scholarly journals A20 VITAMIN D SUPPLEMENTATION REDUCES THE OCCURRENCE OF COLORECTAL POLYPS IN HIGH-LATITUDE LOCATIONS

2020 ◽  
Vol 3 (Supplement_1) ◽  
pp. 23-24
Author(s):  
R L Sutherland ◽  
J Ormsbee ◽  
J Pader ◽  
N Forbes ◽  
R J Hilsden ◽  
...  
Keyword(s):  
Vitamin D ◽  
Smoking Status ◽  
Daily Intake ◽  
Colorectal Polyp ◽  
Vitamin D Supplementation ◽  
Colorectal Polyps ◽  
Logistic Regression Models ◽  
Supplement Use ◽  
Supplemental Vitamin ◽  
Lifestyle Questionnaire

Abstract Background There is suggestive evidence for the role of vitamin D in the development of colorectal cancer (CRC). Furthermore, previous studies have observed associations with vitamin D supplementation and lower incidence of CRC. Due to high latitudes in Canada, many Canadians are vitamin D deficient throughout winter Aims In this analysis, we aimed to examine the association between either vitamin D supplement use or meeting the reccommended daily intake of vitamin D, and either any colorectal polyp, or a known precursor of CRC: high-risk adenomatous polyps (HRAPs). Methods The study population was drawn from the biorepository at the Forzani & MacPhail Colon Cancer Screening Centre (CCSC) in Calgary. Data were obtained from the Diet History Questionnaire (DHQ) I or II, the Health and Lifestyle Questionnaire (HLQ), and through post-colonoscopy reports completed by the endoscopist. Multivariable logistic regression models were used to examine the association between intake of supplemental vitamin D and presence of HRAPs. Models were adjusted for age, sex, BMI, fiber intake, alcohol consumption, and smoking status. Results Individuals between the age of 50 and 74 years (n= 1,409) were included. When examining the association between any supplemental vitamin D use and HRAPs, a protective effect was observed with an ORadj of 0.57 (95% CI: 0.33–0.96). Similarly, meeting the recommended daily intake (RDI) of vitamin D (600 IU) was protective against HRAPs with an ORadj of 0.78 (95% CI: 0.62–0.99). Conclusions This study suggests that adequate vitamin D supplementation can reduce the risk of HRAPs. These results could be used to inform public health recommendations for vitamin D intake with hopes of reducing the risk of HRAPs. Funding Agencies None

Use of Vitamin D and other Dietary Supplements by Finnish Children at the Age of 2 and 3 Years

2004 ◽  
Vol 74 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Marjamäki ◽  
Räsänen ◽  
Uusitalo ◽  
Ahonen ◽  
Veijola ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin A ◽  
Dietary Supplements ◽  
Parental Education ◽  
Daily Intake ◽  
Newborn Infants ◽  
Vitamin D Supplementation ◽  
Birth Cohort Study ◽  
Food Record ◽  
Supplement Use

The aims of this study were to investigate the frequency of the use of vitamin D and other dietary supplements by Finnish children at the age of 2 and 3 years, to evaluate daily nutrient intake from supplements, and to investigate the relation between supplement use and various sociodemographic factors. The families of 534 newborn infants were invited to a birth cohort study in 1996–1997. Families of 292 children at the child's age of 2 years and families of 263 children at the age of 3 years completed a three-day food record from which the daily use of dietary supplements was calculated. The frequency of dietary supplement use was 50% among the two-year-olds, and 37% among the three-year-old children. The most commonly used supplements among the two-year-olds were vitamin D or vitamin A+D combination (38%) and fluoride (16%) and among the three-year-olds fluoride (19%) and multivitamins (16%), respectively. Intake of nutrients other than vitamin D or fluoride from supplements was rare among two-year-olds, whereas 16% of the three-year-olds received also vitamin A, C, E, and several group B vitamins. Mean daily intake of vitamin D from supplements was 6.7 mug at the age of 2 years and 5.3 mug at the age of 3 years, respectively. The level of parental education was positively associated with the child's vitamin D supplementation at the age of 2 years. As the compliance with national recommendations of vitamin D supplementation was low, intensified counseling of the parents is needed at the well-baby clinics in Finland.

scholarly journals Adherence to the infant vitamin D supplementation policy in Ireland; data from two longitudinal, prospective birth cohort studies

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Andrea Hemmingway ◽  
Dawn Fisher ◽  
Teresa Berkery ◽  
Deirdre M. Murray ◽  
Mairead E Kiely
Keyword(s):  
Vitamin D ◽  
Cohort Studies ◽  
Vitamin D Supplementation ◽  
Birth Cohorts ◽  
Health Service Executive ◽  
Supplement Use ◽  
Wide Range ◽  
High Prevalence ◽  
Supplemental Vitamin ◽  
High Level

