Structure and function of the kidney

2010 ◽  
pp. 3809-3816
Author(s):  
A.O. Phillips ◽  
Steve Riley
Keyword(s):  
Vitamin D ◽  
Functional Unit ◽  
Structure And Function ◽  
Acid Base Balance ◽  
Acid Base ◽  
Endocrine Organ ◽  
Glomerular Filtrate ◽  
Base Balance ◽  
And Function ◽  
Sodium And Potassium

The kidney is responsible for control of water, electrolyte (particularly sodium and potassium), and acid–base balance and for excretion of metabolic wastes, and it has important functions as an endocrine organ, including key roles in renin, vitamin D, and erythropoietin production or metabolism. The nephron—beginning at the glomerulus, the functional unit of the kidney is the nephron, through which glomerular filtrate passes to be finally excreted as urine. The nephron is divided into anatomically and functionally distinct sections that work together to maintain homeostasis....

DUNCAN'S DISEASES OF METABOLISM: ENDOCRINOLOGY, ed 7. Edited by Philip K. Bondy and Leon E. Rosenberg. Philadelphia, WB Saunders Co, 1974, $26; 736 pp

PEDIATRICS ◽  
1977 ◽  
Vol 59 (5) ◽  
pp. 794-794
Author(s):  
Lester F. Soyka
Keyword(s):  
Clinical Endocrinology ◽  
Normal Structure ◽  
Acid Base Balance ◽  
Acid Base ◽  
Telephone Directory ◽  
The Past ◽  
Big City ◽  
Recent Developments ◽  
Base Balance ◽  
And Function

The endocrinology section of Duncan's Diseases of Metabolism comprises 736 pages, or about 44% of the total text. The division of this seventh edition of a classic text in the field is perhaps a logical expression of the splitting of endocrinology from metabolism as each field has grown tremendously in the past decade. The endocrinology portion is compact and easy to use because of this division, aided by the employment of thin, though substantial paper and small, but easily readable type. These combine to avoid the feeling of consulting a big-city telephone directory, which is so common with use of many of the standard textbooks of today. The illustrations are generally excellent and the 54-page index, which covers both sections of the book, is unusually thorough. As in all textbooks, many sections are outdated before they appear in print. Although the editors, Philip K. Bondy and Leon E. Rosenberg, propose to avoid this by means of a "last-minute" addendum, only two of the 13 chapters bear such, and one of these lists only three references, all dating to 1972. The other recent-developments section is longer and more helpful. The content is essentially that of general clinical endocrinology, each chapter using the standard approach of considering normal structure and function and then diseases in a gland arrangement, starting with the hypothalamus and traveling downward to the testis and ovary. A small chapter on acid-base balance seems out of place, whereas those on nonendocrine-secreting tumors and serotonin and the carcinoid syndrome are useful extensions of the scope of endocrinology.

(PRO)RENIN RECEPTOR IN THE KIDNEY: FUNCTION AND SIGNIFICANCE

2021 ◽  
Author(s):  
Gertrude Arthur ◽  
Jeffrey L. Osborn ◽  
Frederique B. Yiannikouris
Keyword(s):  
Intracellular Signaling ◽  
Collecting Duct ◽  
Renin Angiotensin System ◽  
Cortical Collecting Duct ◽  
Acid Base Balance ◽  
Acid Base ◽  
Kidney Fibrosis ◽  
Prorenin Receptor ◽  
Base Balance ◽  
And Function

Prorenin receptor (PRR), a 350-amino acid receptor initially thought of as a receptor for the binding of renin and prorenin has been shown to be multifunctional. In addition to its role in the renin angiotensin system (RAS), PRR also transduces several intracellular signaling molecules and is a component of the vacuolar H+-ATPase that participates in autophagy. PRR is found in the kidney and particularly in great abundance in the cortical collecting duct. In the kidney, PRR participates in water and salt balance, acid-base balance, autophagy and plays a role in development and progression of hypertension, diabetic retinopathy, and kidney fibrosis. This review highlights the role of PRR in the development and function of the kidney namely the macula densa, podocyte, proximal and distal convoluted tubule and the principal cells of the collecting duct and focuses on PRR function in body fluid volume homeostasis, blood pressure regulation and acid-base balance. This review also explores new advances in the molecular mechanism involving PRR in normal renal health and pathophysiological states.

