MP034CLARIFY THE INTRACELLULAR STRESS RESPONSE IN EARLY-STAGE ALPORT SYNDROME AND ESTABLISH AN EVALUATION SYSTEM FOR INTRACELLULAR REGULATION OF COL4A5

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i354-i354
Author(s):  
Kohei Omachi ◽  
Misato Kamura ◽  
Keisuke Teramoto ◽  
Haruka Kojima ◽  
Mary Ann Suico ◽  
...  
Publications ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 14
Author(s):  
Eirini Delikoura ◽  
Dimitrios Kouis

Recently significant initiatives have been launched for the dissemination of Open Access as part of the Open Science movement. Nevertheless, two other major pillars of Open Science such as Open Research Data (ORD) and Open Peer Review (OPR) are still in an early stage of development among the communities of researchers and stakeholders. The present study sought to unveil the perceptions of a medical and health sciences community about these issues. Through the investigation of researchers` attitudes, valuable conclusions can be drawn, especially in the field of medicine and health sciences, where an explosive growth of scientific publishing exists. A quantitative survey was conducted based on a structured questionnaire, with 179 valid responses. The participants in the survey agreed with the Open Peer Review principles. However, they ignored basic terms like FAIR (Findable, Accessible, Interoperable, and Reusable) and appeared incentivized to permit the exploitation of their data. Regarding Open Peer Review (OPR), participants expressed their agreement, implying their support for a trustworthy evaluation system. Conclusively, researchers need to receive proper training for both Open Research Data principles and Open Peer Review processes which combined with a reformed evaluation system will enable them to take full advantage of the opportunities that arise from the new scholarly publishing and communication landscape.


2017 ◽  
Vol 14 (2) ◽  
pp. 99 ◽  
Author(s):  
Sharifah Masniah Wan Masra ◽  
K. L. Goh ◽  
Mohd Saufee Muhammad ◽  
Rahardjo Darmanto Djojodibroto ◽  
Rohana Sapawi ◽  
...  

This paper presents the development of a Graphical User Interface (GUI) for calculating the sum of nail-fold (NF) and distal interphalangeal joint (DIP) ratios for all ten fingers. The sum of NF:DIP ratios for all ten fingers leads to the Digital Index (DI) that was used as the measure for identifying and determining the presence of finger clubbing symptom. This GUI system was developed to serve as a simple and user-friendly interface for clinicians to calculate DI value of patients in a busy clinic practice. It is also equipped with the capability to keep the patient’s past diagnosis medical check-up data for future monitoring purposes. The result shows that the developed system helps the clinicians to perform calculation of DI value and identify the presence of finger clubbing in a very short time. The average time taken to measure both NF and DIP circumferences using Finger Clubbing Meter, and to compute DI values using Digital Index Evaluation System (DIES) interface is 6:36 ± 1:24 minutes (Mean ± SD) .This system is expected to contribute in detecting the finger clubbing problem at early stage of so the treatment can be performed immediately.


2020 ◽  
Vol 26 (6) ◽  
pp. 514-527
Author(s):  
Jiabao Li ◽  
Ziren Tang ◽  
Miaorong Xie ◽  
Chenchen Hang ◽  
Yanan Yu ◽  
...  

This study aimed to investigate the possible relationship between the two biomarkers presepsin and procalcitonin (PCT) and monocyte immune function, and to explore their combination in mortality prediction in the early stage of sepsis. A total of 198 patients with bacterial infection and diagnosed with sepsis and 40 healthy control subjects were included. Blood samples were collected on admission within 24 h. Plasma concentrations of presepsin and PCT were measured. Expression of monocyte surface CD14, programmed cell death receptor ligand-1 (PD-L1) and human leucocyte Ag (HLA)-DR were determined using flow cytometry. Levels of plasma presepsin and PCT were significantly higher under septic conditions, and increased with the progression of sepsis. Monocyte CD14 and HLA-DR expression were decreased, while PD-L1 was overexpressed in sepsis compared to control. Presepsin and PCT concentrations were positively correlated with Sequential Organ Failure Assessment score, Acute Physiology and Chronic Health Evaluation System II score and PD-L1, while they were negatively correlated with CD14 and HLA-DR. Presepsin plus monocyte HLA-DR mean fluorescence intensity had the highest prognostic value over other parameters alone or in combination. Presepsin and PCT had a weak correlation with monocyte dysfunction during early sepsis. The combination of presepsin and monocyte HLA-DR could help improve prognostic value.


PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0207949 ◽  
Author(s):  
Margita Márton ◽  
Nikolett Tihanyi ◽  
Pál Gyulavári ◽  
Gábor Bánhegyi ◽  
Orsolya Kapuy

Sign in / Sign up

Export Citation Format

Share Document