Cellular and Molecular Mechanisms of Addiction
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Exposure to drugs of abuse is for most individuals a reinforcing experience which can lead to continued use and the development of an addiction disorder. Evidence indicates that the escalation in use and ultimately compulsive motivation to obtain drug is linked to long lasting cellular changes within the brain reward neurocircuitry. In this chapter we will describe the transition in use from isolated social use to habitual relapse, and within that context will describe the neurocircuitry implicated in this process and the enduring cellular and molecular changes which occur within that circuitry that may mediate preoccupation with drug seeking in the addiction vulnerable individual.
2019 ◽
Vol 21
(4)
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pp. 379-387
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2009 ◽
Vol 22
(2)
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pp. 148-162
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2021 ◽
Vol 22
(23)
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pp. 13035
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