Psychedelics and dissociative substances
Psychedelics and hallucinogens represent some of the most commonly used drugs in the world, with a history of use steeped in spirituality, counter-culture, and more recently latent therapeutic potential. Sharing a common mechanism of action at the 5-HT2a receptor, drugs such as lysergic acid diethylamide (LSD) and psilocybin, while they can rarely induce significant short-term psychopathology, are remarkably safe physiologically, do not cause dependence, and are now being actively researched again for their therapeutic potential in non-psychotic conditions such as anxiety, addictions, and depression. Ketamine is also being explored as a treatment for resistant depression and is in common use as an anaesthetic. However, it has increasingly become recognized as a drug with abuse potential. Although safe in overdose, ketamine carries acute risks related to vulnerability while intoxicated, and chronic use is associated with urinary tract toxicity.