AbstractThe high prevalence of maternal deficiency and the low vitamin D content of breastmilk places newborns and infants at particular risk of vitamin D deficiency. In response to an increase in the incidence of nutritional rickets, the Food Safety Authority of Ireland published an interim infant vitamin D supplementation policy in 2007, which was implemented by the Health Service Executive in Ireland in May 2010. This recommends that all infants be given a 5μg exclusive vitamin D3 supplement daily from birth to 12 months. As adherence is not monitored nationally and the policy has not been evaluated, the aim of this study was to conduct a detailed evaluation of supplementation practices across two maternal-infant cohort studies. Data from the prospective BASELINE (recruited 2008–2011) and COMBINE (recruited 2015–2017) birth cohorts, based in Cork, Ireland, were used to examine supplementation practices. After supplementation policy implementation, BASELINE collected vitamin D supplement use data (n = 1528) at 2, 6 and 12 months. In COMBINE, 7 study visits from birth to 12 months allowed continuous collection of detailed longitudinal supplementation data in 364 participants. Use of supplemental vitamin D was higher in COMBINE than BASELINE at 2 (93 vs. 49%), 6 (89 vs. 64%) and 12 (72 vs. 44%) months (all P < 0.001). In COMBINE, 92% initiated vitamin D supplementation at birth and the median supplementation duration was 51 (40, 52) weeks, although there was a wide range (3–52 weeks). 94% of COMBINE parents used a vitamin D3 only supplement and 88% used the recommended 5μg dose. Half (51%) always supplemented daily; a further 33% supplemented at least 3–6 times/week. Full policy adherence was defined as the provision of a 5μg vitamin D3 supplement daily from birth; 64% adhered fully to 2 months and 52% did so to 6 months. By 12 months, 30% had adhered fully to the policy and a further 16% gave 5μg frequently for the full 12 months. This data indicates a high level of awareness of the supplementation policy amongst new mothers, with substantially higher rates of supplementation in our current cohort compared with BASELINE. While most parents gave an exclusive 5μg vitamin D3 supplement, frequency and duration were the key barriers to full policy adherence. Given the lack of a maternal vitamin D supplementation policy in Ireland and high prevalence of low vitamin D status at birth, supplementation of infants with vitamin D remains a vital public health policy.

scholarly journals Vitamin D Supplementation in Australia: Implications for the Development of Supplementation Guidelines

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Kellie Bilinski ◽  
Peter Talbot
Keyword(s):  
Public Health ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Supplement Use ◽  
The Past ◽  
Threefold Increase ◽  
Vitamin D Supplements ◽  
Vitamin D Supplement ◽  
Potential Public Health

High rates of vitamin D deficiency and testing have been reported in Australia, yet there are few reports regarding vitamin D supplement use. Australian wholesale sales data was obtained for vitamin D supplements for the period 2000–2011. There has been a threefold increase in supplement sales over the past decade, whereby over A$94 million supplements containing vitamin D in Australia were sold during the year 2010. There were eighty-nine manufacturers that produce a variety of 195 vitamin D products. The amount of vitamin D in these products varies considerably, from 40 to 1000 IU per unit, although supplements containing only vitamin D had the highest amount of vitamin D. There was a trend for sales to increase in winter months. Given the potential public health benefits of vitamin D, there is an urgent need for a better understanding of supplementation use and for the development of supplementation.

scholarly journals Development and validation of an interview-administered FFQ for assessment of vitamin D and calcium intakes in Finnish women

2016 ◽  
Vol 115 (6) ◽  
pp. 1100-1107 ◽  
Author(s):  
Suvi T. Itkonen ◽  
Maijaliisa Erkkola ◽  
Essi Skaffari ◽  
Pilvi Saaristo ◽  
Elisa M. Saarnio ◽  
...  
Keyword(s):  
Vitamin D ◽  
Food Groups ◽  
Hydroxyvitamin D ◽  
Supplement Use ◽  
Food Records ◽  
Supplemental Vitamin ◽  
25 Hydroxyvitamin D ◽  
Mean Differences ◽  
Development And Validation ◽  
Supplement Intake

