MO42825-HYDROXYVITAMIN D AND TUBULAR DYSTROPHY IN PATIENTS WITH CKD STAGES 1-3*

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Olga Galkina ◽  
Evdokia Bogdanova ◽  
Irina Zubina ◽  
Elena Levykina ◽  
Anastasiia Anpilova ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Tissue Sample ◽  
Periodic Acid ◽  
Linear Regression Analysis ◽  
Kidney Tissue ◽  
Tubular Damage ◽  
25Ohd Level ◽  
Serum 25Ohd ◽  
Hydroxyvitamin D ◽  
Early Stages

Abstract Background and Aims According to a recent data the 25-hydroxyvitamin D (25OHD) level is known to be reduced in advanced stages of CKD presumably due to i) catabolic activity of CYP24 in damaged tubules and ii) increase in renal excretion of 25OHD/Vitamin D binding protein complex. The association of the 25OHD level with different types of tubular damage in early stages (1-3) of CKD is not well investigated. Method The cross-sectional study included 100 patients (37 male; age 38 (30-50) yrs.) with biopsy proven primary glomerulopathy (membranoproliferative glomerulonephritis (n=9); minimal change disease (n=10); membranous nephropathy (n=11); focal segmental glomerulosclerosis (n=20); IgA nephropathy (n=50)) and CKD stages 1-3 (median eGFR was 64 (33-90) ml/min/1.73 m2). Patients with AKI, infectious diseases, heart failure, respiratory failure and cancer pathology were excluded. The levels of proteinuria, intact parathyroid hormone (PTH) (Beckman Coulter), 25OHD (Abbott) were estimated in all patients. In all cases the following types of tubular damage were analyzed by light microscopy of kidney tissue (hematoxylin and eosin, periodic acid Schiff, Masson's trichrome, Congo red, and Jones' silver) and calculated semi-quantitatively (0 – <10%; 1 – 10-25%; 2 – 26-50% and 3 – >50% of tissue sample): granular dystrophy, hyaline-drop dystrophy, hydropic dystrophy, foamy degeneration and atrophy. The association between clinical and morphological variables was estimated by Spearman’s coefficient and multiple linear regression analysis. Results The patients had a lack or deficiency of 25OHD [Me (Q1-Q3): 13.1 (7.6-19.3) ng/ml]. There was no correlation between serum 25OHD and PTH (r = -0.03, p = 0.86). Proteinuria was negatively associated with level of 25OHD (r = -0.56, p = 0.012). The level of 25OHD was associated with granular (r = -0.39, p <0.05) and hyaline-drop (r = -0.39, p <0.05) tubular dystrophy. In multiple regression analysis the 25OHD level was the independent predictor of the severe hyaline-drop tubular dystrophy (β = -0.33 ± 0.11, p = 0.046) when adjusted for proteinuria (β=0.22±0.11, p=0.062). Conclusion In patients with CKD stages 1-3 decline in serum 25OHD is associated with the severity of tubular dystrophy. 25OHD level may be useful in laboratory diagnosis as a risk factor of tubular damage in early stages of CKD.

scholarly journals Aqueous humor and serum 25-Hydroxyvitamin D levels in patients with cataracts

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Min-Chul Cho ◽  
Rock-Bum Kim ◽  
Ja-Young Ahn ◽  
Woong-Sun Yoo ◽  
Seong-Jae Kim
Keyword(s):  
Vitamin D ◽  
Regression Analysis ◽  
Aqueous Humor ◽  
Linear Regression Analysis ◽  
Senile Cataract ◽  
Multivariate Linear Regression Analysis ◽  
Diabetic Cataract ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D

