advanced medical therapies.


2009 ◽  
Vol 4 (1) ◽  
pp. 191 ◽  
Author(s):  
Etiane De Oliveira Freitas ◽  
Luiza De Oliveira Pitthan ◽  
Laura De Azevedo Guido ◽  
Graciele Fernanda da Costa Linch ◽  
Juliane Umann

ABSTRACTObjectives: to identify the epidemiological profile, factors of cardiovascular risk, clinical manifestations, and coronary angiography findings in patients hospitalized in a Cardiology Intensive Care Unit, after a coronary event. Methods: this is a transversal study. Data were collected through a questionnaire. The criteria of inclusion were: diagnosis of the acute coronary syndrome, conduction of a coronary angiography, age >21 years old, both gender, conscious and able to interact, and with a minimum time hospitalized of 24 hours. In the analysis, the category variables were expressed with percentages or an absolute value, and the data on the average and standard deviation. The Ethics in Research of the Federal University of Santa Maria approved this study (0010.0.243.000-09). Results: the population was constituted by 30 patients, 63.33% male, the age average was 62.3 years. The most prevalent risk factors were SAH (83.3%) and obesity (63.3%). 40% of the patients were diagnosed with angina and coronary lesion of a vessel. They were submitted to PTCA 46.6% of the patients. Conclusions: knowing the characteristics of the patients in a Cardiology Intensive Care Unit enables the nursing team to plan and/or intensify the actions of education in health in order to change life habits of this population. Descriptors: risk factors; cardiovascular diseases; health education.  RESUMOObjetivos: identificar o perfil epidemiológico, fatores de risco cardiovascular, manifestações clínicas e achados cinecoronariográficos em pacientes internados em uma Unidade de Cardiologia Intensiva, após evento coronariano. Métodos: trata-se de estudo transversal cujos dados foram coletados por meio de questionário. Os critérios de inclusão foram: diagnóstico de síndrome coronariana aguda, realização de cineangiocoronariografia, idade >21 anos, ambos os sexos, com capacidade de interação e com tempo mínimo de 24 horas de internação. Para análise, as variáveis categóricas foram expressas com percentual ou valor absoluto, as contínuas como média e desvio padrão. O Comitê de Ética em Pesquisa da Universidade Federal de Santa Maria aprovou este estudo (0010.0.243.000-09). Resultados: a população constituiu-se de 30 pacientes, 63,3% do sexo masculino, média de idade de 62,3 anos. Os fatores de risco prevalentes foram a HAS (83,3%) e a obesidade (63,3%).40,0% dos pacientes tiveram diagnóstico de angina e lesão coronariana de um vaso. Foram submetidos à ACTP 46,6% dos pacientes. Conclusões: conhecer as características dos pacientes em uma Unidade de Cardiologia Intensiva, possibilita à equipe de enfermagem planejar e/ou intensificar ações de educação em saúde, voltada à mudança de hábitos de vida dessa população. Descritores: fatores de risco; doenças cardiovasculares; educação em saúde. RESUMENObjetivos: identificar el perfil epidemiológico, fatores de riesgo cardiovascular, manifestaciones clínicas y hallazgos cinecoronariográficos en pacientes internados en una Unidad de Cardiologia Intensiva, luego de evento coronariano.  Métodos: este es un estudio transversal. Los datos fueron recogidos a través de un cuestionario. Los critérios de inclusión fueron: diagnóstico de síndrome coronariana aguda, realización de cineangiocoronariografia, edad: mayores de 21 años, ambos sexos, que estuvieran concientes,  con capacidad de interacción y con un tiempo mínimo de 24 horas de internación. El análisis, las variables categóricas fueron expresadas con percentual o valor absoluto, las contínuas como media y desvio patrón. El Comité de Ética en Investigación de la Universidad Fedral de Santa Maria aprobó este estúdio (0010.0.243.000-09). Resultados: la población constituye por 30 pacientes, 63,33% sexo masculino. La media de edad fue de 62,3 años. Los fatores de riesgo que prevalecieron fueron las HAS(833%) y la obesidad (63,3%). 40% de los pacientes tuvo diagnóstico de angina y  lesión coronariana de un vaso. Fueron sometidos a ACTP 46,6% de los pacientes. Conclusiones: conocer las características de los pacientes en una Unidad de Cardiologia Intensiva, posibilita al equipo de enfermería planear y/o intensificar acciones  de educación en salud, con foco al cambio de hábitos de vida de dicha población.  Descriptores: factores de riesgo; enfermedades cardiovasculares; educación en salud.  


2013 ◽  
Vol 52 (190) ◽  
Author(s):  
Mani Prasad Gautam ◽  
Guruprasad Sogunuru ◽  
Gangapatnam Subramanyam ◽  
Lekhjung Thapa ◽  
Raju Paudel ◽  
...  