AbstractIncreased vitamin D fortification of dairy products has increased the supply of vitamin D-containing products with different vitamin D contents on the market in Finland. The authors developed a ninety-eight-item FFQ with eight food groups and with a question on supplementation to assess dietary and supplemental vitamin D and Ca intakes in Finnish women (60ºN). The FFQ was validated in subgroups with different habitual vitamin D supplement use (0–57·5 µg/d) against the biomarker serum 25-hydroxyvitamin D (S-25(OH)D) and against 3-d food records (FR) (n29–67). Median total vitamin D intake among participants was 9·4 (range 1·6–30·5) µg/d. Spearman’s correlations for vitamin D and Ca ranged from 0·28 (P0·146, FFQv. S-25(OH)D, persons not using supplements) to 0·75 (P<0·001, FFQv. FR, supplement use included). The correlations between the FFQ and S-25(OH)D concentrations improved within increasing supplement intake. The Bland–Altman analysis showed wide limits of agreement between FFQ and FR: for vitamin D between −7·8 and 8·8 µg/d and for Ca between −938 and 934 mg/d, with mean differences being 0·5 µg/d and 2 mg/d, respectively. The triads method was used to calculate the validity coefficients of the FFQ for vitamin D, resulting in a mean of 1·00 (95 % CI 0·59, 1·00) and a range from 0·33 to 1·00. The perceived variation in the estimates could have been avoided with a longer FR period and larger number of participants. The results are comparable with earlier studies, and the FFQ provides a reasonable estimation of vitamin D and Ca intakes.

scholarly journals Monthly or Weekly Supplementation with Cholecalciferol 20,000 IU in People Living with HIV: Results from a Nested Cohort Study

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Sebastian Noe ◽  
Christine I. Moeckel ◽  
Christiane Schwerdtfeger ◽  
Celia Oldenbuettel ◽  
Hans Jaeger ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Vitamin D Deficiency ◽  
Clinical Care ◽  
Daily Intake ◽  
Vitamin D Supplementation ◽  
People Living With Hiv ◽  
Weekly Dose ◽  
Wide Range ◽  
Living With Hiv

Background. There is still considerable uncertainty in handling vitamin D deficiency in people living with HIV (PLWH), due to a lack of comparative data and the wide range of recommended daily intake. Nondaily supplementation might be preferred in many PLWH, but recommendation on dosing has not been established. We aimed to compare the efficacy of weekly versus monthly supplementation with cholecalciferol 20,000 IU in a group of PLWH with vitamin D deficiency in Western Europe. Study Design. Longitudinal, retrospective nested cohort study of PLWH from two large clinical care centers in Munich, Germany. Results. Of 307 patients with vitamin D deficiency, 124 patients received vitamin D supplementation (weekly supplementation in 84 (67.7%)). 46.4% and 22.5% of patients achieved 25(OH)D levels ≥30 ng/mL after 12 months of weekly and monthly supplementation with cholecalciferol 20,000 IU, respectively (p=0.011). Dosing interval as well as 25(OH)D baseline levels >15 ng/mL were associated with the normalization of 25(OH)D. Conclusion. A higher rate of 25(OH)D level normalization can be achieved via weekly supplementation. For several PLWH, even a weekly dose of cholecalciferol 20,000 IU might not be adequate to maintain 25(OH)D levels >30 ng/mL without an initial “loading” dose. The response to supplementation is poorly predictable at an individual level.

scholarly journals Inadequate iodine intake is associated with subfecundity in mild-to-moderately iodine deficient Norwegian women

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Anne Lise Brantsaeter ◽  
Marianne H. Abel ◽  
Ida H. Caspersen ◽  
Verena Sengpiel ◽  
Bo Jacobsson ◽  
...  
Keyword(s):  
Iodine Deficiency ◽  
Cox Regression ◽  
Smoking Status ◽  
Daily Intake ◽  
Urinary Iodine ◽  
Iodine Intake ◽  
Urinary Iodine Concentration ◽  
Childbearing Age ◽  
Time To Pregnancy ◽  
Supplement Use