Abstract Background Serum 25-hydroxyvitamin D (25 (OH) D) levels are associated with various pathologic ocular conditions. Few studies have assessed 25 (OH) D concentrations in non-serum specimens, and none to date has assessed 25 (OH) D concentrations in human aqueous humor and their association with ocular diseases. This study investigated the possible correlations between 25 (OH) D concentrations in aqueous humor and serum and whether vitamin D concentrations in aqueous humor were associated with cataract. Methods This study prospectively enrolled 136 patients, including 87 with senile cataract and 49 with diabetic cataract, who underwent cataract surgery from January to November 2017. 25 (OH) D was measured in aqueous humor and serum specimens collected from all patients, and their correlation was analyzed statistically. Clinical and laboratory data, including the results of ophthalmologic examinations, were compared in the two groups of cataract patients. Results No correlation was observed between 25 (OH) D concentrations in aqueous humor and serum (P = 0.381). 25 (OH) D concentrations in aqueous humor were significantly higher in patients with diabetic than senile cataract (P = 0.006). Multivariate logistic regression analysis showed that the adjusted odds ratio for diabetic cataract for the highest compared with the lowest quartile of 25 (OH) D concentration in aqueous humor was 4.36 ng/ml (95% confidence interval [CI]: 1.33–14.34 ng/ml; P = 0.015). Multivariate linear regression analysis showed that 25(OH) D concentration in aqueous humor was 2.68 ng/ml (95% CI: 0.34–5.01 ng/ml; P = 0.025) higher in patients with diabetic than senile cataract. Conclusions 25(OH) D concentrations in aqueous humor and serum did not correlate with each other. Higher 25(OH) D level in aqueous humor was associated with diabetic cataract. These findings suggest that studies of vitamin D levels in patients with ocular conditions should include measurements of vitamin D levels in aqueous humor.

scholarly journals Prevalence of vitamin D deficiency and association with parathyroid hormone

2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Alejandro José Ravelo Marrero ◽  
Carlos Antonio Guillén Astete ◽  
Miriam Menacho Román ◽  
Marta Rosillo Coronado ◽  
José Manuel Del Rey Sánchez ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Parathyroid Hormone ◽  
Linear Regression Analysis ◽  
Multiple Logistic Regression Analysis ◽  
Kidney Injury ◽  
Factors Affecting ◽  
Hydroxyvitamin D ◽  
Female Sex ◽  
Study Population ◽  
25 Hydroxyvitamin D

Abstract Objectives We evaluated the prevalence of 25-hydroxyvitamin D (25-(OH)D) deficiency in our setting according to season, sex, and age. We also studied the association with parathyroid hormone (PTH) levels. Methods The study population comprised all patients with requests for assessment of 25-(OH)D between January 1 and December 31, 2018, as registered in the database of the laboratory information system. Major exclusion criteria were pediatric samples (<18 years) and factors affecting 25-(OH)D and/or PTH levels (i.e., kidney injury, liver disease, PTH disorders). Results Among 33,601 patients (24,028 women, 9,573 men), the prevalence of 25-(OH)D deficiency was 48%. Prevalence was greater in males than in females (53% vs. 46%). By age group, deficiency was more prevalent in quartile 1 (Q1, 74–87 years) and less prevalent in quartile 2 (Q2, 60–73 years). By season, deficiency was greater in spring (nonsignificant differences with respect to winter) and lower in summer. The association between 25-(OH)D and PTH was assessed in 9,368 persons. Linear regression analysis showed a weak association (coefficient – 0.303). Multiple logistic regression analysis revealed a significant association between 25-(OH)D deficiency and increased PTH (Odds ratio (OR), 1.63). Other risk factors for increased PTH include female sex (OR, 1.27), season (winter, OR 1.63, spring OR 1.16), and age (quartile 1, OR, 3). Conclusions The prevalence of 25-(OH)D deficiency differed according to sex, age, and season of the year. Furthermore, elevation of PTH is mainly influenced by low 25-(OH)D, female sex, season, and age.

Prevalence and Predictors of Fruit Intake Among Community College Women in the Extended Opportunity Program and Services

2003 ◽  
Vol 1 (1) ◽  
pp. 91-102 ◽  
Author(s):  
Steve E. Shive ◽  
Michelle R. Neyman
Keyword(s):  
Community College ◽  
Weight Loss ◽  
Regression Analysis ◽  
College Women ◽  
Linear Regression Analysis ◽  
Good Health ◽  
Fruit Intake ◽  
Attitudes And Behaviors ◽  
Eating Fruit ◽  
Opportunity Program

This study examined fruit intake among 276 female Extended Opportunity Program and Services (EOPS) community college students. Knowledge, attitudes, and behaviors associated with fruit intake were determined. The attitudes which are potential predictors of daily fruit intake were also examined. Analysis showed that 33% ate fewer than the minimum recommended two daily servings of fruit. Students reported that fruit gave them energy, taste and cost were not barriers to consumption and that it would not be difficult to increase daily fruit consumption. A linear regression analysis revealed that beliefs that eating fruit leads to good health, having a habit of eating fruit, feeling energy, and weight loss accounted for 30% of the variance in fruit intake.