Introduction: Acute coronary syndrome is the major leading cause for coronary care unit admission. Its spectrum comprises a variety of disorders including unstable angina, non ST elevation and ST elevation myocardial infarction.Methods: An observational study was designed to study the spectrum of acute coronary syndrome and associated coronary heart disease risk factors in subjects admitted in intensive care unit from August 2009 to September 2010. Details including coronary risk factors and the categories and outcomes of acute coronary syndrome were analyzed.Results: A total of 57 subjects were included in the study. The majority (63.1%) were males. The mean age was 64.54±13.8 years.  Five (8.8%) patients were ≤45 years and 29 (50.88%) patients were ≥65 years. Majority of the patients were smokers (50.87%). The other major coronary heart disease risk factors were diabetes (43.85%), hypertension (36.87%), dyslipidemia (26.32%) and previous history of coronary heart disease (31.58%). Coronary heart disease figured prominently in the family history as well (26.32%). ST elevation myocardial infarction was the major category (42.11%) followed by non-ST elevation myocardial infarction and unstable angina (31.58% and 26.32% respectively). Myocardial infarction complicated with cardiogenic shock had very high mortality (83.33%).  Conclusions: The ST elevation myocardial infarction was the major clinical form of acute coronary syndrome admitted in intensive care unit. Prevention should be targeted on modifiable risk factors such as the management of risk factors. In addition, the improvement in cardiology service with the establishment of CCU and cathlab might alter the mortality and morbidity in ACS management.Keywords: acute coronary syndrome; coronary risk factors; intensive care unit.


Critical Care ◽  
2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Laura Drikite ◽  
Jonathan P. Bedford ◽  
Liam O’Bryan ◽  
Tatjana Petrinic ◽  
Kim Rajappan ◽  
...  

Abstract Background New-onset atrial fibrillation (NOAF) in patients treated on an intensive care unit (ICU) is common and associated with significant morbidity and mortality. We undertook a systematic scoping review to summarise comparative evidence to inform NOAF management for patients admitted to ICU. Methods We searched MEDLINE, EMBASE, CINAHL, Web of Science, OpenGrey, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects, ISRCTN, ClinicalTrials.gov, EU Clinical Trials register, additional WHO ICTRP trial databases, and NIHR Clinical Trials Gateway in March 2019. We included studies evaluating treatment or prevention strategies for NOAF or acute anticoagulation in general medical, surgical or mixed adult ICUs. We extracted study details, population characteristics, intervention and comparator(s), methods addressing confounding, results, and recommendations for future research onto study-specific forms. Results Of 3,651 citations, 42 articles were eligible: 25 primary studies, 12 review articles and 5 surveys/opinion papers. Definitions of NOAF varied between NOAF lasting 30 s to NOAF lasting > 24 h. Only one comparative study investigated effects of anticoagulation. Evidence from small RCTs suggests calcium channel blockers (CCBs) result in slower rhythm control than beta blockers (1 study), and more cardiovascular instability than amiodarone (1 study). Evidence from 4 non-randomised studies suggests beta blocker and amiodarone therapy may be equivalent in respect to rhythm control. Beta blockers may be associated with improved survival compared to amiodarone, CCBs, and digoxin, though supporting evidence is subject to confounding. Currently, the limited evidence does not support therapeutic anticoagulation during ICU admission. Conclusions From the limited evidence available beta blockers or amiodarone may be superior to CCBs as first line therapy in undifferentiated patients in ICU. The little evidence available does not support therapeutic anticoagulation for NOAF whilst patients are critically ill. Consensus definitions for NOAF, rate and rhythm control are needed.


2021 ◽  
Vol 71 (5) ◽  
pp. 1880-84
Author(s):  
Sadaf Hanif ◽  
Faisal Shamim ◽  
Muhammad Sohaib

Objective: To assess the frequency of new-onset cardiac arrhythmias among patients admitted in surgical intensive care unit as well as associated risk factors. Study Design: Retrospective observational study. Place and Duration of Study: Surgical Intensive Care Unit, Aga Khan University Hospital, Karachi, from Jan 2018 to Dec 2019. Methodology: The medical record numbers of all patients admitted in surgical intensive care unit were obtained from Surgical intensive care unit case log entries and reviewed. Patients` and healthcare providers` identification were kept confidential. Data was analyzed using SPSS version 19. Results: Only 13/1076 patients included in the study had cardiac arrhythmias during their stay in Surgical intensive care unit. Among all patients with arrhythmias (n=13), atrial fibrillation was the most common type of arrhythmia 7 (53.8%). The study found higher occurrence of arrhythmias among the patients in the age category of 66 years or above 8 (4.6%) and when compared to younger patients with age categories 18-40 years 2 (0.3%) and 41-65 years 3 (0.3%) respectively (p-value<0.05). Similarly, arrhythmias were higher among patients who had relatively prolong intensive care unit stay and post-operative status as the primary cause of intensive care unit admission. Conclusion: Occurrence of cardiac arrhythmias is relatively low among patients admitted to surgical intensive care patient population. Patients age (>65 years), prolong intensive care unit stay, post-operative status are positively associated with development of cardiac arrhythmias among critically ill patients admitted in surgical intensive care unit.


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