AbstractIodine is an essential micronutrient and an integral part of the thyroid hormones. In women of childbearing age, the estimated average iodine requirement is 95 μg/day and the recommended daily intake is 150 μg/day. While severe iodine deficiency poses reproductive risks, including infertility and abortions, the potential impact of mild-to-moderate iodine deficiency on subfecundity is unknown.We examined whether iodine intake was associated with risk of subfecundity (i.e. > 12 months trying to get pregnant) in a large cohort of mild-to-moderately iodine deficient women.Women enrolled in the Norwegian Mother and Child Cohort Study in gestational week 15 were asked to report whether the pregnancy was planned and how many months the couple had sexual relations without any contraception before getting pregnant. Information about time to pregnancy, maternal characteristics and iodine intake was available for 56,416 planned pregnancies. The median (interquartile range) time to pregnancy was 1.5 (0.5–6.0) months and the prevalence of subfecundity was 10.8%). We used iodine intake assessed by a validated food frequency questionnaire administered in pregnancy as a proxy for long-term (pre-pregnancy) iodine intake. We used logistic regression to estimate the association between iodine intake and subfecundity, using flexible modelling with restricted cubic splines, and adjusted for maternal age, BMI, parity, education, smoking status, energy intake and fiber intake. The median calculated iodine intake was 121 μg/day and the median urinary iodine concentration in a subsample of n = 2795 women was 69 μg/L.The prevalence of subfecundity was lowest for iodine intakes ~100 μg/day and increased at lower intakes (p overall = 0.005). Compared to an intake of 100 μg/day (reference), intakes ~75 μg/day was associated with 5% (95%CI: 1%, 9%) higher prevalence and intakes ~50 μg/day with 14% (95%CI: 4%, 26%) higher prevalence. Use of dietary supplements was recorded only for the last 6 months prior to conception and women were included in the analysis regardless of their reported supplement use. In a sensitivity analysis, we excluding women who reported iodine-containing supplement use in the period 26–9 weeks before conception and the result remained unchanged. We also modelled time to pregnancy by Cox regression, and the result was consistent with the result for subfecundity.The only good dietary sources of iodine in Norway are milk and white fish, and many women of fertile age have low intakes of these food items. This study shows that low habitual iodine intake may be a risk factor for subfecundity.

scholarly journals Yogurt consumption and colorectal polyps

2020 ◽  
Vol 124 (1) ◽  
pp. 80-91
Author(s):  
Samara B. Rifkin ◽  
Francis M. Giardiello ◽  
Xiangzhu Zhu ◽  
Linda M. Hylind ◽  
Reid M. Ness ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Regression Models ◽  
Hyperplastic Polyp ◽  
Multinomial Logistic Regression ◽  
Colorectal Polyp ◽  
Case Control ◽  
Colorectal Polyps ◽  
Case Control Studies ◽  
Logistic Regression Models ◽  
Serrated Polyp

AbstractDiet modifies the risk of colorectal cancer (CRC), and inconclusive evidence suggests that yogurt may protect against CRC. We analysed the data collected from two separate colonoscopy-based case–control studies. The Tennessee Colorectal Polyp Study (TCPS) and Johns Hopkins Biofilm Study included 5446 and 1061 participants, respectively, diagnosed with hyperplastic polyp (HP), sessile serrated polyp, adenomatous polyp (AP) or without any polyps. Multinomial logistic regression models were used to derive OR and 95 % CI to evaluate comparisons between cases and polyp-free controls and case–case comparisons between different polyp types. We evaluated the association between frequency of yogurt intake and probiotic use with the diagnosis of colorectal polyps. In the TCPS, daily yogurt intake v. no/rare intake was associated with decreased odds of HP (OR 0·54; 95 % CI 0·31, 0·95) and weekly yogurt intake was associated with decreased odds of AP among women (OR 0·73; 95 % CI 0·55, 0·98). In the Biofilm Study, both weekly yogurt intake and probiotic use were associated with a non-significant reduction in odds of overall AP (OR 0·75; 95 % CI 0·54, 1·04) and (OR 0·72; 95 % CI 0·49, 1·06) in comparison with no use, respectively. In summary, yogurt intake may be associated with decreased odds of HP and AP and probiotic use may be associated with decreased odds of AP. Further prospective studies are needed to verify these associations.

scholarly journals Effects of Vitamin D Use on Health-Related Quality of Life of Breast Cancer Patients in Early Survivorship

2019 ◽  
Vol 18 ◽  
pp. 153473541882205 ◽  
Author(s):  
M. Robyn Andersen ◽  
Erin Sweet ◽  
Shelly Hager ◽  
Marcia Gaul ◽  
Fred Dowd ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Patients ◽  
Vitamin D Supplementation ◽  
Blood Levels ◽  
Breast Cancer Patients ◽  
Supplement Use ◽  
Related Quality ◽  
Vitamin D Supplements

