scholarly journals The burden of presumed tuberculosis in hospitalized children in a resource-limited setting in Papua New Guinea: a prospective observational study

2017 ◽  
Vol 9 (6) ◽  
pp. 374-378 ◽  
Author(s):  
Villa Watch ◽  
Jimmy Aipit ◽  
Tina Kote-Yarong ◽  
Allanie Rero ◽  
John W Bolnga ◽  
...  
Keyword(s):  
Papua New Guinea ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Public Health Problem ◽  
New Guinea ◽  
Final Diagnosis ◽  
Severe Malnutrition ◽  
Major Public Health Problem ◽  
Northern Coast ◽  
Fatality Rate

Abstract Background In Papua New Guinea, TB is considered to be a major public health problem, but little is known about the prevalence and prognosis of presumed TB in children. Methods As part of a prospective hospital-based surveillance on the northern coast of mainland Papua New Guinea, the authors investigated the admission prevalence and case fatality rate associated with presumed TB over a 6-year period (2011–2016). All children admitted who were diagnosed with TB were followed-up until discharge or death. Results Of 8992 paediatric admissions, 734 patients (8.2%) were diagnosed with presumed TB and there were 825 deaths, with TB accounting for 102 (12.4%). Extrapulmonary TB was the final diagnosis in 384 admissions {prevalence 4.3% [384/8992 (95% CI 3.9–4.7)]} with a case fatality rate of 21.4% [82/384 (95% CI 17.4–25.9)]. TB meningitis, disseminated TB and pericardial TB had high case fatality rates of 29.0% (53/183), 28.9% (11/38) and 25% (4/16), respectively. Severe malnutrition was more common in patients with pulmonary compared with extrapulmonary TB (25.4% vs 15.6%; p<0.01). Conclusions Improved community-based case detection strategies, routine BCG vaccinations and other effective forms of TB control need revitalization and sustainability to reduce the high case fatality rates associated with childhood TB in Papua New Guinea.

scholarly journals KEPADATAN NYAMUK DEWASA Aedes Sp DI KELURAHAN MALALAYANG I KECAMATAN MALALAYANG MANADO PERIODE JANUARI – PEBRUARI 2010

2013 ◽  
Vol 3 (3) ◽  
Author(s):  
Janno B. B. Bernadus ◽  
Victor D. Pijoh ◽  
Venny Kareth
Keyword(s):  
Aedes Aegypti ◽  
Aedes Albopictus ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Public Health Problem ◽  
Hemorrhagic Fever ◽  
Adult Mosquito ◽  
Fatality Rate ◽  
North Sulawesi ◽  
Culex Sp

Abstract: Dengue Hemorrhagic Fever (DHF) has become a public health problem in Indonesia because of its high prevalence and ability to spread more widely. In North Sulawesi itself Case Fatality Rate of carrying dengue is increasing from year to year. The local village Malalayang has a high potential for spreading this disease. The result of an  entomology survey on adult mosquitos showed that Aedes sp was found in 40 houses of 80 house samples. From these 40 houses we got 71 mosquito samples. From these 71 samples tested and identified, we found three species: Aedes aegypti (30 samples, 42.25%), Aedes albopictus (22 samples, 30.99%), and Culex sp (19 samples, 26.76%). Mosquito density can be seen from the indices of the resting rates, which were 0.375 for Aedes aegypti, 0.275 for Aedes albopictus, and 0.65 for Aedes sp. Key words: density, adult mosquito, Aedes sp., resting rate.   Abstrak: Demam Berdarah Dengue (DBD) merupakan penyakit yang menjadi masalah kesehatan masyarakat di Indonesia karena prevalensinya yang tinggi dan penyebarannya semakin luas. Di Sulawesi Utara, Case Fatality Rate penyakit DBD tercatat terus meningkat dari tahun ke tahun. Kelurahan Malalayang I merupakan daerah yang potensial sebagai daerah penyebaran DBD. Survei entomologi terhadap nyamuk dewasa Aedes sp pada 80 rumah  memperlihatkan bahwa 40 diantaranya terdapat 71 sampel nyamuk. Setelah diperiksa dan diidentifikasi ternyata ditemukan tiga spesies yaitu Aedes aegypti 30 sampel (42,25%), Aedes albopictus 22 sampel (30,99%) dan Culex sp 19 (26,76%). Kepadatan nyamuk  dapat dilihat  dari angka indeks  pada resting rate yaitu Aedes aegypti = 0,375 , Aedes albopictus = 0,275 dan  Aedes sp.= 0,65. Kata kunci:  kepadatan, nyamuk dewasa, Aedes sp., resting rate.

