MO224VCAM-1 LEVELS ASSOCIATED WITH ALBUMINURIA IN MULTIBACILLARY LEPROSY

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Louise Donadello Tessarolo ◽  
Gdayllon Cavalcante Meneses ◽  
Gabriela Freire Bezerra ◽  
Geraldo Bezerra da Silva Junior ◽  
Elizabeth De Francesco Daher ◽  
...  
Keyword(s):  
Clinical Care ◽  
Epidemiological Data ◽  
Skin Lesions ◽  
Cross Sectional Study ◽  
Vascular Involvement ◽  
Clinical Aspects ◽  
Cross Sectional ◽  
Leprosy Patients ◽  
Duration Of Disease ◽  
Multibacillary Leprosy

Abstract Background and Aims Leprosy may present important renal and endothelial abnormalities, and this can worse patients’ prognosis. However, renal and vascular involvement in these patients has been poor investigated. The aim of this study was to investigate if higher systemic endothelial biomarkers levels are associated with renal abnormalities and clinical aspects of leprosy. Method This is a cross-sectional study with leprosy patients before initiation of multidrug therapy enrolled in January 2017 to December 2018 in Fortaleza, northeast Brazil. Leprosy-associated clinical and epidemiological data were collected. Two groups were constructed: Paucibacillary (PB) and Multibacillary (MB) for comparisons. Serum and urine samples were obtained for laboratory analysis. In urine the following parameters were evaluated: creatinine, proteinuria and albuminuria. In serum the endothelial biomarkers were evaluated: VCAM-1 and ICAM-1, using ELISA assay. Results A total of 101 leprosy patients were included, with mean age of 48±15 years, and 71 (70%) were male. The multibacillary form occurred in 81 cases (80%), where 22 had a Virchowian form. VCAM-1 was elevated in MB group and was correlated with the bacteriological index (skin smear) (r = 0.372, p <0.01), duration of disease symptoms (r = 0.234, p = 0.04), and number of skin lesions ( r = 0.331, p <0.001). Moreover, in MB patients who presented albuminuria >15 mg/g of creatinine, VCAM-1 showed a significant correlation (r = 0.341, p <0.05) with increased albuminuria and improve the correlation with number of skin lesions (r = 0.653, p=0.003). Conclusion Multibacillary leprosy patients present high systemic levels of VCAM-1, associated with leprosy clinical features and increased albuminuria, an important marker of kidney disease progression. Further prospective studies are necessary to establish a cause-effect relation and evaluate the preventive role of these biomarkers, aiming to improve clinical care.

scholarly journals Clinical Characteristics of Ulcerative Colitis in Nepalese Population: Experience from a Tertiary Care Center TUTH, Kathmandu, Nepal

2015 ◽  
Vol 4 (1) ◽  
pp. 1-6
Author(s):  
Shaneel Harsh ◽  
Ananya Adhikari ◽  
Rahul Pathak ◽  
Prem K Khadga ◽  
Sashi Sharma
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Characteristics ◽  
Care Center ◽  
Tertiary Care ◽  
Epidemiological Data ◽  
Cross Sectional Study ◽  
Western World ◽  
Asian Countries ◽  
Cross Sectional ◽  
Duration Of Disease

Background and Aim: Rising incidence and prevalence of ulcerative colitis (UC) had been observed in Asian countries. We conducted a study in our center, aiming to describe the demographic and clinical characteristics of UC in Nepalese population.Method: This is a cross sectional study of patients with diagnosis of UC in our hospital from Feb 2014 to Jan 2015. The diagnosis of UC has to satisfy the internationally accepted criteria. All patients were Nepalese and Clinical and epidemiological data were obtained and analysed through SPSS version 20.Results: 60 patients were included in the study. Mean age at diagnosis was 34.6 years. Male had slight preponderance with M:F (1.06:1). Mean duration of disease at diagnosis was 3.7 years. 83% had rectal bleed, Diarrhoea was seen in 77.3%, Tenesmus and Urgency in 70%, Mucus in stool was found in 65%, abdominal pain in 55%. 16.7% had weight loss and extraintestinal manifestations whereas fever was seen in 8.3%. In our patients 38.3% had ulcerative proctitis and 50% had left-sided UC, whereas 11.7% had extensive UC at presentation. The majority presented with mild (53.3%) or moderate (38.3%) disease activity, only 8.3% with severe disease.Conclusions: The peak age of UC was similar to other Western and Asian countries but second peak reported in western countries have not been seen in this study. This finding is similar to reports from East Asia. Similarly the proportion of patients with extra intestinal manifestations was low in our study as compared to studies reported from western world. Our study also showed that it takes longer to diagnose UC in Nepal. This might be related to the unawareness of the patients’ and lack of availability of the diagnostic resources.Journal of Nobel College of Medicine Vol.4(1) 2015: 1-5