Kidneys and chronic renal disease

2018 ◽  
Author(s):  
Hugh Devlin ◽  
Rebecca Craven
Keyword(s):  
Renal Disease ◽  
Chronic Renal Disease ◽  
Clinical Implications ◽  
Electrolyte Balance ◽  
Bleeding Tendency ◽  
Acid Base Balance ◽  
Bone Pathology ◽  
Acid Base ◽  
Base Balance ◽  
And Function

Kidneys and chronic renal disease in relation to dentistry is the topic of this chapter. The chapter starts with the structure and function of the kidneys. The functions of acid-base balance and electrolyte balance are described. Chronic renal disease/failure (CRD/CRF) is then considered in terms of its impact on drug metabolism and excretion, anaemia, and bone pathology. Finally, the bleeding tendency associated with chronic renal failure is discussed, together with its clinical implications.

Acid-base balance and blood and urine electrolytes of man during acclimatization to CO2

1964 ◽  
Vol 19 (1) ◽  
pp. 48-58 ◽  
Author(s):  
K. E. Schaefer ◽  
G. Nichols ◽  
C. R. Carey
Keyword(s):  
Cation Exchange ◽  
Time Course ◽  
Respiratory Acidosis ◽  
Acid Base Balance ◽  
Acid Base ◽  
Low Concentration ◽  
Base Balance ◽  
Urine Electrolytes ◽  
Two Phases ◽  
Sodium And Potassium

Acid-base balance regulation and changes in electrolyte metabolism have been studied in 20 subjects exposed to 1.5% CO2 over a period of 42 days with control periods preceding and subsequent to exposure. During exposure to CO2 a slight uncompensated respiratory acidosis was present during the first 23 days followed by a compensated respiratory acidosis. Deacclimatization was incomplete, even after 4 weeks of recovery on air. Arterial CO2 tension increased 5 mm Hg during exposure and remained at this elevated level during the first 9 days of recovery on air. In chronic respiratory acidosis the concentration of chloride in the red cells and in plasma remains practically normal, indicating that the chloride shift does not operate. Cation exchange was observed under these conditions. Sodium increased while potassium showed an approximately equivalent decrease. Sodium and potassium balance studies indicated that only sodium exhibits a pattern paralleling the two phases of acid-base balance regulation, retention being followed by increased excretion. Body weight was maintained throughout the experiment in spite of a 24–30% reduction in food intake. mild respiratory acidosis and compensation; 1.5% CO2 exposure and recovery; arterial pCO2, chloride shift, and cation exchange; sodium and potassium excretion; sodium potassium and nitrogen balance; acid-base regulation in chronic hypercapnia; time course in acid-base regulations during chronic exposure to low concentration of CO2; acclimatization and deacclimatization to low concentration of CO2 Submitted on July 22, 1963

scholarly journals Does the Minerals Content and Osmolarity of the Fluids Taken during Exercise by Female Field Hockey Players Influence on the Indicators of Water-Electrolyte and Acid-Basic Balance?

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 505
Author(s):  
Joanna Kamińska ◽  
Tomasz Podgórski ◽  
Krzysztof Rachwalski ◽  
Maciej Pawlak
Keyword(s):  
Training Session ◽  
Plasma Osmolality ◽  
The Body ◽  
Field Hockey ◽  
Acid Base Balance ◽  
Acid Base ◽  
Hockey Players ◽  
Before And After ◽  
Base Balance ◽  
Sodium And Potassium

Although it is recognized that dehydration and acidification of the body may reduce the exercise capacity, it remains unclear whether the qualitative and quantitative shares of certain ions in the drinks used by players during the same exertion may affect the indicators of their water–electrolyte and acid–base balance. This question was the main purpose of the publication. The research was carried out on female field hockey players (n = 14) throughout three specialized training sessions, during which the players received randomly assigned fluids of different osmolarity and minerals contents. The water–electrolyte and acid–base balance of the players was assessed on the basis of biochemical blood and urine indicators immediately before and after each training session. There were statistically significant differences in the values of all examined indicators for changes before and after exercise, while the differences between the consumed drinks with different osmolarities were found for plasma osmolality, and concentrations of sodium and potassium ions and aldosterone. Therefore, it can be assumed that the degree of mineralization of the consumed water did not have a very significant impact on the indicators of water–electrolyte and acid–base balance in blood and urine.