Acute severe malnutrition treatment outcomes in children ages 6–59 months admitted to Singa Hospital, Sudan

2020 ◽  
Vol 114 (8) ◽  
pp. 612-617
Author(s):  
Jalal Ali Bilal ◽  
Hatim G Eltahir ◽  
Abdullah Al-Nafeesah ◽  
Osama Al-Wutayd ◽  
Ishag Adam
Keyword(s):  
Case Fatality Rate ◽  
Intestinal Parasites ◽  
Case Fatality ◽  
Clinical Information ◽  
Acute Malnutrition ◽  
World Health ◽  
Severe Malnutrition ◽  
Fatality Rate ◽  
Z Scores ◽  
Acute Severe Malnutrition

Abstract Background Acute malnutrition threatens the lives of 50.5 million children <5 y of age. Consequences of malnutrition include death, among other short-term sequelae. This study was conducted from April to October 2018 to determine the outcomes of children 6–59 months of age with acute severe malnutrition admitted to Singa Hospital in central Sudan. Methods Clinical information for children with a mid-upper arm circumference (MUAC) <115 mm were collected. We measured children's weight and height and calculated weight-for-height z-scores. Treatment was offered according to World Health Organization (WHO) guidelines. Outcomes were recorded as recovered, discharged against medical advice or died. Results This study included 376 malnourished children. The median age was 18 months (interquartile range [IQR] 12−24). The male:female ratio was 1:1. Among children with weight-for-height Z-scores of −4 and −3, 103 (27.3%) had oedematous malnutrition. There were 131 (34.8%) children with malaria parasites, 33 (8.7%) with pyuria and 24 (6.3%) with intestinal parasites. The recovery rate was 89.1%. The case fatality rate was 3.7%. Mortality was significantly increased with diarrhoea and dermatoses. There were no significant differences in the median of age (17.5 months [IQR 6−24] vs 18 [6−24], p = 0.595), MUAC (110 mm [IQR 104–111] vs 110 [100–111], p = 0.741) or sex (p = 0.991) between children who died and those who recovered. Conclusions The case fatality rate was 3.7% and it was associated with diarrhoea and dermatoses.

scholarly journals Dengue Infections in Colombia: Epidemiological Trends of a Hyperendemic Country

2020 ◽  
Vol 5 (4) ◽  
pp. 156
Author(s):  
Hernando Gutierrez-Barbosa ◽  
Sandra Medina-Moreno ◽  
Juan C. Zapata ◽  
Joel V. Chua
Keyword(s):  
Public Health ◽  
Case Fatality ◽  
Public Health Problem ◽  
Epidemiological Surveillance ◽  
Severe Dengue ◽  
Major Public Health Problem ◽  
Seasonal Temperature ◽  
Fatality Rate ◽  
Notification Rate ◽  
Epidemiological Trends

Dengue is a major public health problem in hyperendemic countries like Colombia, the understanding of the epidemiological trends is important for the development of efficient public health policies. We conducted a systematic review of the epidemiologic data on dengue in Colombia from 1971 to 2020. A total of 375 relevant citations were identified, 36 of which fulfilled the inclusion criteria. The data of dengue and severe dengue cases, infection fatality rate, and serotype distribution were used to understand and identify gaps in the epidemiological knowledge in Colombia. The epidemiology of dengue in this country was characterized by five main outbreaks in 1998, 2002, 2010, 2013, and 2019 with high fatality rates in comparison with the average values reported in the Americas. The case fatality rate of severe dengue exceeded 2% and all four serotypes co-circulate throughout the country with some regional variations. Overall, the behavior of dengue in Colombia is influenced by multiple factors including seasonal temperature variation and socioeconomic conditions. Additionally, the most important barriers in the epidemiological surveillance of dengue may be due to the insufficient notification rate in some regions and the low active search for the circulation of different serotypes.

scholarly journals Land Cover Pattern and Case Fatality Rate of COVID-19

2021 ◽  
Author(s):  
Chao Li ◽  
Shunsuke Managi
Keyword(s):  
Land Cover ◽  
Case Fatality Rate ◽  
Green Space ◽  
Case Fatality ◽  
Public Health Problem ◽  
The United States ◽  
Fatality Rate ◽  
Land Cover Data ◽  
Development Goals ◽  
Living Environments

Abstract Coronavirus disease 2019 (COVID‐19) has already caused 1,405,029 deaths worldwide, as of November 25th, 2020. Assessing whether land cover in people’s living environments affects COVID-19 health outcomes is an urgent and crucial public health problem. Here, we examine land cover data associated with the case fatality rate (CFR) of COVID-19 at the county-level, in the United States. A 1% increase in green space in the county is associated with a statistically significant 0.34% (95% confidence interval 0.13%-0.55%) decrease in the county’s COVID-19 CFR, and a 1% increase in emergent herbaceous wetlands are correlated with a 1.65% (0.19%-3.11%) decrease in the CFR. In addition, a 1% increase in high intensity developed area among the total developed area is related to a significant 3.63% (2.14%-5.12%) increase in the CFR, while a 1% increase in medium intensity developed area is associated with a 0.75% (-0.02%-1.51%) decrease. Our research highlights that governments could prevent similar pandemics in the future and even achieve some sustainable development goals by decreasing development intensity and increasing green space in living environments.