scholarly journals Prevalence of dermatoses in adult migrant workers attending dermatology OPD in a tertiary care centre in Puducherry

2021 ◽  
Author(s):  
Bhavana Sampadarao ◽  
Govardhan J. Kumar ◽  
Damayandhi Kaliaperumal ◽  
Jude E. Dileep ◽  
Sucharita Sekar ◽  
...  
Keyword(s):  
Migrant Workers ◽  
Skin Diseases ◽  
Fungal Infections ◽  
Tertiary Care ◽  
Epidemiological Data ◽  
Skin Lesions ◽  
Cross Sectional Study ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Medical College

<p class="abstract"><strong>Background:</strong> Migrant workers are exposed to dangerous and unhygienic work environments, which puts them at risk of developing skin diseases. This study aims to assess the prevalence of skin diseases and provide epidemiological data regarding various dermatoses among migrant workers in Puducherry.</p><p class="abstract"><strong>Methods:</strong> This is a hospital-based, cross-sectional study conducted in Aarupadai Veedu Medical College and Hospital from August 2019 to February 2021. 350 migrant workers were randomly selected and examined for the prevalence of infective and non-infective dermatoses. The observations were documented and data were analyzed using statistical package for the social sciences (SPSS) version 22.<strong></strong></p><p class="abstract"><strong>Results:</strong> A total of 350 migrant workers were included in the study. Of most migrants, 90.9% (n=318) were males, while the remaining 9.1% (n=32) were females. The prevalence of infective dermatoses was found to be 76% (n=266) and the prevalence of non-infective dermatoses was 43.10% (n=151) in this study. Fungal infections are the most common infective dermatoses affecting 51.5% of the workers, followed by bacterial skin lesions in 27.4%.</p><p class="abstract"><strong>Conclusions:</strong> This study reveals a high prevalence of infective and non-infective dermatoses among migrant workers, with fungal infections being the most commonly occurring infective skin disease. Eczema was the commonly occurring non-infective dermatoses, according to this study.</p>

scholarly journals Downregulation of PHEX in multibacillary leprosy patients: observational cross-sectional study

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Sandra R. Boiça Silva ◽  
Ximena Illarramendi ◽  
Antonio J. Tempone ◽  
Pedro H. L. Silva ◽  
José A. C. Nery ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Leprosy Patients ◽  
Multibacillary Leprosy

scholarly journals Clinical and epidemiological profile of multiple sclerosis in a reference center in the State of Bahia, Brazil

2006 ◽  
Vol 64 (3b) ◽  
pp. 727-730 ◽  
Author(s):  
Eduardo Cardoso ◽  
Thiago Fukuda ◽  
Júlio Pereira ◽  
Jamile Seixas ◽  
Rafael Miranda ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Epidemiological Data ◽  
Cross Sectional Study ◽  
The State ◽  
Clinical Aspects ◽  
Cross Sectional ◽  
Relapsing Remitting ◽  
The Central Nervous System ◽  
Epidemiological Profile ◽  
Worse Prognosis

Multiple sclerosis (MS) is an autoimmune, demyelinating and degenerative disease that affects the central nervous system. Its prevalence and clinical aspects vary according to the continent considered, being more frequent in Caucasians and young individuals aged 20 to 40 years. Epidemiological data from Brazil show that prevalence is variable, being more frequent in the Southern and Southeastern areas of the country, rather than in the Northern and Northeastern areas. The purpose of this paper is to describe MS clinical and epidemiological features in the State of Bahia, in the Brazilian Northeastern region. Thus, we held a cross-sectional study over the period from February to May, 2005, in the Multiple Sclerosis Patient Support Center ("Núcleo de Apoio aos Pacientes com Esclerose Múltipla") of Bahia, which included all patients with a diagnosis of MS seen over this period of time. A total of 121 patients were investigated, being 80.2% females (female:male ratio=4:1), with higher frequency in mulatto individuals (64%), and the relapsing-remitting type (91.3%). Most patients (68.7%) had mild MS, and blacks were prone to worse prognosis compared to other patients.