ANALISIS PENGARUH INFLASI, KURS DAN IHSG TERHADAP RETURN REKSA DANA SAHAM PT NIKKO SECURITIES INDONESIA PERIODE 2014-2017

2019 ◽  
Vol 2 (2) ◽  
pp. 103
Author(s):  
Muhammad Rois Rois ◽  
Manarotul Fatati Fatati ◽  
Winda Ihda Magfiroh
Keyword(s):  
Regression Analysis ◽  
Exchange Rate ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Stock Price ◽  
Price Index ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Equity Fund ◽  
Stock Price Index

This study aims to determine the effect of Inflation, Exchange Rate and Composite Stock Price Index (IHSG) to Return of PT Nikko Securities Indonesia Stock Fund period 2014-2017. The study used secondary data obtained through documentation in the form of PT Nikko Securities Indonesia Monthly Net Asset (NAB) report. Data analysis is used with quantitative analysis, multiple linear regression analysis using eviews 9. Population and sample in this research are PT Nikko Securities Indonesia. The result of multiple linear regression analysis was the coefficient of determination (R2) showed the result of 0.123819 or 12%. This means that the Inflation, Exchange Rate and Composite Stock Price Index (IHSG) variables can influence the return of PT Nikko Securities Indonesia's equity fund of 12% and 88% is influenced by other variables. Based on the result of the research, the variables of inflation and exchange rate have a negative and significant effect toward the return of PT Nikko Securities Indonesia's equity fund. While the variable of Composite Stock Price Index (IHSG) has a negative but not significant effect toward Return of Equity Fund of PT Nikko Securities Indonesia

Struktur Organisasi, Desain Kerja, Budaya Organisasi Dan Pengaruhnya Terhadap Produktivitas Karyawan Studi Kasus Pada PT. XX Di Jakarta

Liquidity ◽  
2018 ◽  
Vol 1 (2) ◽  
Author(s):  
Yanti Budiasih
Keyword(s):  
Organizational Culture ◽  
Regression Analysis ◽  
Linear Regression ◽  
Organizational Structure ◽  
Research Method ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Job Design ◽  
Employee Productivity ◽  
Dominant Influence

The objectives of this study are to analyze changes in organizational structure, job design, organizational culture and its influence on employee productivity at PT. XX in Jakarta and to identify variables that have a dominant influence on the productivity of employees. The research method used is using multiple linear regression analysis. The results show that the all variables simultaneously and partially change the organizational structure, job design, and organizational culture has a significant impact on employee productivity at PT. XXin Jakarta.

The Contribution of Sexual Identity Towards the Students’ Perception of Lesbian, Gay, Bisexual, and Transgender

10.32698/0642 ◽  
2019 ◽  
Vol 2 (2) ◽  
pp. 120
Author(s):  
Wiwi Delfita ◽  
Neviyarni S. ◽  
Riska Ahmad
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Sexual Identity ◽  
Student Perceptions ◽  
Undergraduate Students ◽  
Linear Regression Analysis ◽  
Sampling Technique ◽  
Simple Linear Regression ◽  
Simple Linear Regression Analysis ◽  
Bisexual And Transgender

Some students perceive lesbian, gay, bisexual, and transgender (LGBT) positively, even though LGBT is a sexual deviation that is not appropriate with values and norms. There are several factors that influence an individual's perception of LGBT, including sexual identity. This study aims at looking at the contribution of sexual identity to student perceptions about LGBT. This research used a quantitative approach with a descriptive method and a simple linear regression analysis. The sample of this research was 385 taken from 15.752 undergraduate students of Universitas Negeri Padang which the sample was drawn by using the Slovin formula and continued with a Proportional Random Sampling technique. The instrument used was the Guttman model's sexual identity scale and the scale of students' perceptions of the LGBT Likert model. After analyzing the data with the descriptive technique and the simple linear regression analysis, the results showed that sexual identity significantly contributed to the students' perceptions of LGBT. This research has implications as a basis for counselors to help students avoid sexual identity mismatches and prevent the emergence of positive perceptions of LGBT.