scholarly journals Adherence to Community Acquired Pneumonia guideleines and patients outcomes in a peri-urban hospital in Natal, South Africa

2021 ◽  
Vol 15 (09) ◽  
pp. 1321-1327
Author(s):  
Waheeba Madani ◽  
Halima Dawood
Keyword(s):  
Case Fatality Rate ◽  
Case Fatality ◽  
Final Diagnosis ◽  
Community Acquired Pneumonia ◽  
Fatality Rate ◽  
Urban Hospital ◽  
Mortality And Morbidity ◽  
Cd4 Cell Count ◽  
Number Of Patients ◽  
Cd4 Cell

Introduction: Community-acquired pneumonia (CAP) is an important cause of mortality and morbidity worldwide. This issue is further exacerbated by the Human Immunodeficiency Virus (HIV) epidemic. Methodology: The study was a retrospective, clinical record review of hospitalized patients (18 years and older) with a diagnosis of LRTI between the 1st of January 2012 and 31 December 2012, descriptive and comparable analysis was performed. Results: Number of patients was 274; 142 (51.8%) males. The commonest final diagnosis was Pulmonary Tuberclosis (PTB) in 131 (47.8%) and CAP in 127 (46.4%). The case fatality rate was 25.5% (70/274) and was significantly associated with HIV infection (77.4%) (p < 0,01), CD4 cell count ≤ 200 cells (96.3), final diagnosis of TB (65.7%) (p < 0.01), female sex (57%) (p < 0.01), confusion (50%) (p < 0.01), age of 65 years or more (29%) (p < 0.01). CURB-65 score (Confusion, Urea more than 7mmol/l, Respiratory rate (RR) ≥30 breaths /min, low blood pressure (less than 90 mmHg systolic and 60mmHg diastolic) and age ≥ 65 years) was only documented in 4 % (11/274) patients. Only 63 patients (23%) met the admission criteria of two or more points when the CURB-65 score was calculated. Conclusions: Failure to use the CURB-65 score resulted in an increase admission of patients presenting with LRTI. There was an increased case fatality rate in this high HIV prevalence setting.

A Serious Public Health Concern for India due to Newly Discovered Virus (COVID-19): Early Detection of all Possible Cases is the Only Way to Combat

2020 ◽  
Author(s):  
Vijay Kumar Mishra
Keyword(s):  
Public Health ◽  
Surveillance System ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Public Health Problem ◽  
World Health ◽  
Health Concern ◽  
Family Welfare ◽  
Fatality Rate ◽  
Monitoring And Surveillance

Background: It is well known that India is having a massive population (around 130 crores) after China. So, it's more likely to be similar or more positive cases of corona among Indians. However, we are following the ways of social distancing and all possible ways to weaken the corona outbreak. But, India needs a good monitoring and surveillance system to tackle this problem otherwise it may become a serious public health problem. Objectives: This study has done to understand the severity of corona in India and its states and to device a tool based on symptoms suggested by the World Health Organization on the corona. Methods: We have utilized data extracted through the Ministry of Health & Family Welfare, GoI from 30th Jan to 26th March 2020. We have estimated the case fatality rate and cured rate to understand the severity of the newly discovered virus (COVID-19). Results: Out of 694 confirmed corona cases, 47 were foreigners and 647 Indians. Our study found that the case fatality rate due to COVID-19 was 23.1 per 1000 persons in India while the people who were still hospitalized under isolation wards were about 91 percent. The cure rate was estimated at around 64.8 per 1000 persons. Conclusions: Looking at the recovery rate, we may think about the severity of corona among Indians. We can reduce the chances of rapidly increasing corona cases through good monitoring and surveillance system. It is recommended that Government should not only focus on testing the passengers arriving at the airport but also test as much as possible cases based on the symptoms of corona in all the districts so that an actual number of cases can be estimated.