scholarly journals University students’ knowledge and attitudes towards leprosy

2013 ◽  
Vol 7 (09) ◽  
pp. 658-664 ◽  
Author(s):  
Omar Graciano-Machuca ◽  
Erandi Enif Velarde-de la Cruz ◽  
Maria Guadalupe Ramirez-Dueñas ◽  
Anabell Alvarado-Navarro
Keyword(s):  
Negative Attitude ◽  
Skin Lesions ◽  
Cross Sectional Study ◽  
Leprosy Patient ◽  
Educational Strategies ◽  
Cross Sectional ◽  
Negative Attitudes ◽  
Knowledge And Attitudes ◽  
Leprosy Patients ◽  
The University

Introduction: Patients with leprosy may be affected psychologically and socially by the negative attitude of society toward leprosy, caused by widespread ignorance and prevailing stereotypes surrounding the disease. This study aimed to determine the knowledge and attitudes toward leprosy among students at the University of Guadalajara. Methodology: This descriptive cross-sectional study included 1,300 students over 18 years of age from various Thematic University Centres in Guadalajara. Students’ degree subjects included the health sciences, humanities, exact sciences (i.e., chemistry, physics), arts, biological-agricultural sciences, and administration. Students were randomly selected regardless of gender and all students were enrolled in either the first, second, or third year of their undergraduate studies. Results: Overall, students showed an intermediate level of knowledge of leprosy. Results showed that 67% correctly responded that leprosy is an infectious disease, 64% knew of the presence of skin lesions, and 60% knew that a microbe causes the disease. Furthermore, 45% correctly responded that leprosy is a disease associated with poverty and 40% responded that leprosy is disabling. Only 31% stated that leprosy is curable. Negative attitudes were evident regarding the question of employing a leprosy patient (57%) and having a leprosy patient as a spouse or partner (30%). Discussion: The results revealed that there is insufficient knowledge of and poor attitudes toward leprosy among students at the University of Guadalajara. It is necessary to improve current health education measures by using updated educational strategies to reduce the stigma of leprosy and the segregation of leprosy patients and their families.

Suppurative Infections in Hospitalized Patients – An Ongoing MRSA Threat

2020 ◽  
Author(s):  
Sadaf Razzak
Keyword(s):  
Staphylococcus Aureus ◽  
Medical Science ◽  
Great Influence ◽  
Antibiotic Sensitivity ◽  
Skin Lesions ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Inducible Clindamycin Resistance ◽  
Empiric Antibiotic ◽  
Medical Wards

Background: Penicillin resistance among Staphylococcus aureus commonly encountered in the hospital admitted patients. Detection of antibiotic sensitivity in hospital acquired methicillin resistant Staphylococcus aureus infections is important as it has great influence on empiric antibiotic prescription, successful control of infection, prevention of spread of disease and successful patient management. This study aimed to detect the frequency of HA-MRSA from pus samples in a hospital setup with assessment of their antibiotic susceptibility patterns. Method: A cross-sectional study was conducted in the Microbiology department of Basic Medical Science Institute, JPMC, Karachi from January 2015 until December 2015. Pus samples from surgical site wounds, skin lesions, abscesses from surgical and medical wards and ICUs were collected. According to the standards given by CLSI 2014, MRSA testing of the samples was done and susceptibility testing for antibiotics was performed. Inducible clindamycin resistance was detected by D-Test; E Test. determined MIC (minimum inhibitory concentration) for vancomycin. The data was analyzed by SPSS version 16. Result: Out of the 149 MRSA identified from the pus samples, 106 (71.14%) samples were HA-MRSA. The number of male patients was more than the female patients (67.66%). Out of the 106 HA-MRSA, 91(85.8%) were sensitive to TMP/SMX, 98(92.5%) to rifampicin, 12(11.6%) to gentamicin, 85(80.2%) to tetracycline, 11(10.4%) to erythromycin, 37(34.9%) to clindamycin, 20(18.9%) to ciprofloxacin, 106 (100%) to both vancomycin and linezolid. Conclusion: HA-MRSA showed sensitivity to TMP/SMX and vancomycin making them effective drugs to use in combination in superficial infections. The drug linezolid also showed 100% sensitivity.