Pengaruh Kepemimpinan dan Disiplin Kerja Terhadap Kinerja Karyawan: Studi Kasus PT Sucofindo Palembang Indonesia

MBIA ◽  
2019 ◽  
Vol 18 (1) ◽  
pp. 76-84
Author(s):  
Muhammad Idris ◽  
Dian Novita Sari
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Random Sampling ◽  
Linear Regression Analysis ◽  
Secondary Data ◽  
Multiple Linear Regression Analysis ◽  
Primary Data ◽  
Collection Method ◽  
Analysis Techniques ◽  
Analysis Technique

The problem in this study is whether there is an influence of leadership and work discipline on the employees’ performance of PT.Sucofindo Palembang City. This research includes associative research. The sample in this study were 88 respondents, with propotionate random sampling analysis technique. The data used were primary data and secondary data. Data collection method through questionnare. Analysis techniques using multiple linear regression analysis, F test (Simultaneoys) and t test (partial) and determination coeffiecient. The results show that there is influence of leadership and work discipline on the performance of PT.Sucofindo Palembang City.

PENGARUH KUALITAS PRODUK DAN RELIGIUSITAS TERHADAP KEPUTUSAN NASABAH PRODUK SIMPANAN PADA BSM CABANG PURWOKERTO

2017 ◽  
Vol 4 (1) ◽  
pp. 189-215
Author(s):  
Yoiz Shofwa Shafrani
Keyword(s):  
Regression Analysis ◽  
Product Quality ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Analytical Tool ◽  
The Other ◽  
Financial Assets ◽  
Islamic Bank

Perkembangan dunia perbankan syariah tidak lepas dari peran para nasabah yang memberikan kepercayaan terhadap pihak perbankan untuk penyimpanan asset keuangannya. Faktanya banyak kelompok nasabah yang memutuskan untuk menjadi nasabah di perbankan syariah karena faktor religiusitasnya. Faktor lain yang dapat ikut mempengaruhi keputusan nasabah adalah kualitas produk. Di mana kualitas produk merupakan karakteristik yang melekat dari suatu produk. Kemungkinan yang terjadi bahwa kebanyakan nasabah pada perbankan syariah juga masih merupakan nasabah perbankan konvensional.Tujuan yang ingin dicapai dalam penelitian ini adalah untuk mengetahui pengaruh kualitas produk dan tingkat religiusitas nasabah terhadap keputusan nasabah untuk menyimpan dananya atau tidak di BSM Cabang Purwokerto. Alat analisis yang digunakan adalah analisis regresi linier berganda, dengan jumlah sampel 100 nasabah. Diperoleh hasil Y = 5,046 + 0,101X1 + 0,218X2. Berdasarkan uji F yang sudah dilakukan maka dapat diketahui bahwa variabel kualitas produk dan religiusitas secara bersama – sama berpengaruh terhadap keputusan nasabah untuk menyimpan dananya di BSM Cabang Purwokerto. Berdasarkan uji t yang sudah dilakukan dapat diketahui bahwa secara partial baik variabel kualitas produk maupun variabel religiusitas berpengaruh terhadap keputusan nasabah untuk menyimpan dananya di BSM Cabang Purwokerto. The progress of the Islamic bank cannot be separated from the role of its customers who give trust to the bank to deposit their financial assets. It is a fact many groups of customers decide to be the customers of the Islamic bank because of their religiosity. The other influences factor of a customer’s decision is the quality of the product. The aim of this research was to determine the effect of product quality and level of customers’ religiosity towards customers’ decision whether to keep their funds in Syariah Mandiri Bank, Branch of Purwokerto, or not. The analytical tool used was multiple linear regression analysis, with a sample of 100 customers. The results indicate Y = 5,046 + 0,101X1 + 0,218X2. Based on F, it can be seen that both variables of product quality and religiosity simultanously affect the customers’ decision to keep theirfunds in BSM Branch of Purwokerto. Based on t test, it can be seen that independently, either variable of product quality or variables of religiosityinfluences the customers’ decision to keep their funds in BSM Branch of Purwokerto.

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