Background: Vitamin D supplements may prevent recurrence, prolong survival, and improve mood for women with breast cancer, although evidence for these effects is preliminary. Methods: This report describes vitamin D supplement use by 553 breast cancer patient/survivors (193 who used a naturopathic oncology [NO] provider and 360 who did not) participating in a matched cohort study of breast cancer outcomes. Results: We found that more than half of breast cancer patients reported using vitamin D supplements. Women who received care from NO providers in early survivorship may be more likely to use vitamin D supplements ( P < .05). Approximately 30% of breast cancer patients with blood levels recorded in their medical chart were potentially vitamin D deficient (<30 ng/mL). Vitamin D supplement use at study enrollment was associated with higher levels of self-reported health-related quality of life (HRQOL) at enrollment ( P < .05) and predicted better HRQOL at 6-month follow-up ( P < .05). Sufficient blood levels of vitamin D recorded between enrollment and follow-up were also associated with better HRQOL at follow-up ( P < .05). Conclusions: Vitamin D supplementation by breast cancer patients is common both during and after treatment for breast cancer, but deficiency may also be common. NO and conventional providers may be able to promote vitamin D sufficiency through vitamin D supplementation and by encouraging healthy solar exposure. Further studies should be undertaken examining whether vitamin D supplementation and higher blood levels might improve HRQOL among women with breast cancer in early survivorship.

scholarly journals Vitamin D deficiency and insufficiency in pregnant women: a longitudinal study

2009 ◽  
Vol 102 (6) ◽  
pp. 876-881 ◽  
Author(s):  
Valerie A. Holmes ◽  
Maria S. Barnes ◽  
H. Denis Alexander ◽  
Peter McFaul ◽  
Julie M. W. Wallace
Keyword(s):  
Vitamin D ◽  
Longitudinal Study ◽  
Pregnant Women ◽  
Hypovitaminosis D ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Hydroxyvitamin D ◽  
Supplement Use

Maternal vitamin D insufficiency is associated with childhood rickets and longer-term problems including schizophrenia and type 1 diabetes. Whilst maternal vitamin D insufficiency is common in mothers with highly pigmented skin, little is known about vitamin D status of Caucasian pregnant women. The aim was to investigate vitamin D status in healthy Caucasian pregnant women and a group of age-matched non-pregnant controls living at 54–55°N. In a longitudinal study, plasma 25-hydroxyvitamin D (25(OH)D) was assessed in ninety-nine pregnant women at 12, 20 and 35 weeks of gestation, and in thirty-eight non-pregnant women sampled concurrently. Plasma 25(OH)D concentrations were lower in pregnant women compared to non-pregnant women (P < 0·0001). Of the pregnant women, 35, 44 and 16 % were classified as vitamin D deficient (25(OH)D < 25 nmol/l), and 96, 96 and 75 % were classified as vitamin D insufficient (25(OH)D < 50 nmol/l) at 12, 20 and 35 weeks gestation, respectively. Vitamin D status was higher in pregnant women who reported taking multivitamin supplements at 12 (P < 0·0001), 20 (P = 0·001) and 35 (P = 0·001) weeks gestation than in non-supplement users. Vitamin D insufficiency is evident in pregnant women living at 54–55°N. Women reporting use of vitamin D-containing supplements had higher vitamin D status, however, vitamin D insufficiency was still evident even in the face of supplement use. Given the potential consequences of hypovitaminosis D on health outcomes, vitamin D supplementation, perhaps at higher doses than currently available, is needed to improve maternal vitamin D nutriture.

scholarly journals Changes in vitamin D levels and depressive symptoms in later life in England

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Giorgio Di Gessa ◽  
Jane P. Biddulph ◽  
Paola Zaninotto ◽  
Cesar de Oliveira
Keyword(s):  
Vitamin D ◽  
Depressive Symptoms ◽  
Later Life ◽  
Vitamin D Supplementation ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Representative Study ◽  
Increased Risk ◽  
Vitamin D Levels

AbstractInadequate vitamin D levels have been associated with increased risk of depression. However, most of these studies are cross-sectional and failed to investigate the effect of changes in vitamin D levels. This study aimed to investigate the longitudinal association of changes in serum 25-hydroxyvitamin D levels with depressive symptoms in 3365 participants of the English Longitudinal Study of Ageing, a large nationally-representative study of older adults. Based on their vitamin D levels at baseline and follow-up (sufficient ≥ 50 nmol/L; insufficient < 50 nmol/L), participants were classified as follows: with sufficient levels at both waves; with sufficient levels at baseline but not at follow-up; with insufficient levels at baseline but ≥ 50 nmol/L at follow-up; and with levels < 50 nmol/L at each time point. Depressive symptoms were measured using the 8-point CES-D scale. Data were analysed using logistic regression models. Compared with those with sufficient levels of vitamin D at both waves, only those with insufficient levels throughout were more likely to report elevated depressive symptoms (OR = 1.39, 95% CI = 1.00–1.93). Becoming or no longer being vitamin D deficient was, in the short term, not associated with elevated depressive symptoms. Further evidence is required on whether vitamin D supplementation might contribute to the prevention or treatment of depression as well as on the duration of time for changes in vitamin D levels to lead to detectable changes in depressive symptoms.

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