scholarly journals Breathlessness and opioid prescribing in COPD in general practice: a cross-sectional, observational study

2020 ◽  
Vol 6 (2) ◽  
pp. 00299-2019
Author(s):  
David C. Currow ◽  
Miriam J. Johnson ◽  
Allan Pollack ◽  
Diana H. Ferreira ◽  
Slavica Kochovska ◽  
...  
Keyword(s):  
General Practice ◽  
Clinical Care ◽  
Cross Sectional Study ◽  
Prescribing Patterns ◽  
Pain Patient ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Opioid Prescription ◽  
Obstructive Pulmonary Disease ◽  
Health Database

Chronic breathlessness is a disabling syndrome, prevalent in people with advanced chronic obstructive pulmonary disease (COPD). Regular, low-dose, oral sustained-release morphine is approved in Australia to reduce symptomatic chronic breathlessness. We aimed to determine the current prescribing patterns of opioids for chronic breathlessness in COPD in Australian general practice and to define any associated patient and practitioner characteristics.Five years (2011 to 2016) of the Bettering the Evaluation and Care of Health database, an Australian national, continual, cross-sectional study of clinical care in general practice were used. The database included 100 consecutive clinical encounters from almost 1000 general practitioners annually (n=488 100 encounters). Descriptive analyses with subsequent regression models were generated.Breathlessness as a patient-defined reason for encounter was identified in 621 of 4522 encounters where COPD was managed. Opioids were prescribed in 309 of 4522 encounters where COPD was managed (6.8%; (95% CI) 6.1–7.6), of which only 17 were prescribed for breathlessness, and the rest for other conditions almost entirely related to pain. Patient age (45–64 years versus age 80+ years, OR 1.68; 1.19–2.36), Commonwealth Concession Card holders (OR 1.70; 1.23–2.34) and socioeconomic disadvantage (OR 1.30; 1.01–1.68) were associated with increased likelihood of opioid prescription at COPD encounters. The rate of opioid prescriptions rose over the 5 years of study.In primary care encounters for COPD, opioids were prescribed in 6.8% of cases, but almost never for breathlessness. These data create a baseline against which to compare changes in prescribing as the treatment of chronic breathlessness evolves.

scholarly journals Analysis of the relationship between periodontitis and osteoporosis/fractures: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Seok-Jin Hong ◽  
Byoung-Eun Yang ◽  
Dae-Myoung Yoo ◽  
Sung-Jae Kim ◽  
Hyo-Geun Choi ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Bone Destruction ◽  
Epidemiological Data ◽  
Income Group ◽  
Cross Sectional Study ◽  
Inflammatory Factors ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
History Of

Abstract Background Chronic periodontitis is a multifactorial inflammatory disease resulting in patients exhibiting high levels of inflammatory factors causing systemic inflammatory bone destruction that may lead to osteoporosis development. The association between periodontitis and osteoporosis has been documented; however, the findings remain unclear. This study aimed to identify the association between periodontitis and osteoporosis using a cross-sectional study design and Korean Genome and Epidemiology Study (KoGES) health examinee data. Methods This cross-sectional study used epidemiological data from the KoGES during 2004–2016. Of 125,324 participants (age, 40–79 years), 9969 with periodontitis and 115,332 controls (without periodontitis) were selected. We analyzed the history of osteoporosis and fractures of all participants. All participants were examined according to age, sex, income group, obesity, smoking habits, alcohol consumption, and food intake. To analyze the odds ratio (OR) of periodontitis for those with osteoporosis and fractures, a logistic regression model was used. Results The adjusted odds ratio (aOR) of periodontitis for osteoporosis was 2.16 (95% confidence interval [CI], 2.01–2.31; P < 0.001). The aOR of periodontitis for any fracture was 1.54 (95% CI 1.46–1.62; P < 0.001). Conclusion Osteoporosis and fractures are associated with periodontitis. Performing regular oral hygiene and examinations of bone mineral density are recommended to prevent aggravation of osteoporosis and periodontitis.

