Get Moving! Your Brain Will Thank You

Abstract Exercise and cardiovascular fitness are important for physical health and well-being. Recent studies show that exercise is associated with cognitive performance across multiple domains including memory, a common complaint for older adults. Data included a ten-word list of delayed recall, a clock drawing activity, and a three-meter walking course derived from the National Health & Aging Trends Study Database (NHATS Round 9). A total of 4977 participants were included in the analysis which was predominantly white (69.7%), non-Hispanic (94.5%), female (59.2%), and between the ages of 70-84 (62.7%). A hierarchical linear regression revealed that performance on the three-meter walking course positively predicted performance on delayed recall, F(4,3999)=300.257, p<.001, and on the clock drawing activity, which is a common screening task for cognitive decline, F(4,3978)=156.433, p<.001; accounting for 23.1% and 13.6% of the variability, respectively, over and above known demographic variables. Findings suggest that fitness may be one of many factors that is associated with memory and overall cognitive decline. These findings are timely as many individuals slowed down as a result of the COVID-19 pandemic, resulting in decreases in exercise and physical activity. Not being physically active or exercising may be related to poorer physical and cognitive health, with specific concerns regarding memory. Taking into consideration the fear and anxiety associated with declining memory in late life, it is crucial to explore this area further along with other factors that may contribute to the association and develop new ways for older adults to exercise safely during the COVID-19 pandemic.

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Get up and go! An Evaluation of Fitness and Memory

Innovation in Aging ◽

10.1093/geroni/igab046.2881 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. 786-787

Author(s):

Christina Nunez ◽

Alexandria Nuccio ◽

Sophia Perez ◽

Charles Golden

Keyword(s):

Older Adults ◽

Cognitive Decline ◽

Word List ◽

Well Being ◽

Future Research ◽

Functional Fitness ◽

Physically Active ◽

Delayed Recall ◽

Clock Drawing ◽

Sit To Stand

Abstract As we age, exercise is increasingly important for physical health and well-being. Recent studies have shown that exercise is associated with cognitive performance across multiple domains, specifically memory, a common complaint for older adults. Data included a ten-word list of delayed recall, a clock drawing activity, and a sit-to-stand task (i.e., a low impact sub-maximal test of functional fitness) derived from the National Health & Aging Trends Study Database (NHATS Round 9). A total of 4977 participants were included in the analysis which was predominantly white (69.7%), non-Hispanic (94.5%), female (59.2%), and between the ages of 70-84 (62.7%). A hierarchical linear regression revealed that performance on the sit-to-stand task positively predicted performance on delayed recall, F(4,3914)=245.141, p<.001, and on the clock drawing activity, a common screening task for cognitive decline, F(4,2893)=115.470, p<.001; accounting for 20.1% and 10.6% of the variability, respectively, over and above known demographic variables. These findings indicate that exercise may be one of many factors that is associated with memory and cognitive decline. Given the continuation of quarantine procedures, these findings come at a time of significant clinical relevance. Research shows that many individuals slowed down because of the COVID-19 pandemic, and current findings suggest that not being physically active may be related to poorer physical and cognitive health, with specific concerns surrounding memory. Future research is essential in this area to tease out of other factor that may be contributing to this relationship and to develop new and innovated modalities for older adults to safely exercise.

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Fear of Falling and Cognitive Decline in Healthy Aging Adults

Innovation in Aging ◽

10.1093/geroni/igaa057.849 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 265-265

Author(s):

Rebecca Kraut ◽

Roee Holtzer

Keyword(s):