The alphastat hypothesis in respiratory control and acid-base balance

1990 ◽  
Vol 69 (4) ◽  
pp. 1201-1207 ◽  
Author(s):  
E. E. Nattie
Keyword(s):  
Respiratory Control ◽  
Effect Of Temperature ◽  
Acid Base Balance ◽  
Temperature Dependent ◽  
Acid Base ◽  
Central Chemosensitivity ◽  
Ph Changes ◽  
Base Balance ◽  
Definition Of ◽  
And Function

This selective review 1) evaluates recent interpretations that broaden the definition of the alphastat hypothesis, 2) proposes that central chemoreception and acid-base regulation via ion transport involve proteins conforming to the alphastat hypothesis, and 3) describes, using recent evidence, possible candidates for these proteins. The alphastat hypothesis states that proteins that contain appropriate function-determining titratable groups maintain a constant charge state and unaltered function with temperature-dependent pH changes but can be very sensitive to isothermal pH changes. Appropriate groups, e.g., imidazole histidine, are determined by the pK and the effect of temperature on the pK. The hypothesis explains how protein structure and function can be conserved among a diversity of vertebrate and invertebrate pH values. It also suggests a mechanism for sensing or regulating temperature-independent pH changes, e.g., in central chemosensitivity and transmembrane ion exchange. Possible candidates for such alphastat-conforming proteins include two, the glutamate receptor and the Na(+)-H+ antiporter, for which recent evidence indicates the presence of numerous histidines at probable function-determining sites and demonstrates pH sensitivity inhibitable by the histidine blocker diethylpyrocarbonate (DEPC).

scholarly journals Endocrinology and metabolic disorders

2016 ◽  
Author(s):  
Dr Kevin Shotliffe ◽  
Dr Annabel Fountain ◽  
Dr Mike Jones ◽  
Dr Jennifer Gray ◽  
Dr Richard Leach ◽  
...  
Keyword(s):  
Metabolic Disorders ◽  
Diabetic Coma ◽  
Phosphate Metabolism ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance ◽  
Calcium Magnesium ◽  
Sodium And Potassium

Chapter 10 covers endocrinology and metabolic disorders, including diabetes and diabetic coma, abnormalities of sodium and potassium, calcium, magnesium, and phosphate, metabolism, acid-base balance, thyroid emergencies, pituitary emergencies, adrenal emergencies, and toxin-induced hyperthermic syndromes.

Urinary system

2012 ◽  
Keyword(s):  
Renal Plasma Flow ◽  
Carbon Dioxide Partial Pressure ◽  
Renal Tubules ◽  
Acid Base Balance ◽  
Acid Base ◽  
Endocrine Control ◽  
Pressure Filtration ◽  
Glomerular Filtrate ◽  
Base Balance ◽  
Glomerular Capillaries

The kidneys are responsible for maintaining the constant chemical composition of body fluids. This process begins with high-pressure filtration in specialized glomerular capillaries located in the renal cortex. The pressure filtration produces an ultrafiltrate of plasma made up of the water and smaller molecules. As the fluid passes along the renal tubules, water, electrolytes, and non-electrolytes are reabsorbed in the required amounts by a process of selective reabsorption. Some active secretion of unwanted substances also occurs. Following this reabsorption the remaining tubule fluid is passed to the renal pelvis and then down the ureters to the bladder for storage until voided. The effort involved in all this is quite staggering. One-fifth of the daily cardiac output, about 1400 litres of whole blood, including 840 litres of plasma, passes through the kidneys. Of the 540 litres of plasma (the effective renal plasma flow) passing each day through the glomerular capillaries, one-fifth of the plasma water and small molecules are freely filtered at the glomeruli to produce about 170–180 litres per day of glomerular filtrate for the renal tubules. Since typically only 1–2 litres of urine are passed each day (that is about 1 ml per minute) 99 % of the initial filtrate is reabsorbed as the fluid passes along the renal tubules. In oliguria, urine production can fall below 300ml per day, as in severe dehydration. In situations causing polyuria, urine output can rise to several litres per day, or more, as in excessive water intake or untreated diabetes mellitus or diabetes insipidus. The kidney’s main functions are osmoregulation, acid–base balance, and the excretion of waste products of metabolism, notably urea. Osmoregulation is mostly under endocrine control by antidiuretic hormone and the renin–angiotensin–aldosterone system. Acid–base balance is driven mainly by the carbon dioxide partial pressure in renal tubule cells, although kidneys work together with lungs and the control of breathing in overall acid–base balance. The kidney has important endocrine functions. It is the source of erythropoietin, the hormone that stimulates red blood cell production in hypoxia.

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