Impact of hydroxychloroquin/azithromycin protocol on COVID-19 case-fatality rate reduction in Algeria. (Preprint)

2020 ◽  
Author(s):  
Ahmed Youssef Kada
Keyword(s):  
Case Fatality Rate ◽  
Doubling Time ◽  
Case Fatality ◽  
World Health ◽  
Fatality Rate ◽  
Therapeutic Protocol ◽  
First Case ◽  
The World ◽  
The Impact ◽  
At Home

BACKGROUND Covid-19 is an emerging infectious disease like viral zoonosis caused by new coronavirus SARS CoV 2. On December 31, 2019, Wuhan Municipal Health Commission in Hubei province (China) reported cases of pneumonia, the origin of which is a new coronavirus. Rapidly extendable around the world, the World Health Organization (WHO) declares it pandemic on March 11, 2020. This pandemic reaches Algeria on February 25, 2020, date on which the Algerian minister of health, announced the first case of Covid-19, a foreign citizen. From March 1, a cluster is formed in Blida and becomes the epicentre of the coronavirus epidemic in Algeria, its total quarantine is established on March 24, 2020, it will be smoothly alleviated on April 24. A therapeutic protocol based on hydroxychloroquine and azithromycin was put in place on March 23, for complicated cases, it was extended to all the cases confirmed on April 06. OBJECTIVE This study aimed to demonstrate the effectiveness of hydroxychloroquin/azithromycin protocol in Algeria, in particular after its extension to all patients diagnosed COVID-19 positive on RT-PCR test. We were able to illustrate this fact graphically, but not to prove it statistically because the design of our study, indeed in the 7 days which followed generalization of therapeutic protocol, case fatality rate decrease and doubling time increase, thus confirming the impact of wide and early prescription of hydroxychloroquin/azithromycin protocol. METHODS We have analyzed the data collected from press releases and follow-ups published daily by the Ministry of Health, we have studied the possible correlations of these data with certain events or decisions having a possible impact on their development, such as confinement at home and its reduction, the prescription of hydroxychloroquine/azithromycin combination for serious patients and its extension to all positive COVID subjects. Results are presented in graphics, the data collection was closed on 31/05/2020. RESULTS Covid-19 pandemic spreads from February 25, 2020, when a foreign citizen is tested positive, on March 1 a cluster is formed in the city of Blida where sixteen members of the same family are infected during a wedding party. Wilaya of Blida becomes the epicentre of coronavirus epidemic in Algeria and lockdown measures taken, while the number of national cases diagnosed begins to increases In any event, the association of early containment measures combined with a generalized initial treatment for all positive cases, whatever their degree of severity, will have contributed to a reduction in the fatality rate of COVID 19 and a slowing down of its doubling time. CONCLUSIONS In Algeria, the rapid combination of rigorous containment measure at home and early generalized treatment with hydroxychloroquin have demonstrated their effectiveness in terms of morbidity and mortality, the classic measures of social distancing and hygiene will make it possible to perpetuate these results by reducing viral transmission, the only unknown, the reopening procedure which can only be started after being surrounded by precautions aimed at ensuring the understanding of the population. CLINICALTRIAL Algeria, Covid-19, pandemic, hydroxychloroquin, azithromycin, case fatality rate

scholarly journals Author Correction: Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Lei-Ke Zhang ◽  
Yuan Sun ◽  
Haolong Zeng ◽  
Qingxing Wang ◽  
Xiaming Jiang ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Case Fatality Rate ◽  
Channel Blocker ◽  
Case Fatality ◽  
Fatality Rate ◽  
Amlodipine Besylate

A Correction to this paper has been published: https://doi.org/10.1038/s41421-021-00267-0

scholarly journals Early determination of case fatality rate of COVID-19 pandemic during the ongoing Yemeni armed conflict

2021 ◽  
pp. 1-15
Author(s):  
Abdulla Salem Bin Ghouth ◽  
Ali Ahmed Al-Waleedi ◽  
Marhami Fahriani ◽  
Firzan Nainu ◽  
Harapan Harapan
Keyword(s):  
Young Adults ◽  
Intensive Care ◽  
Armed Conflict ◽  
Case Fatality Rate ◽  
Preventive Measures ◽  
Case Fatality ◽  
Fatality Rate ◽  
Mechanical Ventilators ◽  
Poor Outcomes

Abstract Objectives: To determine the case-fatality rate (CFR) of coronavirus disease 2019 (COVID-19) and its associated determinants in order to understand the true magnitude of the problem during ongoing conflict in Yemen. Methods: The CFR among confirmed COVID-19 cases in Yemen was calculated. The data was retrieved from national COVID-19 surveillance between April 10, when the first COVID-19 case reported, and May 31, 2020. Results: A total of 419 confirmed COVID-19 cases were reported. There were 14.1% and 5.7% of cases who required intensive care and mechanical ventilators, respectively. Out of total cases, 95 deaths were reported, giving CFR of 22.6% which is much higher compared to other countries. CFR was significantly higher among elderly compared to young adults and varied between governorates. Mortality was associated with preexisting hypertension (OR: 2.30; 95%CI: 1.58, 3.54) and diabetes (OR: 1.68; 95%CI: 1.08, 2.61). Conclusions: Elderly and those with comorbidities, in particular hypertension and diabetes, have higher risk for poor outcomes and therefore should receive more attention in the clinical setting. Preventive measures should also be prioritized to protect those groups in order to reduce the severe cases and deaths-associated COVID-19 in armed-conflict.

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