Older Adults ◽

Executive Functions ◽

Cognitive Decline ◽

Healthy Aging ◽

Fear Of Falling ◽

Composite Score ◽

Cognitive Measures ◽

Delayed Recall ◽

Memory And Attention ◽

Aging Adults

Abstract Fear of Falling (FOF) is common and associated with poor mobility in aging but whether persistence of FOF endorsement influences cognitive decline has not been reported. Here we determined the effect of FOF, measured dichotomously and after accounting for persistence, on decline in global cognitive function (GCF), memory, and attention/executive functions. Older adults with persistent FOF (n=81; mean age=77.63±6.67 yrs; %female=74.1), transient FOF (n=60; mean age=76.93±6.01 yrs; %female=61.7), and no FOF (n=286; mean age=75.77±6.42 yrs; %female=49.3) were included. FOF was assessed through yes/no responses to “do you have a fear of falling?” at baseline. GCF was assessed using RBANS; memory was assessed using a composite score comprising the immediate and delayed recall index scores from RBANS; attention/executive functions were assessed via a composite score comprising TMT A & B, letter and category fluency tasks, and digit symbol modalities. Cognitive measures were administered annually for up to six years. Linear mixed effects models revealed that persistent FOF was associated with a worse decline in GCF compared to both transient FOF (estimate=0.78, p=.022) and no FOF (estimate=0.75, p=.004). Persistent FOF was also associated with a worse decline in memory compared to those with transient FOF (estimate=0.08, p=.004) and those with no FOF (estimate=0.06, p=.006). Associations between FOF status and decline in attention/executive functions were not significant. These findings demonstrate that persistent FOF is a risk factor for cognitive decline in community-residing older adults.

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Effects of Participation in Social Activities on Cognitive Function Among Middle-Aged and Older Adults in Korea

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph15102315 ◽

2018 ◽

Vol 15 (10) ◽

pp. 2315 ◽

Cited By ~ 3

Author(s):

Jongnam Hwang ◽

Sangmin Park ◽

Sujin Kim

Keyword(s):

Older Adults ◽

Cognitive Function ◽

Cognitive Decline ◽

Social Connectedness ◽

Social Activity ◽

Later Life ◽

Well Being ◽

Social Activities ◽

The Social ◽

Gender Groups

Cognitive function is a critical health issue in later life, the decline of which disrupts well-being and daily life function. Cognitive decline in older ages can also be understood in the context of the social environment such as social connectedness and engagement in personal life. This study aimed to examine: (1) whether participation in social activities contributes to preventing cognitive decline, and (2) what type of social activities are beneficial to maintaining cognitive function. Data from the Korean Longitudinal Study of Aging (KLOSA) 2006–2014, a longitudinal survey of the household-dwelling population aged 45 and older in Korea were used. The results revealed that Mini-Mental State Examination (MMSE) scores decreased with increasing age, at a rate of approximately 0.18 units across all age-gender groups, and the decrease was steeper for adults aged 65 and over. Participation in social gatherings was likely to delay the decline in cognitive function after the age of 65. In a gender-stratified model, social activity may not have an impact on the decline of cognitive function for men, whereas participation in social gatherings was negatively related to the decline of MMSE scores in women. This study suggests the need for a gender-stratified policy for preventing the decline of cognitive function while promoting engagement in social activities in Korean older adults.

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Longitudinal Relationships Between Subjective Cognitive Decline and Objective Memory: Depressive Symptoms Mediate Between-Person Associations

Journal of Alzheimer s Disease ◽

10.3233/jad-210230 ◽

2021 ◽

pp. 1-14

Author(s):

Nikki L. Hill ◽

Sakshi Bhargava ◽

Emily Bratlee-Whitaker ◽

Jennifer R. Turner ◽

Monique J. Brown ◽

...

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Cognitive Decline ◽

Structural Equation ◽

Disease Risk ◽

Well Being ◽

Equation Modeling ◽

Subjective Cognitive Decline ◽

Future Research ◽

Over Time

Background: Subjective cognitive decline (SCD) may be an early indicator of cognitive impairment, but depressive symptoms can confound this relationship. Associations may be influenced by differences between individuals (i.e., between-persons) or how each individual changes in their experiences over time (i.e., within-persons). Objective: We examined depressive symptoms as a mediator of the between- and within-person associations of SCD and objective memory in older adults. Methods: Coordinated analyses were conducted across four datasets drawn from large longitudinal studies. Samples (range: n = 1,889 to n = 15,841) included participants 65 years of age or older with no dementia at baseline. We used multilevel structural equation modeling to examine the mediation of SCD and objective memory through depressive symptoms, as well as direct relationships among SCD, objective memory, and depressive symptoms. Results: Older adults who were more likely to report SCD had lower objective memory on average (between-person associations), and depressive symptoms partially mediated this relationship in three of four datasets. However, changes in depressive symptoms did not mediate the relationship between reports of SCD and declines in objective memory in three of four datasets (within-person associations). Conclusion: Individual differences in depressive symptoms, and not changes in an individual’s depressive symptoms over time, partially explain the link between SCD and objective memory. Older adults with SCD and depressive symptoms may be at greater risk for poor cognitive outcomes. Future research should explore how perceived changes in memory affect other aspects of psychological well-being, and how these relationships influence cognitive decline and Alzheimer’s disease risk.