scholarly journals PREVALENCE OF BRUCELLOSIS IN BLACK BENGAL GOATS IN BANGLADESH

2013 ◽  
Vol 10 (1-2) ◽  
pp. 51-56 ◽  
Author(s):  
M. S. Rahman ◽  
S. Mithu ◽  
M. T. Islam ◽  
M. J. Uddin ◽  
R. R. Sarker ◽  
...  
Keyword(s):  
Epidemiological Data ◽  
Economic Loss ◽  
Cross Sectional Study ◽  
Confirmatory Test ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
Significant Economic Loss ◽  
Sera Samples ◽  
Structured Questionnaire

Brucellosis is an important bacterial zoonotic disease causing significant economic loss in dairy industries worldwide including Bangladesh. But limited studies are devoted to determine the prevalence of brucellosis in goat in all districts of Bangladesh. Therefore, a cross-sectional study was undertaken to determine the seroprevalence of brucellosis in Black Bengal goats in Nilphamari Sadar and Kishoreganj upazillas of Nilphamari district of Bangladesh using Rose Bengal Test (RBT) as screening test and I-ELISA as confirmatory test. A total of 154 sera samples from Black Bengal goats were collected from Nilphamari district. Epidemiological data on the selected Black Bengal goats were collected using a structured questionnaire. The overall seroprevalence of brucellosis was found to be 2.59% in Black Bengal goats. A significantly (p<0.01) higher prevalence of brucellosis was found in Black Bengal goats with the history of previous abortion (33.33%). An insignificant (p>0.05) but higher prevalence of brucellosis was found in adult Black Bengal goats (>24 months) than young. The prevalence was relatively higher in cross-bred than pure Black Bengal goats, in female than male and in pregnant than non-pregnant Black Bengal goats. The result of the study will provide baseline data for control of brucellosis in goat in Bangladesh.DOI: http://dx.doi.org/10.3329/bjvm.v10i1-2.15646

Women’s attitude toward gynecological pain in fertile age: Results from a cross-sectional study among Italian community pharmacies

2018 ◽  
Vol 10 (2) ◽  
pp. 88-94
Author(s):  
Corrado Giua Marassi ◽  
Assunta Pistone ◽  
Fabio Parazzini ◽  
Silvia Vannuccini ◽  
Felice Petraglia
Keyword(s):  
Medical Treatment ◽  
Pelvic Pain ◽  
Epidemiological Data ◽  
Cross Sectional Study ◽  
Community Pharmacies ◽  
Sectional Study ◽  
Self Medication ◽  
Cross Sectional ◽  
Mean Delay ◽  
Italian Community

Introduction: Several epidemiological data on women afferent to clinics for medical treatment of pelvic pain are available, while few studies explored the general population. Thus, this study aimed to investigate women presenting with gynecological pain at the community pharmacy and to evaluate the relevance of pharmacist advice regarding medical treatment. Methods: A cross-sectional study was conducted in a sample of 10 Italian community pharmacies, by administering a structured questionnaire to fertile age women reporting pelvic pain during the last 3 months. Questions were concerning demographic information, pain characteristics, women’s behavior toward gynecological pain, and diagnosis possibly received from a physician. Results: A group of 290 women were interviewed. Severe pain was reported in 58.3%, with a mean ± SD of 4.4 ± 6.8 days of suffering, causing absenteeism from work in 45.3% of cases. Almost half of women reported that the onset of gynecological pain was before 15 years and 72.2% had consulted a physician in the past, with a mean delay of 2.5 ± 4.3 years between the onset of pain and medical consultation. However, only 28% of the overall population received a diagnosis. 51.0% received one treatment, while 39% received two or more. The first therapy was prescribed in 40.2% cases by the physician, while in the remaining it was recommended either by the pharmacist or it was a self-medication. Conclusion: Gynecological pelvic pain is a disabling problem, regardless of the underlying cause, with significant impact on social and working life and requiring a better medical management.

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