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A Meta-Study of Qualitative Research on Social Support Related to Physical Activity Among Older Adults

Kinesiology Review ◽

10.1123/kr.2020-0005 ◽

2020 ◽

pp. 1-15

Author(s):

L. Jayne Beselt ◽

Michelle C. Patterson ◽

Meghan H. McDonough ◽

Jennifer Hewson ◽

Scott MacKay

Keyword(s):

Physical Activity ◽

Social Support ◽

Older Adults ◽

Qualitative Research ◽

Well Being ◽

Future Research ◽

Physically Active ◽

Supportive Behaviors ◽

Study Methodology ◽

Barriers And Challenges

Physical activity (PA) and social support have known benefits for the well-being and health of older adults, and social support is associated with PA behavior and positive affective experiences in PA contexts. The aim of this study was to synthesize qualitative research conducted on the experiences of social support related to PA among older adults (age ≥55 years). Following meta-study methodology, the authors searched nine databases and extracted information from 31 studies. Results were synthesized in terms of common themes and in light of theoretical and methodological perspectives used. The qualitative literature identifies supportive behaviors and social network outcomes which may be useful for informing how best to support older adults to be physically active. This literature rarely reflected the experiences of vulnerable populations, and future research should aim to further understand supportive behaviors which enable older adults to overcome barriers and challenges to being physically active.

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Sleep quality mediates the relationship between frailty and cognitive dysfunction in non-demented middle aged to older adults

International Psychogeriatrics ◽

10.1017/s1041610219000292 ◽

2019 ◽

Vol 31 (06) ◽

pp. 779-788 ◽

Cited By ~ 6

Author(s):

Sonya Kaur ◽

Nikhil Banerjee ◽

Michelle Miranda ◽

Mitchell Slugh ◽

Ni Sun-Suslow ◽

...

Keyword(s):

Older Adults ◽

Executive Function ◽

Sleep Quality ◽

Cognitive Decline ◽

Processing Speed ◽

Poor Sleep ◽

Poor Sleep Quality ◽

Subjective Sleep Quality ◽

Delayed Recall ◽

The Relationship

ABSTRACTObjectives:Frailty is associated with cognitive decline in older adults. However, the mechanisms explaining this relationship are poorly understood. We hypothesized that sleep quality may mediate the relationship between frailty and cognition.Participants:154 participants aged between 50-90 years (mean = 69.1 years, SD = 9.2 years) from the McKnight Brain Registry were included.Measurements:Participants underwent a full neuropsychological evaluation, frailty and subjective sleep quality assessments. Direct relationships between frailty and cognitive function were assessed using linear regression models. Statistical mediation of these relationships by sleep quality was assessed using nonparametric bootstrapping procedures.Results:Frailty severity predicted weaker executive function (B = −2.77, β = −0.30, 95% CI = −4.05 – −1.29) and processing speed (B = −1.57, β = −0.17, 95% CI = −3.10 – −0.16). Poor sleep quality predicted poorer executive function (B = −0.47, β = −0.21, 95% CI = −0.79 – −0.08), processing speed (B = −0.64, β = −0.28, 95% CI = −0.98 – −0.31), learning (B = −0.42, β = −0.19, 95% CI = −0.76 – −0.05) and delayed recall (B = −0.41, β = −0.16, 95% CI = −0.80 – −0.31). Poor sleep quality mediated the relationships between frailty severity and executive function (B = −0.66, β = −0.07, 95% CI = −1.48 – −0.39), learning (B = −0.85, β = −0.07, 95% CI = −1.85 – −0.12), delayed recall (B = −0.47, β = −0.08, 95% CI = −2.12 – −0.39) and processing speed (B = −0.90, β = −0.09, 95% CI = −1.85 – −0.20).Conclusions:Relationships between frailty severity and several cognitive outcomes were significantly mediated by poor sleep quality. Interventions to improve sleep quality may be promising avenues to prevent cognitive decline in frail older adults.

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The Assessment of Fear of COVID-19 among the Elderly Population: A Cross-Sectional Study

Journal of Clinical Medicine ◽

10.3390/jcm10235537 ◽

2021 ◽

Vol 10 (23) ◽

pp. 5537

Author(s):

Siddarth Agrawal ◽

Mateusz Dróżdż ◽

Sebastian Makuch ◽

Alicja Pietraszek ◽

Małgorzata Sobieszczańska ◽

...

Keyword(s):

Mental Health ◽

Older Adults ◽

Well Being ◽

The Elderly ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Policy Makers ◽

Related Information ◽

Fear And Anxiety

The prevailing COVID-19 pandemic has dramatically affected the mental health and well-being of individuals. This cross-sectional study aimed to assess the perceived fear of COVID-19 among older adults in Poland and identify subpopulations with the highest risk of potential mental health disorders. The study was conducted in November–December 2020 on 500 people aged ≥60 years (mean M = 67.9, standard deviation SD = 4.2). In order to collect information on participants’ characteristics and COVID-19-related information, they were asked to complete a questionnaire based on recorded telephone calls. Perceived fear of COVID-19 was measured using our generated and validated seven-item tool: “Scale of fear of COVID-19 infection”, which ranged from 7 to 35. Multiple linear regression was performed to identify factors associated with the perceived fear of COVID-19. Our results showed that the highest level of fear of COVID-19 infection was observed among women (p = 0.025) and patients taking anticoagulants (p = 0.004). Moreover, older adults with higher anxiety levels were more likely to be fearful of COVID-19 (according to the GAS-10 scale; p < 0.001). These findings may help policy makers and healthcare workers to adapt and implement better mental health strategies to help the elderly fight fear and anxiety during the prevailing pandemic.

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Plasma MCP-1 and changes on cognitive function in community-dwelling older adults

Alzheimer s Research & Therapy ◽

10.1186/s13195-021-00940-2 ◽

2022 ◽

Vol 14 (1) ◽

Author(s):

Juan Luis Sanchez-Sanchez ◽

Kelly V. Giudici ◽

Sophie Guyonnet ◽

Julien Delrieu ◽

Yan Li ◽

...

Keyword(s):

Older Adults ◽

Cognitive Function ◽

Episodic Memory ◽

Cognitive Decline ◽

Continuous Variable ◽

Community Dwelling ◽

Clinical Dementia Rating ◽

Delayed Recall ◽

Domain Specific

Abstract Background Monocyte Chemoattractant Protein-1 (MCP-1), a glial-derived chemokine, mediates neuroinflammation and may regulate memory outcomes among older adults. We aimed to explore the associations of plasma MCP-1 levels (alone and in combination with β-amyloid deposition—Aβ42/40) with overall and domain-specific cognitive evolution among older adults. Methods Secondary analyses including 1097 subjects (mean age = 75.3 years ± 4.4; 63.8% women) from the Multidomain Alzheimer Preventive Trial (MAPT). MCP-1 (higher is worse) and Aβ42/40 (lower is worse) were measured in plasma collected at year 1. MCP-1 in continuous and as a dichotomy (values in the highest quartile (MCP-1+)) were used, as well as a dichotomy of Aβ42/40. Outcomes were measured annually over 4 years and included the following: cognitive composite z-score (CCS), the Mini-Mental State Examination (MMSE), and Clinical Dementia Rating (CDR) sum of boxes (overall cognitive function); composite executive function z-score, composite attention z-score, Free and Cued Selective Reminding Test (FCSRT - memory). Results Plasma MCP-1 as a continuous variable was associated with the worsening of episodic memory over 4 years of follow-up, specifically in measures of free and cued delayed recall. MCP-1+ was associated with worse evolution in the CCS (4-year between-group difference: β = −0.14, 95%CI = −0.26, −0.02) and the CDR sum of boxes (2-year: β = 0.19, 95%CI = 0.06, 0.32). In domain-specific analyses, MCP-1+ was associated with declines in the FCSRT delayed recall sub-domains. In the presence of low Aβ42/40, MCP-1+ was not associated with greater declines in cognitive functions. The interaction with continuous biomarker values Aβ42/40× MCP-1 × time was significant in models with CDR sum of boxes and FCSRT DTR as dependent variables. Conclusions Baseline plasma MCP-1 levels were associated with longitudinal declines in overall cognitive and episodic memory performance in older adults over a 4-year follow-up. How plasma MCP-1 interacts with Aβ42/40 to determine cognitive decline at different stages of cognitive decline/dementia should be clarified by further research. The MCP-1 association on cognitive decline was strongest in those with amyloid plaques, as measured by blood plasma Aβ42/40.

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Satisfaction with Life, Subjective Well-Being and Functional Skills in Active Older Adults Based on Their Level of Physical Activity Practice

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17041299 ◽

2020 ◽

Vol 17 (4) ◽

pp. 1299 ◽

Cited By ~ 5

Author(s):

María Antonia Parra-Rizo ◽

Gema Sanchis-Soler

Keyword(s):

Physical Activity ◽

Older Adults ◽

Life Satisfaction ◽

Activities Of Daily Living ◽

Daily Living ◽

Satisfaction With Life ◽

Well Being ◽

Subjective Well Being ◽

Functional Skills ◽

Physically Active

Studies about the influence of physical activity on life satisfaction, functional ability and subjective well-being in physically active older adults without cognitive impairment are very few for the moment. Therefore, the aim of this research was to evaluate the life satisfaction, functional skills and subjective well-being of physically active older adults based on the level of activity practiced. The IPAQ (International Physical Activity), CUBRECAVI and LSIA (Life Satisfaction Index) scales were tested for a sample of 397 Spanish older adults between 61 and 93 years of age (M = 69.65; SD = 4.71). The results showed that those who performed high physical activity obtained higher scores in functional skills (p < 0.01) and in the activities of daily living (p < 0.01). In addition, subjective well-being (p < 0.01) and the functional autonomy of older adults (p < 0.01) were related to the level of physical activity that they practiced. In conclusion, it could be said that the older adults with a high level of physical activity have more functional skills and less difficulties performing the activities of daily living, and that they value their autonomy and health better.

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Differences in Gut Microbiome Composition between Senior Orienteering Athletes and Community-Dwelling Older Adults

Nutrients ◽

10.3390/nu12092610 ◽

2020 ◽

Vol 12 (9) ◽

pp. 2610

Author(s):

Frida Fart ◽

Sukithar Kochappi Rajan ◽

Rebecca Wall ◽

Ignacio Rangel ◽

John Peter Ganda-Mall ◽

...

Keyword(s):

Older Adults ◽

Gut Microbiota ◽

Gastrointestinal Symptoms ◽

Well Being ◽

The Elderly ◽

Community Dwelling ◽

Physically Active ◽

Gastrointestinal Health ◽

Faecalibacterium Prausnitzii ◽

Community Dwelling Older Adults

Background: Gastrointestinal (GI) health is an important aspect of general health. Gastrointestinal symptoms are of specific importance for the elderly, an increasing group globally. Hence, promoting the elderly’s health and especially gastrointestinal health is important. Gut microbiota can influence gastrointestinal health by modulation of the immune system and the gut–brain axis. Diverse gut microbiota have been shown to be beneficial; however, for the elderly, the gut microbiota is often less diverse. Nutrition and physical activity, in particular, are two components that have been suggested to influence composition or diversity. Materials and Methods: In this study, we compared gut microbiota between two groups of elderly individuals: community-dwelling older adults and physically active senior orienteering athletes, where the latter group has less gastrointestinal symptoms and a reported better well-being. With this approach, we explored if certain gut microbiota were related to healthy ageing. The participant data and faecal samples were collected from these two groups and the microbiota was whole-genome sequenced and taxonomically classified with MetaPhlAn. Results: The physically active senior orienteers had a more homogeneous microbiota within the group and a higher abundance of Faecalibacterium prausnitzii compared to the community-dwelling older adults. Faecalibacterium prausnitzii has previously shown to have beneficial properties. Senior orienteers also had a lower abundance of Parasutterella excrementihominis and Bilophila unclassified, which have been associated with impaired GI health. We could not observe any difference between the groups in terms of Shannon diversity index. Interestingly, a subgroup of community-dwelling older adults showed an atypical microbiota profile as well as the parameters for gastrointestinal symptoms and well-being closer to senior orienteers. Conclusions: Our results suggest specific composition characteristics of healthy microbiota in the elderly, and show that certain components of nutrition as well as psychological distress are not as tightly connected with composition or diversity variation in faecal microbiota samples.

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